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Select item 107410961.

Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b⁺ Ly6G⁺ Cells and Increasing the Viral Load in the Cornea

Jing Feng, Lingling Yang, Lili Ran, Xia Qi, Xiaolei Wang, Yangyang Zhang, Zongzheng Zou, Ting Liu, Xiaochuan Wang, Yang Yu, Xiaodong Sun, Qingjun Zhou

Invest Ophthalmol Vis Sci. 2023 Dec; 64(15): 24. Published online 2023 Dec 20. doi: 10.1167/iovs.64.15.24

PMCID:: PMC10741096

Abstract Article PDF–4.0M

Select item 101069652.

Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice

D. Liskiewicz, Q. Zhang, C.S. Barthem, M. Jastroch, A. Liskiewicz, N. Khajavi, G. Grandl, C. Coupland, M. Kleinert, C. Garcia-Caceres, A. Novikoff, G. Maity, U. Boehm, M.H. Tschöp, T.D. Müller

Mol Metab. 2023 Jun; 72: 101714. Published online 2023 Mar 24. doi: 10.1016/j.molmet.2023.101714

PMCID:: PMC10106965

Abstract Article PDF–2.3M

Select item 100338853.

Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice

Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Fumiaki Oka, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Michiyasu Suzuki, Hideyuki Ishihara

Front Pharmacol. 2023; 14: 1138673. Published online 2023 Mar 9. doi: 10.3389/fphar.2023.1138673

PMCID:: PMC10033885

Abstract Article PDF–2.5M

Select item 98968684.

Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice

Lili Ran, Jing Feng, Xia Qi, Ting Liu, Benxiang Qi, Kai Jiang, Zhenzhen Zhang, Yang Yu, Qingjun Zhou, Lixin Xie

Invest Ophthalmol Vis Sci. 2023 Jan; 64(1): 19. Published online 2023 Jan 24. doi: 10.1167/iovs.64.1.19

PMCID:: PMC9896868

Abstract Article PDF–18M

Select item 97845225.

Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression

Pablo Hernández-Ortego, Remedios Torres-Montero, Elvira de la Peña, Félix Viana, Jorge Fernández-Trillo

Int J Mol Sci. 2022 Dec; 23(24): 16164. Published online 2022 Dec 18. doi: 10.3390/ijms232416164

PMCID:: PMC9784522

Abstract Article PDF–4.2M

Select item 95880036.

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine

David Alarcón-Alarcón, David Cabañero, Jorge de Andrés-López, Magdalena Nikolaeva-Koleva, Simona Giorgi, Gregorio Fernández-Ballester, Asia Fernández-Carvajal, Antonio Ferrer-Montiel

Nat Commun. 2022; 13: 6304. Published online 2022 Oct 22. doi: 10.1038/s41467-022-33835-3

PMCID:: PMC9588003

Abstract Article PDF–1.9M

Select item 95198117.

Transient receptor potential melastatin 8 (TRPM8) is required for nitroglycerin and calcitonin gene-related peptide induced migraine-like pain behaviors in mice

Chao Wei, Brian Kim, David D. McKemy

Pain. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Pain. 2022 Dec 1; 163(12): 2380–2389. Published online 2022 Mar 29. doi: 10.1097/j.pain.0000000000002635

PMCID:: PMC9519811

Article PDF–1.6M

Select item 93273588.

Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol

Shiang-Suo Huang, Hsing-Hui Su, Szu-Yu Chien, Hsin-Yi Chung, Sih-Ting Luo, Yu-Ting Chu, Yi-Hsin Wang, Iona J. MacDonald, Hsun-Hua Lee, Yi-Hung Chen

J Neuroinflammation. 2022; 19: 192. Published online 2022 Jul 27. doi: 10.1186/s12974-022-02553-4

PMCID:: PMC9327358

Abstract Article PDF–6.6M

Select item 91667809.

Structures of a mammalian TRPM8 in closed state

Cheng Zhao, Yuan Xie, Lizhen Xu, Fan Ye, Ximing Xu, Wei Yang, Fan Yang, Jiangtao Guo

Nat Commun. 2022; 13: 3113. Published online 2022 Jun 3. doi: 10.1038/s41467-022-30919-y

PMCID:: PMC9166780

Abstract Article PDF–3.8M

Select item 887744810.

In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening

Nunzio Iraci, Carmine Ostacolo, Alicia Medina-Peris, Tania Ciaglia, Anton M. Novoselov, Andrea Altieri, David Cabañero, Asia Fernandez-Carvajal, Pietro Campiglia, Isabel Gomez-Monterrey, Alessia Bertamino, Alexander V. Kurkin

Int J Mol Sci. 2022 Feb; 23(4): 2070. Published online 2022 Feb 13. doi: 10.3390/ijms23042070

PMCID:: PMC8877448

Abstract Article PDF–4.0M

Select item 859613211.

Rational Design of a Modality‐Specific Inhibitor of TRPM8 Channel against Oxaliplatin‐Induced Cold Allodynia

Aerziguli Aierken, Ya‐Kai Xie, Wenqi Dong, Abuliken Apaer, Jia‐Jia Lin, Zihan Zhao, Shilong Yang, Zhen‐Zhong Xu, Fan Yang

Adv Sci (Weinh) 2021 Nov; 8(22): 2101717. Published online 2021 Oct 17. doi: 10.1002/advs.202101717

PMCID:: PMC8596132

Abstract Article PDF–6.4M

Select item 851722212.

Suppressive Effects of Transient Receptor Potential Melastatin 8 Agonist on Epileptiform Discharges and Epileptic Seizures

Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Takao Inoue, Yuichi Fujiyama, Kohei Haji, Yuichi Maruta, Hideyuki Ishihara, Michiyasu Suzuki

Front Pharmacol. 2021; 12: 766782. Published online 2021 Oct 1. doi: 10.3389/fphar.2021.766782

PMCID:: PMC8517222

Abstract Article PDF–1.5M

Select item 851369713.

Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function

Bastián Rivera, Claudio Moreno, Boris Lavanderos, Ji Yeon Hwang, Jorge Fernández-Trillo, Kang-Sik Park, Patricio Orio, Félix Viana, Rodolfo Madrid, María Pertusa

J Neurosci. 2021 Oct 13; 41(41): 8475–8493. doi: 10.1523/JNEUROSCI.0345-21.2021

PMCID:: PMC8513697

Abstract Article PDF–6.1M

Select item 817749014.

TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss

Adriana Lelis Carvalho, Annika Treyball, Daniel J. Brooks, Samantha Costa, Ryan J. Neilson, Michaela R. Reagan, Mary L. Bouxsein, Katherine J. Motyl

PLoS One. 2021; 16(6): e0231060. Published online 2021 Jun 4. doi: 10.1371/journal.pone.0231060

PMCID:: PMC8177490

Abstract Article PDF–3.9M

Select item 769952515.

TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease

Darine Fakih, Christophe Baudouin, Annabelle Réaux-Le Goazigo, Stéphane Mélik Parsadaniantz

Int J Mol Sci. 2020 Nov; 21(22): 8756. Published online 2020 Nov 19. doi: 10.3390/ijms21228756

PMCID:: PMC7699525

Abstract Article PDF–2.4M

Select item 742882416.

Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons

Radhika Palkar, Serra Ongun, Edward Catich, Natalie Li, Neil Borad, Angela Sarkisian, David D. McKemy

J Invest Dermatol. Author manuscript; available in PMC 2020 Aug 16.

Published in final edited form as: J Invest Dermatol. 2018 Jun; 138(6): 1391–1399. Published online 2017 Dec 27. doi: 10.1016/j.jid.2017.12.025

PMCID:: PMC7428824

Abstract Article PDF–610K

Select item 739176717.

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Lizhen Xu, Yalan Han, Xiaoying Chen, Aerziguli Aierken, Han Wen, Wenjun Zheng, Hongkun Wang, Xiancui Lu, Zhenye Zhao, Cheng Ma, Ping Liang, Wei Yang, Shilong Yang, Fan Yang

Nat Commun. 2020; 11: 3790. Published online 2020 Jul 29. doi: 10.1038/s41467-020-17582-x

PMCID:: PMC7391767

Abstract Article PDF–2.4M

Select item 678681518.

Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage

Ricardo Piña, Gonzalo Ugarte, Matías Campos, Almudena Íñigo-Portugués, Erick Olivares, Patricio Orio, Carlos Belmonte, Juan Bacigalupo, Rodolfo Madrid

J Neurosci. 2019 Oct 9; 39(41): 8177–8192. doi: 10.1523/JNEUROSCI.0654-19.2019

PMCID:: PMC6786815

Abstract Article PDF–3.4M

Select item 672930519.

TRPM8 Activation by Menthol, Icilin, and Cold Is Differentially Modulated by Intracellular pH

David A. Andersson, Henry W. N. Chase, Stuart Bevan

J Neurosci. 2004 Jun 9; 24(23): 5364–5369. doi: 10.1523/JNEUROSCI.0890-04.2004

PMCID:: PMC6729305

Abstract Article PDF–578K

Select item 670591720.

Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice

Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, Jose L. Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís

J Neurosci. 2018 Apr 11; 38(15): 3643–3656. doi: 10.1523/JNEUROSCI.3002-17.2018