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Items: 1 to 20 of 133

1.
Alzheimer’s disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory
Eun-Jung Kim, Francisco J. Monje, Lin Li, Harald Höger, Daniela D. Pollak, Gert Lubec
Cell Mol Life Sci. 2013 Feb; 70(4): 743–759. Published online 2012 Sep 25. doi: 10.1007/s00018-012-1168-1
PMCID:
PMC11113176
AbstractArticlePDF–764K
2.
Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling
Shizuka Otsuka, Nicolas Melis, Matthias M. Gaida, Debjani Dutta, Roberto Weigert, Jonathan D. Ashwell
J Clin Invest. 2021 Jun 1; 131(11): e147683. Published online 2021 Jun 1. doi: 10.1172/JCI147683
PMCID:
PMC8159692
AbstractArticlePDF–8.2M
3.
Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers
Shan Feng, Xi Cheng, Lin Zhang, Xuemin Lu, Seema Chaudhary, Ruifang Teng, Christian Frederickson, Matthew M. Champion, Ren Zhao, Liang Cheng, Yiyi Gong, Haiteng Deng, Xin Lu
Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): 10094–10099. Published online 2018 Sep 19. doi: 10.1073/pnas.1800695115
PMCID:
PMC6176562
AbstractArticlePDF–1.2M
4.
Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells
Thomas C. J. Tan, John Knight, Thomas Sbarrato, Kate Dudek, Anne E. Willis, Rose Zamoyska
Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30): E6117–E6126. Published online 2017 Jul 10. doi: 10.1073/pnas.1700939114
PMCID:
PMC5544288
AbstractArticlePDF–1.6M
5.
Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun
Yury V. Shebzukhov, Silke Stanislawiak, Taisiya R. Bezhaeva, Sergei A. Nedospasov, Dmitry V. Kuprash
Sci Rep. 2017; 7: 2339. Published online 2017 May 24. doi: 10.1038/s41598-017-02553-y
PMCID:
PMC5443812
AbstractArticlePDF–1.6M
6.
Constitutive Lck activity drives sensitivity differences between CD8+ memory T cell subsets
Duane Moogk, Shi Zhong, Zhiya Yu, Ivan Liadi, William Rittase, Victoria Fang, Janna Dougherty, Arianne Perez-Garcia, Iman Osman, Cheng Zhu, Navin Varadarajan, Nicholas P. Restifo, Alan B. Frey, Michelle Krogsgaard
J Immunol. Author manuscript; available in PMC 2017 Jul 15.
Published in final edited form as: J Immunol. 2016 Jul 15; 197(2): 644–654. Published online 2016 Jun 6. doi: 10.4049/jimmunol.1600178
PMCID:
PMC4935560
AbstractArticlePDF–1.1M
7.
Lymphocyte Cell Kinase Activation Mediates Neuroprotection during Ischemic Preconditioning
Ok-Nam Bae, Krishnamurthy Rajanikant, Jiangyong Min, Jeremy Smith, Seung-Hoon Baek, Kelsey Serfozo, Siamak Hejabian, Ki Yong Lee, Mounzer Kassab, Arshad Majid
J Neurosci. 2012 May 23; 32(21): 7278–7286. doi: 10.1523/JNEUROSCI.6273-11.2012
PMCID:
PMC3538119
AbstractArticlePDF–1.3M
8.
Differential requirement for Lck during primary and memory CD8+ T cell responses
Kavita Tewari, Jane Walent, John Svaren, Rose Zamoyska, M. Suresh
Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44): 16388–16393. Published online 2006 Oct 23. doi: 10.1073/pnas.0602565103
PMCID:
PMC1637592
AbstractArticlePDF–1.1M
9.
Lck SH3 Domain Function Is Required for T-Cell Receptor Signals Regulating Thymocyte Development
Meghan L. Rudd, Alymarie Tua-Smith, David B. Straus
Mol Cell Biol. 2006 Nov; 26(21): 7892–7900. Published online 2006 Aug 21. doi: 10.1128/MCB.00968-06
PMCID:
PMC1636743
AbstractArticlePDF–408K
10.
Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling
Gabriele Campi, Rajat Varma, Michael L. Dustin
J Exp Med. 2005 Oct 17; 202(8): 1031–1036. doi: 10.1084/jem.20051182
PMCID:
PMC1373686
AbstractArticlePDF–1.1M
11.
p56lck is not essential for the T-cell response to allo-MHC antigens.
H Yamada, Y Y Kong, K Kishihara, T W Mak, K Nomoto
Immunology. 1997 Sep; 92(1): 33–38. doi: 10.1046/j.1365-2567.1997.d01-2297.x
PMCID:
PMC1363978
SummaryPage BrowsePDF–866K
12.
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
S D Levin, S J Anderson, K A Forbush, R M Perlmutter
EMBO J. 1993 Apr; 12(4): 1671–1680. doi: 10.1002/j.1460-2075.1993.tb05812.x
PMCID:
PMC413381
SummaryPage BrowsePDF–1.9M
13.
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.
J D Marth, C Disteche, D Pravtcheva, F Ruddle, E G Krebs, R M Perlmutter
Proc Natl Acad Sci U S A. 1986 Oct; 83(19): 7400–7404. doi: 10.1073/pnas.83.19.7400
PMCID:
PMC386725
SummaryPage BrowsePDF–1.1M
14.
Two lck transcripts containing different 5' untranslated regions are present in T cells.
A F Voronova, H T Adler, B M Sefton
Mol Cell Biol. 1987 Dec; 7(12): 4407–4413. doi: 10.1128/mcb.7.12.4407
PMCID:
PMC368124
SummaryPage BrowsePDF–1.6M
15.
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
J D Marth, J A Cooper, C S King, S F Ziegler, D A Tinker, R W Overell, E G Krebs, R M Perlmutter
Mol Cell Biol. 1988 Feb; 8(2): 540–550. doi: 10.1128/mcb.8.2.540
PMCID:
PMC363178
SummaryPage BrowsePDF–3.5M
16.
Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters.
H T Adler, P J Reynolds, C M Kelley, B M Sefton
J Virol. 1988 Nov; 62(11): 4113–4122. doi: 10.1128/jvi.62.11.4113-4122.1988
PMCID:
PMC253842
SummaryPage BrowsePDF–2.1M
17.
Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase.
T R Hurley, K E Amrein, B M Sefton
J Virol. 1992 Dec; 66(12): 7406–7413. doi: 10.1128/jvi.66.12.7406-7413.1992
PMCID:
PMC240447
SummaryPage BrowsePDF–2.3M
18.
Thymic tumorigenesis induced by overexpression of p56lck.
K M Abraham, S D Levin, J D Marth, K A Forbush, R M Perlmutter
Proc Natl Acad Sci U S A. 1991 May 1; 88(9): 3977–3981. doi: 10.1073/pnas.88.9.3977
PMCID:
PMC51576
SummaryPage BrowsePDF–1.1M
19.
The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP.
A C Carrera, K Alexandrov, T M Roberts
Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2): 442–446. doi: 10.1073/pnas.90.2.442
PMCID:
PMC45679
SummaryPage BrowsePDF–1.4M
20.
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
C Couture, G Baier, A Altman, T Mustelin
Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12): 5301–5305. doi: 10.1073/pnas.91.12.5301
PMCID:
PMC43982
SummaryPage BrowsePDF–1.5M

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