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Select item 111949651.

Deciphering the role of KLRB1: a novel prognostic indicator in hepatocellular carcinoma

Siting Fang, Yinglu Zhou

BMC Gastroenterol. 2024; 24: 210. Published online 2024 Jun 24. doi: 10.1186/s12876-024-03299-4

PMCID:: PMC11194965

Abstract Article PDF–5.8M

Select item 111165392.

Down-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD

Jiu-Ling Chen, Chuang-Yan Wu, Xiang-Yu Luo, Xue-Ying Wang, Fang-Ming Wang, Xin Huang, Wei Yuan, Qiang Guo

Sci Rep. 2024; 14: 11782. Published online 2024 May 23. doi: 10.1038/s41598-024-60414-x

PMCID:: PMC11116539

Abstract Article PDF–11M

Select item 110181933.

A comprehensive analysis of the KLRB1 expression and its clinical implication in testicular germ cell tumors: A review

Luyu Li, Yaorui Hu, Xiao Li, Baojun Ju

Medicine (Baltimore) 2024 Apr 12; 103(15): e37688. Published online 2024 Apr 12. doi: 10.1097/MD.0000000000037688

PMCID:: PMC11018193

Abstract Article PDF–3.3M

Select item 107133944.

Inhibiting KLRB1 expression is associated with impairing cancer immunity and leading to cancer progression and poor prognosis in breast invasive carcinoma patients

Jin-Rong He, Dan Li, Qun-Xian Zhang, Tao Liu, Yu Ding, Chuang-Yan Wu, Shan-Shan Chen, Jiu-Ling Chen

Aging (Albany NY) 2023 Nov 30; 15(22): 13265–13286. Published online 2023 Nov 20. doi: 10.18632/aging.205239

PMCID:: PMC10713394

Abstract Article PDF–2.6M

Select item 99756695.

CD161 Characterizes an Inflamed Subset of Cytotoxic T Lymphocytes Associated with Prolonged Survival in Human Papillomavirus–Driven Oropharyngeal Cancer

Ye Wei, Tingting Xu, Chong Li, Xin Zhou, Wei Qian, Chunying Shen, Qifeng Wang, Xing Xing, Xiaomin Ou, Xiayun He, Hongmei Yin, Chaosu Hu, Yu Wang, Qinghai Ji, Fengtao Su, Xueguan Lu

Cancer Immunol Res. 2023 Mar 1; 11(3): 306–319. Published online 2023 Jan 12. doi: 10.1158/2326-6066.CIR-22-0454

PMCID:: PMC9975669

Abstract Article PDF–15M

Select item 88192996.

Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples

Wang Di, Wenhua Fan, Fan Wu, Zhongfang Shi, Zhiliang Wang, Mingchen Yu, You Zhai, Yuanhao Chang, Changqing Pan, Guanzhang Li, Ulf Dietrich Kahlert, Wei Zhang

Cancer Sci. 2022 Feb; 113(2): 756–769. Published online 2021 Dec 24. doi: 10.1111/cas.15236

PMCID:: PMC8819299

Abstract Article PDF–3.3M

Select item 82995577.

A Pan-Cancer Analysis of CD161, a Potential New Immune Checkpoint

Xiaohan Zhou, Jun Du, Chengdong Liu, Hanyi Zeng, Yuting Chen, Li Liu, Dehua Wu

Front Immunol. 2021; 12: 688215. Published online 2021 Jul 9. doi: 10.3389/fimmu.2021.688215

PMCID:: PMC8299557

Abstract Article PDF–5.4M

Select item 79357728.

Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis

Nathan D. Mathewson, Orr Ashenberg, Itay Tirosh, Simon Gritsch, Elizabeth M. Perez, Sascha Marx, Livnat Jerby-Arnon, Rony Chanoch-Myers, Toshiro Hara, Alyssa R. Richman, Yoshinaga Ito, Jason Pyrdol, Mirco Friedrich, Kathrin Schumann, Michael J. Poitras, Prafulla C. Gokhale, L. Nicolas Gonzalez Castro, Marni E. Shore, Christine M. Hebert, Brian Shaw, Heather L. Cahill, Matthew Drummond, Wubing Zhang, Olamide Olawoyin, Hiroaki Wakimoto, Orit Rozenblatt-Rosen, Priscilla K. Brastianos, X. Shirley Liu, Pamela S. Jones, Daniel P. Cahill, Matthew P. Frosch, David N. Louis, Gordon J. Freeman, Keith L. Ligon, Alexander Marson, E. Antonio Chiocca, David A. Reardon, Aviv Regev, Mario L. Suvà, Kai W. Wucherpfennig

Cell. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: Cell. 2021 Mar 4; 184(5): 1281–1298.e26. Published online 2021 Feb 15. doi: 10.1016/j.cell.2021.01.022

PMCID:: PMC7935772

Abstract Article PDF–3.5M

Select item 67154069.

CD161 contributes to prenatal immune suppression of IFN-γ–producing PLZF⁺ T cells

Joanna Halkias, Elze Rackaityte, Sara L. Hillman, Dvir Aran, Ventura F. Mendoza, Lucy R. Marshall, Tippi C. MacKenzie, Trevor D. Burt

J Clin Invest. 2019 Sep 3; 129(9): 3562–3577. Published online 2019 Jul 29. doi: 10.1172/JCI125957

PMCID:: PMC6715406

Abstract Article PDF–8.0M

Select item 590003210.

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

Ayako Kurioka, Cormac Cosgrove, Yannick Simoni, Bonnie van Wilgenburg, Alessandra Geremia, Sophia Björkander, Eva Sverremark-Ekström, Christine Thurnheer, Huldrych F. Günthard, Nina Khanna, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Lucy Jane Walker, Carolina V. Arancibia-Cárcamo, Evan W. Newell, Christian B. Willberg, Paul Klenerman

Front Immunol. 2018; 9: 486. Published online 2018 Apr 9. doi: 10.3389/fimmu.2018.00486

PMCID:: PMC5900032

Abstract Article PDF–6.5M

Select item 473293911.

CD161^int CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

J.R. Fergusson, M.H. Hühn, L. Swadling, L.J. Walker, A. Kurioka, A. Llibre, A. Bertoletti, G. Holländer, E.W. Newell, M.M. Davis, E. Sverremark-Ekström, F. Powrie, S. Capone, A. Folgori, E. Barnes, C.B. Willberg, J.E. Ussher, P. Klenerman

Mucosal Immunol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Mucosal Immunol. 2016 Mar; 9(2): 401–413. Published online 2015 Jul 29. doi: 10.1038/mi.2015.69

PMCID:: PMC4732939

Abstract Article PDF–2.1M

Select item 467231912.

Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells

Qianting Yang, Qian Xu, Qi Chen, Jin Li, Mingxia Zhang, Yi Cai, Haiying Liu, Yiping Zhou, Guofang Deng, Qunyi Deng, Boping Zhou, Hardy Kornfeld, Xinchun Chen

Sci Rep. 2015; 5: 17918. Published online 2015 Dec 8. doi: 10.1038/srep17918

PMCID:: PMC4672319

Abstract Article PDF–1.4M

Select item 455042513.

The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules

Sascha Rother, Joachim Hundrieser, Claudia Pokoyski, Sonja Kollrich, Katja Borns, Rainer Blasczyk, Daniel Poehnert, Jürgen Klempnauer, Reinhard Schwinzer

PLoS One. 2015; 10(8): e0135682. Published online 2015 Aug 26. doi: 10.1371/journal.pone.0135682

PMCID:: PMC4550425

Abstract Article PDF–1.7M

Select item 440807214.

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

Yolanda Gonzalez, María Teresa Herrera, Esmeralda Juárez, Miguel Angel Salazar-Lezama, Karen Bobadilla, Martha Torres

PLoS One. 2015; 10(4): e0123591. Published online 2015 Apr 23. doi: 10.1371/journal.pone.0123591

PMCID:: PMC4408072

Abstract Article PDF–2.6M

Select item 425083915.

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

Joannah R. Fergusson, Kira E. Smith, Vicki M. Fleming, Neil Rajoriya, Evan W. Newell, Ruth Simmons, Emanuele Marchi, Sophia Björkander, Yu-Hoi Kang, Leo Swadling, Ayako Kurioka, Natasha Sahgal, Helen Lockstone, Dilair Baban, Gordon J. Freeman, Eva Sverremark-Ekström, Mark M. Davis, Miles P. Davenport, Vanessa Venturi, James E. Ussher, Christian B. Willberg, Paul Klenerman

Cell Rep. 2014 Nov 6; 9(3): 1075–1088. Published online 2014 Oct 23. doi: 10.1016/j.celrep.2014.09.045

PMCID:: PMC4250839

Abstract Article PDF–3.4M

Select item 319026016.

Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

Helle Bach Søndergaard, Finn Sellebjerg, Jan Hillert, Tomas Olsson, Ingrid Kockum, Magdalena Lindén, Inger-Lise Mero, Kjell-Morten Myhr, Elisabeth G Celius, Hanne F Harbo, Jeppe Romme Christensen, Lars Börnsen, Per Soelberg Sørensen, Annette Bang Oturai

Eur J Hum Genet. 2011 Oct; 19(10): 1100–1103. Published online 2011 May 25. doi: 10.1038/ejhg.2011.88

PMCID:: PMC3190260

Abstract Article PDF–246K

Select item 284030817.

Analysis of CD161 expression on human CD8⁺ T cells defines a distinct functional subset with tissue-homing properties

Eva Billerbeck, Yu-Hoi Kang, Lucy Walker, Helen Lockstone, Stefanie Grafmueller, Vicki Fleming, Jonathan Flint, Chris B. Willberg, Bertram Bengsch, Bianca Seigel, Narayan Ramamurthy, Nicole Zitzmann, Eleanor J. Barnes, Jonarthan Thevanayagam, Anisha Bhagwanani, Alasdair Leslie, Ye H. Oo, Simon Kollnberger, Paul Bowness, Oliver Drognitz, David H. Adams, Hubert E. Blum, Robert Thimme, Paul Klenerman

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 3006–3011. Published online 2010 Jan 28. doi: 10.1073/pnas.0914839107

PMCID:: PMC2840308

Abstract Article PDF–665K

Select item 269912518.

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

Melanie A. Kleinschek, Katia Boniface, Svetlana Sadekova, Jeff Grein, Erin E. Murphy, Scott P. Turner, Lisa Raskin, Bela Desai, William A. Faubion, Rene de Waal Malefyt, Robert H. Pierce, Terrill McClanahan, Robert A. Kastelein

J Exp Med. 2009 Mar 16; 206(3): 525–534. doi: 10.1084/jem.20081712

PMCID:: PMC2699125

Abstract Article PDF–3.6M

Select item 190641919.

CD161⁺ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver

T IIAI, H WATANABE, T SUDA, H OKAMOTO, T ABO, K HATAKEYAMA

Clin Exp Immunol. 2002 Jul; 129(1): 92–98. doi: 10.1046/j.1365-2249.2002.01886.x

PMCID:: PMC1906419

Abstract Article PDF–482K

Select item 1079270220.

Immune checkpoint CD161/LLT1‐associated immunological landscape and diagnostic value in oral squamous cell carcinoma

Xinyang Hu, Yuexin Dong, Shixin Xie, Yuxian Song, Chenhang Yu, Yijia He, Zhiyong Wang, Qingang Hu, Yanhong Ni, Liang Ding

J Pathol Clin Res. 2024 Mar; 10(2): e353. Published online 2024 Jan 17. doi: 10.1002/cjp2.353

PMCID:: PMC10792702

Abstract Article PDF–53M

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