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Select item 101646601.

Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice

Qian Huang, Yonghong Man, Wei Li, Qi Zhou, Shuo Yuan, Yi Tian Yap, Neha Nayak, Ling Zhang, Shizheng Song, Joseph Dunbar, Todd Leff, Xu Yang, Zhibing Zhang

Endocrinology. 2023 Jun; 164(6): bqad062. Published online 2023 Apr 17. doi: 10.1210/endocr/bqad062

PMCID:: PMC10164660

Abstract Article

Select item 88033302.

JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Cristina Rivellini, Emanuela Porrello, Giorgia Dina, Simona Mrakic-Sposta, Alessandra Vezzoli, Marco Bacigaluppi, Giorgia Serena Gullotta, Linda Chaabane, Letizia Leocani, Silvia Marenna, Emanuela Colombo, Cinthia Farina, Jia Newcombe, Klaus-Armin Nave, Ruggero Pardi, Angelo Quattrini, Stefano C. Previtali

J Clin Invest. 2022 Feb 1; 132(3): e145071. Published online 2022 Feb 1. doi: 10.1172/JCI145071

PMCID:: PMC8803330

Abstract Article PDF–18M

Select item 74433503.

COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis

Qian Huang, Hong Liu, Jing Zeng, Wei Li, Shiyang Zhang, Ling Zhang, Shizhen Song, Ting Zhou, Miriam Sutovsky, Peter Sutovsky, Ruggero Pardi, Rex A Hess, Zhibing Zhang

Biol Reprod. 2020 Feb; 102(1): 233–247. Published online 2019 Aug 2. doi: 10.1093/biolre/ioz154

PMCID:: PMC7443350

Abstract Article PDF–4.7M

Select item 70075564.

Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair

Peng Li, Lulu Gao, Tongxi Cui, Weiyu Zhang, Zixin Zhao, Lingyi Chen

Proc Natl Acad Sci U S A. 2020 Feb 4; 117(5): 2519–2525. Published online 2020 Jan 21. doi: 10.1073/pnas.1915079117

PMCID:: PMC7007556

Abstract Article PDF–1.4M

Select item 62188645.

Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway

Ryan J. Cornelius, Jinge Si, Catherina A. Cuevas, Jonathan W. Nelson, Brittany D.K. Gratreak, Ruggero Pardi, Chao-Ling Yang, David H. Ellison

J Am Soc Nephrol. 2018 Nov; 29(11): 2627–2640. Published online 2018 Oct 9. doi: 10.1681/ASN.2018030333

PMCID:: PMC6218864

Abstract Article

Select item 77699676.

The master developmental regulator Jab1/Cops5/Csn5 is essential for proper bone growth and survival in mice

William E. Samsa, Murali K. Mamidi, Bryan S. Hausman, Lindsay A. Bashur, Edward M. Greenfield, Guang Zhou

Bone. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Bone. 2021 Feb; 143: 115733. Published online 2020 Nov 4. doi: 10.1016/j.bone.2020.115733

PMCID:: PMC7769967

Abstract Article PDF–1.4M

Select item 53800797.

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

Yaw Asare, Miriam Ommer, Florence. A. Azombo, Setareh Alampour-Rajabi, Marieke Sternkopf, Maryam Sanati, Marion J. Gijbels, Corinna Schmitz, Dzmitry Sinitski, Pathricia V. Tilstam, Hongqi Lue, André Gessner, Denise Lange, Johannes A. Schmid, Christian Weber, Martin Dichgans, Joachim Jankowski, Ruggero Pardi, Menno P. J. de Winther, Heidi Noels, Jürgen Bernhagen

Proc Natl Acad Sci U S A. 2017 Mar 28; 114(13): E2766–E2775. Published online 2017 Mar 14. doi: 10.1073/pnas.1618411114

PMCID:: PMC5380079

Abstract Article PDF–1.1M

Select item 44237138.

COPS5 Protein Overexpression Increases Amyloid Plaque Burden, Decreases Spinophilin-immunoreactive Puncta, and Exacerbates Learning and Memory Deficits in the Mouse Brain

Ruizhi Wang, Hongjie Wang, Ivan Carrera, Shaohua Xu, Madepalli K. Lakshmana

J Biol Chem. 2015 Apr 3; 290(14): 9299–9309. Published online 2015 Feb 20. doi: 10.1074/jbc.M114.595926

PMCID:: PMC4423713

Abstract Article PDF–2.9M

Select item 35425329.

CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner

Akihiro Yoshida, Noriko Yoneda-Kato, Jun-ya Kato

Sci Rep. 2013; 3: 1054. Published online 2013 Jan 11. doi: 10.1038/srep01054

PMCID:: PMC3542532

Abstract Article PDF–3.3M

Select item 266200510.

Stable Form of JAB1 Enhances Proliferation and Maintenance of Hematopoietic Progenitors

Masaaki Mori, Noriko Yoneda-Kato, Akihiro Yoshida, Jun-ya Kato

J Biol Chem. 2008 Oct 24; 283(43): 29011–29021. doi: 10.1074/jbc.M804539200

PMCID:: PMC2662005

Abstract Article PDF–794K

Select item 897505611.

Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice

Yujiro Maeoka, Mohammed Z. Ferdaus, Ryan J. Cornelius, Avika Sharma, Xiao-Tong Su, Lauren N. Miller, Joshua A. Robertson, Susan B. Gurley, Chao-Ling Yang, David H. Ellison, James A. McCormick

J Am Soc Nephrol. 2022 Mar; 33(3): 584–600. Published online 2022 Mar. doi: 10.1681/ASN.2021081099

PMCID:: PMC8975056

Abstract Article

Select item 843690812.

Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro

Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang, Yujie Shang

Aging (Albany NY) 2021 Aug 31; 13(16): 20418–20437. Published online 2021 Aug 23. doi: 10.18632/aging.203426

PMCID:: PMC8436908

Abstract Article PDF–2.1M

Select item 508268613.

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice

Ameh Omede, Min Zi, Sukhpal Prehar, Arfa Maqsood, Nicholas Stafford, Mamas Mamas, Elizabeth Cartwright, Delvac Oceandy

Biochem Biophys Res Commun. 2016 Oct 28; 479(4): 708–714. doi: 10.1016/j.bbrc.2016.09.147

PMCID:: PMC5082686

Abstract Article PDF–1.3M

Select item 307807014.

Gfer inhibits Jab1-mediated degradation of p27^kip1 to restrict proliferation of hematopoietic stem cells

Ellen C. Teng, Lance R. Todd, Thomas J. Ribar, William Lento, Leah Dimascio, Anthony R. Means, Uma Sankar

Mol Biol Cell. 2011 Apr 15; 22(8): 1312–1320. doi: 10.1091/mbc.E10-08-0723

PMCID:: PMC3078070

Abstract Article PDF–1.7M

Select item 227102515.

Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development

Martina Panattoni, Francesca Sanvito, Veronica Basso, Claudio Doglioni, Giulia Casorati, Eugenio Montini, Jeffrey R. Bender, Anna Mondino, Ruggero Pardi

J Exp Med. 2008 Feb 18; 205(2): 465–477. doi: 10.1084/jem.20070725