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Items: 1 to 20 of 24

1.
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig
Mol Metab. 2021 Jun; 48: 101210. Published online 2021 Mar 17. doi: 10.1016/j.molmet.2021.101210
PMCID:
PMC8094910
AbstractArticlePDF–3.1M
2.
Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine
Matthew R. McFarlane, Guosheng Liang, Luke J. Engelking
J Biol Chem. 2014 Jan 24; 289(4): 2148–2156. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.524041
PMCID:
PMC3900961
AbstractArticlePDF–2.7M
3.
Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin
Bret M. Evers, Midhat S. Farooqi, John M. Shelton, James A. Richardson, Joseph L. Goldstein, Michael S. Brown, Guosheng Liang
J Invest Dermatol. Author manuscript; available in PMC 2010 Nov 1.
Published in final edited form as: J Invest Dermatol. 2010 May; 130(5): 1237–1248. Published online 2010 Jan 21. doi: 10.1038/jid.2009.442
PMCID:
PMC2929004
AbstractArticlePDF–3.6M
4.
Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song
Nat Commun. 2020; 11: 379. Published online 2020 Jan 17. doi: 10.1038/s41467-019-14231-w
PMCID:
PMC6969111
AbstractArticlePDF–2.3M
5.
Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands
Akiko Suzuki, Junbo Shim, Kenichi Ogata, Hiroki Yoshioka, Junichi Iwata
Development. 2019 Oct 15; 146(20): dev178335. Published online 2019 Oct 17. doi: 10.1242/dev.178335
PMCID:
PMC6826039
AbstractArticle
6.
Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation
James P. Bridges, Angelica Schehr, Yanhua Wang, Liya Huo, Valérie Besnard, Machiko Ikegami, Jeffrey A. Whitsett, Yan Xu
PLoS One. 2014; 9(5): e91376. Published online 2014 May 7. doi: 10.1371/journal.pone.0091376
PMCID:
PMC4012993
AbstractArticlePDF–2.5M
7.
Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
Stefania Carobbio, Rachel M. Hagen, Christopher J. Lelliott, Marc Slawik, Gema Medina-Gomez, Chong-Yew Tan, Audrey Sicard, Helen J. Atherton, Nuria Barbarroja, Mikael Bjursell, Mohammad Bohlooly-Y, Sam Virtue, Antoinette Tuthill, Etienne Lefai, Martine Laville, Tingting Wu, Robert V. Considine, Hubert Vidal, Dominique Langin, Matej Oresic, Francisco J. Tinahones, Jose Manuel Fernandez-Real, Julian L. Griffin, Jaswinder K. Sethi, Miguel López, Antonio Vidal-Puig
Diabetes. 2013 Nov; 62(11): 3697–3708. Published online 2013 Oct 18. doi: 10.2337/db12-1748
PMCID:
PMC3806615
AbstractArticlePDF–1.2M
8.
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
Yien Che Tsai, Gil S. Leichner, Margaret M. P. Pearce, Gaye Lynn Wilson, Richard J. H. Wojcikiewicz, Joseph Roitelman, Allan M. Weissman
Mol Biol Cell. 2012 Dec 1; 23(23): 4484–4494. doi: 10.1091/mbc.E12-08-0631
PMCID:
PMC3510011
AbstractArticlePDF–1.5M
9.
Insig-1 “brakes” lipogenesis in adipocytes and inhibits differentiation of preadipocytes
Jinping Li, Kiyosumi Takaishi, William Cook, Sara Kay McCorkle, Roger H. Unger
Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16): 9476–9481. Published online 2003 Jul 17. doi: 10.1073/pnas.1133426100
PMCID:
PMC170943
AbstractArticlePDF–648K
10.
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
Luke J. Engelking, Bret M. Evers, James A. Richardson, Joseph L. Goldstein, Michael S. Brown, Guosheng Liang
J Clin Invest. 2006 Sep 1; 116(9): 2356–2365. Published online 2006 Sep 1. doi: 10.1172/JCI28988
PMCID:
PMC1555642
AbstractArticlePDF–1.0M
11.
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
Daisuke Yabe, Ryutaro Komuro, Guosheng Liang, Joseph L. Goldstein, Michael S. Brown
Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6): 3155–3160. Published online 2003 Mar 6. doi: 10.1073/pnas.0130116100
PMCID:
PMC152262
AbstractArticlePDF–256K
12.
Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
Luke J. Engelking, Guosheng Liang, Robert E. Hammer, Kiyosumi Takaishi, Hiroshi Kuriyama, Bret M. Evers, Wei-Ping Li, Jay D. Horton, Joseph L. Goldstein, Michael S. Brown
J Clin Invest. 2005 Sep 1; 115(9): 2489–2498. Published online 2005 Aug 11. doi: 10.1172/JCI25614
PMCID:
PMC1184040
AbstractArticlePDF–1.2M
13.
Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman
Development. 2018 Jul 1; 145(13): dev162396. Published online 2018 Jul 9. doi: 10.1242/dev.162396
PMCID:
PMC6053657
AbstractArticle
14.
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
Laurent Vergnes, Robert G. Chin, Thomas de Aguiar Vallim, Loren G. Fong, Timothy F. Osborne, Stephen G. Young, Karen Reue
J Lipid Res. 2016 Mar; 57(3): 410–421. doi: 10.1194/jlr.M064022
PMCID:
PMC4766990
AbstractArticlePDF–1.7M
15.
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
Daisuke Yabe, Michael S. Brown, Joseph L. Goldstein
Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12753–12758. Published online 2002 Sep 19. doi: 10.1073/pnas.162488899
PMCID:
PMC130532
AbstractArticlePDF–296K
16.
Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development
Bernice H. Wong, Jia Pei Chan, Amaury Cazenave-Gassiot, Rebecca W. Poh, Juat Chin Foo, Dwight L. A. Galam, Sujoy Ghosh, Long N. Nguyen, Veluchamy A. Barathi, Sia W. Yeo, Chi D. Luu, Markus R. Wenk, David L. Silver
J Biol Chem. 2016 May 13; 291(20): 10501–10514. Published online 2016 Mar 22. doi: 10.1074/jbc.M116.721340
PMCID:
PMC4865901
AbstractArticlePDF–5.4M
17.
Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis
Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, Linda J. Sandell
PLoS One. 2014; 9(8): e105674. Published online 2014 Aug 22. doi: 10.1371/journal.pone.0105674
PMCID:
PMC4141819
AbstractArticlePDF–21M
18.
Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
Minqing Jiang, Lei Liu, Xuelian He, Haibo Wang, Wensheng Lin, Huimin Wang, Sung O. Yoon, Teresa L. Wood, Q. Richard Lu
Nat Commun. 2016; 7: 12185. Published online 2016 Jul 15. doi: 10.1038/ncomms12185
Correction in:
Nat Commun. 2016; 7: 13767.
PMCID:
PMC4947172
AbstractArticlePDF–4.9M
19.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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