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Select item 111157721.

Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines

Sheng-Ming Wu, Ya-Hui Huang, Yi-Hsin Lu, Ling-Fang Chien, Chau-Ting Yeh, Ming-Ming Tsai, Chen-Hsin Liao, Wei-Jan Chen, Chia-Jung Liao, Wan-Li Cheng, Kwang-Huei Lin

Cell Mol Life Sci. 2010 Jun; 67(11): 1831–1843. Published online 2010 Feb 10. doi: 10.1007/s00018-010-0281-2

PMCID:: PMC11115772

Abstract Article PDF–908K

Select item 87997352.

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

Lucía Barbier-Torres, Ben Murray, Jin Won Yang, Jiaohong Wang, Michitaka Matsuda, Aaron Robinson, Aleksandra Binek, Wei Fan, David Fernández-Ramos, Fernando Lopitz-Otsoa, Maria Luque-Urbano, Oscar Millet, Nirmala Mavila, Hui Peng, Komal Ramani, Roberta Gottlieb, Zhaoli Sun, Suthat Liangpunsakul, Ekihiro Seki, Jennifer E. Van Eyk, Jose M. Mato, Shelly C. Lu

Nat Commun. 2022; 13: 557. Published online 2022 Jan 28. doi: 10.1038/s41467-022-28201-2

PMCID:: PMC8799735

Abstract Article PDF–5.7M

Select item 72719473.

Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene

Jiraporn Panmanee, Svetlana V. Antonyuk, S. Samar Hasnain

Acta Crystallogr D Struct Biol. 2020 Jun 1; 76(Pt 6): 594–607. Published online 2020 May 29. doi: 10.1107/S2059798320006002

PMCID:: PMC7271947

Abstract Article PDF–3.6M

Select item 68292604.

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice

Kelly A. Martin, Nicholas R. Hum, Aimy Sebastian, Wei He, Salma Siddiqui, Paramita M. Ghosh, Chong-xian Pan, Ralph de Vere White, Gabriela G. Loots

Int J Mol Sci. 2019 Oct; 20(20): 4983. Published online 2019 Oct 9. doi: 10.3390/ijms20204983

PMCID:: PMC6829260

Abstract Article PDF–3.4M

Select item 45459305.

Mudd’s disease (MAT I/III deficiency): a survey of data for MAT1A homozygotes and compound heterozygotes

Yin-Hsiu Chien, Jose E. Abdenur, Federico Baronio, Allison Anne Bannick, Fernando Corrales, Maria Couce, Markus G. Donner, Can Ficicioglu, Cynthia Freehauf, Deborah Frithiof, Garrett Gotway, Koichi Hirabayashi, Floris Hofstede, George Hoganson, Wuh-Liang Hwu, Philip James, Sook Kim, Stanley H. Korman, Robin Lachmann, Harvey Levy, Martin Lindner, Lilia Lykopoulou, Ertan Mayatepek, Ania Muntau, Yoshiyuki Okano, Kimiyo Raymond, Estela Rubio-Gozalbo, Sabine Scholl-Bürgi, Andreas Schulze, Rani Singh, Sally Stabler, Mary Stuy, Janet Thomas, Conrad Wagner, William G. Wilson, Saskia Wortmann, Shigenori Yamamoto, Maryland Pao, Henk J. Blom

Orphanet J Rare Dis. 2015; 10: 99. Published online 2015 Aug 20. doi: 10.1186/s13023-015-0321-y

PMCID:: PMC4545930

Abstract Article PDF–1.2M

Select item 35332846.

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma

Heping Yang, Michele E. Cho, Tony W.H. Li, Hui Peng, Kwang Suk Ko, Jose M. Mato, Shelly C. Lu

J Clin Invest. 2013 Jan 2; 123(1): 285–298. Published online 2012 Dec 17. doi: 10.1172/JCI63861

PMCID:: PMC3533284

Abstract Article PDF–8.4M

Select item 31832717.

Inhibition of Human Methionine Adenosyltransferase 1A Transcription by Coding Region Methylation

Maria Lauda Tomasi, Tony W. H. Li, Mei Li, José M. Mato, Shelly C. Lu

J Cell Physiol. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: J Cell Physiol. 2012 Apr; 227(4): 1583–1591. doi: 10.1002/jcp.22875

PMCID:: PMC3183271

Abstract Article PDF–1.1M

Select item 31170508.

MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations

T. Huang, K. Tucker, Y. Lee, J. Crott, L. Parnell, J. Shen, C. Smith, J. Ordovas, D. Li, C. Lai

Nutr Metab Cardiovasc Dis. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Nutr Metab Cardiovasc Dis. 2012 Apr; 22(4): 362–368. Published online 2010 Dec 24. doi: 10.1016/j.numecd.2010.07.015

PMCID:: PMC3117050

Abstract Article PDF–635K

Select item 16840009.

Hepatic methionine adenosyltransferase deficiency in a 31-year-old man.

W A Gahl, J D Finkelstein, K D Mullen, I Bernardini, J J Martin, P Backlund, K G Ishak, J H Hoofnagle, S H Mudd

Am J Hum Genet. 1987 Jan; 40(1): 39–49.

PMCID:: PMC1684000

Summary Page Browse PDF–1.6M

Select item 113438610.

Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.

L Alvarez, F Corrales, A Martín-Duce, J M Mato

Biochem J. 1993 Jul 15; 293(Pt 2): 481–486. doi: 10.1042/bj2930481

PMCID:: PMC1134386

Summary Page Browse PDF–1.2M

Select item 50751811.

Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.

M E Chamberlin, T Ubagai, S H Mudd, W G Wilson, J V Leonard, J Y Chou

J Clin Invest. 1996 Aug 15; 98(4): 1021–1027. doi: 10.1172/JCI118862

PMCID:: PMC507518

Summary PDF–422K

Select item 18583112.

Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.

T Ubagai, K J Lei, S Huang, S H Mudd, H L Levy, J Y Chou

J Clin Invest. 1995 Oct; 96(4): 1943–1947. doi: 10.1172/JCI118240

PMCID:: PMC185831

Summary Page Browse PDF–1.3M

Select item 874549813.

Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis

Po-Ming Chen, Cheng-Hsueh Tsai, Chieh-Cheng Huang, Hau-Hsuan Hwang, Jian-Rong Li, Chun-Chi Liu, Hsin-An Ko, En-Pei Isabel Chiang

Int J Mol Sci. 2022 Jan; 23(1): 481. Published online 2022 Jan 1. doi: 10.3390/ijms23010481

PMCID:: PMC8745498

Abstract Article PDF–1.7M

Select item 744271114.

Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer

Yuan Li, Liqing Lu, Jian Tu, Jing Zhang, Ting Xiong, Wei Fan, Jiaohong Wang, Meng Li, Yibu Chen, Justin Steggerda, Hui Peng, Yongheng Chen, Tony W. H. Li, Zhi-Gang Zhou, José M. Mato, Ekihiro Seki, Ting Liu, Heping Yang, Shelly C. Lu

Hepatology. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Hepatology. 2020 Nov; 72(5): 1682–1700. Published online 2020 Oct 1. doi: 10.1002/hep.31196

PMCID:: PMC7442711

Abstract Article PDF–2.9M

Select item 481473715.

S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells

Sonia Amelia Lozano-Sepulveda, Eduardo Bautista-Osorio, Jose Angel Merino-Mascorro, Marta Varela-Rey, Linda Elsa Muñoz-Espinosa, Paula Cordero-Perez, María Luz Martinez-Chantar, Ana Maria Rivas-Estilla

World J Gastroenterol. 2016 Apr 14; 22(14): 3746–3757. Published online 2016 Apr 14. doi: 10.3748/wjg.v22.i14.3746

PMCID:: PMC4814737

Abstract Article PDF–1.2M

Select item 445601816.

Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine

Paul C. Schröder, Joaquín Fernández-Irigoyen, Emilie Bigaud, Antonio Serna, Rubén Renández-Alcoceba, Shelly C. Lu, José M. Mato, Jesús Prieto, Fernando J. Corrales

J Proteomics. Author manuscript; available in PMC 2015 Jun 4.

Published in final edited form as: J Proteomics. 2012 Jun 6; 75(10): 2855–2868. Published online 2012 Jan 16. doi: 10.1016/j.jprot.2012.01.009

PMCID:: PMC4456018

Abstract Article PDF–1006K

Select item 346382617.

Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation

Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben, Richard M. Weinshilboum

Drug Metab Dispos. 2012 Oct; 40(10): 1984–1992. doi: 10.1124/dmd.112.046953

PMCID:: PMC3463826

Abstract Article PDF–1.2M

Select item 319889818.

Methionine Adenosyltransferase 2A/2B and Methylation: Gene Sequence Variation and Functional Genomics

Kendra K. S. Nordgren, Yi Peng, Linda L. Pelleymounter, Irene Moon, Ryan Abo, Qiping Feng, Bruce Eckloff, Vivien C. Yee, Eric Wieben, Richard M. Weinshilboum

Drug Metab Dispos. 2011 Nov; 39(11): 2135–2147. doi: 10.1124/dmd.111.040857

PMCID:: PMC3198898

Abstract Article PDF–2.4M

Select item 285490819.

MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate

Chao-Qiang Lai, Laurence D Parnell, Aron M Troen, Jian Shen, Heather Caouette, Daruneewan Warodomwichit, Yu-Chi Lee, Jimmy W Crott, Wei Qiao Qiu, Irwin H Rosenberg, Katherine L Tucker, José M Ordovás

Am J Clin Nutr. 2010 May; 91(5): 1377–1386. Published online 2010 Mar 24. doi: 10.3945/ajcn.2009.28923

PMCID:: PMC2854908

Abstract Article PDF–369K

Select item 171252920.

Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.

M E Chamberlin, T Ubagai, S H Mudd, H L Levy, J Y Chou

Am J Hum Genet. 1997 Mar; 60(3): 540–546.

PMCID:: PMC1712529

Summary Page Browse PDF–1.4M

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