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Select item 100465591.

Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission

Elsa Isingrini, Chloé Guinaudie, Léa Perret, Elisa Guma, Victor Gorgievski, Ian D. Blum, Jessica Colby-Milley, Maryia Bairachnaya, Sébastien Mella, Antoine Adamantidis, Kai-Florian Storch, Bruno Giros

Biomolecules. 2023 Mar; 13(3): 511. Published online 2023 Mar 10. doi: 10.3390/biom13030511

PMCID:: PMC10046559

Abstract Article PDF–4.3M

Select item 99963872.

Bespoke library docking for 5-HT2A receptor agonists with anti-depressant activity

Anat Levit Kaplan, Danielle N. Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M. Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John McCorvy, David N. Kamber, James P. Phelan, Luan Carvalho Martins, Vladimir M. Pogorelov, Jeffrey F. DiBerto, Samuel T. Slocum, Xi-Ping Huang, Jain Manish Kumar, Michael J. Robertson, Ouliana Panova, Alpay B. Seven, Autumn Q. Wetsel, William C. Wetsel, John J. Irwin, Georgios Skiniotis, Brian K. Shoichet, Bryan L. Roth, Jonathan A. Ellman

Nature. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Nature. 2022 Oct; 610(7932): 582–591. Published online 2022 Sep 28. doi: 10.1038/s41586-022-05258-z

PMCID:: PMC9996387

Abstract Article PDF–6.4M

Select item 81708283.

Vesicular monoamine transporter 2 mediates fear behavior in mice

Rachel C. Branco, James P. Burkett, Carlie A. Black, Emily Winokur, William Elsworth, Rohan K. Dhamsania, Kelly M. Lohr, Jason P. Schroeder, David Weinshenker, Tanja Jovanovic, Gary W. Miller

Genes Brain Behav. Author manuscript; available in PMC 2021 Jun 2.

Published in final edited form as: Genes Brain Behav. 2020 Jun; 19(5): e12634. Published online 2020 Jan 14. doi: 10.1111/gbb.12634

PMCID:: PMC8170828

Abstract Article PDF–1.8M

Select item 71987024.

Alterations of the Motor and Olfactory Functions Related to Parkinson’s Disease in Transgenic Mice With a VMAT2-Deficiency in Dopaminergic Neurons

Song Jiang, Stefan Berger, Yajuan Hu, Dusan Bartsch, Yanghua Tian

Front Neurosci. 2020; 14: 356. Published online 2020 Apr 28. doi: 10.3389/fnins.2020.00356

PMCID:: PMC7198702

Abstract Article PDF–1.5M

Select item 67860625.

Increased Methamphetamine Neurotoxicity in Heterozygous Vesicular Monoamine Transporter 2 Knock-Out Mice

Fabio Fumagalli, Raul R. Gainetdinov, Yan-Min Wang, Kenneth J. Valenzano, Gary W. Miller, Marc G. Caron

J Neurosci. 1999 Apr 1; 19(7): 2424–2431. doi: 10.1523/JNEUROSCI.19-07-02424.1999

PMCID:: PMC6786062

Abstract Article PDF–145K

Select item 56221356.

Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice

Elsa Isingrini, Chloé Guinaudie, Léa C Perret, Quentin Rainer, Luc Moquin, Alain Gratton, Bruno Giros

Sci Rep. 2017; 7: 12432. Published online 2017 Sep 29. doi: 10.1038/s41598-017-12810-9

PMCID:: PMC5622135

Abstract Article PDF–3.5M

Select item 53362877.

Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo ¹⁸F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging

Chi-Chang Weng, Zi-An Chen, Ko-Ting Chao, Ting-Wei Ee, Kun-Ju Lin, Ming-Huan Chan, Ing-Tsung Hsiao, Tzu-Chen Yen, Mei-Ping Kung, Ching-Han Hsu, Shiaw-Pyng Wey

PLoS One. 2017; 12(3): e0173503. Published online 2017 Mar 3. doi: 10.1371/journal.pone.0173503

PMCID:: PMC5336287

Abstract Article PDF–1.6M

Select item 51142728.

Preliminary Evidence of Apathetic-Like Behavior in Aged Vesicular Monoamine Transporter 2 Deficient Mice

Aron Baumann, Carlos G. Moreira, Marta M. Morawska, Sophie Masneuf, Christian R. Baumann, Daniela Noain

Front Hum Neurosci. 2016; 10: 587. Published online 2016 Nov 18. doi: 10.3389/fnhum.2016.00587

PMCID:: PMC5114272

Abstract Article PDF–1.0M

Select item 50138789.

Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals

Kelly M. Lohr, Merry Chen, Carlie A. Hoffman, Miranda J. McDaniel, Kristen A. Stout, Amy R. Dunn, Minzheng Wang, Alison I. Bernstein, Gary W. Miller

Toxicol Sci. 2016 Sep; 153(1): 79–88. Published online 2016 Jun 10. doi: 10.1093/toxsci/kfw106

PMCID:: PMC5013878

Abstract Article PDF–640K

Select item 485320810.

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour

Elsa Isingrini, Lea Perret, Quentin Rainer, Sara Sagueby, Luc Moquin, Alain Gratton, Bruno Giros

J Psychiatry Neurosci. 2016 May; 41(3): 169–181. Published online 2015 Oct 27. doi: 10.1503/jpn.150028

PMCID:: PMC4853208

Abstract Article PDF–839K

Select item 479373011.

Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration

Shawn P. Alter, Kristen A. Stout, Kelly M. Lohr, Tonya N. Taylor, Kennie R. Shepherd, Minzheng Wang, Thomas S. Guillot, Gary W. Miller

Exp Neurol. Author manuscript; available in PMC 2016 Mar 16.

Published in final edited form as: Exp Neurol. 2016 Jan; 275(Pt 1): 17–24. Published online 2015 Sep 30. doi: 10.1016/j.expneurol.2015.09.016

PMCID:: PMC4793730

Abstract Article PDF–1.4M

Select item 410332512.

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo

Kelly M. Lohr, Alison I. Bernstein, Kristen A. Stout, Amy R. Dunn, Carlos R. Lazo, Shawn P. Alter, Minzheng Wang, Yingjie Li, Xueliang Fan, Ellen J. Hess, Hong Yi, Laura M. Vecchio, David S. Goldstein, Thomas S. Guillot, Ali Salahpour, Gary W. Miller

Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27): 9977–9982. Published online 2014 Jun 16. doi: 10.1073/pnas.1402134111

PMCID:: PMC4103325

Abstract Article PDF–1.1M

Select item 408666113.

Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis

Thomas S. Guillot, Kennie R. Shepherd, Jason R. Richardson, Min Z. Wang, Yingjie Li, Piers C. Emson, Gary W. Miller

J Neurochem. Author manuscript; available in PMC 2014 Jul 8.

Published in final edited form as: J Neurochem. 2008 Sep; 106(5): 2205–2217. Published online 2008 Jul 15. doi: 10.1111/j.1471-4159.2008.05568.x

PMCID:: PMC4086661

Abstract Article PDF–630K

Select item 404909514.

Reduced vesicular storage of catecholamines causes progressive degeneration in the locus ceruleus

Tonya N. Taylor, Shawn P. Alter, Minzheng Wang, David S. Goldstein, Gary W. Miller

Neuropharmacology. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Neuropharmacology. 2014 Jan; 76(0 0): 97–105. Published online 2013 Sep 8. doi: 10.1016/j.neuropharm.2013.08.033

PMCID:: PMC4049095

Abstract Article PDF–3.2M

Select item 338807715.

25-Hydroxyvitamin D Depletion Does Not Exacerbate MPTP-Induced Dopamine Neuron Damage in Mice

E. Danielle Dean, Lydia M. Mexas, Natalie L. Cápiro, Jeanne E. McKeon, Mahlon R. DeLong, Kurt D. Pennell, Jonathan A. Doorn, Vin Tangpricha, Gary W. Miller, Marian L. Evatt

PLoS One. 2012; 7(7): e39227. Published online 2012 Jul 2. doi: 10.1371/journal.pone.0039227

PMCID:: PMC3388077

Abstract Article PDF–2.9M

Select item 281314316.

Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

Tonya N. Taylor, W. Michael Caudle, Kennie R. Shepherd, AliReza Noorian, Chad R. Jackson, P. Michael Iuvone, David Weinshenker, James G. Greene, Gary W. Miller

J Neurosci. 2009 Jun 24; 29(25): 8103–8113. doi: 10.1523/JNEUROSCI.1495-09.2009