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Select item 103348311.

Tsp-1⁺ microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p

Qian Luo, Zihua Jiang, Jingyi Jiang, Linxi Wan, Yan Li, Yuke Huang, Jin Qiu, Keming Yu, Jing Zhuang

Theranostics. 2023; 13(11): 3689–3706. Published online 2023 Jun 26. doi: 10.7150/thno.84236

PMCID:: PMC10334831

Abstract Article PDF–12M

Select item 100663662.

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang

Nat Commun. 2023; 14: 1794. Published online 2023 Mar 31. doi: 10.1038/s41467-023-37515-8

PMCID:: PMC10066366

Abstract Article PDF–14M

Select item 96784133.

Smad3 promotes adverse cardiovascular remodeling and dysfunction in doxorubicin-treated hearts

Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev

Am J Physiol Heart Circ Physiol. 2022 Dec 1; 323(6): H1091–H1107. Published online 2022 Oct 21. doi: 10.1152/ajpheart.00312.2022

PMCID:: PMC9678413

Abstract Article

Select item 87288534.

Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition

Philip Chiu‐Tsun Tang, Jeff Yat‐Fai Chung, Vivian Wei‐wen Xue, Jun Xiao, Xiao‐Ming Meng, Xiao‐Ru Huang, Shuang Zhou, Alex Siu‐Wing Chan, Anna Chi‐Man Tsang, Alfred Sze‐Lok Cheng, Tin‐Lap Lee, Kam‐Tong Leung, Eric W.‐F. Lam, Ka‐Fai To, Patrick Ming‐Kuen Tang, Hui‐Yao Lan

Adv Sci (Weinh) 2022 Jan; 9(1): 2101235. Published online 2021 Nov 17. doi: 10.1002/advs.202101235

PMCID:: PMC8728853

Abstract Article PDF–5.4M

Select item 84953865.

Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy

Yong-Ke You, Wei-Feng Wu, Xiao-Ru Huang, Hai-Di Li, Ye-Ping Ren, Jin-Cheng Zeng, Haiyong Chen, Hui Yao Lan

Int J Biol Sci. 2021; 17(14): 3911–3922. Published online 2021 Sep 21. doi: 10.7150/ijbs.62929

PMCID:: PMC8495386

Abstract Article PDF–5.1M

Select item 79170186.

Transit-amplifying cells coordinate changes in intestinal epithelial cell type composition

Laura E. Sanman, Ina W. Chen, Jake M. Bieber, Veronica Steri, Coralie Trentesaux, Byron Hann, Ophir D. Klein, Lani F. Wu, Steven J. Altschuler

Dev Cell. Author manuscript; available in PMC 2022 Feb 8.

Published in final edited form as: Dev Cell. 2021 Feb 8; 56(3): 356–365.e9. Published online 2021 Jan 22. doi: 10.1016/j.devcel.2020.12.020

PMCID:: PMC7917018

Abstract Article PDF–1.8M

Select item 77616617.

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Morgan E. Carlson, Michael Hsu, Irina M. Conboy

Nature. Author manuscript; available in PMC 2020 Dec 25.

Published in final edited form as: Nature. 2008 Jul 24; 454(7203): 528–532. Published online 2008 Jun 15. doi: 10.1038/nature07034

PMCID:: PMC7761661

Abstract Article PDF–1.5M

Select item 76932808.

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling

Lingling Jiang, Boyang Liu, Yan Qi, Linru Zhu, Xueling Cui, Zhonghui Liu

Sci Rep. 2020; 10: 20623. Published online 2020 Nov 26. doi: 10.1038/s41598-020-77783-8

PMCID:: PMC7693280

Abstract Article PDF–1.8M

Select item 76706889.

Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK

Ying Liu, Lijia Yu, Yaling Xu, Xiaohui Tang, Xijin Wang

J Neuroinflammation. 2020; 17: 342. Published online 2020 Nov 16. doi: 10.1186/s12974-020-02023-9

PMCID:: PMC7670688

Abstract Article PDF–5.3M

Select item 759967010.

Protective Effects of ALDH1A Enzyme Inhibition on Helicobacter-Induced Colitis in Smad3^−/− Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells

Audrey Seamons, Michael Haenisch, Stacey Meeker, Olesya Pershutkina, Thea Brabb, Piper M. Treuting, Jisun Paik

Nutrients. 2020 Oct; 12(10): 2927. Published online 2020 Sep 24. doi: 10.3390/nu12102927

PMCID:: PMC7599670

Abstract Article PDF–1.8M

Select item 647882711.

SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles

Sofia Granados-Aparici, Kate Hardy, Stephen Franks, Isam B. Sharum, Sarah L. Waite, Mark A. Fenwick

Sci Rep. 2019; 9: 6513. Published online 2019 Apr 24. doi: 10.1038/s41598-019-42878-4

PMCID:: PMC6478827

Abstract Article PDF–6.9M

Select item 645971612.

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Ilaria Russo, Michele Cavalera, Shuaibo Huang, Ya Su, Anis Hanna, Bijun Chen, Arti V Shinde, Simon J Conway, Jonathan Graff, Nikolaos G Frangogiannis

Circ Res. Author manuscript; available in PMC 2020 Apr 12.

Published in final edited form as: Circ Res. 2019 Apr 12; 124(8): 1214–1227. doi: 10.1161/CIRCRESAHA.118.314438

PMCID:: PMC6459716

Abstract Article PDF–3.1M

Select item 605874313.

Smad3 Is Required for Normal Follicular Follicle-Stimulating Hormone Responsiveness in the Mouse

Xiaoyan Gong, Elizabeth A. McGee

Biol Reprod. 2009 Oct 1; 81(4): 730–738. doi: 10.1095/biolreprod.108.070086

PMCID:: PMC6058743

Abstract Article PDF–2.0M

Select item 581283814.

Opposing actions of fibroblast and cardiomyocyte Smad3 signaling in the infarcted myocardium: Kong et al. Cell-specific actions of Smad3 in infarction

Ping Kong, Arti V Shinde, Ya Su, Ilaria Russo, Bijun Chen, Amit Saxena, Simon J Conway, Jonathan M Graff, Nikolaos G Frangogiannis

Circulation. Author manuscript; available in PMC 2019 Feb 13.

Published in final edited form as: Circulation. 2018 Feb 13; 137(7): 707–724. Published online 2017 Dec 11. doi: 10.1161/CIRCULATIONAHA.117.029622

PMCID:: PMC5812838

Abstract Article PDF–3.1M

Select item 565815315.

Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension

Sonu Kashyap, Gina Warner, Zeng Hu, Feng Gao, Mazen Osman, Yousif Al Saiegh, Karen R. Lien, Karl Nath, Joseph P. Grande

PLoS One. 2017; 12(10): e0187062. Published online 2017 Oct 26. doi: 10.1371/journal.pone.0187062

PMCID:: PMC5658153

Abstract Article PDF–33M

Select item 561317016.

Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer

Scott G. Daniel, Corbie L. Ball, David G. Besselsen, Tom Doetschman, Bonnie L. Hurwitz

mSystems. 2017 Sep-Oct; 2(5): e00065-17. Published online 2017 Sep 26. doi: 10.1128/mSystems.00065-17

PMCID:: PMC5613170

Abstract Article PDF–1006K

Select item 545154117.

Activin A regulates activation of mouse neutrophils by Smad3 signalling

Yan Qi, Jingyan Ge, Chunhui Ma, Na Wu, Xueling Cui, Zhonghui Liu

Open Biol. 2017 May; 7(5): 160342. Published online 2017 May 17. doi: 10.1098/rsob.160342

PMCID:: PMC5451541

Abstract Article PDF–971K

Select item 536792318.

Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice

Lillian Maggio-Price, Piper Treuting, Weiping Zeng, Mark Tsang, Helle Bielefeldt-Ohmann, Brian M. Iritani

Cancer Res. Author manuscript; available in PMC 2017 Mar 27.

Published in final edited form as: Cancer Res. 2006 Jan 15; 66(2): 828–838. doi: 10.1158/0008-5472.CAN-05-2448

PMCID:: PMC5367923

Abstract Article PDF–3.4M

Select item 532312219.

Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice

Zhengxue Liu, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J. Barnard, Xiao-Fan Wang, Mou-Tuan Huang, Nanjoo Suh, Fang Liu

Oncotarget. 2016 Oct 4; 7(40): 64878–64885. Published online 2016 Aug 30. doi: 10.18632/oncotarget.11713

PMCID:: PMC5323122

Abstract Article PDF–3.0M

Select item 507860620.

Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling

I. van der Pluijm, N. van Vliet, J.H. von der Thusen, J.L. Robertus, Y. Ridwan, P.M. van Heijningen, B.S. van Thiel, M. Vermeij, S.E. Hoeks, R.M.G.B. Buijs-Offerman, H.J.M. Verhagen, R. Kanaar, A.M. Bertoli-Avella, J. Essers

EBioMedicine. 2016 Oct; 12: 280–294. Published online 2016 Sep 10. doi: 10.1016/j.ebiom.2016.09.006