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Select item 107854591.

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [¹⁸F]PSS232 PET/MRI study

Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie

Alzheimers Res Ther. 2024; 16: 9. Published online 2024 Jan 12. doi: 10.1186/s13195-024-01385-z

PMCID:: PMC10785459

Abstract Article PDF–2.9M

Select item 107493582.

Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis

Izabella B. Q. de Lima, Pablo L. Cardozo, Julia S. Fahel, Juliana P. S. Lacerda, Aline S. Miranda, Antônio L. Teixeira, Fabiola M. Ribeiro

Front Immunol. 2023; 14: 1283331. Published online 2023 Dec 11. doi: 10.3389/fimmu.2023.1283331

PMCID:: PMC10749358

Abstract Article PDF–5.8M

Select item 87487903.

mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [¹¹C]ABP688 PET/MR-EEG

Cláudia Régio Brambilla, Tanja Veselinović, Ravichandran Rajkumar, Jörg Mauler, Andreas Matusch, Andrej Ruch, Linda Orth, Shukti Ramkiran, Hasan Sbaihat, Nicolas Kaulen, Nibal Yahya Khudeish, Christine Wyss, Karsten Heekeren, Wolfram Kawohl, Elena Rota Kops, Lutz Tellmann, Jürgen Scheins, Frank Boers, Bernd Neumaier, Johannes Ermert, Markus Lang, Stefan Stüsgen, Hans Herzog, Karl-Josef Langen, N. Jon Shah, Christoph W. Lerche, Irene Neuner

Transl Psychiatry. 2022; 12: 6. Published online 2022 Jan 10. doi: 10.1038/s41398-021-01763-3

PMCID:: PMC8748790

Abstract Article PDF–2.4M

Select item 84246484.

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Chady Nasrallah, Giuseppe Cannone, Julie Briot, Karine Rottier, Alice E. Berizzi, Chia-Ying Huang, Robert B. Quast, Francois Hoh, Jean-Louis Banères, Fanny Malhaire, Ludovic Berto, Anaëlle Dumazer, Joan Font-Ingles, Xavier Gómez-Santacana, Juanlo Catena, Julie Kniazeff, Cyril Goudet, Amadeu Llebaria, Jean-Philippe Pin, Kutti R. Vinothkumar, Guillaume Lebon

Cell Rep. 2021 Aug 31; 36(9): 109648. Published online 2021 Aug 31. doi: 10.1016/j.celrep.2021.109648

PMCID:: PMC8424648

Abstract Article

Select item 83781325.

Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [¹⁸F]FPEB PET

Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck

Neuroimage. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Neuroimage. 2021 Sep; 238: 118217. Published online 2021 May 27. doi: 10.1016/j.neuroimage.2021.118217

PMCID:: PMC8378132

Abstract Article PDF–849K

Select item 83426106.

In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker

Maria Mody, Yoann Petibon, Paul Han, Darshini Kuruppu, Chao Ma, Daniel Yokell, Ramesh Neelamegam, Marc D. Normandin, Georges El Fakhri, Anna-Liisa Brownell

Sci Rep. 2021; 11: 15897. Published online 2021 Aug 5. doi: 10.1038/s41598-021-94967-y

PMCID:: PMC8342610

Abstract Article PDF–1.4M

Select item 79997117.

Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study

James Robert Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, John P. Seibyl, Dean F. Wong, Dejan B. Budimirovic

Int J Mol Sci. 2021 Mar; 22(6): 2863. Published online 2021 Mar 11. doi: 10.3390/ijms22062863

PMCID:: PMC7999711

Abstract Article PDF–1.3M

Select item 76621078.

The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis

Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti

Eur J Histochem. 2020 Oct 19; 64(4): 3175. Published online 2020 Nov 10. doi: 10.4081/ejh.2020.3175

PMCID:: PMC7662107

Abstract Article PDF–517K

Select item 71567029.

Metabotropic glutamate receptor 5 in bulimia nervosa

Yoan Mihov, Valerie Treyer, Funda Akkus, Erika Toman, Gabriella Milos, Simon M. Ametamey, Anass Johayem, Gregor Hasler

Sci Rep. 2020; 10: 6374. Published online 2020 Apr 14. doi: 10.1038/s41598-020-63389-7

PMCID:: PMC7156702

Abstract Article PDF–1.2M

Select item 682565310.

The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu₅ receptor case study

Zoltán Orgován, György G. Ferenczy, György M. Keserű

J Comput Aided Mol Des. 2019; 33(9): 787–797. Published online 2019 Sep 21. doi: 10.1007/s10822-019-00224-w

PMCID:: PMC6825653

Abstract Article PDF–1.2M

Select item 656129811.

In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation

Margaret T. Davis, Ansel Hillmer, Sophie E. Holmes, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo Angarita-Africano, Richard E. Carson, John H. Krystal, Irina Esterlis

Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11490–11495. Published online 2019 May 13. doi: 10.1073/pnas.1818871116

Correction in:: Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13702.

PMCID:: PMC6561298

Abstract Article PDF–807K

Select item 598052012.

Encephalitis with mGluR5 antibodies: Symptoms and antibody effects

Marianna Spatola, Lidia Sabater, Jesús Planagumà, Eugenia Martínez-Hernandez, Thaís Armangué, Harald Prüss, Takahiro Iizuka, Ruben L. Caparó Oblitas, Jean-Christophe Antoine, Richard Li, Nicholas Heaney, Niall Tubridy, Elvira Munteis Olivas, Myrna R. Rosenfeld, Francesc Graus, Josep Dalmau

Neurology. 2018 May 29; 90(22): e1964–e1972. doi: 10.1212/WNL.0000000000005614

PMCID:: PMC5980520

Abstract Article PDF–989K

Select item 597666813.

mGluR5 mediates post-radiotherapy fatigue development in cancer patients

Li Rebekah Feng, Juan Luis Fernández-Martínez, Kristien J.M. Zaal, Enrique J deAndrés-Galiana, Brian S. Wolff, Leorey N. Saligan

Transl Psychiatry. 2018; 8: 110. Published online 2018 May 30. doi: 10.1038/s41398-018-0161-3

PMCID:: PMC5976668

Abstract Article PDF–1.6M

Select item 580258414.

Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder

Funda Akkus, Yoan Mihov, Valerie Treyer, Simon M. Ametamey, Anass Johayem, Smeralda Senn, Susanne Rösner, Alfred Buck, Gregor Hasler

Transl Psychiatry. 2018; 8: 17. Published online 2018 Jan 10. doi: 10.1038/s41398-017-0066-6

PMCID:: PMC5802584

Abstract Article PDF–503K

Select item 556182315.

Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus

Pengbo Yang, Junfeng Zhang, Lingyu Zhao, Qian Jian, Hui Jin, Xinli Xiao, Haixia Zhang, Ming Hu, Haixia Lu, Yong Liu

Neurosci Bull. 2012 Dec; 28(6): 704–714. Published online 2012 Dec 7. doi: 10.1007/s12264-012-1286-7

PMCID:: PMC5561823

Abstract Article PDF–879K

Select item 549915616.

Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

Simona D’Antoni, Michela Spatuzza, Carmela M. Bonaccorso, Sebastiano A. Musumeci, Lucia Ciranna, Ferdinando Nicoletti, Kimberly M. Huber, Maria Vincenza Catania

Neurosci Biobehav Rev. Author manuscript; available in PMC 2017 Jul 6.

Published in final edited form as: Neurosci Biobehav Rev. 2014 Oct; 46(Pt 2): 228–241. Published online 2014 Feb 15. doi: 10.1016/j.neubiorev.2014.02.003

PMCID:: PMC5499156

Abstract Article PDF–562K

Select item 533974917.

Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization

Ismail Sergin, Yuh-Jiin I. Jong, Steven K. Harmon, Vikas Kumar, Karen L. O'Malley

J Biol Chem. 2017 Mar 3; 292(9): 3637–3655. Published online 2017 Jan 17. doi: 10.1074/jbc.M116.757724

PMCID:: PMC5339749

Abstract Article PDF–6.1M

Select item 506858818.

Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688

C DeLorenzo, J Sovago, J Gardus, J Xu, J Yang, R Behrje, J S D Kumar, D P Devanand, G H Pelton, C A Mathis, N S Mason, B Gomez-Mancilla, H Aizenstein, J J Mann, R V Parsey

Transl Psychiatry. 2015 Dec; 5(12): e693. Published online 2015 Dec 8. doi: 10.1038/tp.2015.189

PMCID:: PMC5068588

Abstract Article PDF–436K

Select item 416531119.

Distinct Increased Metabotropic Glutamate Receptor Type 5 (mGluR5) in Temporal Lobe Epilepsy With and Without Hippocampal Sclerosis

Ludmyla Kandratavicius, Pedro Rosa-Neto, Mariana Raquel Monteiro, Marie-Christine Guiot, Joao Alberto Assirati, Carlos Gilberto Carlotti, Eliane Kobayashi, Joao Pereira Leite

Hippocampus. 2013 Dec; 23(12): 1212–1230. Published online 2013 Jul 23. doi: 10.1002/hipo.22160

PMCID:: PMC4165311

Abstract Article PDF–1.5M

Select item 399094520.

Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site

Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn

ACS Chem Neurosci. 2014 Apr 16; 5(4): 282–295. Published online 2014 Feb 16. doi: 10.1021/cn400225x

PMCID:: PMC3990945

Abstract Article PDF–6.4M

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