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Select item 106908821.

TNFSF15 facilitates the differentiation of CD11b⁺ myeloid cells into vascular pericytes in tumors

Xiangxiang Gu, Yipan Zhu, Cancan Zhao, Yixin Cao, Jingying Wang, Qiangzhe Zhang, Luyuan Li

Cancer Biol Med. 2023 Nov 15; 20(11): 869–884. Published online 2023 Nov 2. doi: 10.20892/j.issn.2095-3941.2023.0245

PMCID:: PMC10690882

Abstract Article PDF–2.4M

Select item 88127842.

TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth

Can-Can Zhao, Qiu-Ju Han, Hao-Yan Ying, Xiang-Xiang Gu, Na Yang, Lu-Yuan Li, Qiang-Zhe Zhang

Oncoimmunology. 2022; 11(1): 2032918. Published online 2022 Feb 1. doi: 10.1080/2162402X.2022.2032918

PMCID:: PMC8812784

Abstract Article PDF–3.2M

Select item 86427783.

A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury

Gui-Li Yang, Shizhao Wang, Shu Zhang, Ye Liu, Xiao Liu, Dong Wang, Huijie Wei, Jianhua Xiong, Zhi-Song Zhang, Zengguang Wang, Lu-Yuan Li, Jianning Zhang

ASN Neuro. 2021 Jan-Dec; 13: 17590914211038441. Published online 2021 Oct 1. doi: 10.1177/17590914211038441

PMCID:: PMC8642778

Abstract Article PDF–7.6M

Select item 82998684.

Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders

Hope Steele, Kacey Sachen, Andrew J. McKnight, Rachel Soloff, Rana Herro

Front Immunol. 2021; 12: 692127. Published online 2021 Jul 8. doi: 10.3389/fimmu.2021.692127

PMCID:: PMC8299868

Abstract Article PDF–8.6M

Select item 77053045.

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells

Dan Zhao, Jiaqi Li, Chao Xue, Ke Feng, Lipei Liu, Peng Zeng, Xiaolin Wang, Yuanli Chen, Luyuan Li, Zhisong Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang

J Biol Chem. 2020 Nov 27; 295(48): 16314–16327. Published online 2020 Sep 22. doi: 10.1074/jbc.RA120.015486

PMCID:: PMC7705304

Abstract Article PDF–6.3M

Select item 63938826.

Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

Jinbo Guo, Yuxin Luo, Fengrong Yin, Xiaoxia Huo, Guochao Niu, Mei Song, Shuang Chen, Xiaolan Zhang

J Immunol Res. 2019; 2019: 7657294. Published online 2019 Feb 14. doi: 10.1155/2019/7657294

PMCID:: PMC6393882

Abstract Article PDF–5.9M

Select item 61621607.

Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome

Noam Jacob, Jonathan P. Jacobs, Kotaro Kumagai, Connie W.Y. Ha, Yoshitake Kanazawa, Venu Lagishetty, Katherine Altmayer, Ariel M. Hamill, Aimee Von Arx, R. Balfour Sartor, Suzanne Devkota, Jonathan Braun, Kathrin S. Michelsen, Stephan R Targan, David Q Shih

Mucosal Immunol. Author manuscript; available in PMC 2019 Jan 9.

Published in final edited form as: Mucosal Immunol. 2018 Sep; 11(5): 1466–1476. Published online 2018 Jul 9. doi: 10.1038/s41385-018-0055-y

PMCID:: PMC6162160

Abstract Article PDF–1.3M

Select item 30192148.

Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis

David Q. Shih, Robert Barrett, Xiaolan Zhang, Nicole Yeager, Hon Wai Koon, Piangwarin Phaosawasdi, Yahui Song, Brian Ko, Michelle H. Wong, Kathrin S. Michelsen, Gislaine Martins, Charalabos Pothoulakis, Stephan R. Targan

PLoS One. 2011; 6(1): e16090. Published online 2011 Jan 11. doi: 10.1371/journal.pone.0016090

PMCID:: PMC3019214

Abstract Article PDF–7.3M

Select item 26861979.

Inhibition of endothelial progenitor cell differentiation by VEGI

Fang Tian, Paulina H. Liang, Lu-Yuan Li

Blood. 2009 May 21; 113(21): 5352–5360. Prepublished online 2009 Mar 27. doi: 10.1182/blood-2008-08-173773

PMCID:: PMC2686197

Abstract Article

Select item 237383810.

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

Bhanu P. Pappu, Anna Borodovsky, Timothy S. Zheng, Xuexian Yang, Ping Wu, Xingwen Dong, Shawn Weng, Beth Browning, Martin L. Scott, Li Ma, Lihe Su, Qiang Tian, Pascal Schneider, Richard A. Flavell, Chen Dong, Linda C. Burkly

J Exp Med. 2008 May 12; 205(5): 1049–1062. doi: 10.1084/jem.20071364

PMCID:: PMC2373838

Abstract Article PDF–2.7M

Select item 118347211.

Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter

Qingli Xiao, Chung Y. Hsu, Hong Chen, Xiucui Ma, Jan Xu, Jin-Moo Lee

Biochem J. 2005 Jun 15; 388(Pt 3): 913–920. Prepublished online 2005 Feb 10. Published online 2005 Jun 7. doi: 10.1042/BJ20041739

PMCID:: PMC1183472

Abstract Article PDF–736K

Select item 1123843312.

Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma

Xiaofei Liu, Jintao Zhang, Dong Zhang, Yun Pan, Rong Zeng, Changjuan Xu, Shuochuan Shi, Jiawei Xu, Qian Qi, Xueli Dong, Junfei Wang, Tian Liu, Liang Dong

Respir Res. 2024; 25: 271. Published online 2024 Jul 10. doi: 10.1186/s12931-024-02900-4

PMCID:: PMC11238433

Abstract Article PDF–11M

Select item 1085948313.

Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis

Shangyi Wang, Mina Kozai, Masaya Hiraishi, Md. Zahir Uddin Rubel, Osamu Ichii, Mutsumi Inaba, Kazuhiro Matsuo, Kensuke Takada

Front Immunol. 2024; 15: 1340467. Published online 2024 Jan 29. doi: 10.3389/fimmu.2024.1340467

PMCID:: PMC10859483

Abstract Article PDF–2.0M

Select item 1058036014.

TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

Genghuan Wang, Jian Shen, Liping Zhai, Yingcong Lin, Qiaobing Guan, Heping Shen

CNS Neurosci Ther. 2023 Nov; 29(11): 3588–3597. Published online 2023 Jun 2. doi: 10.1111/cns.14290

PMCID:: PMC10580360

Abstract Article PDF–8.7M

Select item 1033453915.

Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng, Liang Dong

Respir Res. 2023; 24: 182. Published online 2023 Jul 11. doi: 10.1186/s12931-023-02488-1

PMCID:: PMC10334539

Abstract Article PDF–7.9M

Select item 825363316.

Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis

Jia Wenxiu, Yang Mingyue, Han Fei, Luo Yuxin, Wu Mengyao, Li Chenyang, Song Jia, Zhang Hong, David Q. Shih, Stephan R. Targan, Zhang Xiaolan

Mediators Inflamm. 2021; 2021: 5927064. Published online 2021 Jun 25. doi: 10.1155/2021/5927064

PMCID:: PMC8253633

Abstract Article PDF–6.1M

Select item 758458917.

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

Noam Jacob, Kotaro Kumagai, Jay P. Abraham, Yosuke Shimodaira, Yuefang Ye, Justin Luu, Anna Y. Blackwood, Sofi L. Castanon, Dalton T. Stamps, Lisa S. Thomas, Rivkah Gonsky, David Q. Shih, Kathrin S. Michelsen, Stephan R. Targan

Sci Rep. 2020; 10: 18189. Published online 2020 Oct 23. doi: 10.1038/s41598-020-75168-5

PMCID:: PMC7584589

Abstract Article PDF–2.7M

Select item 757798218.

TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling

Rana Herro, Haruka Miki, Gurupreet S. Sethi, David Mills, Amit Kumar Mehta, Xinh-Xinh Nguyen, Carol Feghali-Bostwick, Marina Miller, David H. Broide, Rachel Soloff, Michael Croft

J Immunol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Immunol. 2020 Nov 1; 205(9): 2414–2422. Published online 2020 Sep 21. doi: 10.4049/jimmunol.2000665

PMCID:: PMC7577982

Abstract Article PDF–2.0M

Select item 665214919.

Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease

Melissa Mavers, Federico Simonetta, Hidekazu Nishikii, Jessica V. Ribado, Kristina Maas-Bauer, Maite Alvarez, Toshihito Hirai, Mustafa Turkoz, Jeanette Baker, Robert S. Negrin

Front Immunol. 2019; 10: 1624. Published online 2019 Jul 17. doi: 10.3389/fimmu.2019.01624