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Select item 86330151.

Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2

Lei-lei Ma, Fei-juan Kong, Yuan-ji Ma, Jun-jie Guo, Shi-jun Wang, Zheng Dong, Ai-jun Sun, Yun-zeng Zou, Jun-bo Ge

Acta Pharmacol Sin. 2021 Dec; 42(12): 2004–2015. Published online 2021 Jun 23. doi: 10.1038/s41401-021-00699-0

PMCID:: PMC8633015

Abstract Article PDF–6.3M

Select item 83264222.

Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion

Yong Kwon Han, Ji Su Kim, Gwan Beom Lee, Jae Hang Lim, Kwon Moo Park

Redox Biol. 2021 Oct; 46: 102077. Published online 2021 Jul 21. doi: 10.1016/j.redox.2021.102077

PMCID:: PMC8326422

Abstract Article PDF–12M

Select item 74606113.

IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle

Jeong Hoon Pan, Jingsi Tang, Young Jun Kim, Jin Hyup Lee, Eui-Cheol Shin, Jiangchao Zhao, Kee-Hong Kim, Kyung A. Hwang, Yan Huang, Jae Kyeom Kim

Int J Mol Sci. 2020 Aug; 21(16): 5596. Published online 2020 Aug 5. doi: 10.3390/ijms21165596

PMCID:: PMC7460611

Abstract Article PDF–1.1M

Select item 67709694.

Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice

Jeong Hoon Pan, Jingsi Tang, Mersady C. Redding, Kaleigh E. Beane, Cara L. Conner, Yun Jeong Cho, Jiangchao Zhao, Jun Ho Kim, Byungwhi C. Kong, Jin Hyup Lee, Jae Kyeom Kim

Genes (Basel) 2019 Sep; 10(9): 728. Published online 2019 Sep 19. doi: 10.3390/genes10090728

PMCID:: PMC6770969

Abstract Article PDF–3.7M

Select item 60066795.

IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis

Jung Hyun Park, Hyeong Jun Ku, Jin Hyup Lee, Jeen-Woo Park

Redox Biol. 2018 Jul; 17: 16–24. Published online 2018 Apr 6. doi: 10.1016/j.redox.2018.04.008

PMCID:: PMC6006679

Abstract Article PDF–1.9M

Select item 59169206.

Mitochondrial NADP⁺-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

Min Jung Kong, Sang Jun Han, Jee In Kim, Jeen-Woo Park, Kwon Moo Park

Cell Death Dis. 2018 May; 9(5): 488. Published online 2018 Apr 25. doi: 10.1038/s41419-018-0537-6

PMCID:: PMC5916920

Abstract Article PDF–1.4M

Select item 58043247.

Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration

Jung Hyun Park, Hyeong Jun Ku, Jin Hyup Lee, Jeen-Woo Park

Oxid Med Cell Longev. 2017; 2017: 1595103. Published online 2017 Dec 31. doi: 10.1155/2017/1595103

PMCID:: PMC5804324

Abstract Article PDF–4.4M

Select item 54475148.

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis

Hanvit Cha, Seoyoon Lee, Sung Hwan Kim, Hyunjin Kim, Dong-Seok Lee, Hyun-Shik Lee, Jin Hyup Lee, Jeen-Woo Park

Redox Biol. 2017 Oct; 13: 32–38. Published online 2017 May 20. doi: 10.1016/j.redox.2017.05.009

PMCID:: PMC5447514

Abstract Article PDF–1.1M

Select item 53734479.

Mitochondrial NADP⁺-Dependent Isocitrate Dehydrogenase Deficiency Exacerbates Mitochondrial and Cell Damage after Kidney Ischemia-Reperfusion Injury

Sang Jun Han, Hee-Seong Jang, Mi Ra Noh, Jinu Kim, Min Jung Kong, Jee In Kim, Jeen-Woo Park, Kwon Moo Park

J Am Soc Nephrol. 2017 Apr; 28(4): 1200–1215. Published online 2016 Nov 7. doi: 10.1681/ASN.2016030349

PMCID:: PMC5373447

Abstract Article

Select item 379247410.

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

Chong Chen, Yu Liu, Chao Lu, Justin R. Cross, John P. Morris, IV, Aditya S. Shroff, Patrick S. Ward, James E. Bradner, Craig Thompson, Scott W. Lowe

Genes Dev. 2013 Sep 15; 27(18): 1974–1985. doi: 10.1101/gad.226613.113

PMCID:: PMC3792474

Abstract Article PDF–1.6M

Select item 706803511.

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Xiaotian Zhang, Xinyu Wang, Xue Qing David Wang, Jianzhong Su, Nagireddy Putluri, Ting Zhou, Ying Qu, Mira Jeong, Anna Guzman, Carina Rosas, Yun Huang, Arun Sreekumar, Wei Li, Margaret A. Goodell

Blood. 2020 Mar 12; 135(11): 845–856. Prepublished online 2020 Jan 13. doi: 10.1182/blood.2019003330

PMCID:: PMC7068035

Abstract Article

Select item 602487712.

IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice

Jeong Hoon Pan, Hoe-Sung Kim, Kaleigh Elizabeth Beane, Allison Michelle Montalbano, Jin Hyup Lee, Young Jun Kim, Jun Ho Kim, Byungwhi Caleb Kong, Sangyub Kim, Jeen-Woo Park, Eui-Cheol Shin, Jae Kyeom Kim

Nutrients. 2018 Jun; 10(6): 679. Published online 2018 May 27. doi: 10.3390/nu10060679

PMCID:: PMC6024877

Abstract Article PDF–1.1M

Select item 586491813.

Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

Karessa White, Mi-Jung Kim, Chul Han, Hyo-Jin Park, Dalian Ding, Kevin Boyd, Logan Walker, Paul Linser, Zaimary Meneses, Cole Slade, Jonathan Hirst, Katherine Santostefano, Naohiro Terada, Takuya Miyakawa, Masaru Tanokura, Richard Salvi, Shinichi Someya

Sci Rep. 2018; 8: 5039. Published online 2018 Mar 22. doi: 10.1038/s41598-018-23436-w

PMCID:: PMC5864918

Abstract Article PDF–6.9M

Select item 506561214.

A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

Fang Wang, Jeremy Travins, Zhizhong Lin, Yaguang Si, Yue Chen, Josh Powe, Stuart Murray, Dongwei Zhu, Erin Artin, Stefan Gross, Stephanie Santiago, Mya Steadman, Andrew Kernytsky, Kimberly Straley, Chenming Lu, Ana Pop, Eduard A. Struys, Erwin E. W. Jansen, Gajja S. Salomons, Muriel D. David, Cyril Quivoron, Virginie Penard-Lacronique, Karen S. Regan, Wei Liu, Lenny Dang, Hua Yang, Lee Silverman, Samuel Agresta, Marion Dorsch, Scott Biller, Katharine Yen, Yong Cang, Shin-San Michael Su, Shengfang Jin

J Inherit Metab Dis. 2016; 39(6): 807–820. Published online 2016 Jul 28. doi: 10.1007/s10545-016-9960-y

PMCID:: PMC5065612

Abstract Article PDF–5.7M

Select item 949267915.

miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes

Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim

Commun Biol. 2022; 5: 1002. Published online 2022 Sep 21. doi: 10.1038/s42003-022-03945-1

PMCID:: PMC9492679

Abstract Article PDF–2.0M

Select item 721675216.

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Franco Izzo, Stanley C. Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil D. Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S. Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C. Schulman, Michelle Ki, Priscillia Lhoumaud, Jane A. Skok, Aaron D. Viny, Ross L. Levine, Ephraim Kenigsberg, Omar Abdel-Wahab, Dan A. Landau

Nat Genet. Author manuscript; available in PMC 2020 Sep 23.

Published in final edited form as: Nat Genet. 2020 Apr; 52(4): 378–387. Published online 2020 Mar 23. doi: 10.1038/s41588-020-0595-4

PMCID:: PMC7216752

Abstract Article PDF–2.3M

Select item 685856017.

Coordinated Alterations in RNA Splicing and Epigenetic Regulation Drive Leukemogenesis

Akihide Yoshimi, Kuan-Ting Lin, Daniel H. Wiseman, Mohammad Alinoor Rahman, Alessandro Pastore, Bo Wang, Stanley Chun-Wei Lee, Jean-Baptiste Micol, Xiao Jing Zhang, Stephane de Botton, Virginie Penard-Lacronique, Eytan M. Stein, Hana Cho, Rachel E. Miles, Daichi Inoue, Todd R. Albrecht, Tim C.P. Somervaille, Kiran Batta, Fabio Amaral, Fabrizio Simeoni, Deepti P. Wilks, Catherine Cargo, Andrew M. Intlekofer, Ross L. Levine, Heidi Dvinge, Robert K. Bradley, Eric J. Wagner, Adrian R. Krainer, Omar Abdel-Wahab

Nature. Author manuscript; available in PMC 2020 Apr 2.

Published in final edited form as: Nature. 2019 Oct; 574(7777): 273–277. Published online 2019 Oct 2. doi: 10.1038/s41586-019-1618-0

PMCID:: PMC6858560

Article PDF–8.6M

Select item 675688718.

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions

Unbin Chae, Jeen-Woo Park, Sang-Rae Lee, Hong Jun Lee, Hyun-Shik Lee, Dong-Seok Lee

Aging (Albany NY) 2019 Sep 15; 11(17): 7242–7256. Published online 2019 Sep 10. doi: 10.18632/aging.102259

PMCID:: PMC6756887

Abstract Article PDF–4.5M

Select item 541341319.

Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia

Alan H Shih, Cem Meydan, Kaitlyn Shank, Francine E Garrett-Bakelman, Patrick S Ward, Andrew Intlekofer, Abbas Nazir, Eytan Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Chris Mason, Katharine Yen, Craig B Thompson, Ari Melnick, Ross L Levine

Cancer Discov. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Cancer Discov. 2017 May; 7(5): 494–505. Published online 2017 Feb 13. doi: 10.1158/2159-8290.CD-16-1049

PMCID:: PMC5413413

Abstract Article PDF–1.1M

Select item 502742220.

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

Anja Karlstaedt, Xiaotian Zhang, Heidi Vitrac, Romain Harmancey, Hernan Vasquez, Jing Han Wang, Margaret A. Goodell, Heinrich Taegtmeyer

Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37): 10436–10441. Published online 2016 Aug 31. doi: 10.1073/pnas.1601650113

PMCID:: PMC5027422

Abstract Article PDF–941K

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