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Select item 111583431.

MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients

Radek Lakomy, Jiri Sana, Simona Hankeova, Pavel Fadrus, Leos Kren, Eva Lzicarova, Marek Svoboda, Hana Dolezelova, Martin Smrcka, Rostislav Vyzula, Jaroslav Michalek, Marian Hajduch, Ondrej Slaby

Cancer Sci. 2011 Dec; 102(12): 2186–2190. Published online 2011 Oct 12. doi: 10.1111/j.1349-7006.2011.02092.x

PMCID:: PMC11158343

Abstract Article PDF–216K

Select item 108481062.

Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O⁶‐methylguanine‐DNA methyltransferase gene in glioblastoma

Xi Chen, Jinli Sun, Yukui Li, Weichao Jiang, Zhangyu Li, Jianyao Mao, Liwei Zhou, Sifang Chen, Guowei Tan

CNS Neurosci Ther. 2024 Feb; 30(2): e14415. Published online 2023 Aug 28. doi: 10.1111/cns.14415

PMCID:: PMC10848106

Abstract Article PDF–14M

Select item 108241253.

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression

Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, Shunsaku Takayanagi, Nobuhito Saito, Kazuhiro Kakimi

Front Immunol. 2024; 15: 1328375. Published online 2024 Jan 15. doi: 10.3389/fimmu.2024.1328375

PMCID:: PMC10824125

Abstract Article PDF–6.4M

Select item 108040264.

Preferential MGMT hypermethylation in SDH-deficient wild-type GIST

Olivier T Giger, Rogier ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey

J Clin Pathol. 2024 Jan; 77(1): 34–39. Published online 2022 Oct 5. doi: 10.1136/jcp-2022-208462

PMCID:: PMC10804026

Abstract Article PDF–458K

Select item 107794845.

Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma

Fábio França Vieira e Silva, Marina Di Domenico, Vito Carlo Alberto Caponio, Mario Pérez-Sayáns, Gisela Cristina Vianna Camolesi, Laura Isabel Rojo-Álvarez, Andrea Ballini, Abel García-García, María Elena Padín-Iruegas, Jose Manuel Suaréz-Peñaranda

Int J Mol Sci. 2024 Jan; 25(1): 612. Published online 2024 Jan 3. doi: 10.3390/ijms25010612

PMCID:: PMC10779484

Abstract Article PDF–1.9M

Select item 107316596.

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O⁶-Alkylguanine Adductome

Rasha Abdelhady, Pattama Senthong, Claire E. Eyers, Onrapak Reamtong, Elizabeth Cowley, Luca Cannizzaro, Joanna Stimpson, Kathleen Cain, Oliver J. Wilkinson, Nicholas H. Williams, Perdita E. Barran, Geoffrey P. Margison, David M. Williams, Andrew C. Povey

Chem Res Toxicol. 2023 Dec 18; 36(12): 1921–1929. Published online 2023 Nov 20. doi: 10.1021/acs.chemrestox.3c00207

PMCID:: PMC10731659

Abstract Article PDF–3.4M

Select item 106238467.

Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results

Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski

Acta Neuropathol Commun. 2023; 11: 175. Published online 2023 Nov 2. doi: 10.1186/s40478-023-01680-0

PMCID:: PMC10623846

Abstract Article PDF–2.3M

Select item 103227688.

Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status

Jonathan Weller, Sophie Katzendobler, Sebastian Niedermeyer, Patrick N. Harter, Jochen Herms, Christoph Trumm, Maximilian Niyazi, Niklas Thon, Joerg-Christian Tonn, Veit M. Stoecklein

J Neurooncol. 2023; 163(2): 407–415. Published online 2023 Jun 8. doi: 10.1007/s11060-023-04362-y

PMCID:: PMC10322768

Abstract Article PDF–1.3M

Select item 102973099.

Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma

Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit Cichna-Markl

Cells. 2023 Jun; 12(12): 1639. Published online 2023 Jun 15. doi: 10.3390/cells12121639

PMCID:: PMC10297309

Abstract Article PDF–8.0M

Select item 1019693210.

Association of MGMT Promoter Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy

Connor J. Kinslow, Ann Mercurio, Prashanth Kumar, Ali I. Rae, Markus D. Siegelin, Jack Grinband, Kekoa Taparra, Pavan S. Upadhyayula, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter D. Canoll, Fabio M. Iwamoto, Lisa A. Kachnic, James B. Yu, Simon K. Cheng, Tony J. C. Wang

JAMA Oncol. 2023 Jul; 9(7): 919–927. Published online 2023 May 18. doi: 10.1001/jamaoncol.2023.0990

Correction in:: JAMA Oncol. 2023 Jul; 9(7): 1009.

PMCID:: PMC10196932

Abstract Article

Select item 1017011711.

MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens

Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki, Daisuke Asano, Shuichi Watanabe, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Shinji Tanaka, Minoru Tanabe

Sci Rep. 2023; 13: 7535. Published online 2023 May 9. doi: 10.1038/s41598-023-34666-y

PMCID:: PMC10170117

Abstract Article PDF–1.8M

Select item 1009452812.

Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide

Konstantin R. Brawanski, Susanne Sprung, Christian F. Freyschlag, Romana Hoeftberger, Thomas Ströbel, Johannes Haybaeck, Claudius Thomé, Claudia Manzl, Anna M. Birkl-Toeglhofer

Int J Mol Sci. 2023 Apr; 24(7): 6184. Published online 2023 Mar 24. doi: 10.3390/ijms24076184

PMCID:: PMC10094528

Abstract Article PDF–2.0M

Select item 965411413.

The Significance of MGMT Promoter Methylation Status in Diffuse Glioma

Nikola Jovanović, Milica Lazarević, Vladimir J. Cvetković, Vesna Nikolov, Jelena Kostić Perić, Milena Ugrin, Sonja Pavlović, Tatjana Mitrović

Int J Mol Sci. 2022 Nov; 23(21): 13034. Published online 2022 Oct 27. doi: 10.3390/ijms232113034

PMCID:: PMC9654114

Abstract Article PDF–2.8M

Select item 907248814.

MGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas

Tomohiro Hosoya, Masamichi Takahashi, Mai Honda-Kitahara, Yasuji Miyakita, Makoto Ohno, Shunsuke Yanagisawa, Takaki Omura, Daisuke Kawauchi, Yukie Tamura, Miyu Kikuchi, Tomoyuki Nakano, Akihiko Yoshida, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura, Yoshitaka Narita

J Neurooncol. 2022; 157(3): 561–571. Published online 2022 Apr 10. doi: 10.1007/s11060-022-03999-5

PMCID:: PMC9072488

Abstract Article PDF–2.1M

Select item 879013115.

Evaluation of MGMT Gene Methylation in Neuroendocrine Neoplasms

Rosa Della Monica, Mariella Cuomo, Roberta Visconti, Annabella di Mauro, Michela Buonaiuto, Davide Costabile, Giulia De Riso, Teodolinda Di Risi, Elia Guadagno, Roberto Tafuto, Sabrina Lamia, Alessandro Ottaiano, Paolo Cappabianca, Maria Laura Del Basso de Caro, Fabiana Tatangelo, Juergen Hench, Stephan Frank, Salvatore Tafuto, Lorenzo Chiariotti

Oncol Res. 2022; 28(9): 837–845. Published online 2022 Jan 31. doi: 10.3727/096504021X16214197880808

PMCID:: PMC8790131

Abstract Article PDF–583K

Select item 863621816.

MGMT gene promoter methylation in humoral tissue as biomarker for lung cancer diagnosis: An update meta‐analysis

Bizheng Chen, Xiaozhen Ying, Liming Bao

Thorac Cancer. 2021 Dec; 12(23): 3194–3200. Published online 2021 Oct 15. doi: 10.1111/1759-7714.14186

PMCID:: PMC8636218

Abstract Article PDF–1.2M

Select item 862140217.

Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the MGMT Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set

Katja Zappe, Christine Pirker, Heidi Miedl, Martin Schreiber, Petra Heffeter, Georg Pfeiler, Stefan Hacker, Werner Haslik, Sabine Spiegl-Kreinecker, Margit Cichna-Markl

Int J Mol Sci. 2021 Nov; 22(22): 12527. Published online 2021 Nov 20. doi: 10.3390/ijms222212527

PMCID:: PMC8621402

Abstract Article PDF–4.3M

Select item 846175218.

Identifying the optimal cutoff point for MGMT promoter methylation status in glioblastoma

Ngan Nguyen, Jordan Redfield, Matthew Ballo, Madison Michael, Jeffrey Sorenson, Daniel Dibaba, Jim Wan, Glenda Delgado Ramos, Manjari Pandey

CNS Oncol. 2021 Sep; 10(3): CNS74. Published online 2021 Sep 6. doi: 10.2217/cns-2021-0002

PMCID:: PMC8461752

Abstract Article PDF–900K

Select item 844471019.

MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence

Radhika Mathur, Yalan Zhang, Matthew R Grimmer, Chibo Hong, Michael Zhang, Saumya Bollam, Kevin Petrecca, Jennifer Clarke, Mitchel S Berger, Joanna J Phillips, Nancy Ann Oberheim-Bush, Annette M Molinaro, Susan M Chang, Joseph F Costello

Neuro Oncol. 2020 Nov; 22(11): 1580–1590. Published online 2020 Mar 13. doi: 10.1093/neuonc/noaa059

PMCID:: PMC8444710

Abstract Article PDF–7.8M

Select item 827999520.

Does positive MGMT methylation outbalance the limitation of subtotal resection in glioblastoma IDH-wildtype patients?

Müller Mareike, Staub-Bartelt Franziska, Ehrmann Julia, Hänggi Daniel, Sabel Michael, Felsberg Jörg, Rapp Marion

J Neurooncol. 2021; 153(3): 537–545. Published online 2021 Jun 29. doi: 10.1007/s11060-021-03794-8

PMCID:: PMC8279995

Abstract Article PDF–704K

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