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Select item 90441771.

The G209R Mutant Mouse as a Model for Human PCSK1 Polyendocrinopathy

Manita Shakya, Surbhi, Nicolle K Martin, Anoop Arunagiri, Martin G Martin, Peter Arvan, Malcolm J Low, Iris Lindberg

Endocrinology. 2022 May; 163(5): bqac024. Published online 2022 Mar 4. doi: 10.1210/endocr/bqac024

PMCID:: PMC9044177

Abstract Article

Select item 82532302.

Mice Lacking PC1/3 Expression in POMC-expressing Cells Do Not Develop Obesity

Manita Shakya, Surbhi, Anne White, C Bruce Verchere, Malcolm J Low, Iris Lindberg

Endocrinology. 2021 Jun; 162(6): bqab055. Published online 2021 Mar 10. doi: 10.1210/endocr/bqab055

PMCID:: PMC8253230

Abstract Article

Select item 70601563.

A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes

Nor I. A. Muhsin, Liz Bentley, Ying Bai, Michelle Goldsworthy, Roger D. Cox

Mamm Genome. 2020; 31(1): 17–29. Published online 2020 Jan 23. doi: 10.1007/s00335-020-09826-4

PMCID:: PMC7060156

Abstract Article PDF–5.5M

Select item 40601794.

Defective Transport of the Obesity Mutant PC1/3 N222D Contributes to Loss of Function

Yogikala Prabhu, Elias H. Blanco, Ming Liu, Juan R. Peinado, Matthew C. Wheeler, Nicholas Gekakis, Peter Arvan, Iris Lindberg

Endocrinology. 2014 Jul; 155(7): 2391–2401. Published online 2014 May 14. doi: 10.1210/en.2013-1985

PMCID:: PMC4060179

Abstract Article

Select item 31741835.

Hysteretic Behavior of Proprotein Convertase 1/3 (PC1/3)

Marcelo Y. Icimoto, Nilana M. Barros, Juliana C. Ferreira, Marcelo F. Marcondes, Douglas Andrade, Mauricio F. Machado, Maria A. Juliano, Wagner A. Júdice, Luiz Juliano, Vitor Oliveira

PLoS One. 2011; 6(9): e24545. Published online 2011 Sep 15. doi: 10.1371/journal.pone.0024545

PMCID:: PMC3174183

Abstract Article PDF–463K

Select item 29404886.

Modulation of Prohormone Convertase 1/3 Properties Using Site-Directed Mutagenesis

Akihiko Ozawa, Juan R. Peinado, Iris Lindberg

Endocrinology. 2010 Sep; 151(9): 4437–4445. Published online 2010 Jul 7. doi: 10.1210/en.2010-0296

PMCID:: PMC2940488

Abstract Article

Select item 1249087.

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3

Xiaorong Zhu, Lelio Orci, Raymond Carroll, Christina Norrbom, Mariella Ravazzola, Donald F. Steiner

Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16): 10299–10304. Published online 2002 Jul 22. doi: 10.1073/pnas.162352799

PMCID:: PMC124908

Abstract Article PDF–611K

Select item 521838.

Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.

J Korner, J Chun, D Harter, R Axel

Proc Natl Acad Sci U S A. 1991 Aug 1; 88(15): 6834–6838. doi: 10.1073/pnas.88.15.6834

PMCID:: PMC52183

Summary Page Browse PDF–1.3M

Select item 81705039.

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Georgina K.C. Dowsett, Brian Y.H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S.H. Yeo

Mol Metab. 2021 Nov; 53: 101240. Published online 2021 May 4. doi: 10.1016/j.molmet.2021.101240

PMCID:: PMC8170503

Abstract Article PDF–4.1M

Select item 689242410.

Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D

Timothy S Jarvela, Surbhi, Manita Shakya, Tomas Bachor, Anne White, Malcolm J Low, Iris Lindberg

Endocrinology. 2019 Nov; 160(11): 2630–2645. Published online 2019 Sep 2. doi: 10.1210/en.2019-00418

PMCID:: PMC6892424

Abstract Article

Select item 472597711.

The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel, F. Rodet, A. N. Murgoci, R. Desjardins, H. Gagnon, M. Wisztorski, I. Fournier, R. Day, M. Salzet

Sci Rep. 2016; 6: 19360. Published online 2016 Jan 18. doi: 10.1038/srep19360

PMCID:: PMC4725977

Abstract Article PDF–1.9M

Select item 442219812.

Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry

Atira Hardiman, Theodore C Friedman, William C Grunwald, Jr, Machi Furuta, Ziaorong Zhu, Donald F Steiner, David R Cool

J Mol Endocrinol. Author manuscript; available in PMC 2015 May 6.

Published in final edited form as: J Mol Endocrinol. 2005 Jun; 34(3): 739–751. doi: 10.1677/jme.1.01812

PMCID:: PMC4422198

Abstract Article PDF–935K

Select item 401102413.

NECROSTATIN-1 ATTENUATES MITOCHONDRIAL DYSFUNCTION IN NEURONS AND ASTROCYTES FOLLOWING NEONATAL HYPOXIA–ISCHEMIA

R. CHAVEZ-VALDEZ, L. J. MARTIN, D. L. FLOCK, F. J. NORTHINGTON

Neuroscience. Author manuscript; available in PMC 2014 May 6.

Published in final edited form as: Neuroscience. 2012 Sep 6; 219: 192–203. Published online 2012 May 11. doi: 10.1016/j.neuroscience.2012.05.002

PMCID:: PMC4011024

Abstract Article PDF–1.7M

Select item 330450314.

NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells

Yoshiaki Tamura, Yuko Chiba, Toshihiro Tanioka, Nobuyuki Shimizu, Shohei Shinozaki, Marina Yamada, Kentaro Kaneki, Seijiro Mori, Atsushi Araki, Hideki Ito, Masao Kaneki

FEBS Lett. Author manuscript; available in PMC 2012 Oct 3.

Published in final edited form as: FEBS Lett. 2011 Oct 3; 585(19): 3058–3064. Published online 2011 Aug 28. doi: 10.1016/j.febslet.2011.08.028

PMCID:: PMC3304503

Abstract Article PDF–1.0M

Select item 290832815.

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration

German Kilimnik, Abraham Kim, Donald F. Steiner, Theodore C. Friedman, Manami Hara

Islets. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Islets. 2010 May 1; 2(3): 149–155. doi: 10.4161/isl.2.3.11396

PMCID:: PMC2908328

Abstract Article PDF–2.5M

Select item 289793016.

Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics

Jonathan H. Wardman, Xin Zhang, Sandra Gagnon, Leandro M. Castro, Xiaorong Zhu, Donald F. Steiner, Robert Day, Lloyd D. Fricker

J Neurochem. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: J Neurochem. 2010 Jul; 114(1): 215–225. Published online 2010 Apr 19. doi: 10.1111/j.1471-4159.2010.06760.x

PMCID:: PMC2897930

Abstract Article PDF–362K

Select item 267865617.

Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease

Jimmy D. Dikeakos, Paola Di Lello, Marie-Josée Lacombe, Rodolfo Ghirlando, Pascale Legault, Timothy L. Reudelhuber, James G. Omichinski

Proc Natl Acad Sci U S A. 2009 May 5; 106(18): 7408–7413. Published online 2009 Apr 17. doi: 10.1073/pnas.0809576106

PMCID:: PMC2678656

Abstract Article PDF–572K

Select item 5080618.

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

S P Smeekens, A S Avruch, J LaMendola, S J Chan, D F Steiner

Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2): 340–344. doi: 10.1073/pnas.88.2.340

PMCID:: PMC50806

Summary Page Browse PDF–1.2M

Select item 519971019.

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

Lisa C. Burnett, Charles A. LeDuc, Carlos R. Sulsona, Daniel Paull, Richard Rausch, Sanaa Eddiry, Jayne F. Martin Carli, Michael V. Morabito, Alicja A. Skowronski, Gabriela Hubner, Matthew Zimmer, Liheng Wang, Robert Day, Brynn Levy, Ilene Fennoy, Beatrice Dubern, Christine Poitou, Karine Clement, Merlin G. Butler, Michael Rosenbaum, Jean Pierre Salles, Maithe Tauber, Daniel J. Driscoll, Dieter Egli, Rudolph L. Leibel

J Clin Invest. 2017 Jan 3; 127(1): 293–305. Published online 2016 Dec 12. doi: 10.1172/JCI88648

PMCID:: PMC5199710

Abstract Article PDF–1.3M

Select item 334027320.

Disruption of Proprotein Convertase 1/3 (PC1/3) Expression in Mice Causes Innate Immune Defects and Uncontrolled Cytokine Secretion

Sarah Refaie, Sandra Gagnon, Hugo Gagnon, Roxane Desjardins, François D'Anjou, Pedro D'Orléans-Juste, Xiaorong Zhu, Donald F. Steiner, Nabil G. Seidah, Claude Lazure, Michel Salzet, Robert Day

J Biol Chem. 2012 Apr 27; 287(18): 14703–14717. Published online 2012 Mar 6. doi: 10.1074/jbc.M111.323220

PMCID:: PMC3340273

Abstract Article PDF–4.2M

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