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Items: 1 to 20 of 49

1.
Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function
Pei-Wen Liu, Gregory L. Martin, Weiyu Lin, Wanting Huang, Suchita Pande, Mark J. Aronovitz, Roger J. Davis, Robert M. Blanton
Am J Physiol Heart Circ Physiol. 2022 Sep 1; 323(3): H513–H522. Published online 2022 Jul 22. doi: 10.1152/ajpheart.00660.2021
PMCID:
PMC9448288
AbstractArticle
2.
MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms
Timothy D. Calamaras, Suchita Pande, Robert A.U. Baumgartner, Seung Kyum Kim, Joseph C. McCarthy, Gregory L. Martin, Kelly Tam, Angela L. McLaughlin, Guang-rong Wang, Mark J. Aronovitz, Weiyu Lin, Jonathan I. Aguirre, Paulina Baca, Peiwen Liu, Daniel A. Richards, Roger J. Davis, Richard H. Karas, Iris Z. Jaffe, Robert M. Blanton
JCI Insight. 2021 Sep 22; 6(18): e149075. Published online 2021 Sep 22. doi: 10.1172/jci.insight.149075
PMCID:
PMC8492323
AbstractArticlePDF–3.6M
3.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload
Junyan Wang, Bo Deng, Qing Liu, Yusheng Huang, Weitao Chen, Jing Li, Zheng Zhou, Lu Zhang, Birong Liang, Jiaqi He, Zixin Chen, Cui Yan, Zhongqi Yang, Shaoxiang Xian, Lingjun Wang
Cell Death Dis. 2020 Jul; 11(7): 574. Published online 2020 Jul 24. doi: 10.1038/s41419-020-02777-3
PMCID:
PMC7382480
AbstractArticlePDF–4.9M
4.
Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload
Timothy D. Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin K. Kapur, Richard H. Karas, Robert M. Blanton
Am J Physiol Heart Circ Physiol. 2019 Jan 1; 316(1): H145–H159. Published online 2018 Oct 26. doi: 10.1152/ajpheart.00029.2018
PMCID:
PMC6383356
AbstractArticle
5.
MLK3 regulates fMLP-stimulated neutrophil motility
Oksana Polesskaya, Christopher Wong, Luis Lebron, Jeffrey M. Chamberlain, Harris A. Gelbard, Val Goodfellow, Minsoo Kim, John L. Daiss, Stephen Dewhurst
Mol Immunol. Author manuscript; available in PMC 2015 Apr 1.
Published in final edited form as: Mol Immunol. 2014 Apr; 58(2): 214–222. Published online 2014 Jan 3. doi: 10.1016/j.molimm.2013.11.016
PMCID:
PMC3946811
AbstractArticlePDF–1.2M
6.
MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet
Vidya Gadang, Rohit Kohli, Andriy Myronovych, David Y. Hui, Diego Perez-Tilve, Anja Jaeschke
Am J Physiol Endocrinol Metab. 2013 Aug 15; 305(4): E549–E556. Published online 2013 Jul 16. doi: 10.1152/ajpendo.00197.2013
PMCID:
PMC3891220
AbstractArticle
7.
Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa
Pavlo L. Kovalenko, Lyudmyla Kunovska, Jian Chen, Kathleen A. Gallo, Marc D. Basson
Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15; 303(8): G951–G960. Published online 2012 Aug 23. doi: 10.1152/ajpgi.00158.2012
PMCID:
PMC3469692
AbstractArticle
8.
Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure
Oksana Polesskaya, Lisa L. Cunningham, Shimon P. Francis, Anne E. Luebke, Xiaoxia Zhu, David Collins, Olga N. Vasilyeva, Julie Sahler, Emily A. Desmet, Harris A. Gelbard, Sanjay B. Maggirwar, Joseph P. Walton, Robert D. Frisina, Jr., Stephen Dewhurst
Hear Res. Author manuscript; available in PMC 2011 Dec 1.
Published in final edited form as: Hear Res. 2010 Dec 1; 270(1-2): 21–27. Published online 2010 Oct 27. doi: 10.1016/j.heares.2010.10.008
PMCID:
PMC2997883
AbstractArticlePDF–1.8M
9.
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
Emily A. Desmet, Joseph A. Hollenbaugh, Patricia J. Sime, Terry W. Wright, David J. Topham, Andrea J. Sant, Toru Takimoto, Stephen Dewhurst, Sanjay B. Maggirwar
Virology. Author manuscript; available in PMC 2011 May 10.
Published in final edited form as: Virology. 2010 May 10; 400(2): 224–232. Published online 2010 Feb 25. doi: 10.1016/j.virol.2010.02.001
PMCID:
PMC2844475
AbstractArticlePDF–2.0M
10.
Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades
Deborah Brancho, Juan-Jose Ventura, Anja Jaeschke, Beth Doran, Richard A. Flavell, Roger J. Davis
Mol Cell Biol. 2005 May; 25(9): 3670–3681. doi: 10.1128/MCB.25.9.3670-3681.2005
PMCID:
PMC1084312
AbstractArticlePDF–1.0M
11.
MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells
Anh Thu Ha, Jae Youl Cho, Daewon Kim
Int J Mol Sci. 2022 Sep; 23(18): 10874. Published online 2022 Sep 17. doi: 10.3390/ijms231810874
PMCID:
PMC9501218
AbstractArticlePDF–2.0M
12.
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity
Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Subhash C. Sinha, Rajyasree Emmadi, Kent Hoskins, Oana Danciu, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana
Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7961–7970. Published online 2020 Mar 24. doi: 10.1073/pnas.1921325117
PMCID:
PMC7149389
AbstractArticlePDF–2.4M
13.
Mixed Lineage Kinase 3 Deficiency Promotes Neointima Formation through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells
Vidya Gadang, Eddy Konaniah, David Y. Hui, Anja Jaeschke
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7): 1429–1436. Published online 2014 May 1. doi: 10.1161/ATVBAHA.114.303439
PMCID:
PMC4084683
AbstractArticlePDF–1.3M
14.
Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity
Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, Roger J. Davis
Cell Rep. Author manuscript; available in PMC 2013 Sep 10.
Published in final edited form as: Cell Rep. 2013 Aug 29; 4(4): 681–688. Published online 2013 Aug 15. doi: 10.1016/j.celrep.2013.07.019
PMCID:
PMC3769115
AbstractArticlePDF–2.5M
15.
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
Weiguo Zou, Matthew B. Greenblatt, Jae-Hyuck Shim, Shashi Kant, Bo Zhai, Sutada Lotinun, Nicholas Brady, Dorothy Zhang Hu, Steven P. Gygi, Roland Baron, Roger J. Davis, Dallas Jones, Laurie H. Glimcher
J Clin Invest. 2011 Nov 1; 121(11): 4383–4392. Published online 2011 Oct 3. doi: 10.1172/JCI59041
PMCID:
PMC3204846
AbstractArticlePDF–1.4M
16.
Mixed Lineage Kinase-3 Stabilizes and Functionally Cooperates with TRIBBLES-3 to Compromise Mitochondrial Integrity in Cytokine-induced Death of Pancreatic Beta Cells
Rohan K. Humphrey, Christina J. Newcomb, Shu-Mei A. Yu, Ergeng Hao, Doris Yu, Stan Krajewski, Keyong Du, Ulupi S. Jhala
J Biol Chem. 2010 Jul 16; 285(29): 22426–22436. Published online 2010 Apr 26. doi: 10.1074/jbc.M110.123786
PMCID:
PMC2903363
AbstractArticlePDF–3.6M
17.
TRAF2-MLK3 interaction is essential for TNF-a-induced MLK3 activation
Gautam Sondarva, Chanakya N. Kundu, Suneet Mehrotra, Rajakishore Mishra, Velusamy Rangasamy, Pradeep Sathyanarayana, Rajarshi S. Ray, Basabi Rana, Ajay Rana
Cell Res. Author manuscript; available in PMC 2010 Jul 1.
Published in final edited form as: Cell Res. 2010 Jan; 20(1): 89–98. Published online 2009 Nov 17. doi: 10.1038/cr.2009.125
PMCID:
PMC2801772
AbstractArticlePDF–789K
18.
Mixed Lineage Kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death
Eric T. Cole, Yu Zhan, Widian F. Abi Saab, Amanda C. Korchnak, Brian P. Ashburner, Deborah N. Chadee
Biochim Biophys Acta. Author manuscript; available in PMC 2010 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Dec; 1793(12): 1811–1818. Published online 2009 Sep 25. doi: 10.1016/j.bbamcr.2009.09.014
PMCID:
PMC2788010
AbstractArticlePDF–934K
19.
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells
U Knackmuss, S E Lindner, T Aneichyk, B Kotkamp, Z Knust, A Villunger, S Herzog
Cell Death Differ. 2016 Feb; 23(2): 242–252. Published online 2015 Jul 3. doi: 10.1038/cdd.2015.87
PMCID:
PMC4678593
AbstractArticlePDF–2.9M
20.
Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death
Rohan K. Humphrey, Anamika Ray, Sumati Gonuguntla, Ergeng Hao, Ulupi S. Jhala
J Biol Chem. 2014 Oct 24; 289(43): 29994–30004. Published online 2014 Sep 9. doi: 10.1074/jbc.M114.575613
PMCID:
PMC4208007
AbstractArticlePDF–1.6M

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