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Select item 94960511.

Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujić, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Biomolecules. 2022 Sep; 12(9): 1270. Published online 2022 Sep 9. doi: 10.3390/biom12091270

PMCID:: PMC9496051

Abstract Article PDF–26M

Select item 63578372.

Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet

Sereana Wan, Folkert Kuipers, Rick Havinga, Hiromi Ando, Dennis E. Vance, René L. Jacobs, Jelske N. van der Veen

Hepatol Commun. 2019 Feb; 3(2): 262–276. Published online 2019 Jan 2. doi: 10.1002/hep4.1302

PMCID:: PMC6357837

Abstract Article PDF–1.0M

Select item 53927423.

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E. Vance, René L. Jacobs

J Lipid Res. 2017 Apr; 58(4): 656–667. Published online 2017 Mar 29. doi: 10.1194/jlr.M070631

PMCID:: PMC5392742

Abstract Article PDF–1.5M

Select item 39654434.

Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy

Mayu Watanabe, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Chigusa Higuchi, Akihiro Katayama, Sanae Teshigawara, Jun Eguchi, Daisuke Ogawa, Eijiro Watanabe, Jun Wada, Hirofumi Makino

PLoS One. 2014; 9(3): e92647. Published online 2014 Mar 25. doi: 10.1371/journal.pone.0092647

PMCID:: PMC3965443

Abstract Article PDF–5.6M

Select item 35430335.

Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-deficient Mice via Increased Glucagon Action

Gengshu Wu, Liyan Zhang, Tete Li, Azeret Zuniga, Gary D. Lopaschuk, Liang Li, René L. Jacobs, Dennis E. Vance

J Biol Chem. 2013 Jan 11; 288(2): 837–847. Published online 2012 Nov 25. doi: 10.1074/jbc.M112.415117

PMCID:: PMC3543033

Abstract Article PDF–1.6M

Select item 30895756.

Sequential Synthesis and Methylation of Phosphatidylethanolamine Promote Lipid Droplet Biosynthesis and Stability in Tissue Culture and in Vivo

Gerd Hörl, Andrea Wagner, Laura K. Cole, Roland Malli, Helga Reicher, Petra Kotzbeck, Harald Köfeler, Gerald Höfler, Sasa Frank, Juliane G. Bogner-Strauss, Wolfgang Sattler, Dennis E. Vance, Ernst Steyrer

J Biol Chem. 2011 May 13; 286(19): 17338–17350. Published online 2011 Mar 22. doi: 10.1074/jbc.M111.234534

PMCID:: PMC3089575

Abstract Article PDF–2.0M

Select item 29034127.

Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

René L. Jacobs, Yang Zhao, Debby P. Y. Koonen, Torunn Sletten, Brian Su, Susanne Lingrell, Guoqing Cao, David A. Peake, Ming-Shang Kuo, Spencer D. Proctor, Brian P. Kennedy, Jason R. B. Dyck, Dennis E. Vance

J Biol Chem. 2010 Jul 16; 285(29): 22403–22413. Published online 2010 May 7. doi: 10.1074/jbc.M110.108514

PMCID:: PMC2903412

Abstract Article PDF–1.5M

Select item 28012278.

Dietary Docosahexaenoic Acid Supplementation Modulates Hippocampal Development in the Pemt^−/− Mouse

Kerry-Ann da Costa, Kiranmai S. Rai, Corneliu N. Craciunescu, Komal Parikh, Mihai G. Mehedint, Lisa M. Sanders, Audrey McLean-Pottinger, Steven H. Zeisel

J Biol Chem. 2010 Jan 8; 285(2): 1008–1015. Published online 2009 Nov 4. doi: 10.1074/jbc.M109.017137

PMCID:: PMC2801227

Abstract Article PDF–2.1M

Select item 12232239.

Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline.

Xiaonan Zhu, Jiannan Song, Mei-Heng Mar, Lloyd J Edwards, Steven H Zeisel

Biochem J. 2003 Mar 15; 370(Pt 3): 987–993. doi: 10.1042/BJ20021523

PMCID:: PMC1223223

Summary PDF–153K

Select item 1070605910.

The Role of Phosphatidylethanolamine N-Methyltransferase (PEMT) and Its Waist-Hip-Ratio-Associated Locus rs4646404 in Obesity-Related Metabolic Traits and Liver Disease

Chang Sun, David J. F. Holstein, Natalia Garcia-Cubero, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Esther Guiu-Jurado

Int J Mol Sci. 2023 Dec; 24(23): 16850. Published online 2023 Nov 28. doi: 10.3390/ijms242316850

PMCID:: PMC10706059

Abstract Article PDF–2.4M

Select item 997731411.

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill

JCI Insight. 2023 Jan 24; 8(2): e154314. Published online 2023 Jan 24. doi: 10.1172/jci.insight.154314

PMCID:: PMC9977314

Abstract Article PDF–30M

Select item 698701212.

Methyl-sensing nuclear receptor Liver Receptor Homolog-1 regulates mitochondrial function in mouse hepatocytes

Sungwoo Choi, Bingning Dong, Chih-Chun Janet Lin, Mi Jeong Heo, Kang Ho Kim, Zhen Sun, Martin Wagner, Jae Myoung Suh, Meng C. Wang, David D. Moore

Hepatology. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Hepatology. 2020 Mar; 71(3): 1055–1069. Published online 2019 Dec 23. doi: 10.1002/hep.30884

PMCID:: PMC6987012

Abstract Article PDF–1.6M

Select item 475629813.

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

Atsuko Nakatsuka, Makoto Matsuyama, Satoshi Yamaguchi, Akihiro Katayama, Jun Eguchi, Kazutoshi Murakami, Sanae Teshigawara, Daisuke Ogawa, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Akinobu Takaki, Eijiro Watanabe, Jun Wada

Sci Rep. 2016; 6: 21721. Published online 2016 Feb 17. doi: 10.1038/srep21721

PMCID:: PMC4756298

Abstract Article PDF–3.1M

Select item 285292514.

A Role for Sp1 in Transcriptional Regulation of Phosphatidylethanolamine N-Methyltransferase in Liver and 3T3-L1 Adipocytes

Laura K. Cole, Dennis E. Vance

J Biol Chem. 2010 Apr 16; 285(16): 11880–11891. Published online 2010 Feb 11. doi: 10.1074/jbc.M110.109843

PMCID:: PMC2852925

Abstract Article PDF–4.2M

Select item 243089515.

Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes

Mary Resseguie, Jiannan Song, Mihai D. Niculescu, Kerry-Ann da Costa, Thomas A. Randall, Steven H. Zeisel

FASEB J. Author manuscript; available in PMC 2008 Jun 18.

Published in final edited form as: FASEB J. 2007 Aug; 21(10): 2622–2632. Published online 2007 Apr 24. doi: 10.1096/fj.07-8227com

PMCID:: PMC2430895

Abstract Article PDF–575K

Select item 2423216.

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase

Christopher J. Walkey, Leah Rae Donohue, Rod Bronson, Luis B. Agellon, Dennis E. Vance

Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24): 12880–12885. doi: 10.1073/pnas.94.24.12880

PMCID:: PMC24232

Abstract Article PDF–317K

Select item 721881717.

Phospholipid methylation regulates muscle metabolic rate through Ca²⁺ transport efficiency

Anthony R.P. Verkerke, Patrick J. Ferrara, Chien-Te Lin, Jordan M. Johnson, Terence E. Ryan, J. Alan Maschek, Hiroaki Eshima, Christopher W. Paran, Brenton T. Laing, Piyarat Siripoksup, Trevor S. Tippetts, Edward J. Wentzler, Hu Huang, Espen. E. Spangenburg, Jeffrey J. Brault, Claudio J. Villanueva, Scott A. Summers, William L. Holland, James E. Cox, Dennis E. Vance, P. Darrell Neufer, Katsuhiko Funai

Nat Metab. Author manuscript; available in PMC 2020 May 13.

Published in final edited form as: Nat Metab. 2019 Sep; 1(9): 876–885. Published online 2019 Sep 16. doi: 10.1038/s42255-019-0111-2

PMCID:: PMC7218817

Abstract Article PDF–1.9M

Select item 486757618.

Ces3/TGH Deficiency Attenuates Steatohepatitis

Jihong Lian, Enhui Wei, Jody Groenendyk, Subhash K. Das, Martin Hermansson, Lena Li, Russell Watts, Aducio Thiesen, Gavin Y. Oudit, Marek Michalak, Richard Lehner

Sci Rep. 2016; 6: 25747. Published online 2016 May 16. doi: 10.1038/srep25747

PMCID:: PMC4867576

Abstract Article PDF–2.6M

Select item 454877419.

Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT

Xia Gao, Jelske N. van der Veen, Carlos Fernandez-Patron, Jean E. Vance, Dennis E. Vance, René L. Jacobs

J Lipid Res. 2015 Sep; 56(9): 1701–1710. doi: 10.1194/jlr.M059287

PMCID:: PMC4548774

Abstract Article PDF–1.1M

Select item 688960720.

Alternative splicing of UCP1 by non-cell-autonomous action of PEMT

Jordan M. Johnson, Anthony R.P. Verkerke, J. Alan Maschek, Patrick J. Ferrara, Chien-Te Lin, Kimberly A. Kew, P. Darrell Neufer, Irfan J. Lodhi, James E. Cox, Katsuhiko Funai

Mol Metab. 2020 Jan; 31: 55–66. Published online 2019 Nov 8. doi: 10.1016/j.molmet.2019.10.007

PMCID:: PMC6889607

Abstract Article PDF–2.4M

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