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Items: 1 to 20 of 86

1.
PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway
Jun Li, Da Teng, Wenjuan Jia, Lei Gong, Haibin Dong, Chunxiao Wang, Lihui Zhang, Bowen Xu, Wenlong Wang, Lin Zhong, Jianxun Wang, Jun Yang
Inflamm Res. 2024; 73(6): 1033–1046. Published online 2024 Apr 17. doi: 10.1007/s00011-024-01881-w
PMCID:
PMC11106193
AbstractArticlePDF–2.8M
2.
Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival
Jaekwan Kim, Thomas Nguyen, Jeffrey Cifello, Raheel Ahmad, Yongqing Zhang, Qian Yang, Ji-Eun Lee, Xiang Li, Yan Kai, Supriyo De, Weiqun Peng, Kai Ge, Nan-ping Weng
Front Immunol. 2022; 13: 1095140. Published online 2023 Jan 19. doi: 10.3389/fimmu.2022.1095140
PMCID:
PMC9892454
AbstractArticlePDF–7.8M
3.
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb, and DNA methylation
Delphine Douillet, Christie C Sze, Caila Ryan, Andrea Piunti, Avani P Shah, Michal Ugarenko, Stacy A Marshall, Emily J Rendleman, Didi Zha, Kathryn A Helmin, Zibo Zhao, Kaixiang Cao, Marc A Morgan, Benjamin D Singer, Elizabeth Bartom, Edwin R Smith, Ali Shilatifard
Nat Genet. Author manuscript; available in PMC 2021 Jan 7.
Published in final edited form as: Nat Genet. 2020 Jun; 52(6): 615–625. Published online 2020 May 11. doi: 10.1038/s41588-020-0618-1
PMCID:
PMC7790509
AbstractArticlePDF–4.3M
4.
Expression pattern of Kmt2d in murine craniofacial tissues
Chunmin Dong, Meenakshi Umar, Garrett Bartoletti, Apurva Gahankari, Lauren Fidelak, Fenglei He
Gene Expr Patterns. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Gene Expr Patterns. 2019 Dec; 34: 119060. Published online 2019 Jun 19. doi: 10.1016/j.gep.2019.119060
PMCID:
PMC6878151
AbstractArticlePDF–2.4M
5.
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-enhancers at Tumor Suppressor Genes
Shilpa S. Dhar, Dongyu Zhao, Tao Lin, Bingnan Gu, Khusboo Pal, Sarah J. Wu, Hunain Alam, Jie Lv, Kyuson Yun, Vidya Gopalakrishnan, Elsa R. Flores, Paul A. Northcott, Veena Rajaram, Wei Li, Ali Shilatifard, Roy V. Sillitoe, Kaifu Chen, Min Gyu Lee
Mol Cell. Author manuscript; available in PMC 2019 Jun 7.
Published in final edited form as: Mol Cell. 2018 Jun 7; 70(5): 825–841.e6. Published online 2018 May 31. doi: 10.1016/j.molcel.2018.04.028
PMCID:
PMC6528658
AbstractArticlePDF–4.0M
6.
Mutation of cancer driver MLL2 results in transcription stress and genome instability
Theodoros Kantidakis, Marco Saponaro, Richard Mitter, Stuart Horswell, Andrea Kranz, Stefan Boeing, Ozan Aygün, Gavin P. Kelly, Nik Matthews, Aengus Stewart, A. Francis Stewart, Jesper Q. Svejstrup
Genes Dev. 2016 Feb 15; 30(4): 408–420. doi: 10.1101/gad.275453.115
PMCID:
PMC4762426
AbstractArticlePDF–1.0M
7.
Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome
Hans T. Bjornsson, Joel S. Benjamin, Li Zhang, Jacqueline Weissman, Elizabeth E. Gerber, Yi-Chun Chen, Rebecca G. Vaurio, Michelle C. Potter, Kasper D. Hansen, Harry C. Dietz
Sci Transl Med. Author manuscript; available in PMC 2015 Apr 22.
Published in final edited form as: Sci Transl Med. 2014 Oct 1; 6(256): 256ra135. doi: 10.1126/scitranslmed.3009278
PMCID:
PMC4406328
AbstractArticlePDF–1.8M
8.
Increased Apoptosis and Skewed Differentiation in Mouse Embryonic Stem Cells Lacking the Histone Methyltransferase Mll2
Sandra Lubitz, Stefan Glaser, Julia Schaft, A. Francis Stewart, Konstantinos Anastassiadis
Mol Biol Cell. 2007 Jun; 18(6): 2356–2366. doi: 10.1091/mbc.E06-11-1060
PMCID:
PMC1877088
AbstractArticlePDF–1.3M
9.
Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma
Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, Cun-Yu Wang
Nat Commun. 2024; 15: 6755. Published online 2024 Aug 8. doi: 10.1038/s41467-024-50861-5
PMCID:
PMC11310337
AbstractArticlePDF–5.7M
10.
KMT2D regulates activation, localization, and integrin expression by T-cells
Sarah J. Potter, Li Zhang, Michael Kotliar, Yuehong Wu, Caitlin Schafer, Kurtis Stefan, Leandros Boukas, Dima Qu’d, Olaf Bodamer, Brittany N. Simpson, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson
Front Immunol. 2024; 15: 1341745. Published online 2024 May 3. doi: 10.3389/fimmu.2024.1341745
PMCID:
PMC11099208
AbstractArticlePDF–5.8M
11.
KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans
Allison J. Kalinousky, Teresa R. Luperchio, Katrina M. Schrode, Jacqueline R. Harris, Li Zhang, Valerie B. DeLeon, Jill A. Fahrner, Amanda M. Lauer, Hans T. Bjornsson
Genes (Basel) 2024 Jan; 15(1): 48. Published online 2023 Dec 28. doi: 10.3390/genes15010048
PMCID:
PMC10815913
AbstractArticlePDF–1.9M
12.
Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A
Xiang-Min Meng, Shu-Bao Liu, Tian Deng, De-Yong Li, Lu You, Hao Hong, Qi-Pu Feng, Bing-Mei Zhu
J Cardiovasc Transl Res. 2023; 16(5): 1032–1049. Published online 2023 Mar 22. doi: 10.1007/s12265-023-10373-x
PMCID:
PMC10616223
AbstractArticlePDF–5.4M
13.
KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity
Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi
Int J Cancer. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Int J Cancer. 2023 Aug 1; 153(3): 552–570. Published online 2023 May 4. doi: 10.1002/ijc.34528
PMCID:
PMC10330100
AbstractArticlePDF–1.5M
14.
Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis
Kairong Cui, Zuojia Chen, Yaqiang Cao, Shuai Liu, Gang Ren, Gangqing Hu, Difeng Fang, Danping Wei, Chengyu Liu, Jinfang Zhu, Chuan Wu, Keji Zhao
Immunity. Author manuscript; available in PMC 2024 May 9.
Published in final edited form as: Immunity. 2023 May 9; 56(5): 944–958.e6. Published online 2023 Apr 10. doi: 10.1016/j.immuni.2023.03.006
PMCID:
PMC10175192
AbstractArticlePDF–3.7M
15.
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Ryan M. Boileau, Kevin X. Chen, Robert Blelloch
Genome Biol. 2023; 24: 41. Published online 2023 Mar 3. doi: 10.1186/s13059-023-02883-3
PMCID:
PMC9983171
AbstractArticlePDF–6.9M
16.
Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration
Consiglia Pacelli, Iolanda Adipietro, Natascia Malerba, Gabriella Maria Squeo, Claudia Piccoli, Angela Amoresano, Gabriella Pinto, Pietro Pucci, Ji-Eun Lee, Kai Ge, Nazzareno Capitanio, Giuseppe Merla
Cells. 2020 Jul; 9(7): 1685. Published online 2020 Jul 13. doi: 10.3390/cells9071685
PMCID:
PMC7407568
AbstractArticlePDF–3.7M
17.
Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome
Giovanni A. Carosso, Leandros Boukas, Jonathan J. Augustin, Ha Nam Nguyen, Briana L. Winer, Gabrielle H. Cannon, Johanna D. Robertson, Li Zhang, Kasper D. Hansen, Loyal A. Goff, Hans T. Bjornsson
JCI Insight. 2019 Oct 17; 4(20): e129375. Published online 2019 Oct 17. doi: 10.1172/jci.insight.129375
PMCID:
PMC6824316
AbstractArticlePDF–29M
18.
Precocious chondrocyte differentiation disrupts skeletal growth in Kabuki syndrome mice
Jill A. Fahrner, Wan-Ying Lin, Ryan C. Riddle, Leandros Boukas, Valerie B. DeLeon, Sheetal Chopra, Susan E. Lad, Teresa Romeo Luperchio, Kasper D. Hansen, Hans T. Bjornsson
JCI Insight. 2019 Oct 17; 4(20): e129380. Published online 2019 Oct 17. doi: 10.1172/jci.insight.129380
PMCID:
PMC6824315
AbstractArticlePDF–39M
19.
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
Katarzyna Placek, Gangqing Hu, Kairong Cui, Dunfang Zhang, Yi Ding, Ji-Eun Lee, Younghoon Jang, Chaochen Wang, Joanne Elizabeth Konkel, Jiuzhou Song, Chengyu Liu, Kai Ge, Wanjun Chen, Keji Zhao
Nat Immunol. Author manuscript; available in PMC 2018 Mar 5.
Published in final edited form as: Nat Immunol. 2017 Sep; 18(9): 1035–1045. Published online 2017 Jul 31. doi: 10.1038/ni.3812
PMCID:
PMC5836551
AbstractArticlePDF–2.9M
20.
An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells
Kaixiang Cao, Clayton K. Collings, Marc A. Morgan, Stacy A. Marshall, Emily J. Rendleman, Patrick A. Ozark, Edwin R. Smith, Ali Shilatifard
Sci Adv. 2018 Jan; 4(1): eaap8747. Published online 2018 Jan 31. doi: 10.1126/sciadv.aap8747
PMCID:
PMC5796793
AbstractArticlePDF–9.9M

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