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Select item 105199921.

Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas

Lei Wang, Wenchao Gu, Bingqing Zou, Matthew Kalady, Wei Xin, Lan Zhou

Sci Rep. 2023; 13: 15999. Published online 2023 Sep 25. doi: 10.1038/s41598-023-42234-7

PMCID:: PMC10519992

Abstract Article PDF–8.6M

Select item 86093262.

Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER⁺ breast cancer cells

Nitin Sabherwal, Andrew Rowntree, Elli Marinopoulou, Tom Pettini, Sean Hourihane, Riba Thomas, Ximena Soto, Jochen Kursawe, Nancy Papalopulu

Proc Natl Acad Sci U S A. 2021 Nov 9; 118(45): e2113527118. Published online 2021 Nov 1. doi: 10.1073/pnas.2113527118

PMCID:: PMC8609326

Abstract Article PDF–2.7M

Select item 65989103.

Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting Hes1 rhythm and down-regulating its expression

Xi-Juan Liu, Xuan Jiang, Sheng-Nan Huang, Jin-Yan Sun, Fei Zhao, Wen-Bo Zeng, Min-Hua Luo

Virol Sin. 2017 Jun; 32(3): 188–198. Published online 2017 Apr 24. doi: 10.1007/s12250-017-3956-0

PMCID:: PMC6598910

Abstract Article PDF–1.0M

Select item 64265244.

HES1 Protein Modulates Human Papillomavirus–Mediated Carcinoma of the Uterine Cervix

Richa Tripathi, Gayatri Rath, Vishwas Sharma, Showket Hussain, Shashi Sharma, Mausumi Bharadwaj, Ravi Mehrotra

J Glob Oncol. 2019; 5: JGO.18.00141. Published online 2019 Jan 7. doi: 10.1200/JGO.18.00141

PMCID:: PMC6426524

Abstract Article PDF–1.1M

Select item 59714355.

Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone

Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi

J Biol Chem. 2018 May 25; 293(21): 8285–8294. Published online 2018 Mar 9. doi: 10.1074/jbc.RA118.002316

PMCID:: PMC5971435

Abstract Article PDF–1.8M

Select item 59049896.

The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis

Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu

BMC Cancer. 2018; 18: 436. Published online 2018 Apr 17. doi: 10.1186/s12885-018-4350-5

PMCID:: PMC5904989

Abstract Article PDF–3.0M

Select item 54298577.

Hairy/enhancer of Split Homologue-1 Suppresses Vascular Endothelial Growth Factor-induced Angiogenesis via Downregulation of Osteopontin Expression

Xing-Xing Yao, Jing-Bo Lu, Zhi-Dong Ye, Lei Zheng, Qian Wang, Zhi-Qi Lin, Hao Liu, Heng Wan, Fang-Yong Fu, Xian-Ying Huang, Jian-Chen Xiu, Zheng-Jun Liu, Yan-Wei Hu

Sci Rep. 2017; 7: 898. Published online 2017 Apr 18. doi: 10.1038/s41598-017-01018-6

PMCID:: PMC5429857

Abstract Article PDF–5.1M

Select item 54006268.

HES1 promotes extracellular matrix protein expression and inhibits proliferation and migration in human trabecular meshwork cells under oxidative stress

Linqi Xu, Yan Zhang, Ruru Guo, Wencui Shen, Yan Qi, Qingsong Wang, Zhenglong Guo, Chen Qi, Haifang Yin, Jiantao Wang

Oncotarget. 2017 Mar 28; 8(13): 21818–21833. Published online 2017 Feb 23. doi: 10.18632/oncotarget.15631

PMCID:: PMC5400626

Abstract Article PDF–15M

Select item 53639869.

The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

Sophie K. Kay, Heather A. Harrington, Sarah Shepherd, Keith Brennan, Trevor Dale, James M. Osborne, David J. Gavaghan, Helen M. Byrne

PLoS Comput Biol. 2017 Feb; 13(2): e1005400. Published online 2017 Feb 28. doi: 10.1371/journal.pcbi.1005400

PMCID:: PMC5363986

Abstract Article PDF–3.1M

Select item 500885710.

Loss of Hes1 Differentiates Sessile Serrated Adenoma/polyp from Hyperplastic Polyp

Min Cui, Amad Awadallah, Wendy Liu, Lan Zhou, Wei Xin

Am J Surg Pathol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Am J Surg Pathol. 2016 Jan; 40(1): 113–119. doi: 10.1097/PAS.0000000000000531

PMCID:: PMC5008857

Abstract Article PDF–1.5M

Select item 474220611.

Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway

Sheng-Chun Wang, Xiao-Lin Lin, Hui-Yan Wang, Yu-Juan Qin, Lin Chen, Jing Li, Jun-Shuang Jia, Hong-Fen Shen, Sheng Yang, Rao-Ying Xie, Fang Wei, Fei Gao, Xiao-Xiang Rong, Jie Yang, Wen-Tao Zhao, Ting-Ting Zhang, Jun-Wen Shi, Kai-Tai Yao, Wei-Ren Luo, Yan Sun, Dong Xiao

Oncotarget. 2015 Nov 3; 6(34): 36713–36730. Published online 2015 Oct 2. doi: 10.18632/oncotarget.5457

PMCID:: PMC4742206

Abstract Article PDF–6.9M

Select item 462274112.

Hes1: a key role in stemness, metastasis and multidrug resistance

Zi-Hao Liu, Xiao-Meng Dai, Bin Du

Cancer Biol Ther. 2015 Mar; 16(3): 353–359. Published online 2015 Mar 17. doi: 10.1080/15384047.2015.1016662

PMCID:: PMC4622741

Abstract Article PDF–265K

Select item 458886913.

Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour

Karen A Lillycrop, Paula M Costello, Ai Ling Teh, Robert J Murray, Rebecca Clarke-Harris, Sheila J Barton, Emma S Garratt, Sherry Ngo, Allan M Sheppard, Johnny Wong, Shaillay Dogra, Graham C Burdge, Cyrus Cooper, Hazel M Inskip, Catharine R Gale, Peter D Gluckman, Nicholas C Harvey, Yap-Seng Chong, Fabian Yap, Michael J Meaney, Anne Rifkin-Graboi, Joanna D Holbrook, The Epigen Global Research Consortium, Keith M Godfrey

Int J Epidemiol. 2015 Aug; 44(4): 1263–1276. Published online 2015 Apr 22. doi: 10.1093/ije/dyv052

PMCID:: PMC4588869

Abstract Article PDF–597K

Select item 391248514.

Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer

Fei Gao, YuQin Zhang, ShengChun Wang, YuanQiang Liu, Lin Zheng, JianQuan Yang, Wei Huang, YanFen Ye, WeiRen Luo, Dong Xiao

Sci Rep. 2014; 4: 3963. Published online 2014 Feb 4. doi: 10.1038/srep03963

Correction in:: Sci Rep. 2014; 4: 7287.

PMCID:: PMC3912485

Abstract Article PDF–1.5M

Select item 286491415.

Hijacking HES1: Tumors Co-opt the Anti-differentiation Strategies of Quiescent Cells

Liyun Sang, James M. Roberts, Hilary A. Coller

Trends Mol Med. Author manuscript; available in PMC 2010 May 6.

Published in final edited form as: Trends Mol Med. 2010 Jan; 16(1): 17–26. Published online 2009 Dec 18. doi: 10.1016/j.molmed.2009.11.001

PMCID:: PMC2864914

Abstract Article PDF–560K

Select item 272133516.

Control of the reversibility of cellular quiescence by the transcriptional repressor HES1

Liyun Sang, Hilary A. Coller, James M. Roberts

Science. Author manuscript; available in PMC 2009 Aug 5.

Published in final edited form as: Science. 2008 Aug 22; 321(5892): 1095–1100. doi: 10.1126/science.1155998

PMCID:: PMC2721335

Abstract Article PDF–2.7M

Select item 251849217.

HES-1 Is Involved in Adaptation of Adult Human β-Cells to Proliferation In Vitro

Yael Bar, Holger A. Russ, Sarah Knoller, Limor Ouziel-Yahalom, Shimon Efrat

Diabetes. 2008 Sep; 57(9): 2413–2420. doi: 10.2337/db07-1323

PMCID:: PMC2518492

Abstract Article PDF–453K

Select item 228876118.

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27^Kip1 and p57^Kip2

Orbicia Riccio, Marielle E van Gijn, April C Bezdek, Luca Pellegrinet, Johan H van Es, Ursula Zimber-Strobl, Lothar J Strobl, Tasuku Honjo, Hans Clevers, Freddy Radtke

EMBO Rep. 2008 Apr; 9(4): 377–383. Published online 2008 Feb 15. doi: 10.1038/embor.2008.7

PMCID:: PMC2288761

Abstract Article PDF–434K

Select item 1023841919.

NOTCH4^ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1

Bin Zhang, Shaowei Dong, Jian Wang, Tuxiong Huang, Pan Zhao, Jing Xu, Dongcheng Liu, Li Fu, Lingwei Wang, Guangsuo Wang, Chang Zou

Nat Commun. 2023; 14: 3183. Published online 2023 Jun 2. doi: 10.1038/s41467-023-38833-7

PMCID:: PMC10238419

Abstract Article PDF–5.5M

Select item 777624120.

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De Decker, Marieke Lavaert, Juliette Roels, Laurentijn Tilleman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon

Haematologica. 2021 Jan 1; 106(1): 130–141. Published online 2020 Jan 9. doi: 10.3324/haematol.2019.226126

PMCID:: PMC7776241

Abstract Article PDF–3.2M

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