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Select item 111511021.

Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve

Alison D. Klein, Kayla L. Petruzzi, Chan Lee, Michael Overholtzer

Mol Biol Cell. 2024 May 1; 35(5): ar70. Published online 2024 Apr 16. doi: 10.1091/mbc.E23-08-0332

PMCID:: PMC11151102

Abstract Article PDF–1.9M

Select item 111085662.

PIKfyve inhibition increases exosome release and induces secretory autophagy

Nina Pettersen Hessvik, Anders Øverbye, Andreas Brech, Maria Lyngaas Torgersen, Ida Seim Jakobsen, Kirsten Sandvig, Alicia Llorente

Cell Mol Life Sci. 2016 Dec; 73(24): 4717–4737. Published online 2016 Jul 20. doi: 10.1007/s00018-016-2309-8

PMCID:: PMC11108566

Abstract Article PDF–5.8M

Select item 110859683.

Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes

Mingliang Zhao, Shan Zhang, Weiqiang Wan, Chunyu Zhou, Nana Li, Ruxi Cheng, Yonghui Yu, Xuan Ouyang, Dongsheng Zhou, Jun Jiao, Xiaolu Xiong

Virulence. 2024; 15(1): 2350893. Published online 2024 May 9. doi: 10.1080/21505594.2024.2350893

PMCID:: PMC11085968

Abstract Article PDF–4.0M

Select item 85625694.

Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer

Yuanyuan Qiao, Jae Eun Choi, Jean C. Tien, Stephanie A. Simko, Thekkelnaycke Rajendiran, Josh N. Vo, Andrew D. Delekta, Lisha Wang, Lanbo Xiao, Nathan B. Hodge, Parth Desai, Sergio Mendoza, Kristin Juckette, Alice Xu, Tanu Soni, Fengyun Su, Rui Wang, Xuhong Cao, Jiali Yu, Ilona Kryczek, Xiao-Ming Wang, Xiaoju Wang, Javed Siddiqui, Zhen Wang, Amélie Bernard, Ester Fernandez-Salas, Nora M. Navone, Stephanie J. Ellison, Ke Ding, Eeva-Liisa Eskelinen, Elisabeth I. Heath, Daniel J. Klionsky, Weiping Zou, Arul M. Chinnaiyan

Nat Cancer. Author manuscript; available in PMC 2022 Feb 2.

Published in final edited form as: Nat Cancer. 2021 Sep; 2: 978–993. Published online 2021 Aug 2. doi: 10.1038/s43018-021-00237-1

PMCID:: PMC8562569

Abstract Article PDF–6.8M

Select item 74561575.

Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

Yuan-Lin Kang, Yi-ying Chou, Paul W. Rothlauf, Zhuoming Liu, Timothy K. Soh, David Cureton, James Brett Case, Rita E. Chen, Michael S. Diamond, Sean P. J. Whelan, Tom Kirchhausen

Proc Natl Acad Sci U S A. 2020 Aug 25; 117(34): 20803–20813. Published online 2020 Aug 6. doi: 10.1073/pnas.2007837117

PMCID:: PMC7456157

Abstract Article PDF–2.3M

Select item 45759046.

Identification of novel PIKFYVE gene mutations associated with Fleck corneal dystrophy

Jessica A. Gee, Ricardo F. Frausto, Duk-Won D. Chung, Chulaluck Tangmonkongvoragul, Derek J. Le, Cynthia Wang, Jonathan Han, Anthony. J. Aldave

Mol Vis. 2015; 21: 1093–1100. Published online 2015 Sep 17.

PMCID:: PMC4575904

Abstract Article PDF–1.9M

Select item 32094277.

A novel PIKFYVE mutation in fleck corneal dystrophy

Andreas Kotoulas, Haris Kokotas, Konstantinos Kopsidas, Konstantinos Droutsas, Maria Grigoriadou, Hasret Bajrami, Daniel F. Schorderet, Michael B. Petersen

Mol Vis. 2011; 17: 2776–2781. Published online 2011 Oct 25.

PMCID:: PMC3209427

Abstract Article PDF–561K

Select item 27238308.

PIKfyve Regulation of Endosome-Linked Pathways

Jane de Lartigue, Hannah Polson, Morri Feldman, Kevan Shokat, Sharon A Tooze, Sylvie Urbé, Michael J Clague

Traffic. 2009 Jul; 10(7): 883–893. Prepublished online 2009 Mar 18. Published online 2009 Apr 21. doi: 10.1111/j.1600-0854.2009.00915.x

PMCID:: PMC2723830

Abstract Article PDF–1.4M

Select item 24913989.

PIKfyve: PARTNERS, SIGNIFICANCE, DEBATES AND PARADOXES

Assia Shisheva

Cell Biol Int. Author manuscript; available in PMC 2008 Jul 30.

Published in final edited form as: Cell Biol Int. 2008 Jun; 32(6): 591–604. Published online 2008 Jan 25. doi: 10.1016/j.cellbi.2008.01.006

PMCID:: PMC2491398

Abstract Article PDF–650K

Select item 122619410.

Mutations in PIP5K3 Are Associated with François-Neetens Mouchetée Fleck Corneal Dystrophy

Shouling Li, Leila Tiab, Xiaodong Jiao, Francis L. Munier, Leonidas Zografos, Béatrice E. Frueh, Yuri Sergeev, Janine Smith, Benjamin Rubin, Mario A. Meallet, Richard K. Forster, J. Fielding Hejtmancik, Daniel F. Schorderet

Am J Hum Genet. 2005 Jul; 77(1): 54–63. Published online 2005 May 18. doi: 10.1086/431346

PMCID:: PMC1226194

Abstract Article PDF–3.8M

Select item 1121395311.

PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu, Jonathan Gurkan, Yi Bao, Mahnoor Gondal, Jean Ching-Yi Tien, Tomasz Maj, Sahr Yazdani, Abhijit Parolia, Houjun Xia, JiaJia Zhou, Shuang Wei, Sara Grove, Linda Vatan, Heng Lin, Gaopeng Li, Yang Zheng, Yuping Zhang, Xuhong Cao, Fengyun Su, Rui Wang, Tongchen He, Marcin Cieslik, Michael D. Green, Weiping Zou, Arul M. Chinnaiyan

Nat Commun. 2024; 15: 5487. Published online 2024 Jun 28. doi: 10.1038/s41467-024-48931-9

PMCID:: PMC11213953

Abstract Article PDF–1.8M

Select item 1112705012.

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase

John R. Ferrarone, Jerin Thomas, Arun M. Unni, Yuxiang Zheng, Michal J. Nagiec, Eric E. Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C. Cantley, John Blenis, Neville E. Sanjana, Harold Varmus

Proc Natl Acad Sci U S A. 2024 May 21; 121(21): e2403685121. Published online 2024 May 14. doi: 10.1073/pnas.2403685121

PMCID:: PMC11127050

Abstract Article PDF–1.4M

Select item 863230613.

AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation

Cansu Karabiyik, David C. Rubinsztein

Autophagy. 2021; 17(11): 3877–3878. Published online 2021 Aug 12. doi: 10.1080/15548627.2021.1961409

PMCID:: PMC8632306

Abstract Article PDF–265K

Select item 631932014.

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

Maksim V. Baranov, Frans Bianchi, Anastasiya Schirmacher, Melissa A.C. van Aart, Sjors Maassen, Elke M. Muntjewerff, Ilse Dingjan, Martin ter Beest, Martijn Verdoes, Samantha G.L. Keyser, Carolyn R. Bertozzi, Ulf Diederichsen, Geert van den Bogaart

iScience. 2019 Jan 25; 11: 160–177. Published online 2018 Dec 20. doi: 10.1016/j.isci.2018.12.015

PMCID:: PMC6319320

Abstract Article PDF–9.4M

Select item 603133115.

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Christopher H. Choy, Golam Saffi, Matthew A. Gray, Callen Wallace, Roya M. Dayam, Zhen-Yi A. Ou, Guy Lenk, Rosa Puertollano, Simon C. Watkins, Roberto J. Botelho

J Cell Sci. 2018 May 15; 131(10): jcs213587. Published online 2018 May 21. doi: 10.1242/jcs.213587