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Select item 112039661.

Understanding Hypoxia-Driven Tumorigenesis: The Interplay of HIF1A, DNA Methylation, and Prolyl Hydroxylases in Head and Neck Squamous Cell Carcinoma

Julia Ostapowicz, Kamila Ostrowska, Agnieszka A. Rawłuszko-Wieczorek, Bartosz Wojtera, Sabina Koczot, Wojciech Golusiński, Wiktoria M. Suchorska

Int J Mol Sci. 2024 Jun; 25(12): 6495. Published online 2024 Jun 12. doi: 10.3390/ijms25126495

PMCID:: PMC11203966

Abstract Article PDF–10M

Select item 111596672.

Antisense hypoxia‐inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma

Fengjun Liu, Peijun Wang, Xian Jiang, Gang Tan, Haiquan Qiao, Hongchi Jiang, Geoffrey W. Krissansen, Xueying Sun

Cancer Sci. 2008 Oct; 99(10): 2055–2061. Published online 2008 Oct 14. doi: 10.1111/j.1349-7006.2008.00905.x

PMCID:: PMC11159667

Abstract Article PDF–417K

Select item 111361233.

The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1α

B. Herr, J. Zhou, S. Dröse, B. Brüne

Cell Mol Life Sci. 2007 Dec; 64(24): 3295–3305. Published online 2007 Nov 9. doi: 10.1007/s00018-007-7371-9

PMCID:: PMC11136123

Abstract Article PDF–979K

Select item 111156234.

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

O. O. Ogunshola, X. Antoniou

Cell Mol Life Sci. 2009 Nov; 66(22): 3555–3563. Published online 2009 Sep 11. doi: 10.1007/s00018-009-0141-0

PMCID:: PMC11115623

Abstract Article PDF–212K

Select item 111035025.

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

Sarah Madai, Pinar Kilic, Rolf M. Schmidt, Carlos Bas-Orth, Thomas Korff, Michael Büttner, Glynis Klinke, Gernot Poschet, Hugo H. Marti, Reiner Kunze

Theranostics. 2024; 14(7): 2856–2880. Published online 2024 Apr 29. doi: 10.7150/thno.88223

PMCID:: PMC11103502

Abstract Article PDF–3.5M

Select item 110887846.

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis

İlayda Altınönder, Mustafa Kaya, Sibel P. Yentür, Arman Çakar, Hacer Durmuş, Gülçin Yegen, Berker Özkan, Yeşim Parman, Amr H. Sawalha, Guher Saruhan-Direskeneli

J Neuroinflammation. 2024; 21: 126. Published online 2024 May 11. doi: 10.1186/s12974-024-03095-7

PMCID:: PMC11088784

Abstract Article PDF–1.8M

Select item 110834637.

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

Elena V. Mitroshina, Maria V. Vedunova

Int J Mol Sci. 2024 May; 25(9): 4581. Published online 2024 Apr 23. doi: 10.3390/ijms25094581

PMCID:: PMC11083463

Abstract Article PDF–1.7M

Select item 110752598.

CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration

Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu, Wenwei Hu

Biol Direct. 2024; 19: 36. Published online 2024 May 7. doi: 10.1186/s13062-024-00478-x

PMCID:: PMC11075259

Abstract Article PDF–10M

Select item 110228839.

Correlation Between HIF1-A Expression and Airway Remodeling in COPD

Lingfang Tan, Xuefeng Yang, Jianxin Zhang, Kebing Zhou

Int J Chron Obstruct Pulmon Dis. 2024; 19: 921–931. Published online 2024 Apr 13. doi: 10.2147/COPD.S447256

PMCID:: PMC11022883

Abstract Article PDF–7.3M

Select item 1100710010.

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

Jinyin Xiao, Xiajun Guo, Zhenquan Wang

Front Immunol. 2024; 15: 1385907. Published online 2024 Mar 28. doi: 10.3389/fimmu.2024.1385907

PMCID:: PMC11007100

Abstract Article PDF–2.1M

Select item 1088658811.

Single-Cell RNA Sequencing Reveals HIF1A as a Severity-Sensitive Immunological Scar in Circulating Monocytes of Convalescent Comorbidity-Free COVID-19 Patients

Lilly May, Chang-Feng Chu, Christina E. Zielinski

Cells. 2024 Feb; 13(4): 300. Published online 2024 Feb 6. doi: 10.3390/cells13040300

PMCID:: PMC10886588

Abstract Article PDF–4.5M

Select item 1085554212.

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

Marcus M. Mücke, Nihad El Bali, Katharina M. Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J. Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka, Angela Brieger

Int J Mol Sci. 2024 Feb; 25(3): 1542. Published online 2024 Jan 26. doi: 10.3390/ijms25031542

PMCID:: PMC10855542

Abstract Article PDF–8.4M

Select item 1080867413.

Analysis of HIF-1α expression and genetic polymorphisms in human clear cell renal cell carcinoma

Daniela Vargova, Zuzana Kolková, Jan Dargaj, Lukas Bris, Jan Luptak, Zuzana Dankova, Sona Franova, Jan Svihra, Pavol Slávik, Martina Sutovska

Pathol Oncol Res. 2023; 29: 1611444. Published online 2024 Jan 11. doi: 10.3389/pore.2023.1611444

PMCID:: PMC10808674

Abstract Article PDF–848K

Select item 1076267214.

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

Jinghui Lei, Xiaoyu Jiang, Daoyuan Huang, Ying Jing, Shanshan Yang, Lingling Geng, Yupeng Yan, Fangshuo Zheng, Fang Cheng, Weiqi Zhang, Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Si Wang, Jing Qu

Protein Cell. 2024 Jan; 15(1): 36–51. Published online 2023 May 9. doi: 10.1093/procel/pwad027

PMCID:: PMC10762672

Abstract Article PDF–33M

Select item 1072518615.

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

Liliana M. Sanmarco, Joseph M. Rone, Carolina M. Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni, Kylynne Ferrara, Cristina Gutierrez-Vazquez, Ning Li, Anna Sokolovska, Agustin Plasencia, Camilo Faust Akl, Payal Nanda, Evelin S. Heck, Zhaorong Li, Hong-Gyun Lee, Chun-Cheih Chao, Claudia M. Rejano-Gordillo, Pedro H. Fonseca-Castro, Tomer Illouz, Mathias Linnerbauer, Jessica E. Kenison, Rocky M. Barilla, Daniel Farrenkopf, Nikolas A. Stevens, Gavin Piester, Elizabeth N. Chung, Lucas Dailey, Vijay K. Kuchroo, David Hava, Michael A. Wheeler, Clary Clish, Roni Nowarski, Eduardo Balsa, Jose M. Lora, Francisco J. Quintana

Nature. Author manuscript; available in PMC 2023 Dec 16.

Published in final edited form as: Nature. 2023 Aug; 620(7975): 881–889. Published online 2023 Aug 9. doi: 10.1038/s41586-023-06409-6

PMCID:: PMC10725186

Abstract Article PDF–6.4M

Select item 1065909516.

HIF-1α promotes kidney organoid vascularization and applications in disease modeling

Kexin Peng, Wanqin Xie, Tingting Wang, Yamei Li, Jean de Dieu Habimana, Obed Boadi Amissah, Jufang Huang, Yong Chen, Bin Ni, Zhiyuan Li

Stem Cell Res Ther. 2023; 14: 336. Published online 2023 Nov 19. doi: 10.1186/s13287-023-03528-9

PMCID:: PMC10659095

Abstract Article PDF–15M

Select item 1063766117.

HSP70 via HIF-1 α SUMOylation inhibits ferroptosis inducing lung cancer recurrence after insufficient radiofrequency ablation

Bin Peng, Xiean Ling, Tonghai Huang, Jun Wan

PLoS One. 2023; 18(11): e0294263. Published online 2023 Nov 10. doi: 10.1371/journal.pone.0294263

PMCID:: PMC10637661

Abstract Article PDF–2.3M

Select item 1063063418.

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale, Mehvash Godiwala, Mari-Anna Väänänen, Tiia A. Turunen, Einari Aavik, Nihay Laham-Karam, Seppo Ylä-Herttuala, Minna U. Kaikkonen

J Biol Chem. 2023 Nov; 299(11): 105291. Published online 2023 Sep 23. doi: 10.1016/j.jbc.2023.105291

PMCID:: PMC10630634

Abstract Article PDF–2.5M

Select item 1062141319.

Hypoxia-inducible Factor-1α Suppresses the Innate Immune Response in Cultured Human Proximal Tubular Cells

DAIKI NAGAWA, MICHIKO SHIMADA, MASAMICHI NAKATA, IKUYO NARITA-KINJO, TAKESHI FUJITA, REIICHI MURAKAMI, NORIO NAKAMURA, HIROFUMI TOMITA

In Vivo. 2023 Nov-Dec; 37(6): 2437–2446. Published online 2023 Nov 3. doi: 10.21873/invivo.13349

PMCID:: PMC10621413

Abstract Article PDF–2.7M

Select item 1061638320.

SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cells

Mykyta I. Malkov, Darragh Flood, Cormac T. Taylor

J Biol Chem. 2023 Nov; 299(11): 105280. Published online 2023 Sep 22. doi: 10.1016/j.jbc.2023.105280

PMCID:: PMC10616383

Abstract Article PDF–1.1M

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