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Select item 105759311.

Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease

Wenyan Hao, Hongxian Zhang, Peng Hong, Xin Zhang, Xuyang Zhao, Lulin Ma, Xiaoyan Qiu, Hao Ping, Dan Lu, Yuxin Yin

Cell Death Dis. 2023 Oct; 14(10): 680. Published online 2023 Oct 13. doi: 10.1038/s41419-023-06185-1

PMCID:: PMC10575931

Abstract Article PDF–8.2M

Select item 104573892.

Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease

Madlen Kunke, Hannah Knöfler, Eileen Dahlke, Luis Zanon Rodriguez, Martina Böttner, Alexey Larionov, Makhabbat Saudenova, Gerrit M. Ohrenschall, Magdalena Westermann, Stefan Porubsky, Joana P. Bernardes, Robert Häsler, Jean-Luc Magnin, Hermann Koepsell, François Jouret, Franziska Theilig

Cell Death Dis. 2023 Aug; 14(8): 562. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06074-7

PMCID:: PMC10457389

Abstract Article PDF–6.2M

Select item 88891043.

Deletion of Vhl in Dmp1-Expressing Cells Causes Microenvironmental Impairment of B Cell Lymphopoiesis

Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer, Jennifer O. Manilay

Front Immunol. 2022; 13: 780945. Published online 2022 Feb 16. doi: 10.3389/fimmu.2022.780945

PMCID:: PMC8889104

Abstract Article PDF–10M

Select item 88042404.

Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation

Kaizhe Chen, Jian Zhao, Minglong Qiu, Lianfang Zhang, Kai Yang, Leilei Chang, Peng Jia, Jin Qi, Lianfu Deng, Changwei Li

Front Cell Dev Biol. 2021; 9: 721561. Published online 2022 Jan 18. doi: 10.3389/fcell.2021.721561

PMCID:: PMC8804240

Abstract Article PDF–3.8M

Select item 81679285.

E3 ubiquitin ligase von Hippel-Lindau (VHL) protein promotes Th17 differentiation

Alisha Chitrakar, Scott A. Budda, Jacob G. Henderson, Robert C. Axtell, Lauren A. Zenewicz

J Immunol. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: J Immunol. 2020 Aug 15; 205(4): 1009–1023. Published online 2020 Jul 20. doi: 10.4049/jimmunol.2000243

PMCID:: PMC8167928

Abstract Article PDF–1.2M

Select item 59162406.

Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch

Alexandra Arreola, Laura Beth Payne, Morgan H. Julian, Aguirre A. de Cubas, Anthony B. Daniels, Sarah Taylor, Huaning Zhao, Jordan Darden, Victoria L. Bautch, W. Kimryn Rathmell, John C. Chappell

JCI Insight. 2018 Feb 22; 3(4): e92193. Published online 2018 Feb 22. doi: 10.1172/jci.insight.92193

PMCID:: PMC5916240

Abstract Article PDF–4.1M

Select item 58248567.

Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism

Naomi Dirckx, Robert J. Tower, Evi M. Mercken, Roman Vangoitsenhoven, Caroline Moreau-Triby, Tom Breugelmans, Elena Nefyodova, Ruben Cardoen, Chantal Mathieu, Bart Van der Schueren, Cyrille B. Confavreux, Thomas L. Clemens, Christa Maes

J Clin Invest. 2018 Mar 1; 128(3): 1087–1105. Published online 2018 Feb 12. doi: 10.1172/JCI97794

PMCID:: PMC5824856

Abstract Article PDF–19M

Select item 55830108.

Neuroprotective effects respond to cerebral ischemia without susceptibility to HB-tumorigenesis in VHL heterozygous knockout mice

Ying Wang, Jingyun Yang, Guhong Du, Dexuan Ma, Liangfu Zhou

Mol Carcinog. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Mol Carcinog. 2017 Oct; 56(10): 2342–2351. Published online 2017 Jun 30. doi: 10.1002/mc.22688

PMCID:: PMC5583010

Abstract Article PDF–1.2M

Select item 51421829.

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism

Mary Slingo, Mark Cole, Carolyn Carr, Mary K. Curtis, Michael Dodd, Lucia Giles, Lisa C. Heather, Damian Tyler, Kieran Clarke, Peter A. Robbins

Am J Physiol Heart Circ Physiol. 2016 Sep 1; 311(3): H759–H767. Published online 2016 Jul 15. doi: 10.1152/ajpheart.00912.2015

PMCID:: PMC5142182

Abstract Article

Select item 494219210.

Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis

Qiyuan Zhou, Tianji Chen, Wei Zhang, Melike Bozkanat, Yongchao Li, Lei Xiao, Richard B. van Breemen, John W. Christman, Jacob I. Sznajder, Guofei Zhou

Am J Respir Cell Mol Biol. 2016 May; 54(5): 728–739. doi: 10.1165/rcmb.2015-0111OC

PMCID:: PMC4942192

Abstract Article PDF–1.4M

Select item 492818311.

CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma

Shiruyeh Schokrpur, Junhui Hu, Diana L. Moughon, Peijun Liu, Lucia C. Lin, Kip Hermann, Serghei Mangul, Wei Guan, Matteo Pellegrini, Hua Xu, Lily Wu

Sci Rep. 2016; 6: 29032. Published online 2016 Jun 30. doi: 10.1038/srep29032

PMCID:: PMC4928183

Abstract Article PDF–1.9M

Select item 415069212.

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis

Tujun Weng, Yangli Xie, Lingxian Yi, Junlan Huang, Fengtao Luo, Xiaolan Du, Liang Chen, Chongyang Liu, Di Chen, Lin Chen

Osteoarthritis Cartilage. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Osteoarthritis Cartilage. 2014 Aug; 22(8): 1197–1205. Published online 2014 Jul 4. doi: 10.1016/j.joca.2014.06.031

PMCID:: PMC4150692

Abstract Article PDF–1.7M

Select item 411123313.

Inactivation of Vhl in Osteochondral Progenitor Cells Causes High Bone Mass Phenotype and Protects Against Age-Related Bone Loss in Adult Mice

Tujun Weng, Yangli Xie, Junlan Huang, Fengtao Luo, Lingxian Yi, Qifen He, Di Chen, Lin Chen

J Bone Miner Res. Author manuscript; available in PMC 2014 Jul 25.

Published in final edited form as: J Bone Miner Res. 2014 Apr; 29(4): 820–829. doi: 10.1002/jbmr.2087

PMCID:: PMC4111233

Abstract Article PDF–2.6M

Select item 381009014.

Tubular von Hippel-Lindau Knockout Protects against Rhabdomyolysis-Induced AKI

Michael Fähling, Susanne Mathia, Alexander Paliege, Robert Koesters, Ralf Mrowka, Harm Peters, Pontus Börje Persson, Hans-Hellmut Neumayer, Sebastian Bachmann, Christian Rosenberger

J Am Soc Nephrol. 2013 Nov; 24(11): 1806–1819. Published online 2013 Aug 22. doi: 10.1681/ASN.2013030281

PMCID:: PMC3810090

Abstract Article

Select item 379998315.

The VHL tumor suppressor and HIF: insights from genetic studies in mice

PP Kapitsinou, VH Haase

Cell Death Differ. Author manuscript; available in PMC 2013 Oct 19.

Published in final edited form as: Cell Death Differ. 2008 Apr; 15(4): 650–659. Published online 2008 Jan 25. doi: 10.1038/sj.cdd.4402313

PMCID:: PMC3799983

Abstract Article PDF–2.3M

Select item 359703116.

A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome

Marianne T. Neary, Timothy J. Mohun, Ross A. Breckenridge

Dis Model Mech. 2013 Mar; 6(2): 503–507. Published online 2012 Sep 11. doi: 10.1242/dmm.010587

PMCID:: PMC3597031

Abstract Article

Select item 320419217.

Tubular Deficiency of von Hippel-Lindau Attenuates Renal Disease Progression in Anti-GBM Glomerulonephritis

Franziska Theilig, Anne Kathrin Enke, Brigitte Scolari, Danny Polzin, Sebastian Bachmann, Robert Koesters

Am J Pathol. 2011 Nov; 179(5): 2177–2188. doi: 10.1016/j.ajpath.2011.07.012

PMCID:: PMC3204192

Abstract Article PDF–4.1M

Select item 311366718.

Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function

Sutapa Sinha, Gourish Mondal, Eun Ju Hwang, Da Woon Han, Shamit K. Dutta, Seethalakshmi Iyer, S. Ananth Karumanchi, Keun Il Kim, Fergus J. Couch, Debabrata Mukhopadhyay

J Cell Sci. 2011 Jul 1; 124(13): 2132–2142. doi: 10.1242/jcs.087122