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Select item 56512301.

TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells

Laura F. Corns, Jing-Yi Jeng, Guy P. Richardson, Corné J. Kros, Walter Marcotti

Front Mol Neurosci. 2017; 10: 326. Published online 2017 Oct 18. doi: 10.3389/fnmol.2017.00326

PMCID:: PMC5651230

Abstract Article PDF–3.2M

Select item 92788702.

Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

Nurunisa Akyuz, K. Domenica Karavitaki, Bifeng Pan, Panos I. Tamvakologos, Kelly P. Brock, Yaqiao Li, Debora S. Marks, David P. Corey

Sci Adv. 2022 Jul; 8(28): eabo1126. Published online 2022 Jul 13. doi: 10.1126/sciadv.abo1126

PMCID:: PMC9278870

Abstract Article PDF–2.6M

Select item 83838083.

The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis

Maryline Beurg, Jong-Hoon Nam, Robert Fettiplace

J Gen Physiol. 2021 Oct 4; 153(10): e202112959. Published online 2021 Aug 19. doi: 10.1085/jgp.202112959

PMCID:: PMC8383808

Abstract Article PDF–3.2M

Select item 78805984.

Early peripheral activity alters nascent subplate circuits in the auditory cortex

Xiangying Meng, Didhiti Mukherjee, Joseph P. Y. Kao, Patrick O. Kanold

Sci Adv. 2021 Feb; 7(7): eabc9155. Published online 2021 Feb 12. doi: 10.1126/sciadv.abc9155

PMCID:: PMC7880598

Abstract Article PDF–4.2M

Select item 72987005.

Tmc gene therapy restores auditory function in deaf mice

Charles Askew, Cylia Rochat, Bifeng Pan, Yukako Asai, Hena Ahmed, Erin Child, Bernard L. Schneider, Patrick Aebischer, Jeffrey R. Holt

Sci Transl Med. Author manuscript; available in PMC 2020 Jun 17.

Published in final edited form as: Sci Transl Med. 2015 Jul 8; 7(295): 295ra108. doi: 10.1126/scitranslmed.aab1996

PMCID:: PMC7298700

Abstract Article PDF–1.0M

Select item 69109086.

The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells

Adam C. Goldring, Maryline Beurg, Robert Fettiplace

J Physiol. 2019 Dec 15; 597(24): 5949–5961. Published online 2019 Nov 12. doi: 10.1113/JP278799

PMCID:: PMC6910908

Abstract Article PDF–1.8M

Select item 67899677.

A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells

Maryline Beurg, Amanda Barlow, David N. Furness, Robert Fettiplace

Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20743–20749. Published online 2019 Sep 23. doi: 10.1073/pnas.1908058116

PMCID:: PMC6789967

Abstract Article PDF–1.6M

Select item 63605338.

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

Bifeng Pan, Nurunisa Akyuz, Xiao-Ping Liu, Yukako Asai, Carl Nist-Lund, Kiyoto Kurima, Bruce H. Derfler, Bence György, Walrati Limapichat, Sanket Walujkar, Lahiru N. Wimalasena, Marcos Sotomayor, David P. Corey, Jeffrey R. Holt

Neuron. Author manuscript; available in PMC 2019 Aug 22.

Published in final edited form as: Neuron. 2018 Aug 22; 99(4): 736–753.e6. doi: 10.1016/j.neuron.2018.07.033

PMCID:: PMC6360533

Abstract Article PDF–3.5M

Select item 59887459.

Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea

Maryline Beurg, Runjia Cui, Adam C. Goldring, Seham Ebrahim, Robert Fettiplace, Bechara Kachar

Nat Commun. 2018; 9: 2185. Published online 2018 Jun 5. doi: 10.1038/s41467-018-04589-8

PMCID:: PMC5988745

Abstract Article PDF–3.8M

Select item 578426710.

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Xue Gao, Yong Tao, Veronica Lamas, Mingqian Huang, Wei-Hsi Yeh, Bifeng Pan, Yu-Juan Hu, Johnny H. Hu, David B. Thompson, Yilai Shu, Yamin Li, Hongyang Wang, Shiming Yang, Qiaobing Xu, Daniel B. Polley, M. Charles Liberman, Wei-Jia Kong, Jeffrey R. Holt, Zheng-Yi Chen, David R. Liu

Nature. Author manuscript; available in PMC 2018 Jun 20.

Published in final edited form as: Nature. 2018 Jan 11; 553(7687): 217–221. Published online 2017 Dec 20. doi: 10.1038/nature25164

PMCID:: PMC5784267

Abstract Article PDF–1.8M

Select item 491419711.

Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells

Maryline Beurg, Adam C. Goldring, Anthony J. Ricci, Robert Fettiplace

Proc Natl Acad Sci U S A. 2016 Jun 14; 113(24): 6767–6772. Published online 2016 May 9. doi: 10.1073/pnas.1601067113

PMCID:: PMC4914197

Abstract Article PDF–1.2M

Select item 490815112.

RNA Interference Prevents Autosomal-Dominant Hearing Loss

Seiji B. Shibata, Paul T. Ranum, Hideaki Moteki, Bifeng Pan, Alexander T. Goodwin, Shawn S. Goodman, Paul J. Abbas, Jeffrey R. Holt, Richard J.H. Smith

Am J Hum Genet. 2016 Jun 2; 98(6): 1101–1113. Published online 2016 May 26. doi: 10.1016/j.ajhg.2016.03.028

PMCID:: PMC4908151

Abstract Article PDF–3.1M

Select item 471076413.

Tmc1 Point Mutation Affects Ca²⁺ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

Laura F. Corns, Stuart L. Johnson, Corné J. Kros, Walter Marcotti

J Neurosci. 2016 Jan 13; 36(2): 336–349. doi: 10.1523/JNEUROSCI.2439-15.2016

PMCID:: PMC4710764

Abstract Article PDF–3.5M

Select item 456900214.

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Kiyoto Kurima, Seham Ebrahim, Bifen Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshi Kawashima, Byung Y. Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar

Cell Rep. Author manuscript; available in PMC 2015 Sep 14.

Published in final edited form as: Cell Rep. 2015 Sep 8; 12(10): 1606–1617. Published online 2015 Aug 28. doi: 10.1016/j.celrep.2015.07.058