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Select item 111733281.

Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation

Stephanie A. Azzopardi, Hsiu-Yi Lu, Sebastien Monette, Ariana I. Rabinowitsch, Jane E. Salmon, Hiroaki Matsunami, Carl P. Blobel

Int J Mol Sci. 2024 Jun; 25(11): 6079. Published online 2024 May 31. doi: 10.3390/ijms25116079

PMCID:: PMC11173328

Abstract Article PDF–3.7M

Select item 82332862.

The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Stefan Düsterhöft, Selcan Kahveci-Türköz, Justyna Wozniak, Anke Seifert, Petr Kasparek, Henrike Ohm, Shixin Liu, Jana Kopkanova, Juliane Lokau, Christoph Garbers, Christian Preisinger, Radislav Sedlacek, Matthew Freeman, Andreas Ludwig

Cell Mol Life Sci. 2021 Jun; 78(11): 5015–5040. Published online 2021 May 5. doi: 10.1007/s00018-021-03845-3

PMCID:: PMC8233286

Abstract Article PDF–8.5M

Select item 70399443.

A genome-wide association study in mice reveals a role for Rhbdf2 in skeletal homeostasis

Roei Levy, Clemence Levet, Keren Cohen, Matthew Freeman, Richard Mott, Fuad Iraqi, Yankel Gabet

Sci Rep. 2020; 10: 3286. Published online 2020 Feb 24. doi: 10.1038/s41598-020-60146-8

PMCID:: PMC7039944

Abstract Article PDF–2.5M

Select item 70311404.

Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation

Minxuan Xu, Chenxu Ge, Yuting Qin, Deshuai Lou, Qiang Li, Jing Feng, Yekuan Wu, Linfeng Hu, Bochu Wang, Jun Tan

Mol Metab. 2020 Apr; 34: 112–123. Published online 2020 Jan 22. doi: 10.1016/j.molmet.2020.01.008

PMCID:: PMC7031140

Abstract Article PDF–2.2M

Select item 69093395.

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Marina Badenes, Abdulbasit Amin, Ismael González-García, Inês Félix, Emma Burbridge, Miguel Cavadas, Francisco José Ortega, Érika de Carvalho, Pedro Faísca, Stefania Carobbio, Elsa Seixas, Dora Pedroso, Ana Neves-Costa, Luís F. Moita, José Manuel Fernández-Real, António Vidal-Puig, Ana Domingos, Miguel López, Colin Adrain

Mol Metab. 2020 Jan; 31: 67–84. Published online 2019 Oct 31. doi: 10.1016/j.molmet.2019.10.006

PMCID:: PMC6909339

Abstract Article PDF–2.9M

Select item 61180406.

iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress

Ge Chenxu, Xu Minxuan, Qin Yuting, Gu Tingting, Lv Jinxiao, Wang Mingxing, Wang Sujun, Ma Yongjie, Lou Deshuai, Li Qiang, Hu Linfeng, Tan Jun

Redox Biol. 2018 Oct; 19: 147–157. Published online 2018 Aug 20. doi: 10.1016/j.redox.2018.08.009

PMCID:: PMC6118040

Abstract Article PDF–5.3M

Select item 58305057.

Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury

Jee Hyun Kim, Jihye Kim, Jaeyoung Chun, Changhyun Lee, Jong Pil Im, Joo Sung Kim

Sci Rep. 2018; 8: 3797. Published online 2018 Feb 28. doi: 10.1038/s41598-018-22218-8

Correction in:: Sci Rep. 2018; 8: 7087.

PMCID:: PMC5830505

Abstract Article PDF–1.7M

Select item 58211948.

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction

Damien N. Barnette, Thomas J. Cahill, Mala Gunadasa-Rohling, Carolyn A. Carr, Matthew Freeman, Paul R. Riley

JCI Insight. 2018 Feb 8; 3(3): e98268. Published online 2018 Feb 8. doi: 10.1172/jci.insight.98268

PMCID:: PMC5821194

Abstract Article PDF–3.8M

Select item 110604219.

Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease

Satoshi Kubo, Jill M. Fritz, Hayley M. Raquer-McKay, Rhea Kataria, Ivan Vujkovic-Cvijin, Ahmad Al-Shaibi, Yikun Yao, Lixin Zheng, Juan Zou, Alex D. Waldman, Xinyi Jing, Taylor K. Farley, Ann Y. Park, Andrew J. Oler, Adrian K. Charles, Melanie Makhlouf, Eman H. AbouMoussa, Reem Hasnah, Luis R. Saraiva, Sundar Ganesan, Abdulrahman Ahmed Al-Subaiey, Helen Matthews, Emilio Flano, Hyun Hee Lee, Alexandra F. Freeman, Asena Pınar Sefer, Ersin Sayar, Erkan Çakır, Elif Karakoc-Aydiner, Safa Baris, Yasmine Belkaid, Ahmet Ozen, Bernice Lo, Michael J. Lenardo

Nat Immunol. Author manuscript; available in PMC 2024 Apr 30.

Published in final edited form as: Nat Immunol. 2022 Jan; 23(1): 75–85. Published online 2021 Dec 22. doi: 10.1038/s41590-021-01093-y

PMCID:: PMC11060421

Abstract Article PDF–4.3M

Select item 1099105810.

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Matteo Calligaris, Donatella P. Spanò, Simone Bonelli, Stephan A. Müller, Claudia Carcione, Danilo D’apolito, Giandomenico Amico, Monica Miele, Mariangela Di Bella, Giovanni Zito, Elisa Nuti, Armando Rossello, Carl P. Blobel, Stefan F. Lichtenthaler, Simone D. Scilabra

Cell Mol Life Sci. 2024 Dec; 81(1): 163. Published online 2024 Apr 4. doi: 10.1007/s00018-024-05201-7

PMCID:: PMC10991058

Abstract Article PDF–5.6M

Select item 1055865711.

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Yi Zhang, Fufeng Gao, Xianling Dai, Qin Kuang, Jie Chai, Benkui Zou, Bochu Wang

Adv Sci (Weinh) 2023 Oct; 10(28): 2302130. Published online 2023 Aug 6. doi: 10.1002/advs.202302130

Correction in:: Adv Sci (Weinh). 2023 Dec; 10(36): 2308024.

PMCID:: PMC10558657

Abstract Article PDF–8.2M

Select item 931738012.

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress

Yangwenshu Liu, Qin Kuang, Xianling Dai, Minxia Zhan, Li Zhou, Liancai Zhu, Bochu Wang

Int J Mol Sci. 2022 Jul; 23(14): 7701. Published online 2022 Jul 12. doi: 10.3390/ijms23147701

PMCID:: PMC9317380

Abstract Article PDF–6.2M

Select item 893215813.

Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidaemia and early atherogenesis

Carmen Hannemann, Johannes H Schecker, Alica Brettschneider, Jana Grune, Nicole Rösener, Andrea Weller, Verena Stangl, Edward A Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing

Cardiovasc Res. 2022 Jan; 118(1): 156–168. Published online 2021 Feb 12. doi: 10.1093/cvr/cvab041

PMCID:: PMC8932158

Abstract Article PDF–1.5M

Select item 868842014.

Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells

Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Gross, Pavel Strnad, Stefan Düsterhöft, Andreas Ludwig

Sci Rep. 2021; 11: 24230. Published online 2021 Dec 20. doi: 10.1038/s41598-021-03522-2

PMCID:: PMC8688420

Abstract Article PDF–2.3M

Select item 819133615.

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Jose Lora, Gisela Weskamp, Thomas M. Li, Thorsten Maretzky, Dorjee T.N. Shola, Sébastien Monette, Stefan F. Lichtenthaler, Theresa T. Lu, Chingwen Yang, Carl P. Blobel

J Biol Chem. 2021 Jan-Jun; 296: 100733. Published online 2021 May 4. doi: 10.1016/j.jbc.2021.100733

PMCID:: PMC8191336

Abstract Article PDF–4.8M

Select item 735059116.

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation

Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles

Genome Biol. 2020; 21: 168. Published online 2020 Jul 9. doi: 10.1186/s13059-020-02086-0

PMCID:: PMC7350591

Abstract Article PDF–2.2M

Select item 731653017.

Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

Beiyu Tang, Xue Li, Thorsten Maretzky, Jose Manuel Perez-Aguilar, David McIlwain, Yifang Xie, Yufang Zheng, Tak W. Mak, Harel Weinstein, Carl P. Blobel

FASEB J. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: FASEB J. 2020 Apr; 34(4): 4956–4969. Published online 2020 Feb 26. doi: 10.1096/fj.201902649R

PMCID:: PMC7316530

Abstract Article PDF–2.1M

Select item 658540518.

Loss of RHBDF2 results in an early-onset spontaneous murine colitis

Ramasatyaveni Geesala, Willow Schanz, Mikayla Biggs, Garima Dixit, Joseph Skurski, Prajwal Gurung, David K. Meyerholz, David Elliott, Priya D. Issuree, Thorsten Maretzky

J Leukoc Biol. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: J Leukoc Biol. 2019 Apr; 105(4): 767–781. Published online 2019 Jan 29. doi: 10.1002/JLB.4A0718-283RR

PMCID:: PMC6585405

Abstract Article PDF–2.3M

Select item 587385919.

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

Xiaoping Qing, Yurii Chinenov, Patricia Redecha, Michael Madaio, Joris J.T.H. Roelofs, Gregory Farber, Priya D. Issuree, Laura Donlin, David R. Mcllwain, Tak W. Mak, Carl P. Blobel, Jane E. Salmon

J Clin Invest. 2018 Apr 2; 128(4): 1397–1412. Published online 2018 Mar 5. doi: 10.1172/JCI97650

PMCID:: PMC5873859

Abstract Article PDF–15M

Select item 584491520.

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh

Nat Commun. 2018; 9: 1021. Published online 2018 Mar 9. doi: 10.1038/s41467-018-03470-y

PMCID:: PMC5844915

Abstract Article PDF–3.8M

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