PMC Links for Gene (Select 3080) - PMC

Select item 38324951.

Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation

Hannes U. Eberhardt, Denise Buhlmann, Peter Hortschansky, Qian Chen, Sascha Böhm, Markus J. Kemper, Reinhard Wallich, Andrea Hartmann, Teresia Hallström, Peter F. Zipfel, Christine Skerka

PLoS One. 2013; 8(11): e78617. Published online 2013 Nov 18. doi: 10.1371/journal.pone.0078617

PMCID:: PMC3832495

Abstract Article PDF–3.3M

Select item 83872872.

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration

Laura Lorés-Motta, Anna E. van Beek, Esther Willems, Judith Zandstra, Gerard van Mierlo, Alfred Einhaus, Jean-Luc Mary, Corinne Stucki, Bjorn Bakker, Carel B. Hoyng, Sascha Fauser, Simon J. Clark, Marien I. de Jonge, Everson Nogoceke, Elod Koertvely, Ilse Jongerius, Taco W. Kuijpers, Anneke I. den Hollander

Am J Hum Genet. 2021 Aug 5; 108(8): 1367–1384. Published online 2021 Jul 13. doi: 10.1016/j.ajhg.2021.06.002

PMCID:: PMC8387287

Abstract Article PDF–2.4M

Select item 38712543.

Complement factor H–related hybrid protein deregulates complement in dense deposit disease

Qian Chen, Michael Wiesener, Hannes U. Eberhardt, Andrea Hartmann, Barbara Uzonyi, Michael Kirschfink, Kerstin Amann, Maike Buettner, Tim Goodship, Christian Hugo, Christine Skerka, Peter F. Zipfel

J Clin Invest. 2014 Jan 2; 124(1): 145–155. Published online 2013 Dec 16. doi: 10.1172/JCI71866

PMCID:: PMC3871254

Abstract Article PDF–1.7M

Select item 66096514.

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel, Christine Skerka

Nat Commun. 2019; 10: 2961. Published online 2019 Jul 4. doi: 10.1038/s41467-019-10766-0

PMCID:: PMC6609651

Abstract Article PDF–2.4M

Select item 39267115.

Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1–3 and complement factor H 479

Preeti Chaudhary, Mehmet Hepgur, Sarmen Sarkissian, Richard J.H. Smith, Ilene C. Weitz

Blood Transfus. 2014 Jan; 12(1): 111–113. doi: 10.2450/2013.0107-13

PMCID:: PMC3926711

Article PDF–514K

Select item 36688526.

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

Agustín Tortajada, Hugo Yébenes, Cynthia Abarrategui-Garrido, Jaouad Anter, Jesús M. García-Fernández, Rubén Martínez-Barricarte, María Alba-Domínguez, Talat H. Malik, Rafael Bedoya, Rocío Cabrera Pérez, Margarita López Trascasa, Matthew C. Pickering, Claire L. Harris, Pilar Sánchez-Corral, Oscar Llorca, Santiago Rodríguez de Córdoba

J Clin Invest. 2013 Jun 3; 123(6): 2434–2446. Published online 2013 May 24. doi: 10.1172/JCI68280

PMCID:: PMC3668852

Abstract Article PDF–3.9M

Select item 48840567.

Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk

Anne E. Hughes, Stephen Bridgett, Weihua Meng, Mingyao Li, Christine A. Curcio, Dwight Stambolian, Declan T. Bradley

Invest Ophthalmol Vis Sci. 2016 May; 57(6): 2763–2769. Published online 2016 May 19. doi: 10.1167/iovs.15-18744

PMCID:: PMC4884056

Abstract Article PDF–322K

Select item 24416168.

The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration

Hong Zhang, Margaux A Morrison, Andy DeWan, Scott Adams, Michael Andreoli, Nancy Huynh, Maureen Regan, Alison Brown, Joan W Miller, Ivana K Kim, Josephine Hoh, Margaret M DeAngelis

BMC Med Genet. 2008; 9: 51. Published online 2008 Jun 9. doi: 10.1186/1471-2350-9-51

PMCID:: PMC2441616

Abstract Article PDF–1.6M

Select item 19058369.

Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications

Gregory S. Hageman, Lisa S. Hancox, Andrew J. Taiber, Karen M. Gehrs, Don H. Anderson, Lincoln V. Johnson, Monte J. Radeke, David Kavanagh, Anna Richards, John Atkinson, Seppo Meri, Julie Bergeron, Jana Zernant, Joanna Merriam, Bert Gold, Rando Allikmets, Michael Dean, the AMD Clinical Study Group

Ann Med. Author manuscript; available in PMC 2007 Jul 2.

Published in final edited form as: Ann Med. 2006; 38(8): 592–604.

PMCID:: PMC1905836

Abstract Article PDF–470K

Select item 360697310.

Dimerization of complement factor H-related proteins modulates complement activation in vivo

Elena Goicoechea de Jorge, Joseph J. E. Caesar, Talat H. Malik, Mitali Patel, Matthew Colledge, Steven Johnson, Svetlana Hakobyan, B. Paul Morgan, Claire L. Harris, Matthew C. Pickering, Susan M. Lea

Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12): 4685–4690. Published online 2013 Mar 4. doi: 10.1073/pnas.1219260110

PMCID:: PMC3606973

Abstract Article PDF–731K

Select item 319082611.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011