PMC Links for Gene (Select 16428) - PMC

Select item 85363611.

Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK

Michael P. Gallagher, James M. Conley, Pranitha Vangala, Manuel Garber, Andrea Reboldi, Leslie J. Berg

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2025825118. Published online 2021 Aug 27. doi: 10.1073/pnas.2025825118

PMCID:: PMC8536361

Select item 69931172.

Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection

Lu Huang, Kaixiong Ye, Michael C. McGee, Natalie F. Nidetz, Jessica P. Elmore, Candice B. Limper, Teresa L. Southard, David G. Russell, Avery August, Weishan Huang

Front Immunol. 2019; 10: 3103. Published online 2020 Jan 24. doi: 10.3389/fimmu.2019.03103

PMCID:: PMC6993117

Abstract Article PDF–2.2M

Select item 59568963.

An autoinhibitory role for the Pleckstrin Homology domain of ITK and its interplay with canonical phospholipid recognition

Sujan Devkota, Raji E. Joseph, Scott E. Boyken, D. Bruce Fulton, Amy H. Andreotti

Biochemistry. Author manuscript; available in PMC 2018 May 17.

Published in final edited form as: Biochemistry. 2017 Jun 13; 56(23): 2938–2949. Published online 2017 May 25. doi: 10.1021/acs.biochem.6b01182

PMCID:: PMC5956896

Abstract Article PDF–964K

Select item 57304064.

Requirement for Itk kinase activity for Th1, Th2, Th17 and iNKT cell cytokine production revealed by an allele sensitive mutant

Arun Kannan, YongChan Lee, Qian Qi, Weishan Huang, Ah-Reum Jeong, Sarah Ohnigian, Avery August

Eur J Immunol. Author manuscript; available in PMC 2017 Dec 14.

Published in final edited form as: Eur J Immunol. 2015 Aug; 45(8): 2276–2285. Published online 2015 Jun 10. doi: 10.1002/eji.201445087

PMCID:: PMC5730406

Abstract Article PDF–1.7M

Select item 47820635.

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

Julio Gomez-Rodriguez, Françoise Meylan, Robin Handon, Erika T. Hayes, Stacie M. Anderson, Martha R. Kirby, Richard M. Siegel, Pamela L. Schwartzberg

Nat Commun. 2016; 7: 10857. Published online 2016 Mar 3. doi: 10.1038/ncomms10857

PMCID:: PMC4782063

Abstract Article PDF–1.6M

Select item 43472426.

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Jason A. Dubovsky, Ryan Flynn, Jing Du, Bonnie K. Harrington, Yiming Zhong, Benjamin Kaffenberger, Carrie Yang, William H. Towns, Amy Lehman, Amy J. Johnson, Natarajan Muthusamy, Steven M. Devine, Samantha Jaglowski, Jonathan S. Serody, William J. Murphy, David H. Munn, Leo Luznik, Geoffrey R. Hill, Henry K. Wong, Kelli K.P. MacDonald, Ivan Maillard, John Koreth, Laurence Elias, Corey Cutler, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Angela Panoskaltsis-Mortari, John C. Byrd, Bruce R. Blazar

J Clin Invest. 2014 Nov 3; 124(11): 4867–4876. Published online 2014 Oct 1. doi: 10.1172/JCI75328

PMCID:: PMC4347242

Abstract Article PDF–1.3M

Select item 42871447.

Itk Signals Promote Neuroinflammation by Regulating CD4⁺ T-Cell Activation and Trafficking

Arun K. Kannan, Do-Geun Kim, Avery August, Margaret S. Bynoe

J Neurosci. 2015 Jan 7; 35(1): 221–233. doi: 10.1523/JNEUROSCI.1957-14.2015

Correction in:: J Neurosci. 2016 May 25; 36(21): 5904–5905.

PMCID:: PMC4287144

Abstract Article PDF–2.7M

Select item 41745198.

Characterisation of a K390R ITK Kinase Dead Transgenic Mouse – Implications for ITK as a Therapeutic Target

Angela Deakin, Graham Duddy, Steve Wilson, Steve Harrison, Judi Latcham, Mick Fulleylove, Sylvia Fung, Jason Smith, Mike Pedrick, Tom McKevitt, Leigh Felton, Joanne Morley, Diana Quint, Dilniya Fattah, Brian Hayes, Jade Gough, Roberto Solari

PLoS One. 2014; 9(9): e107490. Published online 2014 Sep 24. doi: 10.1371/journal.pone.0107490

PMCID:: PMC4174519

Abstract Article PDF–1.7M

Select item 30834889.

Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue

Raji E. Joseph, Amy H. Andreotti

Biochemistry. Author manuscript; available in PMC 2012 Jun 16.

Published in final edited form as: Biochemistry. 2011 Jan 18; 50(2): 221–229. Published online 2010 Dec 16. doi: 10.1021/bi101379m

PMCID:: PMC3083488

Abstract Article PDF–1.4M

Select item 306601710.

Disrupting the intermolecular self-association of Itk enhances T cell signaling

Lie Min, Wenfang Wu, Raji E. Joseph, D. Bruce Fulton, Leslie Berg, Amy H. Andreotti

J Immunol. Author manuscript; available in PMC 2011 Mar 29.

Published in final edited form as: J Immunol. 2010 Apr 15; 184(8): 4228–4235. Published online 2010 Mar 17. doi: 10.4049/jimmunol.0901908

PMCID:: PMC3066017

Abstract Article PDF–1.9M

Select item 286329411.

Murine Itk SH3 domain

Andrew Severin, D. Bruce Fulton, Amy H. Andreotti

J Biomol NMR. Author manuscript; available in PMC 2010 May 4.

Published in final edited form as: J Biomol NMR. 2008 Apr; 40(4): 285–290. Published online 2008 Mar 5. doi: 10.1007/s10858-008-9231-9

PMCID:: PMC2863294

Article PDF–1.0M

Select item 283693412.

Naïve and Innate Memory phenotype CD4⁺ T-cells have different requirements for active Itk for their development

Jianfang Hu, Avery August

J Immunol. Author manuscript; available in PMC 2010 Mar 11.

Published in final edited form as: J Immunol. 2008 May 15; 180(10): 6544–6552. doi: 10.4049/jimmunol.180.10.6544

PMCID:: PMC2836934

Abstract Article PDF–985K

Select item 281118113.

Itk Derived Signals Regulate the Expression of Th-POK and Controls the Development of CD4⁺ T Cells

Jianfang Hu, Qian Qi, Avery August

PLoS One. 2010; 5(1): e8891. Published online 2010 Jan 26. doi: 10.1371/journal.pone.0008891

PMCID:: PMC2811181

Abstract Article PDF–900K

Select item 271346514.

Enhanced development of CD4⁺ γδ T cells in the absence of Itk results in elevated IgE production

Qian Qi, Mingcan Xia, Jianfang Hu, Elizabeth Hicks, Archana Iyer, Na Xiong, Avery August

Blood. 2009 Jul 16; 114(3): 564–571. Prepublished online 2009 May 14. doi: 10.1182/blood-2008-12-196345

PMCID:: PMC2713465

Abstract Article

Select item 263657215.

Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells

M.E. Christine Lutsiak, Yutaka Tagaya, Anthony J. Adams, Jeffrey Schlom, Helen Sabzevari

J Immunol. Author manuscript; available in PMC 2009 May 1.

Published in final edited form as: J Immunol. 2008 May 1; 180(9): 5871–5881. doi: 10.4049/jimmunol.180.9.5871

PMCID:: PMC2636572

Abstract Article PDF–1.0M

Select item 221229816.

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

Karen-Qianye Liu, Stephen C. Bunnell, Christine B. Gurniak, Leslie J. Berg

J Exp Med. 1998 May 18; 187(10): 1721–1727. doi: 10.1084/jem.187.10.1721

PMCID:: PMC2212298

Abstract Article PDF–226K

Select item 120055817.

A role for the Tec family kinase ITK in regulating SEB induced Interleukin-2 production in vivo via c-jun phosphorylation

Melanie J Ragin, Jianfang Hu, Andrew J Henderson, Avery August

BMC Immunol. 2005; 6: 19. Published online 2005 Jul 22. doi: 10.1186/1471-2172-6-19

PMCID:: PMC1200558

Abstract Article PDF–426K

Select item 19206618.

Antiviral immune responses in Itk-deficient mice.

M F Bachmann, D R Littman, X C Liao

J Virol. 1997 Oct; 71(10): 7253–7257. doi: 10.1128/jvi.71.10.7253-7257.1997

PMCID:: PMC192066

Summary PDF–172K

Select item 4572519.

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

S D Heyeck, L J Berg

Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2): 669–673. doi: 10.1073/pnas.90.2.669

PMCID:: PMC45725

Summary Page Browse PDF–1.5M

Select item 4480920.

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

A August, S Gibson, Y Kawakami, T Kawakami, G B Mills, B Dupont

Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20): 9347–9351. doi: 10.1073/pnas.91.20.9347

PMCID:: PMC44809

Summary Page Browse PDF–1.3M

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