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Select item 109359211.

Regulatory role of TIGAR on endothelial metabolism and angiogenesis

Xiaochen He, Heng Zeng, Aubrey C. Cantrell, Jian-Xiong Chen

J Cell Physiol. Author manuscript; available in PMC 2024 Mar 13.

Published in final edited form as: J Cell Physiol. 2021 Nov; 236(11): 7578–7590. Published online 2021 Apr 30. doi: 10.1002/jcp.30401

PMCID:: PMC10935921

Abstract Article PDF–967K

Select item 108890852.

TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice

Xiaochen He, Quinesha A. Williams, Aubrey C. Cantrell, Jessie Besanson, Heng Zeng, Jian-Xiong Chen

Int J Mol Sci. 2024 Feb; 25(4): 2433. Published online 2024 Feb 19. doi: 10.3390/ijms25042433

PMCID:: PMC10889085

Abstract Article PDF–4.0M

Select item 93786373.

Knockout of TIGAR Enhances Myocardial Phosphofructokinase Activity and Preserves Diastolic Function in Heart Failure

Xiaochen He, Heng Zeng, Aubrey C Cantrell, Quinesha A Williams, Jian-Xiong Chen

J Cell Physiol. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: J Cell Physiol. 2022 Aug; 237(8): 3317–3327. Published online 2022 May 27. doi: 10.1002/jcp.30790

PMCID:: PMC9378637

Abstract Article PDF–1012K

Select item 90201734.

TIGAR deficiency sensitizes angiotensin‐II‐induced renal fibrosis and glomerular injury

Xiaochen He, Aubrey C. Cantrell, Quinesha A. Williams, Jian‐Xiong Chen, Heng Zeng

Physiol Rep. 2022 Apr; 10(8): e15234. Published online 2022 Apr 20. doi: 10.14814/phy2.15234

PMCID:: PMC9020173

Abstract Article PDF–1.2M

Select item 60307235.

Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice

Haichao Wang, Qing Cheng, Xiaoyan Li, Feifei Hu, Longsen Han, Hao Zhang, Ling Li, Juan Ge, Xiaoyan Ying, Xuejiang Guo, Qiang Wang

Mol Cell Proteomics. 2018 Jul; 17(7): 1354–1364. Published online 2018 May 18. doi: 10.1074/mcp.RA118.000620

PMCID:: PMC6030723

Abstract Article PDF–1.9M

Select item 48917746.

TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis

Jun-Hao Zhou, Tong-Tong Zhang, Dan-Dan Song, Yun-Fei Xia, Zheng-Hong Qin, Rui Sheng

Sci Rep. 2016; 6: 27096. Published online 2016 Jun 3. doi: 10.1038/srep27096

PMCID:: PMC4891774

Abstract Article PDF–1.7M

Select item 111091947.

Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis

Dongdong Wang, Yanxia Li, Hao Yang, Xiaoqi Shen, Xiaolin Shi, Chenyu Li, Yongjing Zhang, Xiaoyu Liu, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Hui Bai, Qing Yang, Wei Gao, Fang Bai, Yong Ji, Qi Chen, Jingjing Ben

Nat Commun. 2024; 15: 4340. Published online 2024 May 21. doi: 10.1038/s41467-024-48708-0

PMCID:: PMC11109194

Abstract Article PDF–3.1M

Select item 91189228.

TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

Mengru Liu, Xinyu Zhou, Yue Li, Shijia Ma, Ling Pan, Xingxian Zhang, Wanqing Zheng, Zhanxun Wu, Ke Wang, Anil Ahsan, Jiaying Wu, Lei Jiang, Yangyang Lu, Weiwei Hu, Zhenghong Qin, Zhong Chen, Xiangnan Zhang

Redox Biol. 2022 Jul; 53: 102323. Published online 2022 May 10. doi: 10.1016/j.redox.2022.102323

PMCID:: PMC9118922

Abstract Article PDF–13M

Select item 73384499.

TIGAR/AP-1 axis accelerates the division of Lgr5⁻ reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation

Fei Chen, Yushuo Zhang, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Longxin Lin, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang, Chunlin Shao

Cell Death Dis. 2020 Jul; 11(7): 501. Published online 2020 Jul 6. doi: 10.1038/s41419-020-2715-6

PMCID:: PMC7338449

Abstract Article PDF–2.7M

Select item 679524510.

A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

Mei Li, Meiling Sun, Lijuan Cao, Jin-hua Gu, Jianbin Ge, Jieyu Chen, Rong Han, Yuan-Yuan Qin, Zhi-Peng Zhou, Yuqiang Ding, Zheng-Hong Qin

J Neurosci. 2014 May 28; 34(22): 7458–7471. doi: 10.1523/JNEUROSCI.4655-13.2014

PMCID:: PMC6795245

Abstract Article PDF–5.4M

Select item 556367811.

Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

Lijuan Cao, Jieyu Chen, Mei Li, Yuan-Yuan Qin, Meiling Sun, Rui Sheng, Feng Han, Guanghui Wang, Zheng-Hong Qin

Neurosci Bull. 2015 Oct; 31(5): 527–540. Published online 2015 Jul 28. doi: 10.1007/s12264-015-1538-4

PMCID:: PMC5563678

Abstract Article PDF–840K

Select item 821251512.

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

Ana Domostegui, Suresh Peddigari, Carol A. Mercer, Flavia Iannizzotto, Marta L. Rodriguez, Marta Garcia-Cajide, Virginia Amador, Sarah T. Diepstraten, Gemma L. Kelly, Ramón Salazar, Sara C. Kozma, Eric P. Kusnadi, Jian Kang, Antonio Gentilella, Richard B. Pearson, George Thomas, Joffrey Pelletier

Blood. 2021 Jun 17; 137(24): 3351–3364. Prepublished online 2021 Jan 14. doi: 10.1182/blood.2020007452

PMCID:: PMC8212515

Abstract Article

Select item 817428113.

Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism

Lanfang Li, Heng Zeng, Xiaochen He, Jian‐Xiong Chen

J Am Heart Assoc. 2021 Mar 2; 10(5): e018913. Published online 2021 Feb 15. doi: 10.1161/JAHA.120.018913

PMCID:: PMC8174281

Abstract Article PDF–2.0M

Select item 455849814.

p53- and p73-independent activation of TIGAR expression in vivo

P Lee, A K Hock, K H Vousden, E C Cheung

Cell Death Dis. 2015 Aug; 6(8): e1842. Published online 2015 Aug 6. doi: 10.1038/cddis.2015.205

PMCID:: PMC4558498

Abstract Article PDF–7.4M

Select item 894776015.

TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling

Yan Tang, Haihong Zong, Hyokjoon Kwon, Yunping Qiu, Jacob B Pessin, Licheng Wu, Katherine A Buddo, Ilya Boykov, Cameron A Schmidt, Chien-Te Lin, P Darrell Neufer, Gary J Schwartz, Irwin J Kurland, Jeffrey E Pessin

eLife. 2022; 11: e73360. Published online 2022 Mar 7. doi: 10.7554/eLife.73360

PMCID:: PMC8947760

Abstract Article PDF–5.5M

Select item 659956216.

p53‐TP53‐Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells

Xue Li, Limei Wu, Morgan Zopp, Shaina Kopelov, Wei Du

Stem Cells. 2019 Jul; 37(7): 937–947. Published online 2019 May 3. doi: 10.1002/stem.3015

PMCID:: PMC6599562

Abstract Article PDF–3.3M

Select item 470197817.

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

Eric C. Cheung, Pearl Lee, Fatih Ceteci, Colin Nixon, Karen Blyth, Owen J. Sansom, Karen H. Vousden

Genes Dev. 2016 Jan 1; 30(1): 52–63. doi: 10.1101/gad.271130.115

PMCID:: PMC4701978

Abstract Article PDF–2.0M

Select item 700824718.

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

Eric C. Cheung, Gina M. DeNicola, Colin Nixon, Karen Blyth, Christiaan F. Labuschagne, David A. Tuveson, Karen H. Vousden

Cancer Cell. 2020 Feb 10; 37(2): 168–182.e4. doi: 10.1016/j.ccell.2019.12.012

PMCID:: PMC7008247

Abstract Article

Select item 368218619.

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

Eric C. Cheung, Dimitris Athineos, Pearl Lee, Rachel A. Ridgway, Wendy Lambie, Colin Nixon, Douglas Strathdee, Karen Blyth, Owen J. Sansom, Karen H. Vousden

Dev Cell. 2013 Jun 10; 25(5): 463–477. doi: 10.1016/j.devcel.2013.05.001