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Select item 112819851.

Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass

Na Ren, Shanshan Lv, Xiang Li, Chong Shao, Ziyuan Wang, Yazhao Mei, Wendi Yang, Wenzhen Fu, Yunqiu Hu, Ling Sha, Weiwei Hu, Zhenlin Zhang, Chun Wang

Osteoporos Int. 2024; 35(8): 1395–1406. Published online 2024 Apr 16. doi: 10.1007/s00198-024-07080-x

PMCID:: PMC11281985

Abstract Article PDF–1.4M

Select item 111313062.

Evolutionary and functional analyses of LRP5 in archaic and extant modern humans

Neus Roca-Ayats, Iago Maceda, Carlos David Bruque, Núria Martínez-Gil, Natàlia Garcia-Giralt, Mónica Cozar, Leonardo Mellibovsky, Wim Van Hul, Oscar Lao, Daniel Grinberg, Susanna Balcells

Hum Genomics. 2024; 18: 53. Published online 2024 May 27. doi: 10.1186/s40246-024-00616-6

PMCID:: PMC11131306

Abstract Article PDF–2.2M

Select item 108322143.

Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women

Jun Li, Ya Li, Siyuan Li, Yunqiu Lu, Partab Rai

J Orthop Surg Res. 2024; 19: 104. Published online 2024 Feb 1. doi: 10.1186/s13018-024-04579-1

PMCID:: PMC10832214

Abstract Article PDF–1.2M

Select item 106855524.

Genetic detection of two novel LRP5 pathogenic variants in patients with familial exudative vitreoretinopathy

Jiayu Li, Chanjuan Wang, Shaochi Zhang, Bo Cai, Bo Pan, Caihong Sun, Xiaolong Qi, Chunmei Ma, Wei Fang, Kangxin Jin, Xiaojun Bi, Zibing Jin, Wenjuan Zhuang

BMC Ophthalmol. 2023; 23: 489. Published online 2023 Nov 29. doi: 10.1186/s12886-023-03243-2

PMCID:: PMC10685552

Abstract Article PDF–11M

Select item 106062545.

LRP5, Bone Mass Polymorphisms and Skeletal Disorders

Jake Littman, Wentian Yang, Jon Olansen, Chanika Phornphutkul, Roy K. Aaron

Genes (Basel) 2023 Oct; 14(10): 1846. Published online 2023 Sep 23. doi: 10.3390/genes14101846

PMCID:: PMC10606254

Abstract Article PDF–1.7M

Select item 101187296.

The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus

Karla Simone Costa de Souza, Marcela Abbott Galvão Ururahy, Yonara Monique da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Raul Hernandes Bortolin, André Ducati Luchessi, Ricardo Fernando Arrais, Rosário Dominguez Crespo Hirata, Maria das Graças Almeida, Mário Hiroyuki Hirata, Adriana Augusto de Rezende

Arch Endocrinol Metab. 2018 Jul-Aug; 62(4): 480–484. Published online 2018 Aug 1. doi: 10.20945/2359-3997000000057

PMCID:: PMC10118729

Abstract Article PDF–138K

Select item 92192007.

Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD and CHD in a Chinese Han population

Dongli Han, Haiying Zhang, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Hongguang Ding, Yongning Xin

BMC Gastroenterol. 2022; 22: 305. Published online 2022 Jun 22. doi: 10.1186/s12876-022-02385-9

PMCID:: PMC9219200

Abstract Article PDF–813K

Select item 88319548.

LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer

Xiaobo Nie, Huiyang Liu, Wenling Ye, Xiaoyun Wei, Lili Fan, Han Ma, Lanqing Li, Wanting Xue, Wenting Qi, Yan‐Dong Wang, Wei‐Dong Chen

J Cell Mol Med. 2022 Feb; 26(4): 1095–1112. Published online 2022 Jan 7. doi: 10.1111/jcmm.17164

PMCID:: PMC8831954

Abstract Article PDF–2.3M

Select item 85097229.

Identification of Rare LRP5 Variants in a Cohort of Males with Impaired Bone Mass

Maria Santa Rocca, Giovanni Minervini, Andrea Di Nisio, Maurizio Merico, Maria Bueno Marinas, Luca De Toni, Kalliopi Pilichou, Andrea Garolla, Carlo Foresta, Alberto Ferlin

Int J Mol Sci. 2021 Oct; 22(19): 10834. Published online 2021 Oct 7. doi: 10.3390/ijms221910834

PMCID:: PMC8509722

Abstract Article PDF–13M

Select item 754574110.

Associations of LRP5 Gene With Bone Mineral Density, Bone Turnover Markers, and Fractures in the Elderly With Osteoporosis

Qi-Fei Wang, Hong-Sen Bi, Ze-Lian Qin, Pu Wang, Fang-Fei Nie, Guang-Wu Zhang

Front Endocrinol (Lausanne) 2020; 11: 571549. Published online 2020 Sep 25. doi: 10.3389/fendo.2020.571549

PMCID:: PMC7545741

Abstract Article PDF–195K

Select item 720413611.

A Study of the Relationship between the Polymorphism and Mutation of rs682429 and rs3781590 in the LRP5 Gene and Bone Metabolism in Postmenopausal Type 2 Diabetic Women in Xinjiang

Jun Li, SiYuan Li, HuiRong Zhao, JiaJia Li, Shuang Wang, YanQiu Shi

J Diabetes Res. 2020; 2020: 3071217. Published online 2020 Apr 28. doi: 10.1155/2020/3071217

PMCID:: PMC7204136

Abstract Article PDF–343K

Select item 701822112.

Influence of LRP5 (rs556442) polymorphism on insulin resistance in healthy Iranian children and adolescents

Nima MONTAZERI-NAJAFABADY, Mohammad Hossein DABBAGHMANESH, Rajeeh MOHAMMADIAN AMIRI, Marzieh BAKHSHAYESHKARAM, Gholamhossein RANJBAR OMRANI

Turk J Med Sci. 2019; 49(2): 490–496. Published online 2019 Apr 18. doi: 10.3906/sag-1809-107

PMCID:: PMC7018221

Abstract Article PDF–87K

Select item 669350613.

Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis

D. Foer, M. Zhu, R. L. Cardone, C. Simpson, R. Sullivan, S. Nemiroff, G. Lee, R. G. Kibbey, K.F. Petersen, K. L. Insogna

Osteoporos Int. Author manuscript; available in PMC 2019 Aug 14.

Published in final edited form as: Osteoporos Int. 2017 Jun; 28(6): 2011–2017. Published online 2017 Mar 10. doi: 10.1007/s00198-017-3977-4

PMCID:: PMC6693506

Abstract Article PDF–260K

Select item 513967614.

LRP5 gene polymorphism and cortical bone

Fulvio Lauretani, Chiara Cepollaro, Stefania Bandinelli, Antonio Cherubini, Alessia Gozzini, Laura Masi, Alberto Falchetti, Francesca Del Monte, Silvia Carbonell-Sala, Francesca Marini, Annalisa Tanini, Anna Maria Corsi, Gian Paolo Ceda, Maria Luisa Brandi, Luigi Ferrucci

Aging Clin Exp Res. Author manuscript; available in PMC 2016 Dec 6.

Published in final edited form as: Aging Clin Exp Res. 2010 Aug; 22(4): 281–288. doi: 10.1007/bf03324935

PMCID:: PMC5139676

Abstract Article PDF–482K

Select item 500784815.

Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women

Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr

J Negat Results Biomed. 2016; 15(1): 16. Published online 2016 Sep 1. doi: 10.1186/s12952-016-0059-7

PMCID:: PMC5007848

Abstract Article PDF–1.8M

Select item 465935916.

Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5

C. A. Simpson, D. Foer, G. S. Lee, J. Bihuniak, B. Sun, R. Sullivan, J. Belsky, K. L. Insogna

Osteoporos Int. Author manuscript; available in PMC 2015 Nov 25.

Published in final edited form as: Osteoporos Int. 2014 Oct; 25(10): 2383–2388. Published online 2014 Jun 14. doi: 10.1007/s00198-014-2767-5

PMCID:: PMC4659359

Abstract Article PDF–316K

Select item 432188617.

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

Nellie Y. Loh, Matt J. Neville, Kyriakoula Marinou, Sarah A. Hardcastle, Barbara A. Fielding, Emma L. Duncan, Mark I. McCarthy, Jonathan H. Tobias, Celia L. Gregson, Fredrik Karpe, Constantinos Christodoulides

Cell Metab. 2015 Feb 3; 21(2): 262–272. doi: 10.1016/j.cmet.2015.01.009

PMCID:: PMC4321886

Abstract Article

Select item 427917918.

Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis

Guang-Yue Xu, Yong Qiu, Hai-Jun Mao

Biomed Res Int. 2014; 2014: 290531. Published online 2014 Dec 14. doi: 10.1155/2014/290531

PMCID:: PMC4279179

Abstract Article PDF–794K

Select item 401202819.

Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Rim Sassi, Hela Sahli, Chiraz Souissi, Hejer El Mahmoudi, Bechir Zouari, Amel Ben Ammar ElGaaied, Slaheddine Sellami, Serge Livio Ferrari

BMC Musculoskelet Disord. 2014; 15: 144. Published online 2014 Apr 30. doi: 10.1186/1471-2474-15-144

PMCID:: PMC4012028

Abstract Article PDF–198K

Select item 400333820.

No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families

Jin-bo Yu, Yao-hua Ke, Jin-wei He, Hao Zhang, Wei-wei Hu, Yun-qiu Hu, Miao Li, Yu-juan Liu, Jie-mei Gu, Wen-zhen Fu, Gao Gao, Hua Yue, Wen-jin Xiao, Zhen-lin Zhang

Acta Pharmacol Sin. 2010 Nov; 31(11): 1464–1469. Published online 2010 Oct 18. doi: 10.1038/aps.2010.92

PMCID:: PMC4003338

Abstract Article PDF–244K

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