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Select item 101698051.

Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators

Valeriya Privalova, Anna Maria Labecka, Ewa Szlachcic, Anna Sikorska, Marcin Czarnoleski

Sci Rep. 2023; 13: 7565. Published online 2023 May 9. doi: 10.1038/s41598-023-34674-y

PMCID:: PMC10169805

Abstract Article PDF–1.3M

Select item 100118312.

The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD

Yu Li, Ji Geng, Suman Rimal, Haochuan Wang, Xiangguo Liu, Bingwei Lu, Shuangxi Li

J Biol Chem. 2023 Mar; 299(3): 102995. Published online 2023 Feb 9. doi: 10.1016/j.jbc.2023.102995

PMCID:: PMC10011831

Abstract Article PDF–2.4M

Select item 93347923.

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila

Peiduo Liu, Kai Chang, Guillermo Requejo, Hua Bai

Front Cell Dev Biol. 2022; 10: 866210. Published online 2022 Jul 15. doi: 10.3389/fcell.2022.866210

PMCID:: PMC9334792

Abstract Article PDF–2.4M

Select item 46148174.

TORC2: a novel target for treating age-associated memory impairment

Jennifer L. Johnson, Wei Huang, Gregg Roman, Mauro Costa-Mattioli

Sci Rep. 2015; 5: 15193. Published online 2015 Oct 22. doi: 10.1038/srep15193

PMCID:: PMC4614817

Abstract Article PDF–973K

Select item 39587175.

An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size

Kohei Shimono, Kazuto Fujishima, Takafumi Nomura, Masayoshi Ohashi, Tadao Usui, Mineko Kengaku, Atsushi Toyoda, Tadashi Uemura

Sci Rep. 2014; 4: 4415. Published online 2014 Mar 19. doi: 10.1038/srep04415

PMCID:: PMC3958717

Abstract Article PDF–1.2M

Select item 44411306.

Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila

Ying Kuo, Huanwei Huang, Tao Cai, Tao Wang

Sci Rep. 2015; 5: 10339. Published online 2015 May 22. doi: 10.1038/srep10339

PMCID:: PMC4441130

Abstract Article PDF–1.4M

Select item 36154487.

mTORC2 controls actin polymerization required for consolidation of long-term memory

Wei Huang, Ping Jun Zhu, Shixing Zhang, Hongyi Zhou, Loredana Stoica, Mauricio Galiano, Krešimir Krnjevic, Gregg Roman, Mauro Costa-Mattioli

Nat Neurosci. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Nat Neurosci. 2013 Apr; 16(4): 441–448. Published online 2013 Mar 3. doi: 10.1038/nn.3351

PMCID:: PMC3615448

Abstract Article PDF–868K

Select item 85805728.

Dissecting the biology of mTORC1 beyond rapamycin

Guang Yang, Deanne Francis, James R. Krycer, Mark Larance, Ziyang Zhang, Chris J. Novotny, Alexis Diaz-Vegas, Kevan M. Shokat, David E. James

Sci Signal. Author manuscript; available in PMC 2022 Mar 21.

Published in final edited form as: Sci Signal. 2021 Sep 21; 14(701): eabe0161. Published online 2021 Sep 21. doi: 10.1126/scisignal.abe0161

PMCID:: PMC8580572

Abstract Article PDF–1.7M

Select item 68218649.

The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development

Kyle J. Connolly, Megan B. O’Hare, Alamin Mohammed, Katelyn M. Aitchison, Niki C. Anthoney, Matthew J. Taylor, Bryan A. Stewart, Richard I. Tuxworth, Guy Tear

Sci Rep. 2019; 9: 15592. Published online 2019 Oct 30. doi: 10.1038/s41598-019-51588-w

PMCID:: PMC6821864

Abstract Article PDF–4.4M

Select item 178346410.

Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex

Mary Y W Wu, Megan Cully, Ditte Andersen, Sally J Leevers

EMBO J. 2007 Jan 24; 26(2): 371–379. Published online 2006 Dec 21. doi: 10.1038/sj.emboj.7601487

PMCID:: PMC1783464

Abstract Article PDF–376K

Select item 838662611.

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

Kai Chang, Ping Kang, Ying Liu, Kerui Huang, Ting Miao, Antonia P. Sagona, Ioannis P. Nezis, Rolf Bodmer, Karen Ocorr, Hua Bai

Autophagy. 2020; 16(10): 1807–1822. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704117

PMCID:: PMC8386626

Abstract Article PDF–17M

Select item 586605612.

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P₃ Production and Akt Activation

Stephen W. Roth, Moshe D. Bitterman, Morris J. Birnbaum, Michelle L. Bland

Cell Rep. Author manuscript; available in PMC 2018 Mar 23.

Published in final edited form as: Cell Rep. 2018 Mar 6; 22(10): 2550–2556. doi: 10.1016/j.celrep.2018.02.033

PMCID:: PMC5866056

Abstract Article PDF–1.0M

Select item 472962513.

Period-regulated feeding behavior and TOR signaling modulate survival of infection

Victoria W. Allen, Reed M. O’Connor, Matt Ulgherait, Clarice G. Zhou, Elizabeth F. Stone, Vanessa M. Hill, Keith R. Murphy, Julie C. Canman, William W. Ja, Mimi M. Shirasu-Hiza

Curr Biol. Author manuscript; available in PMC 2017 Jan 25.

Published in final edited form as: Curr Biol. 2016 Jan 25; 26(2): 184–194. Published online 2015 Dec 31. doi: 10.1016/j.cub.2015.11.051

PMCID:: PMC4729625

Abstract Article PDF–2.1M

Select item 327203714.

Diet and Energy-Sensing Inputs Affect TorC1-Mediated Axon Misrouting but Not TorC2-Directed Synapse Growth in a Drosophila Model of Tuberous Sclerosis

Brian Dimitroff, Katie Howe, Adrienne Watson, Bridget Campion, Hyun-Gwan Lee, Na Zhao, Michael B. O'Connor, Thomas P. Neufeld, Scott B. Selleck

PLoS One. 2012; 7(2): e30722. Published online 2012 Feb 3. doi: 10.1371/journal.pone.0030722

PMCID:: PMC3272037

Abstract Article PDF–3.1M

Select item 182093615.

Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth

Ville Hietakangas, Stephen M. Cohen

Genes Dev. 2007 Mar 15; 21(6): 632–637. doi: 10.1101/gad.416307

PMCID:: PMC1820936

Abstract Article PDF–386K

Select item 695524216.

Sestrins are evolutionarily conserved mediators of exercise benefits

Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee

Nat Commun. 2020; 11: 190. Published online 2020 Jan 13. doi: 10.1038/s41467-019-13442-5