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Select item 82991941.

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma

Ke Zhan, Yang Bai, Shengtao Liao, Hongyu Chen, Lili Kuang, Qingqing Luo, Lin Lv, Liewang Qiu, Zhechuan Mei

Mol Med Rep. 2021 Sep; 24(3): 650. Published online 2021 Jul 13. doi: 10.3892/mmr.2021.12289

PMCID:: PMC8299194

Abstract Article PDF–2.3M

Select item 81215832.

Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease

Stefanos Roumeliotis, Athanasios Roumeliotis, Aikaterini Stamou, Stylianos Panagoutsos, Vangelis G. Manolopoulos, Fotis Tsetsos, Marianthi Georgitsi, Vassilios Liakopoulos

Oxid Med Cell Longev. 2021; 2021: 8817502. Published online 2021 May 6. doi: 10.1155/2021/8817502

PMCID:: PMC8121583

Abstract Article PDF–482K

Select item 78318213.

Clinical significance of EPHX2 deregulation in prostate cancer

Ming-Sheng Liu, Hui Zhao, Chen-Xiang Xu, Ping-Bo Xie, Wei Wang, Ying-Yu Yang, Wen-Hui Lee, Yang Jin, Hong-Qing Zhou

Asian J Androl. 2021 Jan-Feb; 23(1): 109–115. Published online 2020 Jul 17. doi: 10.4103/aja.aja_34_20

PMCID:: PMC7831821

Abstract Article PDF–1.8M

Select item 76696604.

Soluble epoxide hydrolase as a therapeutic target for obesity-induced disorders: roles of gut barrier function involved

Jianan Zhang, Maolin Tu, Zhenhua Liu, Guodong Zhang

Prostaglandins Leukot Essent Fatty Acids. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2020 Nov; 162: 102180. Published online 2020 Sep 19. doi: 10.1016/j.plefa.2020.102180

PMCID:: PMC7669660

Abstract Article PDF–739K

Select item 66729845.

Polymorphisms in the Human Soluble Epoxide Hydrolase Gene EPHX2 Linked to Neuronal Survival after Ischemic Injury

Ines P. Koerner, Rachel Jacks, Andrea E. DeBarber, Dennis Koop, Peizhong Mao, David F. Grant, Nabil J. Alkayed

J Neurosci. 2007 Apr 25; 27(17): 4642–4649. doi: 10.1523/JNEUROSCI.0056-07.2007

PMCID:: PMC6672984

Abstract Article PDF–382K

Select item 61621476.

Association between the EPHX2 p.Lys55Arg Polymorphism and Prognosis Following an Acute Coronary Syndrome

Akinyemi Oni-Orisan, Sharon Cresci, Philip G. Jones, Katherine N. Theken, John A. Spertus, Craig R. Lee

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Prostaglandins Other Lipid Mediat. 2018 Sep; 138: 15–22. Published online 2018 Aug 7. doi: 10.1016/j.prostaglandins.2018.07.005

PMCID:: PMC6162147

Abstract Article PDF–1.1M

Select item 58321797.

Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

Liang Ma, Meihua Yan, Xiaomu Kong, Yongwei Jiang, Tingting Zhao, Hailing Zhao, Qian Liu, Haojun Zhang, Peng Liu, Yongtong Cao, Ping Li

J Diabetes Res. 2018; 2018: 2786470. Published online 2018 Feb 5. doi: 10.1155/2018/2786470

PMCID:: PMC5832179

Abstract Article PDF–656K

Select item 57750438.

Chemical proteomics reveals soluble epoxide hydrolase as a therapeutic target for ocular neovascularization

Rania S. Sulaiman, Bomina Park, Sardar Pasha Sheik Pran Babu, Yubing Si, Rakshin Kharwadkar, Sayak K. Mitter, Bit Lee, Wei Sun, Xiaoping Qi, Michael E. Boulton, Samy Meroueh, Xiang Fei, Seung-Yong Seo, Timothy W. Corson

ACS Chem Biol. Author manuscript; available in PMC 2019 Jan 19.

Published in final edited form as: ACS Chem Biol. 2018 Jan 19; 13(1): 45–52. Published online 2017 Dec 1. doi: 10.1021/acschembio.7b00854

PMCID:: PMC5775043

Abstract Article PDF–866K

Select item 57423719.

Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke

Xingyang Yi, Jing Lin, Jie Li, Qiang Zhou, Zhao Han

J Atheroscler Thromb. 2017 Dec 1; 24(12): 1258–1266. doi: 10.5551/jat.41145

PMCID:: PMC5742371

Abstract Article PDF–135K

Select item 544611210.

Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery

Megan M. Shuey, Frederic T. Billings, IV, Shouzou Wei, Ginger L. Milne, Hui Nian, Chang Yu, Nancy J. Brown

PLoS One. 2017; 12(5): e0175292. Published online 2017 May 26. doi: 10.1371/journal.pone.0175292

PMCID:: PMC5446112

Abstract Article PDF–1.1M

Select item 488292811.

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study

KATHRYN P BURDON, ALLISON B LEHTINEN, CARL D LANGEFELD, J JEFFREY CARR, STEPHEN S RICH, BARRY I FREEDMAN, DAVID HERRINGTON, DONALD W BOWDEN

Diab Vasc Dis Res. Author manuscript; available in PMC 2016 May 27.

Published in final edited form as: Diab Vasc Dis Res. 2008 Jun; 5(2): 128–134. doi: 10.3132/dvdr.2008.021

PMCID:: PMC4882928

Abstract Article PDF–165K

Select item 459107512.

Dysregulation of Soluble Epoxide Hydrolase and Lipidomic Profiles in Anorexia Nervosa

Pei-an Betty Shih, Jun Yang, Christophe Morisseau, J. Bruce German, Ashley Van Zeeland, Aaron M. Armando, Oswald Quehenberger, Andrew W. Bergen, Pierre Magistretti, Wade Berrettini, Katherine Ann Halmi, Nicholas Schork, Bruce D. Hammock, Walter Kaye

Mol Psychiatry. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Mol Psychiatry. 2016 Apr; 21(4): 537–546. Published online 2015 Mar 31. doi: 10.1038/mp.2015.26

PMCID:: PMC4591075

Abstract Article PDF–586K

Select item 452187413.

A 3’-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients

Guillermo Gervasini, Montserrat García-Cerrada, Eliecer Coto, Esther Vergara, Guadalupe García-Pino, Raul Alvarado, Maria Jesús Fernández-Cavada, Beatriz Suárez-Álvarez, Sergio Barroso, Emilio Doblaré, Carmen Díaz-Corte, Carlos López-Larrea, Juan Jose Cubero

PLoS One. 2015; 10(7): e0133563. Published online 2015 Jul 31. doi: 10.1371/journal.pone.0133563

PMCID:: PMC4521874

Abstract Article PDF–345K

Select item 437051014.

Genetic variation in soluble epoxide hydrolase is associated with outcome after aneurysmal subarachnoid hemorrhage

Ross P Martini, Jonathan Ward, Dominic Siler, Jamie M Eastman, Jonathan Nelson, Rohan Borkar, Nabil Alkayed, Aclan Dogan, Justin Cetas

J Neurosurg. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: J Neurosurg. 2014 Dec; 121(6): 1359–1366. Published online 2014 Sep 12. doi: 10.3171/2014.7.JNS131990

PMCID:: PMC4370510

Abstract Article PDF–233K

Select item 425397615.

Arg287Gln VARIANT OF EPHX2 AND EPOXYEICOSATRIENOIC ACIDS ARE ASSOCIATED WITH INSULIN SENSITIVITY IN HUMANS

Claudia E. Ramirez, Megan M. Shuey, Ginger L. Milne, Kimberly Gilbert, Nian Hui, Chang Yu, James M. Luther, Nancy J. Brown

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Prostaglandins Other Lipid Mediat. 2014 Oct; 0: 38–44. Published online 2014 Aug 28. doi: 10.1016/j.prostaglandins.2014.08.001

PMCID:: PMC4253976

Abstract Article PDF–968K

Select item 403194416.

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation

Christophe Morisseau, Aaron T. Wecksler, Catherine Deng, Hua Dong, Jun Yang, Kin Sing S. Lee, Sean D. Kodani, Bruce D. Hammock

J Lipid Res. 2014 Jun; 55(6): 1131–1138. doi: 10.1194/jlr.M049718

PMCID:: PMC4031944

Abstract Article PDF–510K

Select item 385218917.

Evidence for the role of EPHX2 gene variants in anorexia nervosa

A A Scott-Van Zeeland, C S Bloss, R Tewhey, V Bansal, A Torkamani, O Libiger, V Duvvuri, N Wineinger, L Galvez, B F Darst, E N Smith, A Carson, P Pham, T Phillips, N Villarasa, R Tisch, G Zhang, S Levy, S Murray, W Chen, S Srinivasan, G Berenson, H Brandt, S Crawford, S Crow, M M Fichter, K A Halmi, C Johnson, A S Kaplan, M La Via, J E Mitchell, M Strober, A Rotondo, J Treasure, D B Woodside, C M Bulik, P Keel, K L Klump, L Lilenfeld, K Plotnicov, E J Topol, P B Shih, P Magistretti, A W Bergen, W Berrettini, W Kaye, N J Schork

Mol Psychiatry. 2014 Jun; 19(6): 724–732. Published online 2013 Sep 3. doi: 10.1038/mp.2013.91

PMCID:: PMC3852189

Abstract Article PDF–640K

Select item 359781018.

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity

Jonathan W. Nelson, Rishi M. Subrahmanyan, Sol A. Summers, Xiangshu Xiao, Nabil J. Alkayed

J Biol Chem. 2013 Mar 15; 288(11): 7697–7703. Published online 2013 Jan 28. doi: 10.1074/jbc.M112.429258

PMCID:: PMC3597810

Abstract Article PDF–1.4M

Select item 354362319.

Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage

Qian Wang, Wei Pang, Zhuan Cui, Junbao Shi, Yan Liu, Bo Liu, Yunfeng Zhou, Youfei Guan, Bruce D. Hammock, Yue Wang, Yi Zhu

Am J Physiol Renal Physiol. 2013 Jan 15; 304(2): F168–F176. Published online 2012 Nov 14. doi: 10.1152/ajprenal.00129.2012

PMCID:: PMC3543623

Abstract Article

Select item 302091120.

GENETIC VARIATION IN SOLUBLE EPOXIDE HYDROLASE (EPHX2) IS ASSOCIATED WITH FOREARM VASODILATOR RESPONSES IN HUMANS

Craig R. Lee, Mias Pretorius, Robert N. Schuck, Lauranell H. Burch, Jackie Bartlett, Scott M. Williams, Darryl C. Zeldin, Nancy J. Brown

Hypertension. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Hypertension. 2011 Jan; 57(1): 116–122. Published online 2010 Nov 22. doi: 10.1161/HYPERTENSIONAHA.110.161695

PMCID:: PMC3020911

Abstract Article PDF–134K

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