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Items: 19

Select item 101978951.

Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat

Susu Zhang, Jiaxin Zhao, Man Wu, Yongxiu Zhou, Xuejuan Wu, Anyu Du, Yibing Tao, Shanshan Huang, Shufang Cai, Mei Zhou, Tao Wei, Yanren Zhang, Ling Xie, Yanqing Wu, Jian Xiao

Int J Biol Sci. 2023; 19(8): 2475–2494. Published online 2023 May 8. doi: 10.7150/ijbs.80672

PMCID:: PMC10197895

Abstract Article PDF–17M

Select item 48829202.

THE ROLE OF TRPM2 IN HYDROGEN PEROXIDE-INDUCED EXPRESSION OF INFLAMMATORY CYTOKINE AND CHEMOKINE IN RAT TRIGEMINAL GANGLIA

M.-K. CHUNG, J. ASGAR, J. LEE, M. S. SHIM, C. DUMLER, J. Y. RO

Neuroscience. Author manuscript; available in PMC 2016 May 27.

Published in final edited form as: Neuroscience. 2015 Jun 25; 297: 160–169. Published online 2015 Apr 4. doi: 10.1016/j.neuroscience.2015.03.067

PMCID:: PMC4882920

Abstract Article PDF–710K

Select item 42293963.

Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 (TRPM2) channels

Silu Lu, Lusha Xiang, John S. Clemmer, Peter N. Mittwede, Robert L. Hester

Microcirculation. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Microcirculation. 2014 Nov; 21(8): 754–760. doi: 10.1111/micc.12158

PMCID:: PMC4229396

Abstract Article PDF–1.9M

Select item 64596004.

Structures and gating mechanism of human TRPM2

Longfei Wang, Tian-Min Fu, Yiming Zhou, Shiyu Xia, Anna Greka, Hao Wu

Science. Author manuscript; available in PMC 2019 Apr 11.

Published in final edited form as: Science. 2018 Dec 21; 362(6421): eaav4809. Published online 2018 Nov 22. doi: 10.1126/science.aav4809

PMCID:: PMC6459600

Abstract Article PDF–2.6M

Select item 59764365.

Structure of a TRPM2 channel in complex with Ca²⁺ explains unique gating regulation

Zhe Zhang, Balázs Tóth, Andras Szollosi, Jue Chen, László Csanády

eLife. 2018; 7: e36409. Published online 2018 May 10. doi: 10.7554/eLife.36409

PMCID:: PMC5976436

Abstract Article PDF–5.1M

Select item 57275016.

Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium

Esra Yüksel, Mustafa Nazıroğlu, Mehmet Şahin, Bilal Çiğ

Sci Rep. 2017; 7: 17543. Published online 2017 Dec 13. doi: 10.1038/s41598-017-17715-1

PMCID:: PMC5727501

Abstract Article PDF–3.9M

Select item 55431657.

Modulation of activation and inactivation by Ca²⁺ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis

Frank J. P. Kühn, Winking Mathis, Kühn Cornelia, Daniel C. Hoffmann, Andreas Lückhoff

Sci Rep. 2017; 7: 7245. Published online 2017 Aug 3. doi: 10.1038/s41598-017-07652-4

PMCID:: PMC5543165

Abstract Article PDF–3.5M

Select item 51316538.

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

Hatice Akpınar, Mustafa Nazıroğlu, İshak Suat Övey, Bilal Çiğ, Orhan Akpınar

Sci Rep. 2016; 6: 37196. Published online 2016 Nov 22. doi: 10.1038/srep37196

Correction in:: Sci Rep. 2018; 8: 47002.

PMCID:: PMC5131653

Abstract Article PDF–1.5M

Select item 49740569.

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády

eLife. 2016; 5: e17600. Published online 2016 Jul 6. doi: 10.7554/eLife.17600

PMCID:: PMC4974056

Abstract Article PDF–4.6M

Select item 491725210.

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

Frank J. P. Kühn, Cornelia Kühn, Mathis Winking, Daniel C. Hoffmann, Andreas Lückhoff

PLoS One. 2016; 11(6): e0158060. Published online 2016 Jun 22. doi: 10.1371/journal.pone.0158060

PMCID:: PMC4917252

Abstract Article PDF–3.1M

Select item 451648311.

H₂O₂-induced Ca²⁺ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the β-cells: involvement of TRPM2 channels

Muhammad R Bari, Sanian Akbar, Mohamed Eweida, Frank JP Kühn, Amanda Jabin Gustafsson, Andreas Lückhoff, Md Shahidul Islam

J Cell Mol Med. 2009 Sep; 13(9b): 3260–3267. Published online 2009 Mar 6. doi: 10.1111/j.1582-4934.2009.00737.x

PMCID:: PMC4516483

Abstract Article PDF–880K

Select item 430614312.

Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

Frank J. P. Kühn, Cornelia Kühn, Andreas Lückhoff

Sci Rep. 2015; 5: 8032. Published online 2015 Jan 26. doi: 10.1038/srep08032

PMCID:: PMC4306143

Abstract Article PDF–1.7M

Select item 317758213.

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca²⁺ release

Adriana Sumoza-Toledo, Ingo Lange, Hanna Cortado, Harivadan Bhagat, Yasuo Mori, Andrea Fleig, Reinhold Penner, Santiago Partida-Sánchez

FASEB J. 2011 Oct; 25(10): 3529–3542. doi: 10.1096/fj.10-178483

PMCID:: PMC3177582

Abstract Article

Select item 263819914.

Four Ca²⁺ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate

László Csanády, Beáta Törőcsik

J Gen Physiol. 2009 Feb; 133(2): 189–203. doi: 10.1085/jgp.200810109

PMCID:: PMC2638199

Abstract Article PDF–3.0M

Select item 393986915.

TRPM2 channels mediate acetaminophen-induced liver damage

Ehsan Kheradpezhouh, Linlin Ma, Arthur Morphett, Greg J. Barritt, Grigori Y. Rychkov

Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8): 3176–3181. Published online 2014 Feb 3. doi: 10.1073/pnas.1322657111

PMCID:: PMC3939869

Abstract Article PDF–1.1M

Select item 145694716.

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion

Kazuya Togashi, Yuji Hara, Tomoko Tominaga, Tomohiro Higashi, Yasunobu Konishi, Yasuo Mori, Makoto Tominaga

EMBO J. 2006 May 3; 25(9): 1804–1815. Published online 2006 Apr 6. doi: 10.1038/sj.emboj.7601083

PMCID:: PMC1456947

Abstract Article PDF–363K

Select item 761227617.

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

Kun Song, Hong Wang, Gretel B. Kamm, Jörg Pohle, Fernanda de Castro Reis, Paul Heppenstall, Hagen Wende, Jan Siemens

Science. Author manuscript; available in PMC 2022 Jan 27.

Published in final edited form as: Science. 2016 Sep 23; 353(6306): 1393–1398. Published online 2016 Aug 25. doi: 10.1126/science.aaf7537

PMCID:: PMC7612276

Abstract Article PDF–1.9M

Select item 38332218.

High-Density Rat Radiation Hybrid Maps Containing Over 24,000 SSLPs, Genes, and ESTs Provide a Direct Link to the Rat Genome Sequence

Anne E. Kwitek, Jo Gullings-Handley, Jiaming Yu, Danilo C. Carlos, Kimberly Orlebeke, Jeff Nie, Jeffrey Eckert, Angela Lemke, Jaime Wendt Andrae, Susan Bromberg, Dean Pasko, Dan Chen, Todd E. Scheetz, Thomas L. Casavant, M. Bento Soares, Val C. Sheffield, Peter J. Tonellato, Howard J. Jacob

Genome Res. 2004 Apr; 14(4): 750–757. doi: 10.1101/gr.1968704