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Select item 110487931.

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Bethany J. Bogan, Holly C. Williams, Claire M. Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W. Robert Taylor, Amir Rezvan, Alejandra San Martin

Cells. 2024 Apr; 13(8): 658. Published online 2024 Apr 9. doi: 10.3390/cells13080658

PMCID:: PMC11048793

Abstract Article PDF–2.5M

Select item 107955152.

FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Oluwademilade Dairo, Lia DePaula Oliveira, Ethan Schaffer, Thiago Vidotto, Adrianna A. Mendes, Jiayun Lu, Sophie Vo Huynh, Jessica Hicks, Adam G. Sowalsky, Angelo M. De Marzo, Corrine E. Joshu, Brian Hanratty, Karen S. Sfanos, William B. Isaacs, Michael C. Haffner, Tamara L. Lotan

Cancer Res Commun. 2024 Jan; 4(1): 152–163. Published online 2024 Jan 18. doi: 10.1158/2767-9764.CRC-23-0248

PMCID:: PMC10795515

Abstract Article PDF–7.0M

Select item 107879723.

Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer

Lijie Zhou, Kaixuan Du, Yiheng Dai, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Yuanhao Liu, Lailai Zhang, Ronghui Zhu, Dapeng Feng, Fengyan Tian, Chaohui Gu

J Transl Med. 2024; 22: 55. Published online 2024 Jan 13. doi: 10.1186/s12967-024-04867-8

PMCID:: PMC10787972

Abstract Article PDF–4.5M

Select item 105880304.

Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults

Tao Li, Wen Meng, Tian Ci Liu, Yi Zhao Wang, Man Zhang

Lipids Health Dis. 2023; 22: 176. Published online 2023 Oct 19. doi: 10.1186/s12944-023-01936-7

PMCID:: PMC10588030

Abstract Article PDF–3.9M

Select item 102587635.

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

S. M. Naimul Hasan, Jennifer W. Lou, Alexander F. A. Keszei, David L. Dai, Mohammad T. Mazhab-Jafari

Nat Commun. 2023; 14: 3460. Published online 2023 Jun 12. doi: 10.1038/s41467-023-39266-y

PMCID:: PMC10258763

Abstract Article PDF–2.0M

Select item 98471206.

FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma

Ugo Chianese, Chiara Papulino, Ahmad Ali, Fortunato Ciardiello, Salvatore Cappabianca, Lucia Altucci, Vincenzo Carafa, Rosaria Benedetti

J Transl Med. 2023; 21: 32. Published online 2023 Jan 17. doi: 10.1186/s12967-023-03874-5

PMCID:: PMC9847120

Abstract Article PDF–3.0M

Select item 97791797.

Comprehensive Analysis of FASN in Tumor Immune Infiltration and Prognostic Value for Immunotherapy and Promoter DNA Methylation

Mingyang Zhang, Lei Yu, Yannan Sun, Li Hao, Jing Bai, Xinyu Yuan, Rihan Wu, Mei Hong, Pengxia Liu, Xiaojun Duan, Changshan Wang

Int J Mol Sci. 2022 Dec; 23(24): 15603. Published online 2022 Dec 9. doi: 10.3390/ijms232415603

PMCID:: PMC9779179

Abstract Article PDF–11M

Select item 94852538.

FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models

Marie O’Farrell, Greg Duke, Richard Crowley, Douglas Buckley, Eduardo B. Martins, Dipankar Bhattacharya, Scott L. Friedman, George Kemble

Sci Rep. 2022; 12: 15661. Published online 2022 Sep 19. doi: 10.1038/s41598-022-19459-z

PMCID:: PMC9485253

Abstract Article PDF–5.3M

Select item 91241999.

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis

Qiqiao Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, Chunliang Shang, Jieyu Wu, Yuandong Liao, Yili Chen, Jiaming Huang, Hao Tan, Yunhe Zhao, Meng Xia, Junxiu Liu, Shuzhong Yao

Cell Death Dis. 2022 May; 13(5): 488. Published online 2022 May 21. doi: 10.1038/s41419-022-04926-2

PMCID:: PMC9124199

Abstract Article PDF–6.2M

Select item 898251510.

Fatty Acid Synthase Is the Key Regulator of Fatty Acid Metabolism and Is Related to Immunotherapy in Bladder Cancer

Qiao Xiong, Dechao Feng, Ziwei Wang, Yidie Ying, Chuanliang Xu, Qiang Wei, Shuxiong Zeng, Lu Yang

Front Immunol. 2022; 13: 836939. Published online 2022 Mar 22. doi: 10.3389/fimmu.2022.836939

PMCID:: PMC8982515

Abstract Article PDF–6.8M

Select item 855165211.

A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

Krithika P. Karthigeyan, Lizhi Zhang, David R. Loiselle, Timothy A.J. Haystead, Menakshi Bhat, Jacob S. Yount, Jesse J. Kwiek

J Biol Chem. 2021 Nov; 297(5): 101272. Published online 2021 Oct 1. doi: 10.1016/j.jbc.2021.101272

PMCID:: PMC8551652

Abstract Article PDF–1.4M

Select item 848122912.

Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia

Shirli Tay, Gayan S. De Silva, Connor M. Engel, Nikolai Harroun, Amanda S. Penrose, Kshitij A. Desai, Yan Yan, Clay F. Semenkovich, Mohamed A. Zayed

Sci Rep. 2021; 11: 19272. Published online 2021 Sep 29. doi: 10.1038/s41598-021-98479-7

PMCID:: PMC8481229

Abstract Article PDF–2.9M

Select item 843566813.

Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing

Amund Holte Berger, Eirik Bratland, Thea Sjøgren, Marte Heimli, Torgeir Tyssedal, Øyvind Bruserud, Stefan Johansson, Eystein Sverre Husebye, Bergithe Eikeland Oftedal, Anette Susanne Bøe Wolff

Front Immunol. 2021; 12: 722860. Published online 2021 Aug 30. doi: 10.3389/fimmu.2021.722860

PMCID:: PMC8435668

Abstract Article PDF–1.4M

Select item 832913414.

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

Magali Humbert, Kristina Seiler, Severin Mosimann, Vreni Rentsch, Katyayani Sharma, Amit V. Pandey, Sharon L. McKenna, Mario P. Tschan

Cell Death Differ. 2021 Aug; 28(8): 2465–2481. Published online 2021 Mar 19. doi: 10.1038/s41418-021-00768-1

PMCID:: PMC8329134

Abstract Article PDF–4.8M

Select item 820505115.

Exploring a role for fatty acid synthase in prostate cancer cell migration

Mario De Piano, Valeria Manuelli, Giorgia Zadra, Massimo Loda, Gordon Muir, Ash Chandra, Jonathan Morris, Mieke Van Hemelrijck, Claire M. Wells

Small GTPases. 2021; 12(4): 265–272. Published online 2020 Oct 12. doi: 10.1080/21541248.2020.1826781

PMCID:: PMC8205051

Abstract Article PDF–1.6M

Select item 758888316.

Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer

Javier A. Menendez, Inderjit Mehmi, Adriana Papadimitropoulou, Travis Vander Steen, Elisabet Cuyàs, Sara Verdura, Ingrid Espinoza, Luciano Vellon, Ella Atlas, Ruth Lupu

Int J Mol Sci. 2020 Oct; 21(20): 7661. Published online 2020 Oct 16. doi: 10.3390/ijms21207661

PMCID:: PMC7588883

Abstract Article PDF–2.1M

Select item 757627617.

Fatty acid synthase contributes to epithelial‐mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β‐catenin pathway

Wei‐long Zhang, Sha‐sha Wang, Ya‐ping Jiang, Yan Liu, Xiang‐hua Yu, Jing‐biao Wu, Ke Wang, Xin Pang, Peng Liao, Xin‐hua Liang, Ya‐ling Tang

J Cell Mol Med. 2020 Oct; 24(19): 11465–11476. Published online 2020 Aug 20. doi: 10.1111/jcmm.15760

PMCID:: PMC7576276

Abstract Article PDF–2.4M

Select item 732152518.

FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer

Zhi Cao, Yalong Xu, Fei Guo, Xi Chen, Jin Ji, Huan Xu, Jingyi He, Yongwei Yu, Yinghao Sun, Xin Lu, Fubo Wang

Dis Markers. 2020; 2020: 3904947. Published online 2020 Jun 18. doi: 10.1155/2020/3904947

PMCID:: PMC7321525

Abstract Article PDF–1.1M

Select item 713976719.

FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles

Franz L. Ricklefs, Cecile L. Maire, Jakob Matschke, Lasse Dührsen, Thomas Sauvigny, Mareike Holz, Katharina Kolbe, Sven Peine, Christel Herold-Mende, Bob Carter, E. Antonio Chiocca, Sean E. Lawler, Manfred Westphal, Katrin Lamszus

Int J Mol Sci. 2020 Mar; 21(6): 1931. Published online 2020 Mar 12. doi: 10.3390/ijms21061931