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Items: 1 to 20 of 46

1.
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons
Martin Larhammar, Sarah Huntwork-Rodriguez, York Rudhard, Arundhati Sengupta-Ghosh, Joseph W. Lewcock
J Neurosci. 2017 Nov 15; 37(46): 11074–11084. doi: 10.1523/JNEUROSCI.0905-17.2017
PMCID:
PMC6596808
AbstractArticlePDF–4.0M
2.
Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity
Rachel J. Roth Flach, Marina T. DiStefano, Laura V. Danai, Ozlem Senol-Cosar, Joseph C. Yawe, Mark Kelly, Lorena Garcia Menendez, Michael P. Czech
Am J Physiol Endocrinol Metab. 2017 Sep 1; 313(3): E303–E313. Published online 2017 Jun 13. doi: 10.1152/ajpendo.00037.2017
PMCID:
PMC5625083
AbstractArticle
3.
Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia
Rachel J. Roth Flach, Laura V. Danai, Marina T. DiStefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, Michael P. Czech
J Biol Chem. 2016 Jul 29; 291(31): 16221–16230. Published online 2016 May 20. doi: 10.1074/jbc.M116.718932
PMCID:
PMC4965570
AbstractArticlePDF–1.4M
4.
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Myriam Aouadi, Gregory J. Tesz, Sarah M. Nicoloro, Mengxi Wang, My Chouinard, Ernesto Soto, Gary R. Ostroff, Michael P. Czech
Nature. Author manuscript; available in PMC 2010 Jun 1.
Published in final edited form as: Nature. 2009 Apr 30; 458(7242): 1180–1184. doi: 10.1038/nature07774
PMCID:
PMC2879154
AbstractArticlePDF–2.5M
5.
Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function
Rachel J. Roth Flach, Chang-An Guo, Laura V. Danai, Joseph C. Yawe, Sharvari Gujja, Yvonne J. K. Edwards, Michael P. Czech
Mol Cell Biol. 2016 Jun 15; 36(12): 1740–1749. Prepublished online 2016 Apr 4. Published online 2016 May 31. doi: 10.1128/MCB.01121-15
PMCID:
PMC4907094
AbstractArticlePDF–2.7M
6.
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
Rachel J. Roth Flach, Athanasia Skoura, Anouch Matevossian, Laura V. Danai, Wei Zheng, Christian Cortes, Samit K. Bhattacharya, Myriam Aouadi, Nana Hagan, Joseph C. Yawe, Pranitha Vangala, Lorena Garcia Menendez, Marcus P. Cooper, Timothy P. Fitzgibbons, Leonard Buckbinder, Michael P. Czech
Nat Commun. 2015; 6: 8995. Published online 2015 Dec 21. doi: 10.1038/ncomms9995
PMCID:
PMC4703891
AbstractArticlePDF–1.5M
7.
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
Laura V. Danai, Adilson Guilherme, Kalyani V. Guntur, Juerg Straubhaar, Sarah M. Nicoloro, Michael P. Czech
J Lipid Res. 2013 Oct; 54(10): 2697–2707. doi: 10.1194/jlr.M038802
PMCID:
PMC3770083
AbstractArticlePDF–1.5M
8.
TNF-α Involvement in Insulin Resistance Induced by Experimental Scorpion Envenomation
Aouatef Ait-Lounis, Fatima Laraba-Djebari
PLoS Negl Trop Dis. 2012 Jul; 6(7): e1740. Published online 2012 Jul 17. doi: 10.1371/journal.pntd.0001740
PMCID:
PMC3398957
AbstractArticlePDF–1.6M
9.
The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors
Martin Baumgartner, Amy L. Sillman, Elizabeth M. Blackwood, Jyoti Srivastava, Nikki Madson, James W. Schilling, Jocelyn H. Wright, Diane L. Barber
Proc Natl Acad Sci U S A. 2006 Sep 5; 103(36): 13391–13396. Published online 2006 Aug 25. doi: 10.1073/pnas.0605950103
PMCID:
PMC1569174
AbstractArticlePDF–930K
10.
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport
Xiaoqing Tang, Adilson Guilherme, Abhijit Chakladar, Aimee M. Powelka, Silvana Konda, Joseph V. Virbasius, Sarah M. C. Nicoloro, Juerg Straubhaar, Michael P. Czech
Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7): 2087–2092. Published online 2006 Feb 3. doi: 10.1073/pnas.0507660103
PMCID:
PMC1413698
AbstractArticlePDF–579K
11.
The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit
Lawrence L. LeClaire, Manish Rana, Martin Baumgartner, Diane L. Barber
J Cell Biol. 2015 Jan 19; 208(2): 161–170. doi: 10.1083/jcb.201404095
PMCID:
PMC4298681
AbstractArticlePDF–2.6M
12.
Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation
Mengxi Wang, Shinya U. Amano, Rachel J. Roth Flach, Anil Chawla, Myriam Aouadi, Michael P. Czech
Mol Cell Biol. 2013 Feb; 33(4): 678–687. doi: 10.1128/MCB.00618-12
PMCID:
PMC3571342
AbstractArticlePDF–3.0M
13.
RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis
Hui-Yu Peng, Yu-Chih Liang, Tse-Hua Tan, Huai-Chia Chuang, Ying-Ju Lin, Jung-Chun Lin
Int J Mol Sci. 2018 Sep; 19(9): 2646. Published online 2018 Sep 6. doi: 10.3390/ijms19092646
PMCID:
PMC6163301
AbstractArticlePDF–2.7M
14.
FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway
Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno, Keizo Kanasaki, Daisuke Koya
Cell Death Dis. 2017 Aug; 8(8): e2965. Published online 2017 Aug 3. doi: 10.1038/cddis.2017.353
PMCID:
PMC5596544
AbstractArticlePDF–3.0M
15.
Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues
Laura V. Danai, Rachel J. Roth Flach, Joseph V. Virbasius, Lorena Garcia Menendez, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Michael P. Czech
Mol Cell Biol. 2015 Jul; 35(13): 2356–2365. Prepublished online 2015 Apr 27. Published online 2015 Jun 4. doi: 10.1128/MCB.00150-15
PMCID:
PMC4456439
AbstractArticlePDF–2.7M
16.
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance
Huai-Chia Chuang, Wayne H. -H. Sheu, Yi-Ting Lin, Ching-Yi Tsai, Chia-Yu Yang, Yu-Jhen Cheng, Pau-Yi Huang, Ju-Pi Li, Li-Li Chiu, Xiaohong Wang, Min Xie, Michael D. Schneider, Tse-Hua Tan
Nat Commun. 2014 Aug 6; 5: 4602. Published online 2014 Aug 6. doi: 10.1038/ncomms5602
PMCID:
PMC4143962
AbstractArticlePDF–3.3M
17.
MicroRNA-30d Induces Insulin Transcription Factor MafA and Insulin Production by Targeting Mitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic β-Cells
Xiaomin Zhao, Ramkumar Mohan, Sabire Özcan, Xiaoqing Tang
J Biol Chem. 2012 Sep 7; 287(37): 31155–31164. Published online 2012 Jun 25. doi: 10.1074/jbc.M112.362632
PMCID:
PMC3438947
AbstractArticlePDF–2.3M
18.
Map4k4 Negatively Regulates Peroxisome Proliferator-activated Receptor (PPAR) γ Protein Translation by Suppressing the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Cultured Adipocytes
Kalyani V. P. Guntur, Adilson Guilherme, Liting Xue, Anil Chawla, Michael P. Czech
J Biol Chem. 2010 Feb 26; 285(9): 6595–6603. Published online 2009 Dec 28. doi: 10.1074/jbc.M109.068502
PMCID:
PMC2825455
AbstractArticlePDF–1.3M
19.
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.
Y C Su, J Han, S Xu, M Cobb, E Y Skolnik
EMBO J. 1997 Mar 17; 16(6): 1279–1290. doi: 10.1093/emboj/16.6.1279
PMCID:
PMC1169726
SummaryPDF–920K
20.
Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation
Elena Becker, Uyen Huynh-Do, Sacha Holland, Tony Pawson, Tom O. Daniel, Edward Y. Skolnik
Mol Cell Biol. 2000 Mar; 20(5): 1537–1545. doi: 10.1128/mcb.20.5.1537-1545.2000
PMCID:
PMC85333
AbstractArticlePDF–1.2M

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