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Select item 108545021.

Investigation into Cardiac Myhc-α 334–352-Specific TCR Transgenic Mice Reveals a Role for Cytotoxic CD4 T Cells in the Development of Cardiac Autoimmunity

Meghna Sur, Mahima T. Rasquinha, Kiruthiga Mone, Chandirasegaran Massilamany, Ninaad Lasrado, Channabasavaiah Gurumurthy, Raymond A. Sobel, Jay Reddy

Cells. 2024 Feb; 13(3): 234. Published online 2024 Jan 26. doi: 10.3390/cells13030234

PMCID:: PMC10854502

Abstract Article PDF–11M

Select item 84532922.

Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy

Yiyuan Huang, Haisong Lu, Xianfeng Ren, Fazhao Li, Weiming Bu, Wenjie Liu, William P Dailey, Harumi Saeki, Kathleen Gabrielson, Roselle Abraham, Roderic Eckenhoff, Wei Dong Gao

Cardiovasc Res. 2020 May 1; 116(6): 1175–1185. Published online 2019 Aug 19. doi: 10.1093/cvr/cvz218

PMCID:: PMC8453292

Abstract Article PDF–1.0M

Select item 78299233.

A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette–Guèrin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-α

Kazuko Tajiri, Kyoko Imanaka-Yoshida, Yusuke Tsujimura, Kazuhiro Matsuo, Michiaki Hiroe, Kazutaka Aonuma, Masaki Ieda, Yasuhiro Yasutomi

Int J Mol Sci. 2021 Jan; 22(2): 794. Published online 2021 Jan 14. doi: 10.3390/ijms22020794

PMCID:: PMC7829923

Abstract Article PDF–5.3M

Select item 70779654.

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

Christopher N. Toepfer, Amanda C. Garfinkel, Gabriela Venturini, Hiroko Wakimoto, Giuliana Repetti, Lorenzo Alamo, Arun Sharma, Radhika Agarwal, Jourdan F. Ewoldt, Paige Cloonan, Justin Letendre, Mingyue Lun, Iacopo Olivotto, Steve Colan, Euan Ashley, Daniel Jacoby, Michelle Michels, Charles S. Redwood, Hugh C. Watkins, Sharlene M. Day, James F. Staples, Raúl Padrón, Anant Chopra, Carolyn Y. Ho, Christopher S. Chen, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman

Circulation. 2020 Mar 10; 141(10): 828–842. Published online 2020 Jan 27. doi: 10.1161/CIRCULATIONAHA.119.042339

Correction in:: Circulation. 2020 Mar 10; 141(10): e645.

PMCID:: PMC7077965

Abstract Article PDF–2.8M

Select item 61131685.

The Role of the L-Type Ca²⁺ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy

Helena M. Viola, Victoria P.A. Johnstone, Henrietta Cserne Szappanos, Tara R. Richman, Tatiana Tsoutsman, Aleksandra Filipovska, Christopher Semsarian, Jonathan G. Seidman, Christine E. Seidman, Livia C. Hool

JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2): 61–72. Published online 2016 Feb 13. doi: 10.1016/j.jacbts.2015.12.001

PMCID:: PMC6113168

Abstract Article PDF–1.9M

Select item 53984116.

Early Remodeling of Repolarizing K⁺ Currents in the αMHC^403/+ Mouse Model of Familial Hypertrophic Cardiomyopathy

Rocco Hueneke, Adam Adenwala, Rebecca L. Mellor, Jonathan G. Seidman, Christine E. Seidman, Jeanne M. Nerbonne

J Mol Cell Cardiol. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2017 Feb; 103: 93–101. Published online 2017 Jan 13. doi: 10.1016/j.yjmcc.2017.01.006

PMCID:: PMC5398411

Abstract Article PDF–1.0M

Select item 47844357.

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Eric M. Green, Hiroko Wakimoto, Robert L. Anderson, Marc J. Evanchik, Joshua M. Gorham, Brooke C. Harrison, Marcus Henze, Raja Kawas, Johan D. Oslob, Hector M. Rodriguez, Yonghong Song, William Wan, Leslie A. Leinwand, James A. Spudich, Robert S. McDowell, J. G. Seidman, Christine E. Seidman

Science. Author manuscript; available in PMC 2016 Apr 5.

Published in final edited form as: Science. 2016 Feb 5; 351(6273): 617–621. doi: 10.1126/science.aad3456

PMCID:: PMC4784435

Abstract Article PDF–1.4M

Select item 45583438.

Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic

Emily K. Pugach, Phillip A. Richmond, Joseph G. Azofeifa, Robin D. Dowell, Leslie A. Leinwand

J Mol Cell Cardiol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: J Mol Cell Cardiol. 2015 Sep; 86: 54–61. Published online 2015 Jul 2. doi: 10.1016/j.yjmcc.2015.06.019

PMCID:: PMC4558343

Abstract Article PDF–1.6M

Select item 41005539.

Allele-specific Silencing of Mutant Myh6 Allele in Mice Suppresses Hypertrophic Cardiomyopathy

Jianming Jiang, Hiroko Wakimoto, J. G. Seidman, Christine E. Seidman

Science. Author manuscript; available in PMC 2014 Jul 16.

Published in final edited form as: Science. 2013 Oct 4; 342(6154): 111–114. doi: 10.1126/science.1236921

PMCID:: PMC4100553

Abstract Article PDF–676K

Select item 337901410.

Cell-Intrinsic Functional Effects of the α-Cardiac Myosin Arg-403-Gln Mutation in Familial Hypertrophic Cardiomyopathy

Peiying Chuan, Sivaraj Sivaramakrishnan, Euan A. Ashley, James A. Spudich

Biophys J. 2012 Jun 20; 102(12): 2782–2790. doi: 10.1016/j.bpj.2012.04.049

PMCID:: PMC3379014

Abstract Article PDF–477K

Select item 132324711.

Soy diet worsens heart disease in mice

Brian L. Stauffer, John P. Konhilas, Elizabeth D. Luczak, Leslie A. Leinwand

J Clin Invest. 2006 Jan 4; 116(1): 209–216. doi: 10.1172/JCI24676

PMCID:: PMC1323247

Abstract Article PDF–514K

Select item 130751312.

Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia

Cordula M. Wolf, Ivan P. G. Moskowitz, Scott Arno, Dorothy M. Branco, Christopher Semsarian, Scott A. Bernstein, Michael Peterson, Michael Maida, Gregory E. Morley, Glenn Fishman, Charles I. Berul, Christine E. Seidman, J. G. Seidman

Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50): 18123–18128. Published online 2005 Dec 6. doi: 10.1073/pnas.0509145102

PMCID:: PMC1307513

Abstract Article PDF–673K

Select item 38146813.

An abnormal Ca²⁺ response in mutant sarcomere protein–mediated familial hypertrophic cardiomyopathy

Diane Fatkin, Bradley K. McConnell, James O. Mudd, Christopher Semsarian, Ivan G.P. Moskowitz, Frederick J. Schoen, Michael Giewat, Christine E. Seidman, J.G. Seidman

J Clin Invest. 2000 Dec 1; 106(11): 1351–1359. doi: 10.1172/JCI11093

PMCID:: PMC381468

Abstract Article PDF–1.1M

Select item 15094914.

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

Christopher Semsarian, Imran Ahmad, Michael Giewat, Dimitrios Georgakopoulos, Joachim P. Schmitt, Bradley K. McConnell, Steven Reiken, Ulrike Mende, Andrew R. Marks, David A. Kass, Christine E. Seidman, J.G. Seidman

J Clin Invest. 2002 Apr 15; 109(8): 1013–1020. doi: 10.1172/JCI14677

PMCID:: PMC150949

Abstract Article PDF–2.4M

Select item 1047427015.

α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

Naijin Zhang, Ying Zhang, Jiaqi Xu, Pengbo Wang, Boquan Wu, Saien Lu, Xinxin Lu, Shilong You, Xinyue Huang, Mohan Li, Yuanming Zou, Mengke Liu, Yuanhui Zhao, Guozhe Sun, Wenbin Wang, Danxi Geng, Jingwei Liu, Liu Cao, Yingxian Sun

Cell Res. 2023 Sep; 33(9): 679–698. Published online 2023 Jul 13. doi: 10.1038/s41422-023-00844-w

PMCID:: PMC10474270

Abstract Article PDF–14M

Select item 928237816.

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Hübner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho

Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2204174119. Published online 2022 Jul 5. doi: 10.1073/pnas.2204174119

PMCID:: PMC9282378

Abstract Article PDF–2.2M

Select item 775862317.

Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites

Xinrui Wang, Amelia Lauth, Tina C. Wan, John W. Lough, John A. Auchampach

Dis Model Mech. 2020 Dec 1; 13(12): dmm046375. Published online 2020 Dec 18. doi: 10.1242/dmm.046375

PMCID:: PMC7758623

Abstract Article

Select item 659285318.

Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the Hippo signalling pathway

Wei‐Bo Zhao, Qun Lu, My‐Nhan Nguyen, Yidan Su, Mark Ziemann, Li‐Na Wang, Helen Kiriazis, Hamsa Puthalakath, Junichi Sadoshima, Hou‐Yuan Hu, Xiao‐Jun Du

Br J Pharmacol. 2019 Jul; 176(14): 2465–2481. Published online 2019 May 30. doi: 10.1111/bph.14674

PMCID:: PMC6592853

Abstract Article PDF–4.6M

Select item 451271019.

A Murine Myh6^MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction

Jianyun Yan, Lu Zhang, Nishat Sultana, David S. Park, Akshay Shekhar, Lei Bu, Jun Hu, Shegufta Razzaque, Chen-Leng Cai

PLoS One. 2015; 10(7): e0133472. Published online 2015 Jul 23. doi: 10.1371/journal.pone.0133472

PMCID:: PMC4512710

Abstract Article PDF–26M

Select item 408690720.

β–Myosin Heavy Chain Variant Met606Val Causes Very Mild Hypertrophic Cardiomyopathy in Mice, but Exacerbates HCM Phenotypes in Mice Carrying Other HCM Mutations

Robert Blankenburg, Katarzyna Hackert, Sebastian Wurster, René Deenen, J.G. Seidman, Christine E. Seidman, Martin J. Lohse, Joachim P. Schmitt

Circ Res. Author manuscript; available in PMC 2015 Jul 7.

Published in final edited form as: Circ Res. 2014 Jul 7; 115(2): 227–237. Published online 2014 May 14. doi: 10.1161/CIRCRESAHA.115.303178

PMCID:: PMC4086907

Abstract Article PDF–1.7M

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