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Select item 94826381.

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W. Wright, James D. Phelan, Da Wei Huang, James W. Lord, Callie K. Van Winkle, Xin Yu, Jan Wisniewski, James Q. Wang, Frances A. Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A. Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J. Thomas, Ryan M. Young

Nat Commun. 2022; 13: 5469. Published online 2022 Sep 17. doi: 10.1038/s41467-022-33142-x

Correction in:: Nat Commun. 2022; 13: 5830.

PMCID:: PMC9482638

Abstract Article PDF–4.9M

Select item 69336942.

Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

Aurélie Delacrétaz, Anaïs Glatard, Céline Dubath, Mehdi Gholam-Rezaee, Jose Vicente Sanchez-Mut, Johannes Gräff, Armin von Gunten, Philippe Conus, Chin B. Eap

Clin Epigenetics. 2019; 11: 198. Published online 2019 Dec 26. doi: 10.1186/s13148-019-0792-0

PMCID:: PMC6933694

Abstract Article PDF–769K

Select item 66069563.

(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution

Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher

EBioMedicine. 2019 Jun; 44: 476–488. Published online 2019 May 30. doi: 10.1016/j.ebiom.2019.05.050

PMCID:: PMC6606956

Abstract Article PDF–787K

Select item 48375174.

CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

Maite Mendioroz, Naiara Celarain, Miren Altuna, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Idoya Rubio, Rosa Larumbe, María Elena Erro, Iván Méndez, Carmen Echávarri

Alzheimers Res Ther. 2016; 8: 15. Published online 2016 Apr 19. doi: 10.1186/s13195-016-0183-0

PMCID:: PMC4837517

Abstract Article PDF–1.3M

Select item 42277735.

Requirement of CRTC1 coactivator for hepatitis B virus transcription

Hei-Man Vincent Tang, Wei-Wei Gao, Chi-Ping Chan, Yun Cheng, Vidyanath Chaudhary, Jian-Jun Deng, Kit-San Yuen, Chun-Ming Wong, Irene Oi-Lin Ng, Kin-Hang Kok, Jie Zhou, Dong-Yan Jin

Nucleic Acids Res. 2014 Nov 10; 42(20): 12455–12468. Published online 2014 Oct 9. doi: 10.1093/nar/gku925

PMCID:: PMC4227773

Abstract Article PDF–623K

Select item 37450236.

Clock and Light Regulation of the CREB Coactivator CRTC1 in the Suprachiasmatic Circadian Clock

Kensuke Sakamoto, Frances E. Norona, Diego Alzate-Correa, Daniel Scarberry, Kari R. Hoyt, Karl Obrietan

J Neurosci. 2013 May 22; 33(21): 9021–9027. doi: 10.1523/JNEUROSCI.4202-12.2013

PMCID:: PMC3745023

Abstract Article PDF–2.1M

Select item 35187557.

Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation

Avanita S. Prabowo, Jasper J. Anink, Martin Lammens, Mark Nellist, Ans M. W. van den Ouweland, Homa Adle‐Biassette, Harvey B. Sarnat, Laura Flores‐Sarnat, Peter B. Crino, Eleonora Aronica

Brain Pathol. 2013 Jan; 23(1): 45–59. Published online 2012 Aug 30. doi: 10.1111/j.1750-3639.2012.00616.x

PMCID:: PMC3518755

Abstract Article PDF–7.3M

Select item 33835978.

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

Marina Kolesnichenko, Lixin Hong, Rong Liao, Peter K. Vogt, Peiqing Sun

Cell Cycle. 2012 Jun 15; 11(12): 2391–2401. doi: 10.4161/cc.20683

PMCID:: PMC3383597

Abstract Article PDF–1.0M

Select item 98655069.

Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens

Shunpei Yamanaka, Susumu Suzuki, Hideaki Ito, Karnan Sivasundaram, Ichiro Hanamura, Ikuko Okubo, Kazuhiro Yoshikawa, Shoya Ono, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Ryuzo Ueda, Tetsuya Ogawa, Yasushi Fujimoto

Int J Mol Sci. 2023 Jan; 24(2): 1722. Published online 2023 Jan 15. doi: 10.3390/ijms24021722

PMCID:: PMC9865506

Abstract Article PDF–2.9M

Select item 811919410.

The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

Zirong Chen, Wei Ni, Jian-Liang Li, Shuibin Lin, Xin Zhou, Yuping Sun, Jennifer W. Li, Marino E. Leon, Maria D. Hurtado, Sergei Zolotukhin, Chen Liu, Jianrong Lu, James D. Griffin, Frederic J. Kaye, Lizi Wu

JCI Insight. 2021 Apr 8; 6(7): e139497. Published online 2021 Apr 8. doi: 10.1172/jci.insight.139497

PMCID:: PMC8119194

Abstract Article PDF–15M

Select item 798849811.

Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion

Abdullah Alholle, Marie Karanian, Anna T Brini, Mark R Morris, Vinodh Kannappan, Stefania Niada, Angela Niblett, Dominique Ranchère-Vince, Daniel Pissaloux, Christophe Delfour, Aurelie Maran Gonzalez, Cristina R Antonescu, Vaiyapuri Sumathi, Franck Tirode, Farida Latif

J Pathol. Author manuscript; available in PMC 2021 Mar 24.

Published in final edited form as: J Pathol. 2018 Jun; 245(2): 186–196. Published online 2018 Apr 16. doi: 10.1002/path.5071

Correction in:: J Pathol. 2019 Mar; 247(3): 406.

PMCID:: PMC7988498

Abstract Article PDF–2.1M

Select item 722761312.

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Takefumi Komiya, Amy Coxon, Yoonsoo Park, Wei-dong Chen, Maria Zajac-Kaye, Paul Meltzer, Tatiana Karpova, Frederic J. Kaye

Oncogene. Author manuscript; available in PMC 2020 May 15.

Published in final edited form as: Oncogene. 2010 Mar 18; 29(11): 1672–1680. Published online 2009 Dec 14. doi: 10.1038/onc.2009.453

PMCID:: PMC7227613

Abstract Article PDF–948K

Select item 511667113.

The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation

Hwijin Kim

Sci Rep. 2016; 6: 37280. Published online 2016 Nov 21. doi: 10.1038/srep37280

PMCID:: PMC5116671

Abstract Article PDF–2.0M

Select item 462416614.

Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells

Jie Chen, Jian-Liang Li, Zirong Chen, James D. Griffin, Lizi Wu

BMC Cancer. 2015; 15: 803. Published online 2015 Oct 26. doi: 10.1186/s12885-015-1827-3

PMCID:: PMC4624166

Abstract Article PDF–1.7M

Select item 427107815.

Role of LKB1-CRTC1 on Glycosylated COX-2 and Response to COX-2 Inhibition in Lung Cancer

Chunxia Cao, Ruli Gao, Min Zhang, Antonio L. Amelio, Mohammad Fallahi, Zirong Chen, Yumei Gu, Chengbin Hu, Eric A. Welsh, Brienne E. Engel, Eric B. Haura, W. Douglas Cress, Lizi Wu, Maria Zajac-Kaye, Frederic J. Kaye

J Natl Cancer Inst. 2015 Jan; 107(1): dju358. Published online 2014 Dec 2. doi: 10.1093/jnci/dju358

PMCID:: PMC4271078

Abstract Article PDF–1.7M

Select item 415120816.

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells

Sian M. Henson, Alessio Lanna, Natalie E. Riddell, Ornella Franzese, Richard Macaulay, Stephen J. Griffiths, Daniel J. Puleston, Alexander Scarth Watson, Anna Katharina Simon, Sharon A. Tooze, Arne N. Akbar

J Clin Invest. 2014 Sep 2; 124(9): 4004–4016. Published online 2014 Aug 1. doi: 10.1172/JCI75051

PMCID:: PMC4151208

Abstract Article PDF–3.5M

Select item 292331417.

Central Mucoepidermoid Carcinoma, A Case Report with Molecular Analysis of the TORC1/MAML2 Gene Fusion

Haseeb Ahmed Khan, Asif Loya, Rafay Azhar, Nasir Ud Din, Diana Bell

Head Neck Pathol. 2010 Sep; 4(3): 261–264. Published online 2010 Jul 13. doi: 10.1007/s12105-010-0191-5

PMCID:: PMC2923314

Abstract Article PDF–391K

Select item 263581018.

The coactivator CRTC1 promotes cell proliferation and transformation via AP-1

Gianluca Canettieri, Sonia Coni, Michele Della Guardia, Valentina Nocerino, Laura Antonucci, Laura Di Magno, Robert Screaton, Isabella Screpanti, Giuseppe Giannini, Alberto Gulino

Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5): 1445–1450. Published online 2009 Jan 21. doi: 10.1073/pnas.0808749106

PMCID:: PMC2635810

Abstract Article PDF–944K

Select item 257515519.

Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation

Yeung-Tung Siu, Yick-Pang Ching, Dong-Yan Jin

Mol Biol Cell. 2008 Nov; 19(11): 4750–4761. doi: 10.1091/mbc.E08-04-0369

PMCID:: PMC2575155

Abstract Article PDF–1.2M

Select item 148905720.

TORC1 and TORC2 Coactivators Are Required for Tax Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeats

Yeung-Tung Siu, King-Tung Chin, Kam-Leung Siu, Elizabeth Yee Wai Choy, Kuan-Teh Jeang, Dong-Yan Jin

J Virol. 2006 Jul; 80(14): 7052–7059. doi: 10.1128/JVI.00103-06

PMCID:: PMC1489057

Abstract Article PDF–405K

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