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Select item 38605901.

Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-loss Diets: the POUNDS LOST Trial

Min Xu, Qibin Qi, Jun Liang, George A. Bray, Frank B. Hu, Frank M. Sacks, Lu Qi

Circulation. Author manuscript; available in PMC 2014 Mar 26.

Published in final edited form as: Circulation. 2013 Mar 26; 127(12): 10.1161/CIRCULATIONAHA.112.000586. Published online 2013 Feb 27. doi: 10.1161/CIRCULATIONAHA.112.000586

PMCID:: PMC3860590

Abstract Article PDF–156K

Select item 18766812.

Identification of a novel PP2C-type mitochondrial phosphatase

Mandar Joshi, Nam Ho Jeoung, Kirill M. Popov, Robert A. Harris

Biochem Biophys Res Commun. Author manuscript; available in PMC 2007 May 24.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Apr 27; 356(1): 38–44. Published online 2007 Feb 28. doi: 10.1016/j.bbrc.2007.02.108

Correction in:: volume 361 on page 1061

PMCID:: PMC1876681

Abstract Article PDF–570K

Select item 99865183.

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome

Liangshan Mu, Zhenhong Ye, Junhao Hu, Yurong Zhang, Kai Chen, Haipeng Sun, Rong Li, Weian Mao, Xiaoyu Long, Chunmei Zhang, Yuchen Lai, Jun Liu, Yue Zhao, Jie Qiao

eBioMedicine. 2023 Mar; 89: 104492. Published online 2023 Feb 28. doi: 10.1016/j.ebiom.2023.104492

PMCID:: PMC9986518

Abstract Article PDF–3.9M

Select item 59904714.

The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase

Phillip J. White, Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan Haldeman, Thomas Grenier-Larouche, Jie An, Amanda L Lapworth, Inna Astapova, Sarah A. Hannou, Tabitha George, Michelle Arlotto, Lyra B. Olson, Michelle Lai, Guofang Zhang, Olga Ilkayeva, Mark A. Herman, R. Max Wynn, David T. Chuang, Christopher B. Newgard

Cell Metab. Author manuscript; available in PMC 2019 Jun 5.

Published in final edited form as: Cell Metab. 2018 Jun 5; 27(6): 1281–1293.e7. Published online 2018 May 17. doi: 10.1016/j.cmet.2018.04.015

PMCID:: PMC5990471

Abstract Article PDF–1.5M

Select item 33087985.

Structural and Biochemical Characterization of Human Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Phosphatase

R. Max Wynn, Jun Li, Chad A. Brautigam, Jacinta L. Chuang, David T. Chuang

J Biol Chem. 2012 Mar 16; 287(12): 9178–9192. Published online 2012 Jan 30. doi: 10.1074/jbc.M111.314963

PMCID:: PMC3308798

Abstract Article PDF–1.9M

Select item 83666586.

Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease

Wen Hu, Ziyu Liu, Weinan Yu, Surong Wen, Xiaoqing Wang, Xing Qi, Hairong Hao, Yanwen Lu, Jing Li, Shayan Li, Hongwen Zhou

Ann Med. 2021; 53(1): 1317–1327. Published online 2021 Aug 12. doi: 10.1080/07853890.2021.1965204

PMCID:: PMC8366658

Abstract Article PDF–1.4M

Select item 48162307.

Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells

Bang-fen Pan, Chen Gao, Shu-xun Ren, Yi-bin Wang, Hai-peng Sun, Mei-yi Zhou

Acta Pharmacol Sin. 2015 Dec; 36(12): 1480–1486. Published online 2015 Nov 23. doi: 10.1038/aps.2015.119

PMCID:: PMC4816230

Abstract Article PDF–1.1M

Select item 18385308.

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development

Gang Lu, Shuxun Ren, Paavo Korge, Jayoung Choi, Yuan Dong, James Weiss, Carla Koehler, Jau-nian Chen, Yibin Wang

Genes Dev. 2007 Apr 1; 21(7): 784–796. doi: 10.1101/gad.1499107

PMCID:: PMC1838530

Abstract Article PDF–1.1M

Select item 29860659.

Screening for replication of genome-wide SNP associations in sporadic ALS

Simon Cronin, Barbara Tomik, Daniel G Bradley, Agnieszka Slowik, Orla Hardiman

Eur J Hum Genet. 2009 Feb; 17(2): 213–218. Published online 2008 Nov 5. doi: 10.1038/ejhg.2008.194

PMCID:: PMC2986065

Abstract Article PDF–106K

Select item 438878410.

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Coffee and Caffeine Genetics Consortium, Marilyn C Cornelis, Enda M Byrne, Tõnu Esko, Michael A Nalls, Andrea Ganna, Nina Paynter, Keri L Monda, Najaf Amin, Krista Fischer, Frida Renstrom, Julius S Ngwa, Ville Huikari, Alana Cavadino, Ilja M Nolte, Alexander Teumer, Kai Yu, Pedro Marques-Vidal, Rajesh Rawal, Ani Manichaikul, Mary K Wojczynski, Jacqueline M Vink, Jing Hua Zhao, George Burlutsky, Jari Lahti, Vera Mikkilä, Rozenn N Lemaitre, Joel Eriksson, Solomon K Musani, Toshiko Tanaka, Frank Geller, Jian’an Luan, Jennie Hui, Reedik Mägi, Maria Dimitriou, Melissa E Garcia, Weang-Kee Ho, Margaret J Wright, Lynda M Rose, Patrik KE Magnusson, Nancy L Pedersen, David Couper, Ben A Oostra, Albert Hofman, Mohammad Arfan Ikram, Henning W Tiemeier, Andre G Uitterlinden, Frank JA van Rooij, Inês Barroso, Ingegerd Johansson, Luting Xue, Marika Kaakinen, Lili Milani, Chris Power, Harold Snieder, Ronald P Stolk, Sebastian E Baumeister, Reiner Biffar, Fangyi Gu, François Bastardot, Zoltán Kutalik, David R Jacobs, Jr, Nita G Forouhi, Evelin Mihailov, Lars Lind, Cecilia Lindgren, Karl Michaëlsson, Andrew Morris, Majken Jensen, Kay-Tee Khaw, Robert N Luben, Jie Jin Wang, Satu Männistö, Mia-Maria Perälä, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Dariush Mozaffarian, Kenneth Mukamal, Bruce M Psaty, Angela Döring, Andrew C Heath, Grant W Montgomery, Norbert Dahmen, Teresa Carithers, Katherine L Tucker, Luigi Ferrucci, Heather A Boyd, Mads Melbye, Jorien L Treur, Dan Mellström, Jouke Jan Hottenga, Inga Prokopenko, Anke Tönjes, Panos Deloukas, Stavroula Kanoni, Mattias Lorentzon, Denise K Houston, Yongmei Liu, John Danesh, Asif Rasheed, Marc A Mason, Alan B Zonderman, Lude Franke, Bruce S Kristal, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), UK Brain Expression Consortium (UKBEC), Juha Karjalainen, Danielle R Reed, Harm-Jan Westra, Michele K Evans, Danish Saleheen, Tamara B Harris, George Dedoussis, Gary Curhan, Michael Stumvoll, John Beilby, Louis R Pasquale, Bjarke Feenstra, Stefania Bandinelli, Jose M Ordovas, Andrew T Chan, Ulrike Peters, Claes Ohlsson, Christian Gieger, Nicholas G Martin, Melanie Waldenberger, David S Siscovick, Olli Raitakari, Johan G Eriksson, Paul Mitchell, David J Hunter, Peter Kraft, Eric B Rimm, Dorret I Boomsma, Ingrid B Borecki, Ruth JF Loos, Nicholas J Wareham, Peter Vollenweider, Neil Caporaso, Hans Jörgen Grabe, Marian L Neuhouser, Bruce HR Wolffenbuttel, Frank B Hu, Elina Hyppönen, Marjo-Riitta Järvelin, L Adrienne Cupples, Paul W Franks, Paul M Ridker, Cornelia M van Duijn, Gerardo Heiss, Andres Metspalu, Kari E North, Erik Ingelsson, Jennifer A Nettleton, Rob M van Dam, Daniel I Chasman

Mol Psychiatry. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mol Psychiatry. 2015 May; 20(5): 647–656. Published online 2014 Oct 7. doi: 10.1038/mp.2014.107

PMCID:: PMC4388784

Article PDF–511K

Select item 360503311.

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Johannes Kettunen, Taru Tukiainen, Antti-Pekka Sarin, Alfredo Ortega-Alonso, Emmi Tikkanen, Leo-Pekka Lyytikäinen, Antti J Kangas, Pasi Soininen, Peter Würtz, Kaisa Silander, Danielle M Dick, Richard J Rose, Markku J Savolainen, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Kirsi H Pietiläinen, Michael Inouye, Mark I McCarthy, Antti Jula, Johan Eriksson, Olli T Raitakari, Veikko Salomaa, Jaakko Kaprio, Marjo-Riitta Järvelin, Leena Peltonen, Markus Perola, Nelson B Freimer, Mika Ala-Korpela, Aarno Palotie, Samuli Ripatti

Nat Genet. Author manuscript; available in PMC 2013 Mar 21.

Published in final edited form as: Nat Genet. 2012 Jan 29; 44(3): 269–276. Published online 2012 Jan 29. doi: 10.1038/ng.1073

PMCID:: PMC3605033

Abstract Article PDF–1.8M

Select item 342092112.

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Michael Inouye, Samuli Ripatti, Johannes Kettunen, Leo-Pekka Lyytikäinen, Niku Oksala, Pirkka-Pekka Laurila, Antti J. Kangas, Pasi Soininen, Markku J. Savolainen, Jorma Viikari, Mika Kähönen, Markus Perola, Veikko Salomaa, Olli Raitakari, Terho Lehtimäki, Marja-Riitta Taskinen, Marjo-Riitta Järvelin, Mika Ala-Korpela, Aarno Palotie, Paul I. W. de Bakker

PLoS Genet. 2012 Aug; 8(8): e1002907. Published online 2012 Aug 16. doi: 10.1371/journal.pgen.1002907

PMCID:: PMC3420921

Abstract Article PDF–919K

Select item 460561013.

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome

Julianne H. Grose, Kelsey Langston, Xiaohui Wang, Shayne Squires, Soumyajit Banerjee Mustafi, Whitney Hayes, Jonathan Neubert, Susan K. Fischer, Matthew Fasano, Gina Moore Saunders, Qiang Dai, Elisabeth Christians, E. Douglas Lewandowski, Peipei Ping, Ivor J. Benjamin

PLoS One. 2015; 10(10): e0133994. Published online 2015 Oct 14. doi: 10.1371/journal.pone.0133994

PMCID:: PMC4605610

Abstract Article PDF–6.8M

Select item 406425414.

An atlas of genetic influences on human blood metabolites

So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo

Nat Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982

PMCID:: PMC4064254

Abstract Article PDF–2.4M

Select item 262894615.

Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication

Renate König, Yingyao Zhou, Daniel Elleder, Tracy L. Diamond, Ghislain M.C. Bonamy, Jeffrey T. Irelan, Chih-yuan Chiang, Buu P. Tu, Paul D. De Jesus, Caroline E. Lilley, Shannon Seidel, Amanda M. Opaluch, Jeremy S. Caldwell, Matthew D. Weitzman, Kelli L. Kuhen, Sourav Bandyopadhyay, Trey Ideker, Anthony P. Orth, Loren J. Miraglia, Frederic D. Bushman, John A. Young, Sumit K. Chanda

Cell. Author manuscript; available in PMC 2009 Oct 3.

Published in final edited form as: Cell. 2008 Oct 3; 135(1): 49–60. doi: 10.1016/j.cell.2008.07.032

PMCID:: PMC2628946

Abstract Article PDF–3.4M

Select item 499245616.

Mitochondrial protein interaction mapping identifies new regulators of respiratory chain function

Brendan J. Floyd, Emily M. Wilkerson, Mike T. Veling, Catie E. Minogue, Chuanwu Xia, Emily T. Beebe, Russell L. Wrobel, Holly Cho, Laura S. Kremer, Charlotte L. Alston, Katarzyna A. Gromek, Brendan K. Dolan, Arne Ulbrich, Jonathan A. Stefely, Sarah L. Bohl, Kelly M. Werner, Adam Jochem, Michael S. Westphall, Jarred W. Rensvold, Robert W. Taylor, Holger Prokisch, Jung-Ja P. Kim, Joshua J. Coon, David J. Pagliarini

Mol Cell. Author manuscript; available in PMC 2017 Aug 18.

Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 621–632. Published online 2016 Aug 4. doi: 10.1016/j.molcel.2016.06.033

PMCID:: PMC4992456

Abstract Article PDF–1.7M

Select item 566346517.

A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome

Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar

Mol Cell. Author manuscript; available in PMC 2017 Oct 31.

Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004

PMCID:: PMC5663465

Abstract Article PDF–2.1M

Select item 294347618.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 318838819.

Leveraging the power of next-generation sequencing to generate interactome datasets

Haiyuan Yu, Leah Tardivo, Stanley Tam, Evan Weiner, Fana Gebreab, Changyu Fan, Nenad Svrzikapa, Tomoko Hirozane-Kishikawa, Edward Rietman, Xinping Yang, Julie Sahalie, Kourosh Salehi-Ashtiani, Tong Hao, Michael E. Cusick, David E. Hill, Frederick P. Roth, Pascal Braun, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Methods. 2011 Jun; 8(6): 478–480. Published online 2011 Apr 24. doi: 10.1038/nmeth.1597

PMCID:: PMC3188388

Abstract Article PDF–932K

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

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