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Select item 107834901.

Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex

Matthias Breindl, Dominika Spitzer, Rūta Gerasimaitė, Visvaldas Kairys, Thomas Schubert, Ramona Henfling, Uwe Schwartz, Gražvydas Lukinavičius, Laura Manelytė

Nucleic Acids Res. 2024 Jan 11; 52(1): 337–354. Published online 2023 Nov 24. doi: 10.1093/nar/gkad1096

PMCID:: PMC10783490

Abstract Article PDF–2.4M

Select item 80498402.

The Master Regulator protein BAZ2B can reprogram human hematopoietic lineage-committed progenitors into a multipotent state.

Karthik Arumugam, William Shin, Valentina Schiavone, Lukas Vlahos, Xiaochuan Tu, Davide Carnevali, Jordan Kesner, Evan O Paull, Neus Romo, Prem Subramaniam, Jeremy Worley, Xiangtian Tan, Andrea Califano, Maria Pia Cosma

Cell Rep. Author manuscript; available in PMC 2021 Jun 8.

Published in final edited form as: Cell Rep. 2020 Dec 8; 33(10): 108474. doi: 10.1016/j.celrep.2020.108474

PMCID:: PMC8049840

Abstract Article PDF–1.3M

Select item 72627393.

BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability and autism spectrum disorder

Tiana M. Scott, Hui Guo, Evan E. Eichler, Jill A. Rosenfeld, Kaifang Pang, Zhandong Liu, Seema Lalani, Bi Weimin, Yaping Yang, Carlos A. Bacino, Haley Streff, Andrea M. Lewis, Mary K. Koenig, Isabelle Thiffault, Allison Bellomo, David B. Everman, Julie R. Jones, Roger E. Stevenson, Raphael Bernier, Christian Gilissen, Rolph Pfundt, Susan M. Hiatt, Gregory M. Cooper, Jimmy L. Holder, Jr., Daryl A. Scott

Hum Mutat. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Hum Mutat. 2020 May; 41(5): 921–925. Published online 2020 Feb 7. doi: 10.1002/humu.23992

PMCID:: PMC7262739

Abstract Article PDF–477K

Select item 69727704.

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény

Nat Commun. 2020; 11: 419. Published online 2020 Jan 21. doi: 10.1038/s41467-020-14299-9

PMCID:: PMC6972770

Abstract Article PDF–1.6M

Select item 56638695.

A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding

Sebastian Kostrhon, Georg Kontaxis, Tanja Kaufmann, Erika Schirghuber, Stefan Kubicek, Robert Konrat, Dea Slade

J Biol Chem. 2017 Oct 27; 292(43): 17643–17657. Published online 2017 Sep 1. doi: 10.1074/jbc.M117.801464

PMCID:: PMC5663869

Abstract Article PDF–3.4M

Select item 56238706.

Expansion of the ISWI chromatin remodeler family with new active complexes

Mariano Oppikofer, Tianyi Bai, Yutian Gan, Benjamin Haley, Peter Liu, Wendy Sandoval, Claudio Ciferri, Andrea G Cochran

EMBO Rep. 2017 Oct; 18(10): 1697–1706. Published online 2017 Aug 11. doi: 10.15252/embr.201744011

PMCID:: PMC5623870

Abstract Article PDF–1.3M

Select item 44583777.

Binding Hotspots of BAZ2B Bromodomain: Histone Interaction Revealed by Solution NMR Driven Docking

Fleur M. Ferguson, David M. Dias, João P. G. L. M. Rodrigues, Hans Wienk, Rolf Boelens, Alexandre M. J. J. Bonvin, Chris Abell, Alessio Ciulli

Biochemistry. Author manuscript; available in PMC 2015 Jun 7.

Published in final edited form as: Biochemistry. 2014 Oct 28; 53(42): 6706–6716. Published online 2014 Oct 15. doi: 10.1021/bi500909d

PMCID:: PMC4458377

Abstract Article PDF–1.6M

Select item 44415368.

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

Ludovic Drouin, Sally McGrath, Lewis R. Vidler, Apirat Chaikuad, Octovia Monteiro, Cynthia Tallant, Martin Philpott, Catherine Rogers, Oleg Fedorov, Manjuan Liu, Wasim Akhtar, Angela Hayes, Florence Raynaud, Susanne Müller, Stefan Knapp, Swen Hoelder

J Med Chem. 2015 Mar 12; 58(5): 2553–2559. Published online 2015 Feb 26. doi: 10.1021/jm501963e

PMCID:: PMC4441536

Abstract Article PDF–2.3M

Select item 39056949.

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

Fleur M. Ferguson, Oleg Fedorov, Apirat Chaikuad, Martin Philpott, Joao R. C. Muniz, Ildiko Felletar, Frank von Delft, Tom Heightman, Stefan Knapp, Chris Abell, Alessio Ciulli

J Med Chem. 2013 Dec 27; 56(24): 10183–10187. Published online 2013 Dec 4. doi: 10.1021/jm401582c

PMCID:: PMC3905694

Abstract Article PDF–1.4M

Select item 312811110.

Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals

Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Naima Carter-Monroe, Kari S. Kaikkonen, Marja-Leena Kortelainen, Gabrielle Boucher, Caroline Lagacé, Anna Moes, XiaoQing Zhao, Frank Kolodgie, Fernando Rivadeneira, Albert Hofman, Jacqueline C. M. Witteman, André G. Uitterlinden, Roos F. Marsman, Raha Pazoki, Abdennasser Bardai, Rudolph W. Koster, Abbas Dehghan, Shih-Jen Hwang, Pallav Bhatnagar, Wendy Post, Gina Hilton, Ronald J. Prineas, Man Li, Anna Köttgen, Georg Ehret, Eric Boerwinkle, Josef Coresh, W. H. Linda Kao, Bruce M. Psaty, Gordon F. Tomaselli, Nona Sotoodehnia, David S. Siscovick, Greg L. Burke, Eduardo Marbán, Peter M. Spooner, L. Adrienne Cupples, Jonathan Jui, Karen Gunson, Y. Antero Kesäniemi, Arthur A. M. Wilde, Jean-Claude Tardif, Christopher J. O'Donnell, Connie R. Bezzina, Renu Virmani, Bruno H. C. h. Stricker, Hanno L. Tan, Christine M. Albert, Aravinda Chakravarti, John D. Rioux, Heikki V. Huikuri, Sumeet S. Chugh

PLoS Genet. 2011 Jun; 7(6): e1002158. Published online 2011 Jun 30. doi: 10.1371/journal.pgen.1002158

PMCID:: PMC3128111

Abstract Article PDF–320K

Select item 661076011.

GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer.

Samantha M. Bevill, Jose F. Olivares-Quintero, Noah Sciaky, Brian T. Golitz, Darshan Singh, Adriana S. Beltran, Naim U. Rashid, Timothy J. Stuhlmiller, Andrew Hale, Nathaniel J. Moorman, Charlene M. Santos, Steven P. Angus, Jon S. Zawistowski, Gary L. Johnson

Mol Cancer Res. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Mol Cancer Res. 2019 Jul; 17(7): 1503–1518. Published online 2019 Apr 18. doi: 10.1158/1541-7786.MCR-18-1121

PMCID:: PMC6610760

Abstract Article PDF–2.5M

Select item 541584812.

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains

Alessio Bortoluzzi, Anastasia Amato, Xavier Lucas, Manuel Blank, Alessio Ciulli

Biochem J. 2017 May 15; 474(10): 1633–1651. Prepublished online 2017 Mar 24. Published online 2017 May 4. doi: 10.1042/BCJ20161053

PMCID:: PMC5415848

Abstract Article PDF–1.3M

Select item 301259613.

Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study

Weihong Tang, Saonli Basu, Xiaoxiao Kong, James S. Pankow, Nena Aleksic, Adrian Tan, Mary Cushman, Eric Boerwinkle, Aaron R. Folsom

Blood. 2010 Dec 2; 116(23): 5032–5036. Prepublished online 2010 Aug 27. doi: 10.1182/blood-2010-05-283739

PMCID:: PMC3012596

Abstract Article

Select item 558759114.

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu, Shi-Min Zhao, Wei Xu

Nat Commun. 2017; 8: 464. Published online 2017 Sep 6. doi: 10.1038/s41467-017-00489-5

PMCID:: PMC5587591

Abstract Article PDF–2.4M

Select item 399262615.

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

Samuel A. Jensen, Andrea E. Calvert, Giora Volpert, Fotini M. Kouri, Lisa A. Hurley, Janina P. Luciano, Yongfei Wu, Alexandra Chalastanis, Anthony H. Futerman, Alexander H. Stegh

Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15): 5682–5687. Published online 2014 Mar 31. doi: 10.1073/pnas.1316700111

PMCID:: PMC3992626

Abstract Article PDF–1.3M

Select item 429813816.

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Fade Gong, Li-Ya Chiu, Ben Cox, François Aymard, Thomas Clouaire, Justin W. Leung, Michael Cammarata, Mercedes Perez, Poonam Agarwal, Jennifer S. Brodbelt, Gaëlle Legube, Kyle M. Miller

Genes Dev. 2015 Jan 15; 29(2): 197–211. doi: 10.1101/gad.252189.114