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Select item 107115491.

Human lysyl-tRNA synthetase phosphorylation promotes HIV-1 proviral DNA transcription

Yingke Tang, Ryan T Behrens, Corine St Gelais, Siqi Wu, Saravanan Vivekanandan, Ehud Razin, Pengfei Fang, Li Wu, Nathan Sherer, Karin Musier-Forsyth

Nucleic Acids Res. 2023 Dec 11; 51(22): 12111–12123. Published online 2023 Nov 2. doi: 10.1093/nar/gkad941

PMCID:: PMC10711549

Abstract Article PDF–1.2M

Select item 82518832.

Bi‐allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease

Gerarda Cappuccio, Camilla Ceccatelli Berti, Enrico Baruffini, Jennifer Sullivan, Vandana Shashi, Tamison Jewett, Tara Stamper, Silvia Maitz, Francesco Canonico, Anya Revah‐Politi, Gabriel S. Kupchik, Kwame Anyane‐Yeboa, Vimla Aggarwal, Andreas Benneche, Eirik Bratland, Siren Berland, Felice D'Arco, Cesar A. Alves, Adeline Vanderver, Daniela Longo, Enrico Bertini, Annalaura Torella, Vincenzo Nigro, Telethon Undiagnosed Diseases Program, Alessandra D'Amico, Marjo S. van der Knaap, Paola Goffrini, Nicola Brunetti‐Pierri

Hum Mutat. 2021 Jun; 42(6): 745–761. Published online 2021 May 11. doi: 10.1002/humu.24210

PMCID:: PMC8251883

Abstract Article PDF–3.6M

Select item 74435063.

Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain

Sheng Liu, Maryanne Refaei, Shuohui Liu, Aaron Decker, Jennifer M. Hinerman, Andrew B. Herr, Mike Howell, Karin Musier-Forsyth, Pearl Tsang

J Biol Chem. 2020 Aug 21; 295(34): 12071–12085. Published online 2020 Jul 1. doi: 10.1074/jbc.RA120.013852

PMCID:: PMC7443506

Abstract Article PDF–3.1M

Select item 62135414.

Nucleic Acid-Dependent Structural Transition of the Intrinsically Disordered N-Terminal Appended Domain of Human Lysyl-tRNA Synthetase

Soon Bin Kwon, Ji Eun Yu, Chan Park, Jiseop Lee, Baik L. Seong

Int J Mol Sci. 2018 Oct; 19(10): 3016. Published online 2018 Oct 3. doi: 10.3390/ijms19103016

PMCID:: PMC6213541

Abstract Article PDF–3.7M

Select item 36830455.

Induced tRNA Import into Human Mitochondria: Implication of a Host Aminoacyl-tRNA-Synthetase

Ali Gowher, Alexandre Smirnov, Ivan Tarassov, Nina Entelis

PLoS One. 2013; 8(6): e66228. Published online 2013 Jun 14. doi: 10.1371/journal.pone.0066228

PMCID:: PMC3683045

Abstract Article PDF–1.4M

Select item 33126046.

DFNB89, a novel autosomal recessive nonsyndromic hearing impairment locus on chromosome 16q21-q23.2

Sulman Basit, Kwanghyuk Lee, Rabia Habib, Leon Chen, Umm-e-Kalsoom, Regie Lyn P. Santos-Cortez, Zahid Azeem, Paula Andrade, Muhammad Ansar, Wasim Ahmad, Suzanne M. Leal

Hum Genet. Author manuscript; available in PMC 2012 Mar 26.

Published in final edited form as: Hum Genet. 2011 Apr; 129(4): 379–385. Published online 2010 Dec 22. doi: 10.1007/s00439-010-0934-0

PMCID:: PMC3312604

Abstract Article PDF–1.0M

Select item 29488047.

Compound Heterozygosity for Loss-of-Function Lysyl-tRNA Synthetase Mutations in a Patient with Peripheral Neuropathy

Heather M. McLaughlin, Reiko Sakaguchi, Cuiping Liu, Takao Igarashi, Davut Pehlivan, Kristine Chu, Ram Iyer, Pedro Cruz, Praveen F. Cherukuri, Nancy F. Hansen, James C. Mullikin, NISC Comparative Sequencing Program, Leslie G. Biesecker, Thomas E. Wilson, Victor Ionasescu, Garth Nicholson, Charles Searby, Kevin Talbot, Jeffrey M. Vance, Stephan Züchner, Kinga Szigeti, James R. Lupski, Ya-Ming Hou, Eric D. Green, Anthony Antonellis

Am J Hum Genet. 2010 Oct 8; 87(4): 560–566. doi: 10.1016/j.ajhg.2010.09.008

PMCID:: PMC2948804

Abstract Article PDF–728K

Select item 92813828.

Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy

Marjo S. van der Knaap, Marianna Bugiani, Marisa I. Mendes, Lisa G. Riley, Desiree E.C. Smith, Joëlle Rudinger-Thirion, Magali Frugier, Marjolein Breur, Joanna Crawford, Judith van Gaalen, Meyke Schouten, Marjolaine Willems, Quinten Waisfisz, Frederic Tran Mau-Them, Richard J. Rodenburg, Ryan J. Taft, Boris Keren, John Christodoulou, Christel Depienne, Cas Simons, Gajja S. Salomons, Fanny Mochel

Neurology. 2019 Mar 12; 92(11): e1225–e1237. doi: 10.1212/WNL.0000000000007098

Correction in:: Neurology. 2019 Nov 26; 93(22): 982.

PMCID:: PMC9281382

Abstract Article PDF–367K

Select item 62054149.

Lysyl-tRNA synthetase–expressing colon spheroids induce M2 macrophage polarization to promote metastasis

Seo Hee Nam, Doyeun Kim, Doohyung Lee, Hye-Mi Lee, Dae-Geun Song, Jae Woo Jung, Ji Eon Kim, Hye-Jin Kim, Nam Hoon Kwon, Eun-Kyeong Jo, Sunghoon Kim, Jung Weon Lee

J Clin Invest. 2018 Nov 1; 128(11): 5034–5055. Published online 2018 Oct 8. doi: 10.1172/JCI99806

PMCID:: PMC6205414

Abstract Article PDF–28M

Select item 549660910.

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells

Sang Bum Kim, Hye Rim Kim, Min Chul Park, Seongmin Cho, Peter C. Goughnour, Daeyoung Han, Ina Yoon, YounHa Kim, Taehee Kang, Eunjoo Song, Pilhan Kim, Hyosun Choi, Ji Young Mun, Chihong Song, Sangmin Lee, Hyun Suk Jung, Sunghoon Kim

J Cell Biol. 2017 Jul 3; 216(7): 2201–2216. doi: 10.1083/jcb.201605118

PMCID:: PMC5496609

Abstract Article PDF–2.6M

Select item 467329411.

Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels

Seo Hee Nam, Doyeun Kim, Mi-Sook Lee, Doohyung Lee, Tae Kyoung Kwak, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Haeng Eun Song, Jungeun Choi, Gyu-Ho Lee, Sang-Yeob Kim, Song Hwa Park, Dae Gyu Kim, Nam Hoon Kwon, Tai Young Kim, Jean Paul Thiery, Sunghoon Kim, Jung Weon Lee

Oncotarget. 2015 Aug 28; 6(25): 21655–21674. Published online 2015 May 12. doi: 10.18632/oncotarget.4130

Correction in:: Oncotarget. 2016 Feb 9; 7(6): 7367.

PMCID:: PMC4673294

Abstract Article PDF–19M

Select item 371076412.

Mutations in KARS, Encoding Lysyl-tRNA Synthetase, Cause Autosomal-Recessive Nonsyndromic Hearing Impairment DFNB89

Regie Lyn P. Santos-Cortez, Kwanghyuk Lee, Zahid Azeem, Patrick J. Antonellis, Lana M. Pollock, Saadullah Khan, Irfanullah, Paula B. Andrade-Elizondo, Ilene Chiu, Mark D. Adams, Sulman Basit, Joshua D. Smith, University of Washington Center for Mendelian Genomics, Deborah A. Nickerson, Brian M. McDermott, Jr., Wasim Ahmad, Suzanne M. Leal

Am J Hum Genet. 2013 Jul 11; 93(1): 132–140. doi: 10.1016/j.ajhg.2013.05.018

PMCID:: PMC3710764

Abstract Article PDF–988K

Select item 351674213.

Dual Role for Motif 1 Residues of Human Lysyl-tRNA Synthetase in Dimerization and Packaging into HIV-1

Varun Dewan, Min Wei, Lawrence Kleiman, Karin Musier-Forsyth

J Biol Chem. 2012 Dec 7; 287(50): 41955–41962. Published online 2012 Oct 24. doi: 10.1074/jbc.M112.421842

PMCID:: PMC3516742

Abstract Article PDF–1.0M

Select item 333512714.

Mitochondrial Lysyl-tRNA Synthetase Independent Import of tRNA Lysine into Yeast Mitochondria

Naresh Babu V. Sepuri, Madhavi Gorla, Michael P. King

PLoS One. 2012; 7(4): e35321. Published online 2012 Apr 23. doi: 10.1371/journal.pone.0035321

PMCID:: PMC3335127

Abstract Article PDF–334K

Select item 333083315.

Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

Varun Dewan, Tao Liu, Kuan-Ming Chen, Ziqing Qian, Yong Xiao, Lawrence Kleiman, Kiran V. Mahasenan, Chenglong Li, Hiroshi Matsuo, Dehua Pei, Karin Musier-Forsyth

ACS Chem Biol. 2012 Apr 20; 7(4): 761–769. Published online 2012 Jan 25. doi: 10.1021/cb200450w