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Select item 110376671.

Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration

Gregory P. Adams, John E. McCartney, Ellen J. Wolf, Jamie Eisenberg, Mei-Sheng Tai, James S. Huston, Walter F. Stafford, III, Michael A. Bookman, L. L. Houston, Louis M. Weiner

Cancer Immunol Immunother. 1995 Sep; 40(5): 299–306. doi: 10.1007/BF01519629

PMCID:: PMC11037667

Abstract Article PDF–843K

Select item 108798692.

The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c/JNK pathway and inducing profilin-mediated lamellipodia degradation

Rongjun Zou, Wanting Shi, Xing Chang, Miao Zhang, Songtao Tan, Ruibing Li, Hao Zhou, Yukun Li, Ge Wang, Weihui Lv, Xiaoping Fan

Theranostics. 2024; 14(4): 1561–1582. Published online 2024 Feb 4. doi: 10.7150/thno.92650

PMCID:: PMC10879869

Abstract Article PDF–11M

Select item 105515983.

Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models

Naoya Kemmotsu, Li Zhu, Joji Nagasaki, Yoshihiro Otani, Youki Ueda, Hiromichi Dansako, Yue Fang, Isao Date, Yosuke Togashi

Cancer Sci. 2023 Oct; 114(10): 3848–3856. Published online 2023 Jul 23. doi: 10.1111/cas.15911

PMCID:: PMC10551598

Abstract Article PDF–3.0M

Select item 105504054.

Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors

Hideki Ikeda, Joji Nagasaki, Daiki Shimizu, Yuki Katsuya, Hidehito Horinouchi, Yukio Hosomi, Etsuko Tanji, Takekazu Iwata, Makiko Itami, Masahito Kawazu, Yuichiro Ohe, Takuji Suzuki, Yosuke Togashi

JTO Clin Res Rep. 2023 Oct; 4(10): 100573. Published online 2023 Sep 9. doi: 10.1016/j.jtocrr.2023.100573

PMCID:: PMC10550405

Abstract Article PDF–3.5M

Select item 103722505.

Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism

Masaki WATANABE, Momoka KAKUTANI, Ryo ANDO, Koki HIURA, Hayato SASAKI, Tadashi OKAMURA, Nobuya SASAKI

J Vet Med Sci. 2023 Jul; 85(7): 702–704. Published online 2023 May 29. doi: 10.1292/jvms.23-0115

PMCID:: PMC10372250

Abstract Article PDF–1.8M

Select item 102885546.

Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice

Yimeng Zhu, Wenxia Jiang, Brian J. Lee, Angelina Li, Steven Gershik, Shan Zha

Proc Natl Acad Sci U S A. 2023 Jun 20; 120(25): e2221894120. Published online 2023 Jun 12. doi: 10.1073/pnas.2221894120

PMCID:: PMC10288554

Abstract Article PDF–4.2M

Select item 100281167.

Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells

Jiawen Han, Minjie Wan, Zhanchuan Ma, Huanfa Yi

Cancer Med. 2023 Mar; 12(5): 5939–5952. Published online 2022 Nov 13. doi: 10.1002/cam4.5387

PMCID:: PMC10028116

Abstract Article PDF–15M

Select item 100103328.

Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration

Takao Morinaga, Takashi Inozume, Masahito Kawazu, Youki Ueda, Nicolas Sax, Kazuo Yamashita, Shusuke Kawashima, Joji Nagasaki, Toshihide Ueno, Jason Lin, Yuuki Ohara, Takeshi Kuwata, Hiroki Yukami, Akihito Kawazoe, Kohei Shitara, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yu Kawahara, Yasuhiro Nakamura, Yukiko Kiniwa, Ayako Morita, Eiki Ichihara, Katsuyuki Kiura, Tomohiro Enokida, Makoto Tahara, Yoshinori Hasegawa, Hiroyuki Mano, Yutaka Suzuki, Hiroyoshi Nishikawa, Yosuke Togashi

Cancer Res Commun. 2022 Jul; 2(7): 739–753. Published online 2022 Jul 28. doi: 10.1158/2767-9764.CRC-22-0050

PMCID:: PMC10010332

Abstract Article PDF–6.0M

Select item 94004839.

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection

Rana Abdelnabi, Caroline S. Foo, Suzanne J. F. Kaptein, Robbert Boudewijns, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts

J Virol. 2022 Aug; 96(16): e00758-22. Published online 2022 Aug 4. doi: 10.1128/jvi.00758-22

PMCID:: PMC9400483

Abstract Article PDF–874K

Select item 860329010.

TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment

Shusuke Kawashima, Takashi Inozume, Masahito Kawazu, Toshihide Ueno, Joji Nagasaki, Etsuko Tanji, Akiko Honobe, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Tomonori Kawasaki, Yukiko Kiniwa, Osamu Yamasaki, Satoshi Fukushima, Yuzuru Ikehara, Hiroyuki Mano, Yutaka Suzuki, Hiroyoshi Nishikawa, Hiroyuki Matsue, Yosuke Togashi

J Immunother Cancer. 2021; 9(11): e003134. Published online 2021 May 10. doi: 10.1136/jitc-2021-003134

PMCID:: PMC8603290

Abstract Article PDF–3.7M

Select item 790228911.

DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival

David K. Harrison, Zachary J. Waldrip, Lyle Burdine, Sara C. Shalin, Marie Schluterman Burdine

Transplantation. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Transplantation. 2021 Mar 1; 105(3): 540–549. doi: 10.1097/TP.0000000000003442

PMCID:: PMC7902289

Abstract Article PDF–1019K

Select item 747995012.

The critical role of CD4⁺ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma

Joji Nagasaki, Yosuke Togashi, Takeaki Sugawara, Makiko Itami, Nobuhiko Yamauchi, Junichiro Yuda, Masato Sugano, Yuuki Ohara, Yosuke Minami, Hirohisa Nakamae, Masayuki Hino, Masahiro Takeuchi, Hiroyoshi Nishikawa

Blood Adv. 2020 Sep 8; 4(17): 4069–4082. Published online 2020 Sep 1. doi: 10.1182/bloodadvances.2020002098

PMCID:: PMC7479950

Abstract Article PDF–1.9M

Select item 678261113.

Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice

C. J. Serpe, A. P. Kohm, C. B. Huppenbauer, V. M. Sanders, K. J. Jones

J Neurosci. 1999 Jun 1; 19(11): RC7. doi: 10.1523/JNEUROSCI.19-11-j0004.1999

PMCID:: PMC6782611

Abstract PDF–564K

Select item 625097814.

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

Simon R. Scutts, Stuart W. Ember, Hongwei Ren, Chao Ye, Christopher A. Lovejoy, Michela Mazzon, David L. Veyer, Rebecca P. Sumner, Geoffrey L. Smith

Cell Rep. 2018 Nov 13; 25(7): 1953–1965.e4. Published online 2018 Nov 13. doi: 10.1016/j.celrep.2018.10.034

PMCID:: PMC6250978

Abstract Article PDF–4.2M

Select item 592085515.

A novel SCID Mouse Model for Studying Spontaneous Metastasis of Human Lung Cancer to Human Tissue

Seigo Teraoka, Seishi Kyoizumi, Toshio Seyama, Michio Yamakido, Mitoshi Akiyama

Jpn J Cancer Res. 1995 May; 86(5): 419–423. doi: 10.1111/j.1349-7006.1995.tb03073.x

PMCID:: PMC5920855

Summary PDF–933K

Select item 539955016.

A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration

Alaknanda Mishra, Barun Das, Madhu Nath, Srikanth Iyer, Ashwani Kesarwani, Jashdeep Bhattacharjee, Shailendra Arindkar, Preeti Sahay, Kshama Jain, Parul Sahu, Prakriti Sinha, Thirumurthy Velpandian, Perumal Nagarajan, Pramod Upadhyay

Biol Open. 2017 Apr 15; 6(4): 449–462. Published online 2017 Mar 3. doi: 10.1242/bio.021618

PMCID:: PMC5399550

Abstract Article PDF–4.3M

Select item 537164517.

DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts

Emad A. Ahmed, Eukene Vélaz, Michael Rosemann, Klaus-P. Gilbertz, Harry Scherthan

Chromosoma. 2017; 126(2): 287–298. Published online 2016 May 2. doi: 10.1007/s00412-016-0590-9

PMCID:: PMC5371645

Abstract Article PDF–3.4M

Select item 533381418.

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

Eisuke Miyaki, Nobuhiko Hiraga, Michio Imamura, Takuro Uchida, Hiromi Kan, Masataka Tsuge, Hiromi Abe-Chayama, C. Nelson Hayes, Grace Naswa Makokha, Masahiro Serikawa, Hiroshi Aikata, Hidenori Ochi, Yuji Ishida, Chise Tateno, Hideki Ohdan, Kazuaki Chayama

PLoS One. 2017; 12(3): e0172412. Published online 2017 Mar 2. doi: 10.1371/journal.pone.0172412

PMCID:: PMC5333814

Abstract Article PDF–1.1M

Select item 507095419.

Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues

Aaron J. Martin, Matthew Clark, Gregory Gojanovich, Fatima Manzoor, Keith Miller, Douglas E. Kline, Y. Maurice Morillon, Bo Wang, Roland Tisch

JCI Insight. 2016 Oct 20; 1(17): e87636. Published online 2016 Oct 20. doi: 10.1172/jci.insight.87636

PMCID:: PMC5070954

Abstract Article PDF–1.3M

Select item 492501620.

Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone

Lauren A. Lawres, Aprajita Garg, Vidya Kumar, Igor Bruzual, Isaac P. Forquer, Isaline Renard, Azan Z. Virji, Pierre Boulard, Eduardo X. Rodriguez, Alexander J. Allen, Sovitj Pou, Keith W. Wegmann, Rolf W. Winter, Aaron Nilsen, Jialing Mao, Douglas A. Preston, Alexia A. Belperron, Linda K. Bockenstedt, David J. Hinrichs, Michael K. Riscoe, J. Stone Doggett, Choukri Ben Mamoun

J Exp Med. 2016 Jun 27; 213(7): 1307–1318. doi: 10.1084/jem.20151519

PMCID:: PMC4925016

Abstract Article PDF–2.1M

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