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Select item 111269941.

Exploring the activation mechanism of metabotropic glutamate receptor 2

Xiaohong Zhu, Mengqi Luo, Ke An, Danfeng Shi, Tingjun Hou, Arieh Warshel, Chen Bai

Proc Natl Acad Sci U S A. 2024 May 21; 121(21): e2401079121. Published online 2024 May 13. doi: 10.1073/pnas.2401079121

PMCID:: PMC11126994

Abstract Article PDF–3.2M

Select item 88229032.

G-protein activation by a metabotropic glutamate receptor

Alpay B. Seven, Ximena Barros-Álvarez, Marine de Lapeyrière, Makaía M. Papasergi-Scott, Michael J. Robertson, Chensong Zhang, Robert M. Nwokonko, Yang Gao, Justin G. Meyerowitz, Jean-Philippe Rocher, Dominik Schelshorn, Brian K. Kobilka, Jesper M. Mathiesen, Georgios Skiniotis

Nature. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Nature. 2021 Jul; 595(7867): 450–454. Published online 2021 Jun 30. doi: 10.1038/s41586-021-03680-3

PMCID:: PMC8822903

Abstract Article PDF–5.5M

Select item 84405903.

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Anne-Marinette Cao, Robert B. Quast, Fataneh Fatemi, Philippe Rondard, Jean-Philippe Pin, Emmanuel Margeat

Nat Commun. 2021; 12: 5426. Published online 2021 Sep 14. doi: 10.1038/s41467-021-25620-5

PMCID:: PMC8440590

Abstract Article PDF–3.6M

Select item 79046304.

Conformational rearrangement during activation of a metabotropic glutamate receptor

Brandon Wey-Hung Liauw, Hamid Samareh Afsari, Reza Vafabakhsh

Nat Chem Biol. Author manuscript; available in PMC 2021 Jul 4.

Published in final edited form as: Nat Chem Biol. 2021 Mar; 17(3): 291–297. Published online 2021 Jan 4. doi: 10.1038/s41589-020-00702-5

PMCID:: PMC7904630

Abstract Article PDF–5.1M

Select item 49888875.

Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

Steve Davidson, Judith P. Golden, Bryan A. Copits, Pradipta R. Ray, Sherri K. Vogt, Manouela V. Valtcheva, Robert E. Schmidt, Andrea Ghetti, Theodore Price, Robert W. Gereau, IV

Pain. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Pain. 2016 Sep; 157(9): 2081–2088. doi: 10.1097/j.pain.0000000000000621

PMCID:: PMC4988887

Abstract Article PDF–1.7M

Select item 47284246.

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

Maarten L J Doornbos, Laura Pérez‐Benito, Gary Tresadern, Thea Mulder‐Krieger, Ilse Biesmans, Andrés A Trabanco, Jose María Cid, Hilde Lavreysen, Adriaan P IJzerman, Laura H Heitman

Br J Pharmacol. 2016 Feb; 173(3): 588–600. Published online 2016 Jan 13. doi: 10.1111/bph.13390

PMCID:: PMC4728424

Abstract Article PDF–1.5M

Select item 44031017.

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2

A Farinha, H Lavreysen, L Peeters, B Russo, S Masure, A A Trabanco, J Cid, G Tresadern

Br J Pharmacol. 2015 May; 172(9): 2383–2396. Published online 2015 Feb 27. doi: 10.1111/bph.13065

PMCID:: PMC4403101

Abstract Article PDF–1.0M

Select item 34796128.

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

Driss El Moustaine, Sébastien Granier, Etienne Doumazane, Pauline Scholler, Rita Rahmeh, Patrick Bron, Bernard Mouillac, Jean-Louis Banères, Philippe Rondard, Jean-Philippe Pin

Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40): 16342–16347. Published online 2012 Sep 17. doi: 10.1073/pnas.1205838109

PMCID:: PMC3479612

Abstract Article PDF–905K

Select item 34116069.

Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR

Agostino Bruno, Gabriele Costantino, Gianni de Fabritiis, Manuel Pastor, Jana Selent

PLoS One. 2012; 7(8): e42023. Published online 2012 Aug 1. doi: 10.1371/journal.pone.0042023

Correction in:: PLoS One. 2012; 7(11): 10.1371/annotation/b3d4540a-9b4b-4855-b570-6324b40232fe.

PMCID:: PMC3411606

Abstract Article PDF–387K

Select item 269843710.

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

Hyoung-gon Lee, Xiongwei Zhu, Gemma Casadesus, Mercé Pallàs, Antoni Camins, Michael J. O’Neill, Shigetada Nakanishi, George Perry, Mark A. Smith

Brain Res. Author manuscript; available in PMC 2009 Jun 18.

Published in final edited form as: Brain Res. 2009 Jan 16; 1249: 244–250. Published online 2008 Nov 5. doi: 10.1016/j.brainres.2008.10.055

PMCID:: PMC2698437

Abstract Article PDF–842K

Select item 1045455711.

Heterodimerization of Chemoreceptors TAS1R3 and mGlu₂ in Human Blood Leukocytes

Lena Ball, Julia Bauer, Dietmar Krautwurst

Int J Mol Sci. 2023 Aug; 24(16): 12942. Published online 2023 Aug 18. doi: 10.3390/ijms241612942

PMCID:: PMC10454557

Abstract Article PDF–3.0M

Select item 1010300912.

The crosstalk between 5-HT_2AR and mGluR2 in schizophrenia

Somdatta Saha, Javier González-Maeso

Neuropharmacology. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Neuropharmacology. 2023 Jun 1; 230: 109489. Published online 2023 Mar 6. doi: 10.1016/j.neuropharm.2023.109489

PMCID:: PMC10103009

Abstract Article PDF–1.6M

Select item 371117613.

Rescue of Infralimbic mGluR₂ Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence

Marcus W. Meinhardt, Anita C. Hansson, Stephanie Perreau-Lenz, Christina Bauder-Wenz, Oliver Stählin, Markus Heilig, Clive Harper, Karla U. Drescher, Rainer Spanagel, Wolfgang H. Sommer

J Neurosci. 2013 Feb 13; 33(7): 2794–2806. doi: 10.1523/JNEUROSCI.4062-12.2013

PMCID:: PMC3711176

Abstract Article PDF–1.9M

Select item 282651214.

Elevated Level of Metabotropic Glutamate Receptor 2/3 in the Prefrontal Cortex in Major Depression

Anteneh M. Feyissa, William L. Woolverton, Jose J. Miguel-Hidalgo, Zhixia Wang, Patrick B. Kyle, Gregor Hasler, Craig A. Stockmeier, Abiye H. Iyo, Beata Karolewicz

Prog Neuropsychopharmacol Biol Psychiatry. Author manuscript; available in PMC 2011 Mar 17.

Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17; 34(2): 279–283. Published online 2009 Nov 26. doi: 10.1016/j.pnpbp.2009.11.018

PMCID:: PMC2826512

Abstract Article PDF–727K

Select item 274949315.

Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia

Subroto Ghose, Jeremy M. Crook, Cynthia L. Bartus, Thomas G. Sherman, Mary M. Herman, Thomas M. Hyde, Joel E. Kleinman, Mayada Akil

Int J Neurosci. Author manuscript; available in PMC 2009 Nov 1.

Published in final edited form as: Int J Neurosci. 2008 Nov; 118(11): 1609–1627. doi: 10.1080/00207450802330702

PMCID:: PMC2749493

Abstract Article PDF–1.1M

Select item 274595616.

Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease

Yuesong Gong, Carol F. Lippa, Jinghua Zhu, Qishan Lin, Andrea L. Rosso

Brain Res. Author manuscript; available in PMC 2009 Sep 25.

Published in final edited form as: Brain Res. 2009 Oct 6; 1292: 191–198. Published online 2009 Jul 25. doi: 10.1016/j.brainres.2009.07.056

PMCID:: PMC2745956

Abstract Article PDF–231K

Select item 421487517.

Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics

Natalie Matosin, Francesca Fernandez-Enright, Elisabeth Frank, Chao Deng, Jenny Wong, Xu-Feng Huang, Kelly A. Newell

J Psychiatry Neurosci. 2014 Nov; 39(6): 407–416. Prepublished online 2014 Jun 24. doi: 10.1503/jpn.130242

PMCID:: PMC4214875

Abstract Article PDF–546K

Select item 866893818.

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu

Cell Discov. 2021; 7: 119. Published online 2021 Dec 14. doi: 10.1038/s41421-021-00357-z

Correction in:: Cell Discov. 2021; 7: 124.

PMCID:: PMC8668938

Abstract Article PDF–3.9M

Select item 481916619.

Allosteric signaling through an mGlu2 and 5-HT_2A heteromeric receptor complex and its potential contribution to schizophrenia

José L. Moreno, Patricia Miranda-Azpiazu, Aintzane García-Bea, Jason Younkin, Meng Cui, Alexey Kozlenkov, Ariel Ben-Ezra, Georgios Voloudakis, Amanda K. Fakira, Lia Baki, Yongchao Ge, Anastasios Georgakopoulos, José A. Morón, Graeme Milligan, Juan F. López-Giménez, Nikolaos K. Robakis, Diomedes E. Logothetis, J. Javier Meana, Javier González-Maeso

Sci Signal. Author manuscript; available in PMC 2017 Jan 12.

Published in final edited form as: Sci Signal. 2016; 9(410): ra5. Published online 2016 Jan 12. doi: 10.1126/scisignal.aab0467

PMCID:: PMC4819166

Abstract Article PDF–1.0M

Select item 353174520.

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT_2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

José L. Moreno, Carolina Muguruza, Adrienne Umali, Steven Mortillo, Terrell Holloway, Fuencisla Pilar-Cuéllar, Giuseppe Mocci, Jeremy Seto, Luis F. Callado, Rachael L. Neve, Graeme Milligan, Stuart C. Sealfon, Juan F. López-Giménez, J. Javier Meana, Deanna L. Benson, Javier González-Maeso

J Biol Chem. 2012 Dec 28; 287(53): 44301–44319. Published online 2012 Nov 5. doi: 10.1074/jbc.M112.413161

PMCID:: PMC3531745

Abstract Article PDF–3.3M

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