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Select item 79370281.

Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis

Ittai B Muller, Marry Lin, Willem F Lems, Marieke M ter Wee, Anna Wojtuszkiewicz, Michael T Nurmohamed, Jacqueline Cloos, Yehuda G Assaraf, Gerrit Jansen, Robert de Jonge

Rheumatology (Oxford) 2021 Mar; 60(3): 1273–1281. Published online 2020 Sep 17. doi: 10.1093/rheumatology/keaa428

PMCID:: PMC7937028

Abstract Article PDF–296K

Select item 74506962.

Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells

Sung-Eun Kim, Toshinori Hinoue, Michael S. Kim, Kyoung-Jin Sohn, Robert C. Cho, Daniel J. Weisenberger, Peter W. Laird, Young-In Kim

J Nutr Biochem. Author manuscript; available in PMC 2020 Aug 27.

Published in final edited form as: J Nutr Biochem. 2016 Mar; 29: 27–35. Published online 2015 Nov 17. doi: 10.1016/j.jnutbio.2015.10.019

PMCID:: PMC7450696

Abstract Article PDF–1.0M

Select item 73740873.

FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia

Sung-Liang Yu, Hui Zhang, Bing-Ching Ho, Chih-Hsiang Yu, Chia-Ching Chang, Yin-Chen Hsu, Yu-Ling Ni, Kai-Hsin Lin, Shiann-Tarng Jou, Meng-Yao Lu, Shu-Huey Chen, Kang-Hsi Wu, Shih-Chung Wang, Hsiu-Hao Chang, Ching-Hon Pui, Jun J. Yang, Jinghui Zhang, Dong-Tsamn Lin, Shu-Wha Lin, Xiaotu Ma, Yung-Li Yang

Sci Rep. 2020; 10: 12074. Published online 2020 Jul 21. doi: 10.1038/s41598-020-69059-y

PMCID:: PMC7374087

Abstract Article PDF–1.4M

Select item 53909074.

Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma

Chengli Miao, Ding Liu, Feng Zhang, Youxin Wang, Yanbin Zhang, Junhui Yu, Zhanzhi Zhang, Gang Liu, Bing Li, Xing Liu, Chenghua Luo

Sci Rep. 2015; 5: 9079. Published online 2015 Mar 13. doi: 10.1038/srep09079

PMCID:: PMC5390907

Abstract Article PDF–706K

Select item 51897225.

Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia

Zhen Huang, Hong-Fei Tong, Yuan Li, Jiang-Chao Qian, Ju-Xiang Wang, Zhe Wang, Ji-Chen Ruan

Med Sci Monit. 2016; 22: 4967–4971. Published online 2016 Dec 17. doi: 10.12659/MSM.899021

PMCID:: PMC5189722

Abstract Article PDF–737K

Select item 50044756.

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Anna Wojtuszkiewicz, Yehuda G. Assaraf, Mirthe Hoekstra, Rocco Sciarrillo, Gerrit Jansen, Godefridus J. Peters, Rob Pieters, Edwin Sonneveld, Gabriele Escherich, Gertjan J.L. Kaspers, Jacqueline Cloos

Haematologica. 2016 Jul; 101(7): e291–e294. doi: 10.3324/haematol.2016.142794

PMCID:: PMC5004475

Article PDF–329K

Select item 42534277.

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia

Shachar Raz, Michal Stark, Yehuda G. Assaraf

Oncotarget. 2014 Oct; 5(19): 9183–9198. Published online 2014 Aug 27. doi: 10.18632/oncotarget.2399

PMCID:: PMC4253427

Abstract Article PDF–1.7M

Select item 28054138.

Concentration-Dependent Processivity of Multiple Glutamate Ligations Catalyzed by Folylpoly-γ-glutamate Synthetase

John W. Tomsho, Richard G. Moran, James K. Coward

Biochemistry. Author manuscript; available in PMC 2010 Jan 12.

Published in final edited form as: Biochemistry. 2008 Aug 26; 47(34): 9040–9050. Published online 2008 Aug 2. doi: 10.1021/bi800406w

PMCID:: PMC2805413

Abstract Article PDF–859K

Select item 15132449.

Analysis of folylpoly-γ-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells

Guy J Leclerc, Gilles M Leclerc, Ting Ting Hsieh Kinser, Julio C Barredo

BMC Cancer. 2006; 6: 132. Published online 2006 May 17. doi: 10.1186/1471-2407-6-132

PMCID:: PMC1513244

Abstract Article PDF–731K

Select item 5008310.

Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure.

T A Garrow, A Admon, B Shane

Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19): 9151–9155. doi: 10.1073/pnas.89.19.9151

PMCID:: PMC50083

Summary Page Browse PDF–1.1M

Select item 747271511.

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Morten Tulstrup, Takaya Moriyama, Chuang Jiang, Marie Grosjean, Jacob Nersting, Jonas Abrahamsson, Kathrine Grell, Lisa Lyngsie Hjalgrim, Ólafur Gísli Jónsson, Jukka Kanerva, Bendik Lund, Stine Nygaard Nielsen, Rikke Linnemann Nielsen, Ulrik Overgaard, Petter Quist-Paulsen, Kaie Pruunsild, Goda Vaitkeviciene, Benjamin Ole Wolthers, Hui Zhang, Ramneek Gupta, Jun J. Yang, Kjeld Schmiegelow

Blood. 2020 Sep 3; 136(10): 1161–1168. Prepublished online 2020 May 11. doi: 10.1182/blood.2020005064

PMCID:: PMC7472715

Abstract Article

Select item 734901712.

Association of NUDT15 c.415C>T and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia

Sunitha Kodidela, Patchava Dorababu, Dimpal N. Thakkar, Biswajit Dubashi, Rajan Sundaram, Niveditha Muralidharan, Ravi Prasad Nidanapu, Anil Aribandi, Suresh Chandra Pradhan, Chakradhara Rao Satyanarayana Uppugunduri

Genes (Basel) 2020 Jun; 11(6): 594. Published online 2020 May 28. doi: 10.3390/genes11060594

PMCID:: PMC7349017

Abstract Article PDF–605K

Select item 420028713.

Mammalian Mitochondrial and Cytosolic Folylpolyglutamate Synthetase Maintain the Subcellular Compartmentalization of Folates

Scott A. Lawrence, Steven A. Titus, Jennifer Ferguson, Amy L. Heineman, Shirley M. Taylor, Richard G. Moran

J Biol Chem. 2014 Oct 17; 289(42): 29386–29396. Published online 2014 Aug 27. doi: 10.1074/jbc.M114.593244

PMCID:: PMC4200287

Abstract Article PDF–3.2M

Select item 364594014.

Folylpoly-Glutamate Synthetase Expression is associated with Tumor Response and Outcome from Pemetrexed-based Chemotherapy in Malignant Pleural Mesothelioma

Daniel C. Christoph, Bernadette Reyna Asuncion, Celine Mascaux, Cindy Tran, Xian Lu, Murry W. Wynes, Thomas C. Gauler, Jeremias Wohlschlaeger, Dirk Theegarten, Volker Neumann, Rodrigo Hepp, Stefan Welter, Georgios Stamatis, Andrea Tannapfel, Martin Schuler, Wilfried E. Eberhardt, Fred R. Hirsch

J Thorac Oncol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: J Thorac Oncol. 2012 Sep; 7(9): 1440–1448. doi: 10.1097/JTO.0b013e318260deaa

PMCID:: PMC3645940

Abstract Article PDF–1.6M

Select item 325389515.

Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study

Sarah J Oppeneer, Julie A Ross, Woon-Puay Koh, Jian-Min Yuan, Kim Robien

Mol Genet Metab. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Mol Genet Metab. 2012 Jan; 105(1): 73–78. Published online 2011 Oct 6. doi: 10.1016/j.ymgme.2011.09.035

PMCID:: PMC3253895

Abstract Article PDF–591K

Select item 573541916.

Correlation Between Polymorphisms of the Reduced Folate Carrier Gene (SLC19A1) and Survival After Pemetrexed-Based Therapy in Non-small Cell Lung Cancer: A North Central Cancer Treatment Group-Based Exploratory Study

Araba A. Adjei, Oreste E. Salavaggione, Sumithra J. Mandrekar, Grace K. Dy, Katie L. Allen Ziegler, Chiaki Endo, Julian R. Molina, Steven E. Schild, Alex A. Adjei

J Thorac Oncol. Author manuscript; available in PMC 2017 Dec 19.

Published in final edited form as: J Thorac Oncol. 2010 Sep; 5(9): 1346–1353. doi: 10.1097/JTO.0b013e3181ec18c4

PMCID:: PMC5735419

Abstract Article PDF–1.3M

Select item 499144517.

Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome

Robert Fred Henry Walter, Fabian Dominik Mairinger, Robert Werner, Claudia Vollbrecht, Thomas Hager, Kurt Werner Schmid, Jeremias Wohlschlaeger, Daniel Christian Christoph

Oncotarget. 2016 Apr 12; 7(15): 20166–20179. Published online 2016 Feb 26. doi: 10.18632/oncotarget.7737

PMCID:: PMC4991445

Abstract Article PDF–2.6M

Select item 493753118.

Yoko Karube, Satoru Kobayashi, Sumiko Maeda, Tetsu Sado, Hiromi Ishihama, Masayuki Chida

J Cardiothorac Surg. 2016; 11: 85. Published online 2016 May 26. doi: 10.1186/s13019-016-0468-1

PMCID:: PMC4937531

Abstract Article PDF–788K

Select item 476088819.

Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European‐Americans and Egyptians

IS Hamadeh, MH Shahin, SM Lima, F Oliveira, L Wilson, SI Khalifa, TY Langaee, RM Cooper‐DeHoff, LH Cavallari, JA Johnson

Clin Transl Sci. 2016 Feb; 9(1): 36–42. Published online 2016 Jan 19. doi: 10.1111/cts.12385

PMCID:: PMC4760888

Abstract Article PDF–488K

Select item 416782820.

Folic acid pathway single nucleotide polymorphisms associated with methotrexate significant adverse events in United States veterans with rheumatoid arthritis

Lisa A. Davis, Brooke Polk, Alyse Mann, Roger K. Wolff, Gail S. Kerr, Andreas M. Reimold, Grant W. Cannon, Ted R. Mikuls, Liron Caplan

Clin Exp Rheumatol. Author manuscript; available in PMC 2014 Sep 19.

Published in final edited form as: Clin Exp Rheumatol. 2014 May-Jun; 32(3): 324–332. Published online 2014 Jan 20.

PMCID:: PMC4167828

Abstract Article PDF–488K

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