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Select item 110923871.

Bromodomain-containing protein 4 (BRD4): A key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics

Zonghui Ma, Andrew A. Bolinger, Jia Zhou, Bing Tian

Expert Opin Ther Targets. Author manuscript; available in PMC 2024 May 14.

Published in final edited form as: Expert Opin Ther Targets. 2023 Jan; 27(1): 1–7. Published online 2023 Feb 7. doi: 10.1080/14728222.2023.2175317

PMCID:: PMC11092387

Abstract Article PDF–821K

Select item 105761452.

A deregulated m⁶A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair–targeted therapy

Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye, Wen Liu, Han You

Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41): e2304534120. Published online 2023 Oct 2. doi: 10.1073/pnas.2304534120

PMCID:: PMC10576145

Abstract Article PDF–2.6M

Select item 104354833.

High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription

Annkatrin Bressin, Olga Jasnovidova, Mirjam Arnold, Elisabeth Altendorfer, Filip Trajkovski, Thomas A. Kratz, Joanna E. Handzlik, Denes Hnisz, Andreas Mayer

Nat Commun. 2023; 14: 4971. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40633-y

PMCID:: PMC10435483

Abstract Article PDF–2.5M

Select item 103314684.

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier

Front Immunol. 2023; 14: 1212770. Published online 2023 Jun 26. doi: 10.3389/fimmu.2023.1212770

PMCID:: PMC10331468

Abstract Article PDF–3.5M

Select item 102933385.

High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma

Li Li, Lin Gao, Hong Zhou, Chao Shi, Xiaojuan Zhang, Dongmei Zhang, Hongbin Liu

Dig Dis Sci. 2023; 68(7): 2997–3008. Published online 2023 Mar 18. doi: 10.1007/s10620-023-07907-3

PMCID:: PMC10293338

Abstract Article PDF–12M

Select item 101243066.

BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors

Yu Fu, Bin Yang, Yaoyuan Cui, Xingyuan Hu, Xi Li, Funian Lu, Tianyu Qin, Li Zhang, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Wenting Li, Xu Qin, Dianxing Hu, Wenju Peng, Jingbo Liu, Beibei Wang, Gordon B Mills, Gang Chen, Chaoyang Sun

J Immunother Cancer. 2023; 11(4): e006070. Published online 2023 Apr 17. doi: 10.1136/jitc-2022-006070

PMCID:: PMC10124306

Abstract Article PDF–13M

Select item 100362157.

Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription

Xiaoyang Yu, Quanxin Long, Sheng Shen, Zhentao Liu, Jithin Chandran, Junjie Zhang, Hao Ding, Hu Zhang, Dawei Cai, Elena S. Kim, Yufei Huang, Haitao Guo

Antiviral Res. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Antiviral Res. 2023 Mar; 211: 105552. Published online 2023 Feb 1. doi: 10.1016/j.antiviral.2023.105552

PMCID:: PMC10036215

Abstract Article PDF–2.4M

Select item 99909078.

The Epigenetic Regulator BRD4 is Required for Myofibroblast Differentiation of Knee Fibroblasts

Amel Dudakovic, Banu Bayram, Jacob W. Bettencourt, Afton K. Limberg, M. Lizeth Galvan, Margarita E Carrasco, Britta Stans, Roman Thaler, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Andre J. van Wijnen, Matthew P. Abdel

J Cell Biochem. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: J Cell Biochem. 2023 Feb; 124(2): 320–334. Published online 2023 Jan 17. doi: 10.1002/jcb.30368

PMCID:: PMC9990907

Abstract Article PDF–2.6M

Select item 98877389.

BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease

Yifei Duan, Siyi Zhou, Jianmiao Wang

Respir Res. 2023; 24: 37. Published online 2023 Jan 31. doi: 10.1186/s12931-023-02348-y

PMCID:: PMC9887738

Abstract Article PDF–1.7M

Select item 982700110.

Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironment

Venkatesh Pooladanda, Sowjanya Thatikonda, Sai Priya Muvvala, Chandraiah Godugu

Int Immunopharmacol. 2023 Feb; 115: 109701. Published online 2023 Jan 9. doi: 10.1016/j.intimp.2023.109701

PMCID:: PMC9827001

Abstract Article PDF–14M

Select item 976794211.

Regulation of programmed cell death by Brd4

Jinfeng Hu, Dun Pan, Guo Li, Kunqi Chen, Xiangming Hu

Cell Death Dis. 2022 Dec; 13(12): 1059. Published online 2022 Dec 20. doi: 10.1038/s41419-022-05505-1

PMCID:: PMC9767942

Abstract Article PDF–1.8M

Select item 972897012.

Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair

Liu Liu, Baicheng Lin, Shasha Yin, Lauren E. Ball, Joe R. Delaney, David T. Long, Wenjian Gan

Sci Adv. 2022 Dec; 8(49): eadd8928. Published online 2022 Dec 7. doi: 10.1126/sciadv.add8928

PMCID:: PMC9728970

Abstract Article PDF–2.4M

Select item 969126213.

BET-ting on histone proteomics in schizophrenia

Marija Kundakovic

Trends Neurosci. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Trends Neurosci. 2022 Oct; 45(10): 716–717. Published online 2022 Jun 16. doi: 10.1016/j.tins.2022.06.001

PMCID:: PMC9691262

Abstract Article PDF–163K

Select item 956325014.

Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach

Johannes Jarausch, Lisa Neuenroth, Reiner Andag, Andreas Leha, Andreas Fischer, Abdul R. Asif, Christof Lenz, Abass Eidizadeh

Cells. 2022 Oct; 11(19): 3086. Published online 2022 Sep 30. doi: 10.3390/cells11193086

PMCID:: PMC9563250

Abstract Article PDF–2.2M

Select item 945091015.

Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor

Andrew D. Woods, Noah E. Berlow, Michael V. Ortiz, Filemon Dela Cruz, Armaan Siddiquee, Diego F. Coutinho, Reshma Purohit, Katherine E. Tranbarger Freier, Joel E. Michalek, Melvin Lathara, Kevin Matlock, Ganapati Srivivasa, Brigitte Royer-Pokora, Renata Veselska, Andrew L. Kung, Charles Keller

Pediatr Blood Cancer. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Pediatr Blood Cancer. 2022 Feb; 69(2): e29401. Published online 2021 Oct 24. doi: 10.1002/pbc.29401

PMCID:: PMC9450910

Abstract Article PDF–1.0M

Select item 903377616.

Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze

Nat Commun. 2022; 13: 2195. Published online 2022 Apr 22. doi: 10.1038/s41467-022-29922-0

PMCID:: PMC9033776

Abstract Article PDF–2.3M

Select item 895854617.

Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models

Siyi Zhang, Ping Bai, Dan Lei, Yingxia Liang, Sherri Zhen, Grisilda Bakiasi, Hao Pang, Se Hoon Choi, Changning Wang, Rudolph E. Tanzi, Can Zhang

J Biol Chem. 2022 Apr; 298(4): 101794. Published online 2022 Mar 3. doi: 10.1016/j.jbc.2022.101794

PMCID:: PMC8958546

Abstract Article PDF–2.0M

Select item 893308118.

BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study

Guang-Zhi Zhang, Hai-Wei Chen, Ya-jun Deng, Ming-Qiang Liu, Zuo-Long Wu, Zhan-Jun Ma, Xue-Gang He, Yi-Cheng Gao, Xue-Wen Kang

Oxid Med Cell Longev. 2022; 2022: 9181412. Published online 2022 Mar 11. doi: 10.1155/2022/9181412

PMCID:: PMC8933081

Abstract Article PDF–8.2M

Select item 883768319.

Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives

Lu Feng, Guan Wang, Yi Chen, Gu He, Bo Liu, Jie Liu, Cheng-Ming Chiang, Liang Ouyang

Med Res Rev. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Med Res Rev. 2022 Mar; 42(2): 710–743. Published online 2021 Oct 11. doi: 10.1002/med.21859

PMCID:: PMC8837683

Abstract Article PDF–4.5M

Select item 883298220.

BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer

Beibei Liu, Xinhua Liu, Lulu Han, Xing Chen, Xiaodi Wu, Jiajing Wu, Dong Yan, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Yongfeng Shang

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2109133119. Published online 2022 Feb 1. doi: 10.1073/pnas.2109133119

PMCID:: PMC8832982

Abstract Article PDF–2.1M

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