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Select item 100065171.

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization

Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im

J Adv Res. 2023 Mar; 45: 1–13. Published online 2022 May 31. doi: 10.1016/j.jare.2022.05.013

PMCID:: PMC10006517

Abstract Article PDF–4.3M

Select item 91517062.

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, Atsushi Umemura, Akiko Eguchi, Tsuneo Ikenoue, Yoshihiro Hirata, Motonari Uesugi, Ryosuke Tateishi, Keisuke Tateishi, Mitsuhiro Fujishiro, Kazuhiko Koike, Hayato Nakagawa

J Clin Invest. 2022 Jun 1; 132(11): e151895. Published online 2022 Jun 1. doi: 10.1172/JCI151895

PMCID:: PMC9151706

Abstract Article PDF–28M

Select item 82407293.

DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice

Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, Stanley Andrisse

J Endocrinol. 2021 Aug 1; 250(2): 49–65. Published online 2021 Jun 1. doi: 10.1530/JOE-21-0040

PMCID:: PMC8240729

Abstract Article PDF–3.1M

Select item 45139974.

Scap is required for sterol synthesis and crypt growth in intestinal mucosa

Matthew R. McFarlane, Mary Jo Cantoria, Albert G. Linden, Brandon A. January, Guosheng Liang, Luke J. Engelking

J Lipid Res. 2015 Aug; 56(8): 1560–1571. doi: 10.1194/jlr.M059709

PMCID:: PMC4513997

Abstract Article PDF–2.3M

Select item 27955085.

SCAP is required for timely and proper myelin membrane synthesis

Mark H. G. Verheijen, Nutabi Camargo, Valerie Verdier, Karim Nadra, Anne-Sophie de Preux Charles, Jean-Jacques Médard, Adrienne Luoma, Michelle Crowther, Hideyo Inouye, Hitoshi Shimano, Su Chen, Jos F. Brouwers, J. Bernd Helms, M. Laura Feltri, Lawrence Wrabetz, Daniel Kirschner, Roman Chrast, August. B. Smit

Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50): 21383–21388. Published online 2009 Nov 30. doi: 10.1073/pnas.0905633106

PMCID:: PMC2795508

Abstract Article PDF–2.0M

Select item 26350586.

Deletion of Scap in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Role for Pulmonary Lipofibroblasts

Valérie Besnard, Susan E. Wert, Mildred T. Stahlman, Anthony D. Postle, Yan Xu, Machiko Ikegami, Jeffrey A. Whitsett

J Biol Chem. 2009 Feb 6; 284(6): 4018–4030. doi: 10.1074/jbc.M805388200

PMCID:: PMC2635058

Abstract Article PDF–1020K

Select item 91178197.

Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING–NF-κB Signaling Pathway

Xinyu Huang, Yingcheng Yao, Xiaoli Hou, Li Wei, Yuhan Rao, Yu Su, Guo Zheng, Xiong Z. Ruan, Danyang Li, Yaxi Chen

Cell Mol Gastroenterol Hepatol. 2022; 14(1): 1–26. Published online 2022 Mar 31. doi: 10.1016/j.jcmgh.2022.03.006

PMCID:: PMC9117819

Abstract Article PDF–14M

Select item 56564298.

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Li Zhang, Prashant Rajbhandari, Christina Priest, Jaspreet Sandhu, Xiaohui Wu, Ryan Temel, Antonio Castrillo, Thomas Q de Aguiar Vallim, Tamer Sallam, Peter Tontonoz

eLife. 2017; 6: e28766. Published online 2017 Oct 25. doi: 10.7554/eLife.28766

PMCID:: PMC5656429

Abstract Article PDF–1.8M

Select item 50358539.

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP

Masami Shimizu-Albergine, Brian Van Yserloo, Martin G. Golkowski, Shao-En Ong, Joseph A. Beavo, Karin E. Bornfeldt

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): E5685–E5693. Published online 2016 Sep 6. doi: 10.1073/pnas.1611424113

PMCID:: PMC5035853

Abstract Article PDF–1.8M

Select item 478338210.

Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling

Autumn G. York, Kevin J. Williams, Joseph P. Argus, Quan D. Zhou, Gurpreet Brar, Laurent Vergnes, Elizabeth E. Gray, Anjie Zhen, Nicholas C. Wu, Douglas H. Yamada, Cameron R. Cunningham, Elizabeth J. Tarling, Moses Q. Wilks, David Casero, David H. Gray, Amy K. Yu, Eric S. Wang, David G. Brooks, Ren Sun, Scott G. Kitchen, Ting-Ting Wu, Karen Reue, Daniel B. Stetson, Steven J. Bensinger

Cell. Author manuscript; available in PMC 2016 Dec 17.

Published in final edited form as: Cell. 2015 Dec 17; 163(7): 1716–1729. Published online 2015 Dec 10. doi: 10.1016/j.cell.2015.11.045

PMCID:: PMC4783382

Abstract Article PDF–2.8M

Select item 476266211.

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

Wei Chen, Senlin Li, Huansha Yu, Xing Liu, Lulu Huang, Qiang Wang, Heng Liu, Ye Cui, Yijun Tang, Peng Zhang, Chen Wang

PLoS Pathog. 2016 Feb; 12(2): e1005462. Published online 2016 Feb 22. doi: 10.1371/journal.ppat.1005462

PMCID:: PMC4762662

Abstract Article PDF–7.7M

Select item 391949812.

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

Kevin J. Williams, Joseph P. Argus, Yue Zhu, Moses Q. Wilks, Beth N. Marbois, Autumn G. York, Yoko Kidani, Alexandra L. Pourzia, David Akhavan, Dominique N. Lisiero, Evangelia Komisopoulou, Amy H. Henkin, Horacio Soto, Brian T. Chamberlain, Laurent Vergnes, Michael E. Jung, Jorge Z. Torres, Linda M. Liau, Heather R. Christofk, Robert M. Prins, Paul S. Mischel, Karen Reue, Thomas G. Graeber, Steven J. Bensinger

Cancer Res. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Cancer Res. 2013 May 1; 73(9): 2850–2862. Published online 2013 Feb 25. doi: 10.1158/0008-5472.CAN-13-0382-T

PMCID:: PMC3919498

Abstract Article PDF–1.7M

Select item 362165413.

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

Ryo Suzuki, Heather A. Ferris, Melissa J. Chee, Eleftheria Maratos-Flier, C. Ronald Kahn

PLoS Biol. 2013 Apr; 11(4): e1001532. Published online 2013 Apr 9. doi: 10.1371/journal.pbio.1001532

PMCID:: PMC3621654

Abstract Article PDF–2.0M

Select item 300625114.

Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium

Michael C. Rudolph, Jenifer Monks, Valerie Burns, Meridee Phistry, Russell Marians, Monica R. Foote, Dale E. Bauman, Steven M. Anderson, Margaret C. Neville

Am J Physiol Endocrinol Metab. 2010 Dec; 299(6): E918–E927. Published online 2010 Aug 24. doi: 10.1152/ajpendo.00376.2010

PMCID:: PMC3006251

Abstract Article

Select item 31380115.

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

Morihiro Matsuda, Bobby S. Korn, Robert E. Hammer, Young-Ah Moon, Ryutaro Komuro, Jay D. Horton, Joseph L. Goldstein, Michael S. Brown, Iichiro Shimomura

Genes Dev. 2001 May 15; 15(10): 1206–1216. doi: 10.1101/gad.891301

PMCID:: PMC313801

Abstract Article PDF–456K

Select item 1010489316.

Hepatocyte SREBP signaling mediates clock communication within the liver

Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar

J Clin Invest. 2023 Apr 17; 133(8): e163018. Published online 2023 Apr 17. doi: 10.1172/JCI163018

PMCID:: PMC10104893

Abstract Article PDF–1.6M

Select item 670962217.

Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms

Alus M. Xiaoli, Ziyi Song, Fajun Yang

J Biol Chem. 2019 Aug 23; 294(34): 12743–12753. Published online 2019 Jul 3. doi: 10.1074/jbc.RA119.009644

PMCID:: PMC6709622

Abstract Article PDF–2.0M

Select item 670958118.

The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair

Anthony Kusnadi, Sung Ho Park, Ruoxi Yuan, Tania Pannellini, Eugenia Giannopoulou, David Oliver, Theresa Lu, Kyung-Hyun Park-Min, Lionel B. Ivashkiv

Immunity. Author manuscript; available in PMC 2020 Aug 20.

Published in final edited form as: Immunity. 2019 Aug 20; 51(2): 241–257.e9. Published online 2019 Jul 11. doi: 10.1016/j.immuni.2019.06.005

PMCID:: PMC6709581

Abstract Article PDF–1.2M

Select item 608676519.

Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes

Dongyin Guan, Ying Xiong, Patricia C. Borck, Cholsoon Jang, Paschalis-Thomas Doulias, Romeo Papazyan, Bin Fang, Chunjie Jiang, Yuxiang Zhang, Erika R. Briggs, Wenxiang Hu, David Steger, Harry Ischiropoulos, Joshua D. Rabinowitz, Mitchell A. Lazar

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 831–842.e12. Published online 2018 Jul 26. doi: 10.1016/j.cell.2018.06.031

PMCID:: PMC6086765

Abstract Article PDF–1.0M

Select item 555892320.

The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ

Yuxiang Zhang, Romeo Papazyan, Manashree Damle, Bin Fang, Jennifer Jager, Dan Feng, Lindsey C. Peed, Dongyin Guan, Zheng Sun, Mitchell A. Lazar

Genes Dev. 2017 Jun 15; 31(12): 1202–1211. doi: 10.1101/gad.302323.117

PMCID:: PMC5558923

Abstract Article PDF–3.7M

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