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Select item 93021921.

Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia

Alyssa Grogan, Andrew Coleman, Humberto Joca, Henk Granzier, Mark W. Russel, Christopher W. Ward, Aikaterini Kontrogianni-Konstantopoulos

Basic Res Cardiol. Author manuscript; available in PMC 2022 Jul 21.

Published in final edited form as: Basic Res Cardiol. 2020 Sep 10; 115(6): 60. Published online 2020 Sep 10. doi: 10.1007/s00395-020-00818-8

PMCID:: PMC9302192

Abstract Article PDF–3.3M

Select item 88357212.

Impaired Intracellular Ca²⁺ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice

Enrico Pierantozzi, Péter Szentesi, Cecilia Paolini, Beatrix Dienes, János Fodor, Tamás Oláh, Barbara Colombini, Dilson E. Rassier, Egidio Maria Rubino, Stephan Lange, Daniela Rossi, László Csernoch, Maria Angela Bagni, Carlo Reggiani, Vincenzo Sorrentino

Int J Mol Sci. 2022 Feb; 23(3): 1319. Published online 2022 Jan 24. doi: 10.3390/ijms23031319

PMCID:: PMC8835721

Abstract Article PDF–2.3M

Select item 72475463.

Proteomic Analysis of Myocardia Containing the Obscurin R4344Q Mutation Linked to Hypertrophic Cardiomyopathy

Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

Front Physiol. 2020; 11: 478. Published online 2020 May 18. doi: 10.3389/fphys.2020.00478

PMCID:: PMC7247546

Abstract Article PDF–1.0M

Select item 54625024.

Deregulated Ca²⁺ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Li-Yen R. Hu, Maegen A. Ackermann, Peter A. Hecker, Benjamin L. Prosser, Brendan King, Kelly A. O’Connell, Alyssa Grogan, Logan C. Meyer, Christopher E. Berndsen, Nathan T. Wright, W. Jonathan Lederer, Aikaterini Kontrogianni-Konstantopoulos

Sci Adv. 2017 Jun; 3(6): e1603081. Published online 2017 Jun 7. doi: 10.1126/sciadv.1603081

PMCID:: PMC5462502

Abstract Article PDF–4.4M

Select item 52838965.

Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice

D. Randazzo, B. Blaauw, C. Paolini, E. Pierantozzi, S. Spinozzi, S. Lange, J. Chen, F. Protasi, C. Reggiani, V. Sorrentino

Am J Physiol Cell Physiol. 2017 Jan 1; 312(1): C16–C28. Published online 2016 Oct 26. doi: 10.1152/ajpcell.00098.2016

PMCID:: PMC5283896

Abstract Article

Select item 35755406.

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity

Davide Randazzo, Emiliana Giacomello, Stefania Lorenzini, Daniela Rossi, Enrico Pierantozzi, Bert Blaauw, Carlo Reggiani, Stephan Lange, Angela K. Peter, Ju Chen, Vincenzo Sorrentino

J Cell Biol. 2013 Feb 18; 200(4): 523–536. doi: 10.1083/jcb.201205118

PMCID:: PMC3575540

Abstract Article PDF–3.5M

Select item 29093167.

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum

Stephan Lange, Kunfu Ouyang, Gretchen Meyer, Li Cui, Hongqiang Cheng, Richard L. Lieber, Ju Chen

J Cell Sci. 2009 Aug 1; 122(15): 2640–2650. Published online 2009 Jul 7. doi: 10.1242/jcs.046193

PMCID:: PMC2909316

Abstract Article

Select item 28339688.

Developmental Expression and Differential Cellular Localization of Obscurin and Obscurin-Associated Kinase in Cardiac Muscle Cells

Andrei B. Borisov, Maide Ö. Raeker, Mark W. Russell

J Cell Biochem. Author manuscript; available in PMC 2010 Mar 8.

Published in final edited form as: J Cell Biochem. 2008 Apr 1; 103(5): 1621–1635. doi: 10.1002/jcb.21551

Correction in:: volume 104 on page 357

PMCID:: PMC2833968

Abstract Article PDF–2.5M

Select item 39164419.

Obscurins: Goliaths and Davids Take over Non-Muscle Tissues

Maegen A. Ackermann, Marey Shriver, Nicole A. Perry, Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

PLoS One. 2014; 9(2): e88162. Published online 2014 Feb 6. doi: 10.1371/journal.pone.0088162

Correction in:: PLoS One. 2018; 13(1): e0190842.

PMCID:: PMC3916441

Abstract Article PDF–37M

Select item 650913810.

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism

Jordan Blondelle, Valeria Marrocco, Madison Clark, Patrick Desmond, Stephanie Myers, Jim Nguyen, Matthew Wright, Shannon Bremner, Enrico Pierantozzi, Samuel Ward, Eric Estève, Vincenzo Sorrentino, Majid Ghassemian, Stephan Lange

Commun Biol. 2019; 2: 178. Published online 2019 May 9. doi: 10.1038/s42003-019-0405-7

PMCID:: PMC6509138

Abstract Article PDF–2.9M

Select item 273548911.

The Rho-Guanine Nucleotide Exchange Factor Domain of Obscurin Activates RhoA Signaling in Skeletal Muscle

Diana L. Ford-Speelman, Joseph A. Roche, Amber L. Bowman, Robert J. Bloch

Mol Biol Cell. 2009 Sep 1; 20(17): 3905–3917. doi: 10.1091/mbc.E08-10-1029

PMCID:: PMC2735489

Abstract Article PDF–3.3M

Select item 252669312.

The Rho-Guanine Nucleotide Exchange Factor Domain of Obscurin Regulates Assembly of Titin at the Z-Disk through Interactions with Ran Binding Protein 9

Amber L. Bowman, Dawn H. Catino, John C. Strong, William R. Randall, Aikaterini Kontrogianni-Konstantopoulos, Robert J. Bloch

Mol Biol Cell. 2008 Sep; 19(9): 3782–3792. doi: 10.1091/mbc.E08-03-0237

PMCID:: PMC2526693

Abstract Article PDF–1.6M

Select item 269580313.

Obscurin Interacts with a Novel Isoform of MyBP-C Slow at the Periphery of the Sarcomeric M-Band and Regulates Thick Filament Assembly

Maegen A. Ackermann, Li-Yen R. Hu, Amber L. Bowman, Robert J. Bloch, Aikaterini Kontrogianni-Konstantopoulos

Mol Biol Cell. 2009 Jun 15; 20(12): 2963–2978. doi: 10.1091/mbc.E08-12-1251

PMCID:: PMC2695803

Abstract Article PDF–4.4M

Select item 338621314.

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

Stephan Lange, Sue Perera, Phildrich Teh, Ju Chen

Mol Biol Cell. 2012 Jul 1; 23(13): 2490–2504. doi: 10.1091/mbc.E12-01-0052

PMCID:: PMC3386213

Abstract Article PDF–4.8M

Select item 363381615.

The kinase domains of obscurin interact with intercellular adhesion proteins

Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

FASEB J. 2013 May; 27(5): 2001–2012. doi: 10.1096/fj.12-221317

PMCID:: PMC3633816

Abstract Article

Select item 258155816.

Obscurin Targets Ankyrin-B and Protein Phosphatase 2A to the Cardiac M-line

Shane R. Cunha, Peter J. Mohler

J Biol Chem. 2008 Nov 14; 283(46): 31968–31980. doi: 10.1074/jbc.M806050200

PMCID:: PMC2581558

Abstract Article PDF–1.1M

Select item 569466717.

Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway

Maegen A. Ackermann, Brendan King, Nicole A.P. Lieberman, Prameela J. Bobbili, Michael Rudloff, Christopher E. Berndsen, Nathan T. Wright, Peter A. Hecker, Aikaterini Kontrogianni-Konstantopoulos

J Mol Cell Cardiol. Author manuscript; available in PMC 2017 Nov 19.

Published in final edited form as: J Mol Cell Cardiol. 2017 Oct; 111: 27–39. Published online 2017 Aug 4. doi: 10.1016/j.yjmcc.2017.08.004

PMCID:: PMC5694667

Abstract Article PDF–3.3M

Select item 595554018.

Genomic variants in an inbred mouse model predict mania-like behaviors

Michael C. Saul, Sharon A. Stevenson, Changjiu Zhao, Terri M. Driessen, Brian E. Eisinger, Stephen C. Gammie

PLoS One. 2018; 13(5): e0197624. Published online 2018 May 16. doi: 10.1371/journal.pone.0197624

PMCID:: PMC5955540

Abstract Article PDF–3.1M

Select item 1117884219.

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Sci Rep. 2024; 14: 13727. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64608-1