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Select item 107843981.

Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo

Marina Paul, Anna Paredes Barreda, Amy Gregson, Richard Kahl, Madeline King, Waleed M. Hussein, Frederick R. Walker, Roger Smith, Tamas Zakar, Jonathan W. Paul

Reprod Sci. 2024 Jan; 31(1): 150–161. Published online 2023 Aug 30. doi: 10.1007/s43032-023-01333-6

PMCID:: PMC10784398

Abstract Article PDF–3.6M

Select item 103541702.

20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index

Marina Paul, Tamas Zakar, Jason Phung, Amy Gregson, Anna Paredes Barreda, Trent A. Butler, Frederick R. Walker, Craig Pennell, Roger Smith, Jonathan W. Paul

Reprod Sci. 2023 Aug; 30(8): 2512–2523. Published online 2023 Feb 10. doi: 10.1007/s43032-023-01183-2

PMCID:: PMC10354170

Abstract Article PDF–2.7M

Select item 94637173.

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Xin Zuo, Hao Zeng, Bowen Wang, Xue Yang, Dalian He, Li Wang, Hong Ouyang, Jin Yuan

Invest Ophthalmol Vis Sci. 2022 Sep; 63(10): 3. Published online 2022 Sep 6. doi: 10.1167/iovs.63.10.3

PMCID:: PMC9463717

Abstract Article PDF–4.5M

Select item 82619714.

Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor

Xuenan Liu, Xiaomin Lian, Xuejiao Liu, Yangge Du, Yuan Zhu, Menglong Hu, Ping Zhang, Yunsong Liu, Yongsheng Zhou

Stem Cell Res Ther. 2021; 12: 383. Published online 2021 Jul 7. doi: 10.1186/s13287-021-02425-3

PMCID:: PMC8261971

Abstract Article PDF–2.7M

Select item 75033555.

Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema

Sandro Michelini, Pietro Chiurazzi, Valerio Marino, Daniele Dell’Orco, Elena Manara, Mirko Baglivo, Alessandro Fiorentino, Paolo Enrico Maltese, Michele Pinelli, Karen Louise Herbst, Astrit Dautaj, Matteo Bertelli

Int J Mol Sci. 2020 Sep; 21(17): 6264. Published online 2020 Aug 29. doi: 10.3390/ijms21176264

PMCID:: PMC7503355

Abstract Article PDF–1.4M

Select item 72941276.

Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells

Chen Zhou, Guowen Shen, Fan Yang, Jingling Duan, Zhen Wu, Mingqing Yang, Yi Liu, Xueli Du, Xiaoling Zhang, Shengjun Xiao

J Cell Mol Med. 2020 Jun; 24(11): 6438–6447. Published online 2020 Apr 19. doi: 10.1111/jcmm.15291

PMCID:: PMC7294127

Abstract Article PDF–1.8M

Select item 70191587.

The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer

Hong Zhu, Yan Hu, Chenming Zeng, Linlin Chang, Fujin Ge, Weihua Wang, Fangjie Yan, Qinxin Zhao, Ji Cao, Meidan Ying, Yongchuan Gu, Lin Zheng, Qiaojun He, Bo Yang

Theranostics. 2020; 10(5): 2188–2200. Published online 2020 Jan 12. doi: 10.7150/thno.39151

PMCID:: PMC7019158

Abstract Article PDF–2.1M

Select item 65588988.

AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang, Michael Hsiao

J Exp Clin Cancer Res. 2019; 38: 245. Published online 2019 Jun 10. doi: 10.1186/s13046-019-1256-2

PMCID:: PMC6558898

Abstract Article PDF–4.5M

Select item 57710859.

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer

Hong ZHU, Lin-Lin CHANG, Fang-Jie YAN, Yan HU, Chen-Ming ZENG, Tian-Yi ZHOU, Tao YUAN, Mei-Dan YING, Ji CAO, Qiao-Jun HE, Bo YANG

Theranostics. 2018; 8(3): 676–692. Published online 2018 Jan 1. doi: 10.7150/thno.21463

PMCID:: PMC5771085

Abstract Article PDF–4.0M

Select item 293927710.

Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors

Stephan Steckelbroeck, Dieter Lütjohann, David R. Bauman, Michael Ludwig, Anke Friedl, Volkmar H.J. Hans, Trevor M. Penning, Dietrich Klingmüller

Biochim Biophys Acta. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2010 Nov; 1801(11): 1221–1231. Published online 2010 Jul 29. doi: 10.1016/j.bbalip.2010.07.005

PMCID:: PMC2939277

Abstract Article PDF–811K

Select item 266505611.

Human Cytosolic Hydroxysteroid Dehydrogenases of the Aldo-ketoreductase Superfamily Catalyze Reduction of Conjugated Steroids: IMPLICATIONS FOR PHASE I AND PHASE II STEROID HORMONE METABOLISM

Yi Jin, Ling Duan, Seon Hwa Lee, Helenius J. Kloosterboer, Ian A. Blair, Trevor M. Penning

J Biol Chem. 2009 Apr 10; 284(15): 10013–10022. doi: 10.1074/jbc.M809465200

PMCID:: PMC2665056

Abstract Article PDF–563K

Select item 862362712.

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death

Nang Lae Lae Phoo, Pornngarm Dejkriengkraikul, Patompong Khaw-On, Supachai Yodkeeree

Int J Mol Sci. 2021 Nov; 22(22): 12512. Published online 2021 Nov 19. doi: 10.3390/ijms222212512

PMCID:: PMC8623627

Abstract Article PDF–6.5M

Select item 504813213.

Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells

Ryuji Matsumoto, Masumi Tsuda, Kazuhiko Yoshida, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Takashige Abe, Nobuo Shinohara, Katsuya Nonomura, Shinya Tanaka

Sci Rep. 2016; 6: 34625. Published online 2016 Oct 4. doi: 10.1038/srep34625

PMCID:: PMC5048132

Abstract Article PDF–1.4M

Select item 500830414.

The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death

Wei Li, Guixue Hou, Dianrong Zhou, Xiaomin Lou, Yang Xu, Siqi Liu, Xiaohang Zhao

Oncotarget. 2016 Apr 19; 7(16): 21542–21555. Published online 2016 Feb 27. doi: 10.18632/oncotarget.7775

PMCID:: PMC5008304

Abstract Article PDF–5.4M

Select item 301310615.

Modeling Single Nucleotide Polymorphisms in the Human AKR1C1 and AKR1C2 Genes: Implications for Functional and Genotyping Analyses

Jonathan W. Arthur, Juergen K. V. Reichardt

PLoS One. 2010; 5(12): e15604. Published online 2010 Dec 31. doi: 10.1371/journal.pone.0015604

PMCID:: PMC3013106

Abstract Article PDF–353K

Select item 113830616.

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

Y Deyashiki, A Ogasawara, T Nakayama, M Nakanishi, Y Miyabe, K Sato, A Hara

Biochem J. 1994 Apr 15; 299(Pt 2): 545–552. doi: 10.1042/bj2990545

PMCID:: PMC1138306

Summary Page Browse PDF–1.2M

Select item 688306617.

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

Mara Gagliardi, Diego Cotella, Claudio Santoro, Davide Corà, Nickolai A. Barlev, Mauro Piacentini, Marco Corazzari

Cell Death Dis. 2019 Dec; 10(12): 902. Published online 2019 Nov 28. doi: 10.1038/s41419-019-2143-7

PMCID:: PMC6883066

Abstract Article PDF–1.2M

Select item 448447918.

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

Huiyoung Yun, Jianping Xie, Aria F. Olumi, Rita Ghosh, Addanki P. Kumar

Oncotarget. 2015 May 10; 6(13): 11600–11613. Published online 2015 Mar 24. doi: 10.18632/oncotarget.3417

PMCID:: PMC4484479

Abstract Article PDF–2.7M

Select item 387046819.

Role of Aldo-Keto Reductase Family 1 (AKR1) Enzymes in Human Steroid Metabolism

Tea Lanišnik Rižner, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Steroids. 2014 Jan; 79: 10.1016/j.steroids.2013.10.012. Published online 2013 Nov 1. doi: 10.1016/j.steroids.2013.10.012