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Select item 112995061.

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis

Ashleigh R. Poh, Megan O’Brien, David Chisanga, Hong He, David Baloyan, Jasmin Traichel, Christine Dijkstra, Michaël Chopin, Stephen Nutt, Lachlan Whitehead, Louis Boon, Ashleigh Parkin, Clifford Lowell, Marina Pajic, Wei Shi, Mehrdad Nikfarjam, Matthias Ernst

Cell Rep. Author manuscript; available in PMC 2024 Aug 5.

Published in final edited form as: Cell Rep. 2022 Oct 11; 41(2): 111479. doi: 10.1016/j.celrep.2022.111479

PMCID:: PMC11299506

Abstract Article PDF–1.4M

Select item 84354562.

Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway

Weibo Liu, Teng Li, Wenhao Hu, Quanbo Ji, Fanqi Hu, Qi Wang, Xiaoqing Yang, Dengbin Qi, Hui Chen, Xuesong Zhang

J Cell Mol Med. 2021 Sep; 25(18): 8789–8795. Published online 2021 Aug 7. doi: 10.1111/jcmm.16836

PMCID:: PMC8435456

Abstract Article PDF–896K

Select item 71879073.

Genetic ablation of hematopoietic cell kinase accelerates Alzheimer’s disease-like neuropathology in Tg2576 mice

Siok Lam Lim, Diana Nguyen Tran, Zanett Kieu, Christine Chen, Emmanuel Villanueva, Sagar Ghiaar, Victoria Gallup, Joannee Zumkehr, David H. Cribbs, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa

Mol Neurobiol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Mol Neurobiol. 2020 May; 57(5): 2447–2460. Published online 2020 Mar 7. doi: 10.1007/s12035-020-01894-6

PMCID:: PMC7187907

Abstract Article PDF–1.9M

Select item 54077164.

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis

Chengguo Wei, Li Li, Madhav C. Menon, Weijia Zhang, Jia Fu, Brian Kidd, Karen L. Keung, Christopher Woytovich, Ilana Greene, Wenzhen Xiao, Fadi Salem, Zhengzi Yi, John Cijiang He, Joel T. Dudley, Barbara Murphy

J Am Soc Nephrol. 2017 May; 28(5): 1385–1393. Published online 2016 Dec 7. doi: 10.1681/ASN.2016020238

PMCID:: PMC5407716

Abstract Article

Select item 50707145.

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis

Céline Cougoule, Véronique Le Cabec, Renaud Poincloux, Talal Al Saati, Jean-Louis Mège, Guillaume Tabouret, Clifford A. Lowell, Nathalie Laviolette-Malirat, Isabelle Maridonneau-Parini

Blood. 2010 Feb 18; 115(7): 1444–1452. Prepublished online 2009 Sep 6. doi: 10.1182/blood-2009-04-218735

Correction in:: Blood. 2010 Sep 23; 116(12): 2195.

PMCID:: PMC5070714

Abstract Article

Select item 40461686.

Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors

Christel Vérollet, Anne Gallois, Romain Dacquin, Claire Lastrucci, Subramanya N. M. Pandruvada, Nathalie Ortega, Renaud Poincloux, Annie Behar, Céline Cougoule, Clifford Lowell, Talal Al Saati, Pierre Jurdic, Isabelle Maridonneau-Parini

FASEB J. 2013 Sep; 27(9): 3608–3618. doi: 10.1096/fj.13-232736

PMCID:: PMC4046168

Abstract Article

Select item 21939967.

Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response

Matthias Ernst, Melissa Inglese, Glen M. Scholz, Kenneth W. Harder, Fiona J. Clay, Steven Bozinovski, Paul Waring, Rima Darwiche, Tom Kay, Peter Sly, Rachel Collins, Debra Turner, Margaret L. Hibbs, Gary P. Anderson, Ashley R. Dunn

J Exp Med. 2002 Sep 2; 196(5): 589–604. doi: 10.1084/jem.20020873

PMCID:: PMC2193996

Abstract Article PDF–844K

Select item 3610498.

Functional analysis and nucleotide sequence of the promoter region of the murine hck gene.

P Lock, E Stanley, D A Holtzman, A R Dunn

Mol Cell Biol. 1990 Sep; 10(9): 4603–4611. doi: 10.1128/mcb.10.9.4603

PMCID:: PMC361049

Summary Page Browse PDF–2.0M

Select item 3064939.

Nucleotide sequence of the mouse hck gene.

M J Klemsz, S R McKercher, R A Maki

Nucleic Acids Res. 1987 Nov 25; 15(22): 9600. doi: 10.1093/nar/15.22.9600

PMCID:: PMC306493

Summary Page Browse PDF–123K

Select item 29953510.

Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.

D A Holtzman, W D Cook, A R Dunn

Proc Natl Acad Sci U S A. 1987 Dec; 84(23): 8325–8329. doi: 10.1073/pnas.84.23.8325

PMCID:: PMC299535

Summary Page Browse PDF–1.1M

Select item 13105911.

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells

Agata Klejman, Steven J. Schreiner, Malgorzata Nieborowska-Skorska, Artur Slupianek, Matthew Wilson, Thomas E. Smithgall, Tomasz Skorski

EMBO J. 2002 Nov 1; 21(21): 5766–5774. doi: 10.1093/emboj/cdf562

PMCID:: PMC131059

Abstract Article PDF–230K

Select item 11514112.

Role of Hck in the Pathogenesis of Encephalomyocarditis Virus-Induced Diabetes in Mice

K. S. Choi, H. S. Jun, H. N. Kim, H. J. Park, Y. W. Eom, H. L. Noh, H. Kwon, H. M. Kim, J. W. Yoon

J Virol. 2001 Feb; 75(4): 1949–1957. doi: 10.1128/JVI.75.4.1949-1957.2001

PMCID:: PMC115141

Abstract Article PDF–2.0M

Select item 1035407513.

HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

Man Chen, Madhav C. Menon, Wenlin Wang, Jia Fu, Zhengzi Yi, Zeguo Sun, Jessica Liu, Zhengzhe Li, Lingyun Mou, Khadija Banu, Sui-Wan Lee, Ying Dai, Nanditha Anandakrishnan, Evren U. Azeloglu, Kyung Lee, Weijia Zhang, Bhaskar Das, John Cijiang He, Chengguo Wei

Nat Commun. 2023; 14: 4297. Published online 2023 Jul 18. doi: 10.1038/s41467-023-40086-3

PMCID:: PMC10354075

Abstract Article PDF–8.1M

Select item 806458814.

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

Ashleigh R. Poh, Amy R. Dwyer, Moritz F. Eissmann, Ashwini L. Chand, David Baloyan, Louis Boon, Michael W. Murrey, Lachlan Whitehead, Megan O'Brien, Clifford A. Lowell, Tracy L. Putoczki, Fiona J. Pixley, Robert J.J. O'Donoghue, Matthias Ernst

Cancer Immunol Res. Author manuscript; available in PMC 2021 Apr 23.

Published in final edited form as: Cancer Immunol Res. 2020 Apr; 8(4): 428–435. Published online 2020 Jan 28. doi: 10.1158/2326-6066.CIR-19-0623

PMCID:: PMC8064588

Abstract Article PDF–1.1M

Select item 664569015.

Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer’s disease-like neuropathology

Siok Lam Lim, Diana Nguyen Tran, Joannee Zumkehr, Christine Chen, Sagar Ghiaar, Zanett Kieu, Emmanuel Villanueva, Victoria Gallup, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa

Glia. Author manuscript; available in PMC 2019 Jul 22.

Published in final edited form as: Glia. 2018 Dec; 66(12): 2700–2718. Published online 2018 Sep 12. doi: 10.1002/glia.23522

PMCID:: PMC6645690

Abstract Article PDF–3.5M

Select item 650553516.

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N. MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J. Campbell, Louise E. Purton, Harshal Nandurkar

Sci Rep. 2019; 9: 7050. Published online 2019 May 7. doi: 10.1038/s41598-019-43373-6

PMCID:: PMC6505535

Abstract Article PDF–2.8M

Select item 610366117.

Suppression of autophagy and HCK signaling promotes PTGS2^high FCGR3⁻ NK cell differentiation triggered by ectopic endometrial stromal cells

Jie Mei, Wen-Jie Zhou, Xiao-Yong Zhu, Han Lu, Ke Wu, Hui-Li Yang, Qiang Fu, Chun-Yan Wei, Kai-Kai Chang, Li-Ping Jin, Jian Wang, Yong-Ming Wang, Da-Jin Li, Ming-Qing Li

Autophagy. 2018; 14(8): 1376–1397. Published online 2018 Jul 20. doi: 10.1080/15548627.2018.1476809