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Items: 1 to 20 of 136

1.
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager, David N Zacks
J Neuroinflammation. 2024; 21: 74. Published online 2024 Mar 25. doi: 10.1186/s12974-024-03062-2
PMCID:
PMC10964713
AbstractArticlePDF–9.1M
2.
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice
Ran Sun, Min Han, Yan Liu, Yong Su, Qifeng Shi, Lei Huang, Liangliang Kong, Weizu Li, Weiping Li
Mol Med Rep. 2024 Jan; 29(1): 13. Published online 2023 Nov 27. doi: 10.3892/mmr.2023.13136
PMCID:
PMC10704556
AbstractArticlePDF–7.0M
3.
Molecular Modification of Transient Receptor Potential Canonical 6 Channels Modulates Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia
Jose Rafael Lopez, Arkady Uryash, Jose Adams, Philip M. Hopkins, Paul D. Allen
Anesthesiology. Author manuscript; available in PMC 2023 Jan 12.
Published in final edited form as: Anesthesiology. 2021 Feb 1; 134(2): 234–247. doi: 10.1097/ALN.0000000000003635
PMCID:
PMC9836077
AbstractArticlePDF–741K
4.
Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
Yamina El Hamdaoui, Fang Zheng, Nikolas Fritz, Lian Ye, Mai Anh Tran, Kevin Schwickert, Tanja Schirmeister, Albert Braeuning, Dajana Lichtenstein, Ute A. Hellmich, Dorothee Weikert, Markus Heinrich, Giulia Treccani, Michael K. E. Schäfer, Gabriel Nowak, Bernd Nürnberg, Christian Alzheimer, Christian P. Müller, Kristina Friedland
Mol Psychiatry. 2022; 27(12): 5070–5085. Published online 2022 Oct 12. doi: 10.1038/s41380-022-01804-3
PMCID:
PMC9763113
AbstractArticlePDF–3.7M
5.
New Positive TRPC6 Modulator Penetrates Blood–Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice
Nikita Zernov, Alexander V. Veselovsky, Vladimir V. Poroikov, Daria Melentieva, Anastasia Bolshakova, Elena Popugaeva
Int J Mol Sci. 2022 Nov; 23(21): 13552. Published online 2022 Nov 4. doi: 10.3390/ijms232113552
PMCID:
PMC9653995
AbstractArticlePDF–2.3M
6.
Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models
Brittney J. Brown, Kimber L. Boekell, Brian R. Stotter, Brianna E. Talbot, Johannes S. Schlondorff
PLoS One. 2022; 17(8): e0272313. Published online 2022 Aug 1. doi: 10.1371/journal.pone.0272313
PMCID:
PMC9342776
AbstractArticlePDF–2.8M
7.
Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets
Kimber L. Boekell, Brittney J. Brown, Brianna E. Talbot, Johannes S. Schlondorff
PLoS One. 2022; 17(6): e0270431. Published online 2022 Jun 24. doi: 10.1371/journal.pone.0270431
PMCID:
PMC9231752
AbstractArticlePDF–3.6M
8.
Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction
Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Yiling Fu, Lance T. Jaynes, Jaylan Sears, Xuan Li, Alan J. Mouton, Ana Carolina M. Omoto, Brittney P. Xu, John E. Hall
Am J Physiol Regul Integr Comp Physiol. 2022 Jul 1; 323(1): R81–R97. Published online 2022 May 10. doi: 10.1152/ajpregu.00097.2021
PMCID:
PMC9190745
AbstractArticle
9.
Role of TRPC6 in kidney damage after acute ischemic kidney injury
Zhihuang Zheng, Dmitry Tsvetkov, Theda Ulrike Patricia Bartolomaeus, Cem Erdogan, Ute Krügel, Johanna Schleifenbaum, Michael Schaefer, Bernd Nürnberg, Xiaoning Chai, Friedrich-Alexander Ludwig, Gabriele N’diaye, May-Britt Köhler, Kaiyin Wu, Maik Gollasch, Lajos Markó
Sci Rep. 2022; 12: 3038. Published online 2022 Feb 22. doi: 10.1038/s41598-022-06703-9
PMCID:
PMC8864023
AbstractArticlePDF–15M
10.
Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension
Zhen Wang, Yiling Fu, Jussara M. do Carmo, Alexandre A. da Silva, Xuan Li, Alan Mouton, Ana Carolina M. Omoto, Jaylan Sears, John E. Hall
Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F76–F88. Published online 2021 Dec 6. doi: 10.1152/ajprenal.00296.2021
PMCID:
PMC8742740
AbstractArticle
11.
Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis
Jinting Yang, Lihui Tang, Fengjiang Zhang, Tingting Yang, Ting Lu, Kai Sun, Na Sun, Jinxuan Ren, Min Yan
Stem Cell Res Ther. 2021; 12: 584. Published online 2021 Nov 22. doi: 10.1186/s13287-021-02649-3
PMCID:
PMC8607627
AbstractArticlePDF–6.7M
12.
Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes
Yingjun Zang, Shuang Liu, Aili Cao, Xiangyu Shan, Wenjuan Deng, Zhijun Li, Hao Wang, Yunman Wang, Li Wang, Wen Peng
Mol Biol Rep. 2021; 48(2): 1453–1464. Published online 2021 Feb 19. doi: 10.1007/s11033-021-06204-4
PMCID:
PMC7925475
AbstractArticlePDF–4.4M
13.
Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice
Zoltan Nemeth, Emily Hildebrandt, Michael J. Ryan, Joey P. Granger, Heather A. Drummond
Am J Physiol Heart Circ Physiol. 2020 Jul 1; 319(1): H42–H50. Published online 2020 May 15. doi: 10.1152/ajpheart.00126.2020
PMCID:
PMC7474446
AbstractArticle
14.
Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels
Otto Lindemann, Jan Rossaint, Karolina Najder, Sandra Schimmelpfennig, Verena Hofschröer, Mike Wälte, Benedikt Fels, Hans Oberleithner, Alexander Zarbock, Albrecht Schwab
J Mol Med (Berl) 2020; 98(3): 349–360. Published online 2020 Jan 16. doi: 10.1007/s00109-020-01872-4
PMCID:
PMC7080674
AbstractArticlePDF–1.0M
15.
Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)
Caleigh M. Azumaya, Francisco Sierra-Valdez, Julio F. Cordero-Morales, Terunaga Nakagawa
J Biol Chem. 2018 Jun 29; 293(26): 10381–10391. Published online 2018 May 11. doi: 10.1074/jbc.RA118.003183
PMCID:
PMC6028952
AbstractArticlePDF–2.6M
16.
Mammalian Target of Rapamycin Complex 2 Signaling Pathway Regulates Transient Receptor Potential Cation Channel 6 in Podocytes
Fangrui Ding, Xiaoyan Zhang, Xuejuan Li, Yanqin Zhang, Baihong Li, Jie Ding
PLoS One. 2014; 9(11): e112972. Published online 2014 Nov 13. doi: 10.1371/journal.pone.0112972
PMCID:
PMC4231083
AbstractArticlePDF–2.1M
17.
Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity
Gentzon Hall, Janelle Rowell, Federica Farinelli, Rasheed A. Gbadegesin, Peter Lavin, Guanghong Wu, Alison Homstad, Andrew Malone, Thomas Lindsey, Ruiji Jiang, Robert Spurney, Gordon F. Tomaselli, David A. Kass, Michelle P. Winn
Am J Physiol Renal Physiol. 2014 Jun 15; 306(12): F1442–F1450. Published online 2014 Apr 16. doi: 10.1152/ajprenal.00212.2013
PMCID:
PMC4059973
AbstractArticle
18.
Transient Receptor Potential Channel 6 (TRPC6) Protects Podocytes during Complement-mediated Glomerular Disease
Andreas D. Kistler, Geetika Singh, Mehmet M. Altintas, Hao Yu, Isabel C. Fernandez, Changkyu Gu, Cory Wilson, Sandeep Kumar Srivastava, Alexander Dietrich, Katherina Walz, Dontscho Kerjaschki, Phillip Ruiz, Stuart Dryer, Sanja Sever, Amit K. Dinda, Christian Faul, Jochen Reiser
J Biol Chem. 2013 Dec 20; 288(51): 36598–36609. Published online 2013 Nov 5. doi: 10.1074/jbc.M113.488122
PMCID:
PMC3868772
AbstractArticlePDF–5.4M
19.
A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo
Jennifer Davis, Adam R. Burr, Gregory F. Davis, Lutz Birnbaumer, Jeffery D. Molkentin
Dev Cell. Author manuscript; available in PMC 2013 Apr 16.
Published in final edited form as: Dev Cell. 2012 Oct 16; 23(4): 705–715. Published online 2012 Sep 27. doi: 10.1016/j.devcel.2012.08.017
PMCID:
PMC3505601
AbstractArticlePDF–6.0M
20.
Expression of TRPC6 in Renal Cortex and Hippocampus of Mouse during Postnatal Development
Pengjuan Xu, Jing Xu, Zhigui Li, Zhuo Yang
PLoS One. 2012; 7(6): e38503. Published online 2012 Jun 6. doi: 10.1371/journal.pone.0038503
PMCID:
PMC3368853
AbstractArticlePDF–3.0M

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