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Items: 1 to 20 of 113

1.
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
Long-Sheng Chang, Janet L. Oblinger, Abbi E. Smith, Marc Ferrer, Steven P. Angus, Eric Hawley, Alejandra M. Petrilli, Roberta L. Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K. Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S. Burns, Thomas S. K. Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A. H. Dixon, Andrea Masters, David R. Jones, Charles W. Yates, Stephen J. Haggarty, Salvatore La Rosa, D. Bradley Welling, Anat O. Stemmer-Rachamimov, Scott R. Plotkin, James F. Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L. Johnson, Jaishri O. Blakeley, D. Wade Clapp, on behalf of the Synodos for NF2 Consortium
PLoS One. 2021; 16(7): e0252048. Published online 2021 Jul 15. doi: 10.1371/journal.pone.0252048
PMCID:
PMC8282008
AbstractArticlePDF–4.5M
2.
Merlin Inhibits Neurite Outgrowth in the CNS
Alexander Schulz, Katja J. Geissler, Sujeet Kumar, Gregor Leichsenring, Helen Morrison, Stephan L. Baader
J Neurosci. 2010 Jul 28; 30(30): 10177–10186. doi: 10.1523/JNEUROSCI.0840-10.2010
PMCID:
PMC6633373
AbstractArticlePDF–2.1M
3.
How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations
Hubert Rehrauer, Licun Wu, Walter Blum, Lazslo Pecze, Thomas Henzi, Véronique Serre-Beinier, Catherine Aquino, Bart Vrugt, Marc de Perrot, Beat Schwaller, Emanuela Felley-Bosco
Oncogene. 2018; 37(20): 2645–2659. Published online 2018 Mar 6. doi: 10.1038/s41388-018-0153-z
PMCID:
PMC5955862
AbstractArticlePDF–3.9M
4.
Nf2 mutation in Schwann cells delays functional neural recovery following injury
Kristy Truong, Iram Ahmad, J. Jason Clark, Alison Seline, Tyler Bertroche, Brian Mostaert, Douglas J. Van Daele, Marlan R. Hansen
Neuroscience. Author manuscript; available in PMC 2019 Mar 15.
Published in final edited form as: Neuroscience. 2018 Mar 15; 374: 205–213. Published online 2018 Feb 3. doi: 10.1016/j.neuroscience.2018.01.054
PMCID:
PMC5841622
AbstractArticlePDF–661K
5.
Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2
Benjamin M. Wahle, Eric T. Hawley, Yongzheng He, Abbi E. Smith, Jin Yuan, Andi R. Masters, David R. Jones, Jeffrey R. Gehlhausen, Su-Jung Park, Simon J. Conway, D. Wade Clapp, Charles W. Yates
Oncotarget. 2018 Jan 2; 9(1): 718–725. Published online 2017 Oct 24. doi: 10.18632/oncotarget.22002
PMCID:
PMC5787503
AbstractArticlePDF–2.6M
6.
Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration
Alexander Schulz, Robert Büttner, Andrea Toledo, Stephan L. Baader, Julia von Maltzahn, Andrey Irintchev, Reinhard Bauer, Helen Morrison
PLoS One. 2016; 11(7): e0159718. Published online 2016 Jul 28. doi: 10.1371/journal.pone.0159718
PMCID:
PMC4965074
AbstractArticlePDF–12M
7.
Clinico-pathological features and somatic gene alterations in refractory ceramic fibre-induced murine mesothelioma reveal mineral fibre-induced mesothelioma identities
Pascal Andujar, Céline Lecomte, Annie Renier, Jocelyne Fleury-Feith, Laurence Kheuang, Julien Daubriac, Anne Janin, Marie-Claude Jaurand
Carcinogenesis. Author manuscript;
Published in final edited form as: Carcinogenesis. 2007 Jul; 28(7): 1599–1605. Published online 2007 Feb 1. doi: 10.1093/carcin/bgm023
PMCID:
PMC4749665
AbstractArticle
8.
Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model
Xing Gao, Yingchao Zhao, Anat O. Stemmer-Rachamimov, Hao Liu, Peigen Huang, ShanMin Chin, Martin K. Selig, Scott R. Plotkin, Rakesh K. Jain, Lei Xu
Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47): 14676–14681. Published online 2015 Nov 9. doi: 10.1073/pnas.1512570112
PMCID:
PMC4664377
AbstractArticlePDF–1.6M
9.
Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury
Iram Ahmad, Augusta Fernando, Richard Gurgel, J. Jason Clark, Linjing Xu, Marlan R. Hansen
Neurobiol Dis. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Neurobiol Dis. 2015 Oct; 82: 114–122. Published online 2015 Jun 6. doi: 10.1016/j.nbd.2015.05.021
PMCID:
PMC4641051
AbstractArticlePDF–1.6M
10.
Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation
Ansgar Zoch, Steffen Mayerl, Alexander Schulz, Thomas Greither, Lucien Frappart, Juliane Rübsam, Heike Heuer, Marco Giovannini, Helen Morrison
PLoS One. 2015; 10(8): e0129151. Published online 2015 Aug 10. doi: 10.1371/journal.pone.0129151
PMCID:
PMC4530865
AbstractArticlePDF–29M
11.
A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation
Jeffrey R. Gehlhausen, Su-Jung Park, Ann E. Hickox, Matthew Shew, Karl Staser, Steven D. Rhodes, Keshav Menon, Jacquelyn D. Lajiness, Muithi Mwanthi, Xianlin Yang, Jin Yuan, Paul Territo, Gary Hutchins, Grzegorz Nalepa, Feng-Chun Yang, Simon J. Conway, Michael G. Heinz, Anat Stemmer-Rachamimov, Charles W. Yates, D. Wade Clapp
Hum Mol Genet. 2015 Jan 1; 24(1): 1–8. Published online 2014 Aug 11. doi: 10.1093/hmg/ddu414
PMCID:
PMC4262489
AbstractArticlePDF–905K
12.
Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture
Jonas Larsson, Masanobu Ohishi, Brian Garrison, Marie Aspling, Viktor Janzen, Gregor B Adams, Marcello Curto, Andrea I McClatchey, Ernestina Schipani, David T Scadden
Cell Stem Cell. Author manuscript; available in PMC 2014 Oct 14.
Published in final edited form as: Cell Stem Cell. 2008 Aug 7; 3(2): 221–227. doi: 10.1016/j.stem.2008.06.005
PMCID:
PMC4197168
AbstractArticlePDF–2.0M
13.
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus
Wei Li, Jonathan Cooper, Matthias A. Karajannis, Filippo G. Giancotti
EMBO Rep. 2012 Mar; 13(3): 204–215. Published online 2012 Feb 21. doi: 10.1038/embor.2012.11
PMCID:
PMC3323126
AbstractArticlePDF–981K
14.
FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function
Timmy Mani, Robert F. Hennigan, Lauren A. Foster, Deborah G. Conrady, Andrew B. Herr, Wallace Ip
Mol Cell Biol. 2011 May; 31(10): 1983–1996. doi: 10.1128/MCB.00609-10
PMCID:
PMC3133355
AbstractArticlePDF–3.4M
15.
Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma
Didier Jean, Emilie Thomas, Elodie Manié, Annie Renier, Aurélien de Reynies, Céline Lecomte, Pascal Andujar, Jocelyne Fleury-Feith, Françoise Galateau-Sallé, Marco Giovannini, Jessica Zucman-Rossi, Marc-Henri Stern, Marie-Claude Jaurand
Am J Pathol. 2011 Feb; 178(2): 881–894. doi: 10.1016/j.ajpath.2010.10.039
PMCID:
PMC3070549
AbstractArticlePDF–1.7M
16.
Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes
Robert F. Hennigan, Lauren A. Foster, Mary F. Chaiken, Timmy Mani, Michelle M. Gomes, Andrew B. Herr, Wallace Ip
Mol Cell Biol. 2010 Jan; 30(1): 54–67. Published online 2009 Nov 2. doi: 10.1128/MCB.00248-09
PMCID:
PMC2798298
AbstractArticlePDF–2.9M
17.
Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma
Srirupa Bhattacharyya, Janet L Oblinger, Roberta L Beauchamp, Zhenzhen Yin, Serkan Erdin, Priya Koundinya, Anna D Ware, Marc Ferrer, Justin T Jordan, Scott R Plotkin, Lei Xu, Long-Sheng Chang, Vijaya Ramesh
Neuro Oncol. 2023 Sep; 25(9): 1617–1630. Published online 2023 Feb 20. doi: 10.1093/neuonc/noad037
PMCID:
PMC10479743
AbstractArticlePDF–7.7M
18.
Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma
Yuwaraj Kadariya, Eleonora Sementino, Ujjawal Shrestha, Greg Gorman, Jonathan M White, Eric A Ross, Margie L Clapper, Nouri Neamati, Mark Steven Miller, Joseph R Testa
Carcinogenesis. 2022 Dec; 43(12): 1137–1148. Published online 2022 Nov 10. doi: 10.1093/carcin/bgac089
PMCID:
PMC10122428
AbstractArticlePDF–39M
19.
CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma
Monserrat Gerardo-Ramírez, Friederike L. Keggenhoff, Vanessa Giam, Diana Becker, Marco Groth, Nils Hartmann, Beate K. Straub, Helen Morrison, Peter R. Galle, Jens U. Marquardt, Peter Herrlich, Monika Hartmann
Int J Mol Sci. 2022 Aug; 23(15): 8616. Published online 2022 Aug 3. doi: 10.3390/ijms23158616
PMCID:
PMC9368984
AbstractArticlePDF–4.1M
20.
Merlin deficiency alters the redox management program in breast cancer
Mateus Mota, Brandon J. Metge, Dominique C. Hinshaw, Heba A. Alsheikh, Dongquan Chen, Rajeev S. Samant, Lalita A. Shevde
Mol Oncol. 2021 Apr; 15(4): 942–956. Published online 2021 Feb 1. doi: 10.1002/1878-0261.12896
PMCID:
PMC8024723
AbstractArticlePDF–1.6M

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