PMC Links for Gene (Select 288079) - PMC

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Items: 12

Select item 46719581.

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

Joseph A. Newman, Christopher D.O. Cooper, Hazel Aitkenhead, Opher Gileadi

Structure. 2015 Dec 1; 23(12): 2319–2330. doi: 10.1016/j.str.2015.10.014

PMCID:: PMC4671958

Abstract Article PDF–4.8M

Select item 43511792.

Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta

Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y. Ozdemir, Richard T. Pomerantz

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Nat Struct Mol Biol. 2015 Mar; 22(3): 230–237. Published online 2015 Feb 2. doi: 10.1038/nsmb.2961

PMCID:: PMC4351179

Abstract Article PDF–2.2M

Select item 33153063.

Promiscuous DNA synthesis by human DNA polymerase θ

Matthew Hogg, A. Elisabeth Sauer-Eriksson, Erik Johansson

Nucleic Acids Res. 2012 Mar; 40(6): 2611–2622. Published online 2011 Nov 30. doi: 10.1093/nar/gkr1102

PMCID:: PMC3315306

Abstract Article PDF–12M

Select item 26652234.

Human DNA polymerase θ possesses 5′-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

Rajendra Prasad, Matthew J. Longley, Farida S. Sharief, Esther W. Hou, William C. Copeland, Samuel H. Wilson

Nucleic Acids Res. 2009 Apr; 37(6): 1868–1877. Published online 2009 Feb 2. doi: 10.1093/nar/gkp035

PMCID:: PMC2665223

Abstract Article PDF–2.6M

Select item 2754565.

POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells

Mineaki Seki, Federica Marini, Richard D. Wood

Nucleic Acids Res. 2003 Nov 1; 31(21): 6117–6126. doi: 10.1093/nar/gkg814

PMCID:: PMC275456

Abstract Article PDF–509K

Select item 47183066.

Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination

Pedro A. Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M. Miller, Eros Lazzerini-Denchi, Agnel Sfeir

Nature. Author manuscript; available in PMC 2016 Jan 19.

Published in final edited form as: Nature. 2015 Feb 12; 518(7538): 254–257. Published online 2015 Feb 2. doi: 10.1038/nature14157

PMCID:: PMC4718306

Abstract Article PDF–6.2M

Select item 12767177.

The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation

Hong Zan, Naoko Shima, Zhenming Xu, Ahmed Al-Qahtani, Albert J Evinger III, Yuan Zhong, John C Schimenti, Paolo Casali

EMBO J. 2005 Nov 2; 24(21): 3757–3769. Published online 2005 Oct 13. doi: 10.1038/sj.emboj.7600833

PMCID:: PMC1276717

Abstract Article PDF–708K

Select item 12365618.

DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

Keiji Masuda, Rika Ouchida, Arata Takeuchi, Takashi Saito, Haruhiko Koseki, Kiyoko Kawamura, Masatoshi Tagawa, Takeshi Tokuhisa, Takachika Azuma, Jiyang O-Wang

Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39): 13986–13991. Published online 2005 Sep 19. doi: 10.1073/pnas.0505636102

PMCID:: PMC1236561

Abstract Article PDF–463K

Select item 14624829.

Phenotype-based identification of mouse chromosome instability mutants.

Naoko Shima, Suzanne A Hartford, Ted Duffy, Lawriston A Wilson, Kerry J Schimenti, John C Schimenti

Genetics. 2003 Mar; 163(3): 1031–1040. doi: 10.1093/genetics/163.3.1031

PMCID:: PMC1462482

Summary PDF–238K

Select item 441560210.

Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair

Raphael Ceccaldi, Jessica C. Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I.R. Petalcorin, Kevin W. O'Connor, Panagiotis A. Konstantinopoulos, Stephen J. Elledge, Simon J. Boulton, Timur Yusufzai, Alan D. D'Andrea

Nature. Author manuscript; available in PMC 2015 Aug 12.

Published in final edited form as: Nature. 2015 Feb 12; 518(7538): 258–262. Published online 2015 Feb 2. doi: 10.1038/nature14184