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Select item 31144751.

The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu, E W Kraegen

J Endocrinol. 2011 Jul; 210(1): 81–92. Prepublished online 2011 May 4. doi: 10.1530/JOE-11-0039

PMCID:: PMC3114475

Abstract Article PDF–307K

Select item 45710022.

Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus

Sabrina Prudente, Prapaporn Jungtrakoon, Antonella Marucci, Ornella Ludovico, Patinut Buranasupkajorn, Tommaso Mazza, Timothy Hastings, Teresa Milano, Eleonora Morini, Luana Mercuri, Diego Bailetti, Christine Mendonca, Federica Alberico, Giorgio Basile, Marta Romani, Elide Miccinilli, Antonio Pizzuti, Massimo Carella, Fabrizio Barbetti, Stefano Pascarella, Piero Marchetti, Vincenzo Trischitta, Rosa Di Paola, Alessandro Doria

Am J Hum Genet. 2015 Jul 2; 97(1): 177–185. doi: 10.1016/j.ajhg.2015.05.011

PMCID:: PMC4571002

Abstract Article PDF–983K

Select item 36066293.

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

Peter M Schmid, Markus Resch, Christian Schach, Christoph Birner, Guenter A Riegger, Andreas Luchner, Dierk H Endemann

Cardiovasc Diabetol. 2013; 12: 46. Published online 2013 Mar 18. doi: 10.1186/1475-2840-12-46

PMCID:: PMC3606629

Abstract Article PDF–597K

Select item 30842584.

Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis

Min Park, ByungSoo Youn, Xi-long Zheng, Donghai Wu, Aimin Xu, Gary Sweeney

PLoS One. 2011; 6(4): e19143. Published online 2011 Apr 28. doi: 10.1371/journal.pone.0019143

PMCID:: PMC3084258

Abstract Article PDF–844K

Select item 88065915.

PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway

Lina Bai, Junhua Yang, Hong Zhang, Wei Liao, Yunguang Cen

Bioengineered. 2021; 12(1): 4385–4396. Published online 2021 Jul 24. doi: 10.1080/21655979.2021.1954841

PMCID:: PMC8806591

Abstract Article PDF–2.4M

Select item 30462296.

An APPL1/Akt Signaling Complex Regulates Dendritic Spine and Synapse Formation in Hippocampal Neurons

Devi Majumdar, Caroline A. Nebhan, Lan Hu, Bridget Anderson, Donna J. Webb

Mol Cell Neurosci. Author manuscript; available in PMC 2012 Mar 1.

Published in final edited form as: Mol Cell Neurosci. 2011 Mar; 46(3): 633–644. Published online 2011 Jan 12. doi: 10.1016/j.mcn.2011.01.003

PMCID:: PMC3046229

Abstract Article PDF–2.8M

Select item 47280377.

Appl1 and Appl2 are Expendable for Mouse Development but are Essential for HGF-induced Akt Activation and Migration in Mouse Embryonic Fibroblasts

Yinfei Tan, Xiaoban Xin, Francis J. Coffey, David L. Wiest, Lily Q. Dong, Joseph R. Testa

J Cell Physiol. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: J Cell Physiol. 2016 May; 231(5): 1142–1150. Published online 2015 Oct 21. doi: 10.1002/jcp.25211

PMCID:: PMC4728037

Abstract Article PDF–1.6M

Select item 41238808.

AdipoR1/APPL1 Potentiates the Protective Effects of Globular Adiponectin on Angiotensin II-Induced Cardiac Hypertrophy and Fibrosis in Neonatal Rat Atrial Myocytes and Fibroblasts

Tengwei Cao, Zhen Gao, Lingyun Gu, Minglong Chen, Bing Yang, Kejiang Cao, He Huang, Mingfang Li

PLoS One. 2014; 9(8): e103793. Published online 2014 Aug 6. doi: 10.1371/journal.pone.0103793

PMCID:: PMC4123880

Abstract Article PDF–1.4M

Select item 19334029.

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

Guangyu Zhu, Jia Chen, Jay Liu, Joseph S Brunzelle, Bo Huang, Nancy Wakeham, Simon Terzyan, Xuemei Li, Zihe Rao, Guangpu Li, Xuejun C Zhang

EMBO J. 2007 Jul 25; 26(14): 3484–3493. Published online 2007 Jun 21. doi: 10.1038/sj.emboj.7601771

PMCID:: PMC1933402

Abstract Article PDF–433K

Select item 420170810.

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway

Liufeng Mao, Wanhua Lin, Tao Nie, Xiaoyan Hui, Xuefei Gao, Kuai Li, Mengxiao Ding, Xiaofeng Tang, Peng Li, Yu Wang, Aimin Xu, Pentao Liu, Donghai Wu

Cell Biosci. 2014; 4: 60. Published online 2014 Oct 2. doi: 10.1186/2045-3701-4-60

PMCID:: PMC4201708

Abstract Article PDF–2.5M

Select item 381029711.

Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides

Heidi J. Chial, Ruping Wu, Carolyn V. Ustach, Linda C. McPhail, William C. Mobley, Yong Q. Chen

Traffic. Author manuscript; available in PMC 2013 Oct 28.

Published in final edited form as: Traffic. 2008 Feb; 9(2): 215–229. Published online 2007 Dec 18. doi: 10.1111/j.1600-0854.2007.00680.x

Correction in:: volume 9 on page 623

PMCID:: PMC3810297

Abstract Article PDF–1.7M

Select item 314982812.

Interactions between GIPC–APPL and GIPC–TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

Rajendra Kedlaya, Gokul Kandala, Tie Fu Liu, Nityanand Maddodi, Sulochana Devi, Vijayasaradhi Setaluri

Arch Biochem Biophys. Author manuscript; available in PMC 2011 Aug 4.

Published in final edited form as: Arch Biochem Biophys. 2011 Apr 15; 508(2): 227–233. Published online 2011 Feb 1. doi: 10.1016/j.abb.2011.01.021

PMCID:: PMC3149828

Abstract Article PDF–1.0M

Select item 279723113.

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

Changhua Wang, Xiaoban Xin, Ruihua Xiang, Fresnida J. Ramos, Meilian Liu, Hak Joo Lee, Hongzhi Chen, Xuming Mao, Chintan K. Kikani, Feng Liu, Lily Q. Dong

J Biol Chem. 2009 Nov 13; 284(46): 31608–31615. Published online 2009 Aug 6. doi: 10.1074/jbc.M109.010355

PMCID:: PMC2797231

Abstract Article PDF–2.8M

Select item 480799814.

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

Jie Song, Yabing Mu, Chunyan Li, Anders Bergh, Marta Miaczynska, Carl-Henrik Heldin, Marene Landström

Oncotarget. 2016 Jan 5; 7(1): 279–292. Published online 2015 Nov 18. doi: 10.18632/oncotarget.6346

PMCID:: PMC4807998

Abstract Article PDF–1.3M

Select item 434203015.

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages

Jeremy C. Yeo, Adam A. Wall, Lin Luo, Jennifer L. Stow

Mol Biol Cell. 2015 Mar 1; 26(5): 952–965. doi: 10.1091/mbc.E14-10-1457

PMCID:: PMC4342030

Abstract Article PDF–7.3M

Select item 338055716.

Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment

Anna Urbanska, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska

Traffic. 2011 Sep; 12(9): 1227–1241. Published online 2011 Jul 3. doi: 10.1111/j.1600-0854.2011.01226.x

PMCID:: PMC3380557

Abstract Article PDF–28M

Select item 318302217.

Retrolinkin cooperates with endophilin A1 to mediate BDNF–TrkB early endocytic trafficking and signaling from early endosomes

Xiuping Fu, Yanrui Yang, Chenchang Xu, Yang Niu, Tielin Chen, Qin Zhou, Jia-Jia Liu

Mol Biol Cell. 2011 Oct 1; 22(19): 3684–3698. doi: 10.1091/mbc.E11-04-0308

PMCID:: PMC3183022

Abstract Article PDF–8.7M

Select item 270933718.

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

Sajid Rashid, Iwona Pilecka, Anna Torun, Marta Olchowik, Beata Bielinska, Marta Miaczynska

J Biol Chem. 2009 Jul 3; 284(27): 18115–18128. Published online 2009 May 11. doi: 10.1074/jbc.M109.007237

PMCID:: PMC2709337

Abstract Article PDF–4.2M

Select item 674264619.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 263705020.

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

Patricia A. Gonzales, Trairak Pisitkun, Jason D. Hoffert, Dmitry Tchapyjnikov, Robert A. Star, Robert Kleta, Nam Sun Wang, Mark A. Knepper

J Am Soc Nephrol. 2009 Feb; 20(2): 363–379. doi: 10.1681/ASN.2008040406

PMCID:: PMC2637050

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