PMC Links for Gene (Select 201973) - PMC

Stephanie Tirman, Annabel Quinet, Matthew Wood, Alice Meroni, Emily Cybulla, Jessica Jackson, Silvia Pegoraro, Antoine Simoneau, Lee Zou, Alessandro Vindigni

Mol Cell. Author manuscript; available in PMC 2022 Oct 7.

Published in final edited form as: Mol Cell. 2021 Oct 7; 81(19): 4026–4040.e8. doi: 10.1016/j.molcel.2021.09.013

PMCID:: PMC8555837

Abstract Article PDF–1.4M

Select item 85352295.

Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis

Gustavo Carvalho, Alberto Díaz-Talavera, Patricia A. Calvo, Luis Blanco, María I. Martínez-Jiménez

Genes (Basel) 2021 Oct; 12(10): 1487. Published online 2021 Sep 24. doi: 10.3390/genes12101487

PMCID:: PMC8535229

Abstract Article PDF–1.8M

Select item 83730646.

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart

Patricia A Calvo, María I Martínez-Jiménez, Marcos Díaz, Gorazd Stojkovic, Kazutoshi Kasho, Susana Guerra, Sjoerd Wanrooij, Juan Méndez, Luis Blanco

Nucleic Acids Res. 2021 Aug 20; 49(14): 8199–8213. Published online 2021 Jul 24. doi: 10.1093/nar/gkab634

PMCID:: PMC8373064

Abstract Article PDF–4.1M

Select item 82808177.

PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks

Daniel González‐Acosta, Elena Blanco‐Romero, Patricia Ubieto‐Capella, Karun Mutreja, Samuel Míguez, Susana Llanos, Fernando García, Javier Muñoz, Luis Blanco, Massimo Lopes, Juan Méndez

EMBO J. 2021 Jul 15; 40(14): e106355. Published online 2021 Jun 15. doi: 10.15252/embj.2020106355

PMCID:: PMC8280817

Abstract Article PDF–2.6M

Select item 82419998.

Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase

Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash, Aneel K. Aggarwal

Nat Commun. 2021; 12: 4020. Published online 2021 Jun 29. doi: 10.1038/s41467-021-24317-z

PMCID:: PMC8241999

Abstract Article PDF–2.2M

Select item 82254409.

Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol

E. John Tokarsky, Petra C. Wallenmeyer, Kenneth K. Phi, Zucai Suo

DNA Repair (Amst) Author manuscript; available in PMC 2021 Jun 24.

Published in final edited form as: DNA Repair (Amst). 2017 Jan; 49: 51–59. Published online 2016 Nov 25. doi: 10.1016/j.dnarep.2016.11.003

PMCID:: PMC8225440

Abstract Article PDF–540K

Select item 772960110.

Strand Displacement Activity of PrimPol

Elizaveta O. Boldinova, Ekaterina A. Belousova, Diana I. Gagarinskaya, Ekaterina A. Maltseva, Svetlana N. Khodyreva, Olga I. Lavrik, Alena V. Makarova

Int J Mol Sci. 2020 Dec; 21(23): 9027. Published online 2020 Nov 27. doi: 10.3390/ijms21239027

PMCID:: PMC7729601

Abstract Article PDF–2.4M

Select item 767399011.

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann

Nat Commun. 2020; 11: 5863. Published online 2020 Nov 17. doi: 10.1038/s41467-020-19570-7

PMCID:: PMC7673990

Abstract Article PDF–1.8M

Select item 648654312.

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

Laura J Bailey, Julie Bianchi, Aidan J Doherty

Nucleic Acids Res. 2019 May 7; 47(8): 4026–4038. Published online 2019 Jan 31. doi: 10.1093/nar/gkz056

PMCID:: PMC6486543

Abstract Article PDF–1004K

Select item 636207213.

A cancer-associated point mutation disables the steric gate of human PrimPol

Alberto Díaz-Talavera, Patricia A. Calvo, Daniel González-Acosta, Marcos Díaz, Guillermo Sastre-Moreno, Luis Blanco-Franco, Susana Guerra, Maria I. Martínez-Jiménez, Juan Méndez, Luis Blanco

Sci Rep. 2019; 9: 1121. Published online 2019 Feb 4. doi: 10.1038/s41598-018-37439-0

PMCID:: PMC6362072

Abstract Article PDF–2.2M

Select item 559726014.

Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol

Elizaveta O. Boldinova, Gorazd Stojkovič, Rafil Khairullin, Sjoerd Wanrooij, Alena V. Makarova

PLoS One. 2017; 12(9): e0184489. Published online 2017 Sep 13. doi: 10.1371/journal.pone.0184489

PMCID:: PMC5597260

Abstract Article PDF–7.3M

Select item 553607115.

DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

Elizaveta O. Boldinova, Paulina H. Wanrooij, Evgeniy S. Shilkin, Sjoerd Wanrooij, Alena V. Makarova

Int J Mol Sci. 2017 Jul; 18(7): 1584. Published online 2017 Jul 21. doi: 10.3390/ijms18071584

PMCID:: PMC5536071

Abstract Article PDF–1.2M

Select item 539049616.

Mitochondrial DNA replication: a PrimPol perspective

Laura J. Bailey, Aidan J. Doherty

Biochem Soc Trans. 2017 Apr 15; 45(2): 513–529. Published online 2017 Apr 13. doi: 10.1042/BST20160162

PMCID:: PMC5390496

Abstract Article PDF–896K

Select item 508864217.

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

Olga Rechkoblit, Yogesh K. Gupta, Radhika Malik, Kanagalaghatta R. Rajashankar, Robert E. Johnson, Louise Prakash, Satya Prakash, Aneel K. Aggarwal

Sci Adv. 2016 Oct; 2(10): e1601317. Published online 2016 Oct 21. doi: 10.1126/sciadv.1601317

PMCID:: PMC5088642

Abstract Article PDF–829K

Select item 470422718.

Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol

Andrea C. Mislak, Karen S. Anderson

Antimicrob Agents Chemother. 2016 Jan; 60(1): 561–569. Prepublished online 2015 Nov 9. Published online 2015 Dec 31. doi: 10.1128/AAC.02270-15

PMCID:: PMC4704227

Abstract Article PDF–1.0M

Select item 433337819.

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert, Walter J. Chazin, Aidan J. Doherty

Nucleic Acids Res. 2015 Jan 30; 43(2): 1056–1068. Published online 2014 Dec 29. doi: 10.1093/nar/gku1321