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Select item 109044231.

Rheb1 is required for limb growth through regulating chondrogenesis in growth plate

Yuwei Zhang, Jiaxin Wen, Ruijun Lai, Jiahuan Zhang, Kai Li, Yue Zhang, Anling Liu, Xiaochun Bai

Cell Tissue Res. 2024; 395(3): 261–269. Published online 2024 Jan 23. doi: 10.1007/s00441-024-03861-2

PMCID:: PMC10904423

Abstract Article PDF–7.1M

Select item 89698692.

Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells

Minghao Li, Yanjie Lan, Juan Gao, Shengnan Yuan, Shuaibing Hou, Tengxiao Guo, Fei Zhao, Yuxia Wang, Weiping Yuan, Xiaomin Wang

Front Cell Dev Biol. 2022; 10: 779159. Published online 2022 Mar 17. doi: 10.3389/fcell.2022.779159

PMCID:: PMC8969869

Abstract Article PDF–3.1M

Select item 68213543.

Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway

Wen Meng, Xiuci Liang, Ting Xiao, Jing Wang, Jie Wen, Hairong Luo, Jianhui Teng, Yanquan Fei, Qinghai Zhang, Bilian Liu, Fang Hu, Juli Bai, Meilian Liu, Zhiguang Zhou, Feng Liu

J Mol Cell Biol. 2019 Sep; 11(9): 781–790. Published online 2019 Jul 22. doi: 10.1093/jmcb/mjz056

PMCID:: PMC6821354

Abstract Article PDF–19M

Select item 63554974.

Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo

Xiaomin Wang, Yanan Gao, Juan Gao, Minghao Li, Mi Zhou, Jinhong Wang, Yakun Pang, Hui Cheng, Chase Yuan, Yajing Chu, Yu Jiang, Jianfeng Zhou, Hongbo R. Luo, Zhenyu Ju, Tao Cheng, Weiping Yuan

Haematologica. 2019 Feb; 104(2): 245–255. Prepublished online 2018 Sep 27. doi: 10.3324/haematol.2018.194811

PMCID:: PMC6355497

Abstract Article PDF–2.4M

Select item 58645495.

Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

Mark W. Urban, Biswarup Ghosh, Laura R. Strojny, Cole G. Block, Sara M. Blazejewski, Megan C. Wright, George M. Smith, Angelo C. Lepore

Exp Neurol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Exp Neurol. 2018 May; 303: 108–119. Published online 2018 Feb 14. doi: 10.1016/j.expneurol.2018.02.007

PMCID:: PMC5864549

Abstract Article PDF–1.3M

Select item 57452196.

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

Qi Tian, Pavel Gromov, Joachim H. Clement, Yingming Wang, Marc Riemann, Falk Weih, Xiao-Xin Sun, Mu-Shui Dai, Lev M. Fedorov

GeroScience. 2017 Dec; 39(5-6): 557–570. Published online 2017 Sep 10. doi: 10.1007/s11357-017-9997-3

PMCID:: PMC5745219

Abstract Article PDF–1.4M

Select item 52092467.

Forebrain Depletion of Rheb Elicits Spatial Memory Deficits in Mice

Neelam Shahani, Wen-Chin Huang, Megan Varnum, Damon T. Page, Srinivasa Subramaniam

Neurobiol Aging. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Neurobiol Aging. 2017 Feb; 50: 134–143. Published online 2016 Nov 21. doi: 10.1016/j.neurobiolaging.2016.11.006

PMCID:: PMC5209246

Abstract Article PDF–892K

Select item 39078828.

Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism

Wanchun Yang, Wanxiang Jiang, Liping Luo, Jicheng Bu, Dejiang Pang, Jing Wei, Chongyangzi Du, Xiaoqiang Xia, Yiyuan Cui, Shuang Liu, Qing Mao, Mina Chen

Int J Mol Sci. 2014 Jan; 15(1): 1499–1510. Published online 2014 Jan 21. doi: 10.3390/ijms15011499

PMCID:: PMC3907882

Abstract Article PDF–1.0M

Select item 38411479.

Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts

Marlous J. Groenewoud, Susan M. I. Goorden, Jorien Kassies, Wendy Pellis-van Berkel, Richard F. Lamb, Ype Elgersma, Fried J. T. Zwartkruis

PLoS One. 2013; 8(11): e81649. Published online 2013 Nov 26. doi: 10.1371/journal.pone.0081649

PMCID:: PMC3841147

Abstract Article PDF–2.0M

Select item 276567610.

Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation

Timothy B. Campbell, Sunanda Basu, Giao Hangoc, Wen Tao, Hal E. Broxmeyer

Blood. 2009 Oct 15; 114(16): 3392–3401. Prepublished online 2009 Aug 18. doi: 10.1182/blood-2008-12-195214

PMCID:: PMC2765676

Abstract Article

Select item 269003111.

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

Xiaoming Zhou, Tsuneo Ikenoue, Xiaowei Chen, Li Li, Ken Inoki, Kun-Liang Guan

Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22): 8923–8928. Published online 2009 May 20. doi: 10.1073/pnas.0903621106

PMCID:: PMC2690031

Abstract Article PDF–972K

Select item 1083085512.

Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9

Ting Wang, Chaoran Zhao, Jiahuan Zhang, Shengfa Li, Youming Zhang, Yan Gong, Yingyue Zhou, Lei Yan, Sheng Zhang, Zhongmin Zhang, Hongling Hu, Anling Liu, Xiaochun Bai, Zhipeng Zou

iScience. 2024 Feb 16; 27(2): 108857. Published online 2024 Jan 11. doi: 10.1016/j.isci.2024.108857

PMCID:: PMC10830855

Abstract Article PDF–8.6M

Select item 896580613.

Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver

Chongyangzi Du, Wanchun Yang, Zongyan Yu, Qiuyun Yuan, Dejiang Pang, Ping Tang, Wanxiang Jiang, Mina Chen, Bo Xiao

Front Cell Dev Biol. 2022; 10: 808140. Published online 2022 Mar 16. doi: 10.3389/fcell.2022.808140

PMCID:: PMC8965806

Abstract Article PDF–2.5M

Select item 819146714.

Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells

Juan Gao, Shuaibing Hou, Shengnan Yuan, Yuxia Wang, Yanan Gao, Xiaolu Sun, Weili Wang, Yajing Chu, Yuan Zhou, Xiaoming Feng, Hongbo R. Luo, Tao Cheng, Jun Shi, Weiping Yuan, Xiaomin Wang

Front Cell Dev Biol. 2021; 9: 650599. Published online 2021 May 27. doi: 10.3389/fcell.2021.650599

PMCID:: PMC8191467

Abstract Article PDF–3.4M

Select item 818681415.

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity

Martina Proietti Onori, Linda M. C. Koene, Carmen B. Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M. van Woerden

PLoS Biol. 2021 May; 19(5): e3001279. Published online 2021 May 26. doi: 10.1371/journal.pbio.3001279

PMCID:: PMC8186814

Abstract Article PDF–5.0M

Select item 748706716.

Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain

Xiaqing Ma, Wenjie Du, Wenying Wang, Limin Luo, Min Huang, Haiyan Wang, Raozhou Lin, Zhongping Li, Haibo Shi, Tifei Yuan, Wei Jiang, Paul F. Worley, Tao Xu

Cell Death Dis. 2020 Sep; 11(9): 747. Published online 2020 Sep 12. doi: 10.1038/s41419-020-02966-0

PMCID:: PMC7487067

Abstract Article PDF–1.8M

Select item 664937317.

Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model

Linda M. C. Koene, Saskia E. van Grondelle, Martina Proietti Onori, Ilse Wallaard, Nathalie H. R. M. Kooijman, Annabel van Oort, Jadwiga Schreiber, Ype Elgersma

Ann Clin Transl Neurol. 2019 Jul; 6(7): 1273–1291. Published online 2019 Jun 24. doi: 10.1002/acn3.50829

PMCID:: PMC6649373

Abstract Article PDF–2.6M

Select item 646139818.

ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

Erik A. Blackwood, Christoph Hofmann, Michelle Santo Domingo, Alina S. Bilal, Anup Sarakki, Winston Stauffer, Adrian Arrieta, Donna J. Thuerauf, Fred W. Kolkhorst, Oliver J. Müller, Tobias Jakobi, Christoph Dieterich, Hugo A. Katus, Shirin Doroudgar, Christopher C. Glembotski

Circ Res. Author manuscript; available in PMC 2020 Jan 4.

Published in final edited form as: Circ Res. 2019 Jan 4; 124(1): 79–93. doi: 10.1161/CIRCRESAHA.118.313854

PMCID:: PMC6461398

Abstract Article PDF–3.3M

Select item 566335119.

mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Kaushal Asrani, Akshay Sood, Alba Torres, Dan Georgess, Pornima Phatak, Harsimar Kaur, Amber Dubin, C. Conover Talbot, Jr., Loubna Elhelu, Andrew J. Ewald, Bo Xiao, Paul Worley, Tamara L. Lotan

J Clin Invest. 2017 Nov 1; 127(11): 4001–4017. Published online 2017 Sep 25. doi: 10.1172/JCI92893